Maytansinol (1) is the common precursor of maytansinoids (2), which are the 3-0-acyl derivatives of 1 and generally show antitumor activities in animal trials.Maytansinol 1 has been obtained in quantity by means of fe...Maytansinol (1) is the common precursor of maytansinoids (2), which are the 3-0-acyl derivatives of 1 and generally show antitumor activities in animal trials.Maytansinol 1 has been obtained in quantity by means of fermentation and converted synthetically into maytansinoids by Japanese investigators. The novel and complicated structure of 1 was looked upon as a challenge to synthetic chemists.展开更多
Brassinolide (1) is a highly active plant growth+promoting agent. Its structure was determined by X-ray crystallography by Grove and co-workers in 1979. A number of papers related to the synthesis of 1 and its analogs...Brassinolide (1) is a highly active plant growth+promoting agent. Its structure was determined by X-ray crystallography by Grove and co-workers in 1979. A number of papers related to the synthesis of 1 and its analogs have been published. The construction of the A/B ring system and the stereoselective construction of the four展开更多
文摘Maytansinol (1) is the common precursor of maytansinoids (2), which are the 3-0-acyl derivatives of 1 and generally show antitumor activities in animal trials.Maytansinol 1 has been obtained in quantity by means of fermentation and converted synthetically into maytansinoids by Japanese investigators. The novel and complicated structure of 1 was looked upon as a challenge to synthetic chemists.
文摘Brassinolide (1) is a highly active plant growth+promoting agent. Its structure was determined by X-ray crystallography by Grove and co-workers in 1979. A number of papers related to the synthesis of 1 and its analogs have been published. The construction of the A/B ring system and the stereoselective construction of the four
