目的:探讨脂蛋白相关磷脂酶A2 (lipoprotein-associated phospholipase A2,下称磷脂酶A2)与甘油三酯葡萄糖指数(Triglyceride-Glucose index,下称TyG指数)、甘油三酯葡萄糖身体质量指数(Triglyceride-Glucose-Body Mass Index,下称TyG-B...目的:探讨脂蛋白相关磷脂酶A2 (lipoprotein-associated phospholipase A2,下称磷脂酶A2)与甘油三酯葡萄糖指数(Triglyceride-Glucose index,下称TyG指数)、甘油三酯葡萄糖身体质量指数(Triglyceride-Glucose-Body Mass Index,下称TyG-BMI)与合并2型糖尿病的慢性冠状动脉综合征(Chronic Coronary Syndrome,下称CCS)患者冠状动脉Gensini评分及主要心血管不良事件(Major Cardiovascular Advertise Events,下称MACEs)的相关性。方法:回顾性收集2021年10月至2022年10月在青岛大学附属医院诊治的289例行非急症冠状动脉造影的2型糖尿病患者作为研究对象,按Gensini评分分为对照(非CCS)组69例(Gensini积分 = 0分)、低积分组77例(2.5分 ≤ Gensini积分 P P P P Objective: To explore the correlation of lipoprotein-associated phospholipase A2 (hereinafter referred to as phospholipase A2) on Triglyceride-Glucose index (hereinafter referred to as TyG index) and Triglyceride-Glucose-Body Mass Index (hereinafter referred to as TyG-BMI) in coronary Gensini score and Major Adverse Cardiovascular Events (hereinafter referred to as MACEs) in Chronic Coronary Syndrome (hereinafter referred to as CCS) patients combined with type 2 diabetes mellitus. Methods: 289 patients with type 2 diabetes mellitus who underwent non-emergency coronary angiography in the Affiliated Hospital of Qingdao University from October 2021 to October 2022 were retrospectively collected as study objects, and according to Gensini scores, there were 69 cases in the observation (non-CCS) group (Gensini score = 0), 77 cases in the low score group (2.5 points ≤ Gensini score P P P P < 0.05). ROC curve analysis showed that the areas under the ROC curve plotted with the combined application of serum phospholipase A2 and TyG index and TyG-BMI were 0.767 (95%CI 0.704~0.831) and 0.789 (95%CI 0.727~0.851), respectively. Phospholipase A2 combined with TyG index predicted the highest value of MACEs in CCS patients. Multi-factor Cox proportional risk model showed that changes in serum phospholipase A2 level and TyG index may be influencing factors for major cardiovascular adverse events in CCS patients with diabetes mellitus. Conclusion: Serum phospholipase A2 and TyG index are risk factors for the increase of coronary Gensini score, and the combination of phospholipase A2 and TyG index and TyG-BMI may have a certain predictive value for the occurrence of major cardiovascular adverse events in CCS patients combined with type 2 diabetes mellitus.展开更多
文摘目的:探讨脂蛋白相关磷脂酶A2 (lipoprotein-associated phospholipase A2,下称磷脂酶A2)与甘油三酯葡萄糖指数(Triglyceride-Glucose index,下称TyG指数)、甘油三酯葡萄糖身体质量指数(Triglyceride-Glucose-Body Mass Index,下称TyG-BMI)与合并2型糖尿病的慢性冠状动脉综合征(Chronic Coronary Syndrome,下称CCS)患者冠状动脉Gensini评分及主要心血管不良事件(Major Cardiovascular Advertise Events,下称MACEs)的相关性。方法:回顾性收集2021年10月至2022年10月在青岛大学附属医院诊治的289例行非急症冠状动脉造影的2型糖尿病患者作为研究对象,按Gensini评分分为对照(非CCS)组69例(Gensini积分 = 0分)、低积分组77例(2.5分 ≤ Gensini积分 P P P P Objective: To explore the correlation of lipoprotein-associated phospholipase A2 (hereinafter referred to as phospholipase A2) on Triglyceride-Glucose index (hereinafter referred to as TyG index) and Triglyceride-Glucose-Body Mass Index (hereinafter referred to as TyG-BMI) in coronary Gensini score and Major Adverse Cardiovascular Events (hereinafter referred to as MACEs) in Chronic Coronary Syndrome (hereinafter referred to as CCS) patients combined with type 2 diabetes mellitus. Methods: 289 patients with type 2 diabetes mellitus who underwent non-emergency coronary angiography in the Affiliated Hospital of Qingdao University from October 2021 to October 2022 were retrospectively collected as study objects, and according to Gensini scores, there were 69 cases in the observation (non-CCS) group (Gensini score = 0), 77 cases in the low score group (2.5 points ≤ Gensini score P P P P < 0.05). ROC curve analysis showed that the areas under the ROC curve plotted with the combined application of serum phospholipase A2 and TyG index and TyG-BMI were 0.767 (95%CI 0.704~0.831) and 0.789 (95%CI 0.727~0.851), respectively. Phospholipase A2 combined with TyG index predicted the highest value of MACEs in CCS patients. Multi-factor Cox proportional risk model showed that changes in serum phospholipase A2 level and TyG index may be influencing factors for major cardiovascular adverse events in CCS patients with diabetes mellitus. Conclusion: Serum phospholipase A2 and TyG index are risk factors for the increase of coronary Gensini score, and the combination of phospholipase A2 and TyG index and TyG-BMI may have a certain predictive value for the occurrence of major cardiovascular adverse events in CCS patients combined with type 2 diabetes mellitus.
