发育性髋关节脱位(development dislocation of the hip, DDH),是在髋关节发育不良的基础上,伴有或不伴有股骨头脱位或半脱位于髋臼之外的下肢畸形。其病理改变不同可能会导致严重程度不一的早期骨关节炎(osteoarthritis, OA)。DDH的一...发育性髋关节脱位(development dislocation of the hip, DDH),是在髋关节发育不良的基础上,伴有或不伴有股骨头脱位或半脱位于髋臼之外的下肢畸形。其病理改变不同可能会导致严重程度不一的早期骨关节炎(osteoarthritis, OA)。DDH的一个重要病理变化是关节软骨的退化及退变,但目前关于DDH软骨退变的机制尚未明确。一些研究发现软骨细胞的自噬与骨关节炎密切相关,其中PI3K/AKT信号通路可以促进软骨细胞增殖,并且抑制软骨细胞自噬。本文旨在探讨PI3K/AKT信号通路对软骨细胞自噬的调控作用,为DDH后期的诊疗提供新的思路。展开更多
The shear-horizontal(SH) waves excited by the shear source in a borehole are easy to analyze due to the simple waveform. The borehole-side structures make the formation properties discontinuous. We consider a cylindri...The shear-horizontal(SH) waves excited by the shear source in a borehole are easy to analyze due to the simple waveform. The borehole-side structures make the formation properties discontinuous. We consider a cylindrical double layer structure and study the borehole shear-horizontal and transverse-electric(SH-TE) seismoelectric waves. We first derive the expressions of the basic field quantities, and simulate the acoustic field and electric field using the real axis integral method. Compared with the wave fields of an infinitely homogeneous porous medium outside the borehole, the cylindrical layered structure makes the multi-mode cylindrical Love waves and their accompanying electric fields excited.Next, in order to study the interface response law of the inducing electric fields, we use the secant integral method to calculate the interface converted electromagnetic waves and analyze the causes of each component. It is found that an interface response occurs each time the SH wave impinges the interface in the layered porous medium. The results show that the SH-TE mode has a potential application for borehole-side interface detection in geophysical logs.展开更多
文摘发育性髋关节脱位(development dislocation of the hip, DDH),是在髋关节发育不良的基础上,伴有或不伴有股骨头脱位或半脱位于髋臼之外的下肢畸形。其病理改变不同可能会导致严重程度不一的早期骨关节炎(osteoarthritis, OA)。DDH的一个重要病理变化是关节软骨的退化及退变,但目前关于DDH软骨退变的机制尚未明确。一些研究发现软骨细胞的自噬与骨关节炎密切相关,其中PI3K/AKT信号通路可以促进软骨细胞增殖,并且抑制软骨细胞自噬。本文旨在探讨PI3K/AKT信号通路对软骨细胞自噬的调控作用,为DDH后期的诊疗提供新的思路。
基金Project supported by the Natural Science Foundation of Jilin Province of China(Grant No.20180101282JC)the National Natural Science Foundation of China(Grant Nos.40974067 and 42074139)。
文摘The shear-horizontal(SH) waves excited by the shear source in a borehole are easy to analyze due to the simple waveform. The borehole-side structures make the formation properties discontinuous. We consider a cylindrical double layer structure and study the borehole shear-horizontal and transverse-electric(SH-TE) seismoelectric waves. We first derive the expressions of the basic field quantities, and simulate the acoustic field and electric field using the real axis integral method. Compared with the wave fields of an infinitely homogeneous porous medium outside the borehole, the cylindrical layered structure makes the multi-mode cylindrical Love waves and their accompanying electric fields excited.Next, in order to study the interface response law of the inducing electric fields, we use the secant integral method to calculate the interface converted electromagnetic waves and analyze the causes of each component. It is found that an interface response occurs each time the SH wave impinges the interface in the layered porous medium. The results show that the SH-TE mode has a potential application for borehole-side interface detection in geophysical logs.
