目的:探讨分析新型冠状病毒肺炎(COVID-19)成人患者合并肺炎支原体感染的临床特征。方法:回顾性分析2020年1月至3月,鄂州市中心医院收治的COVID-19患者,将入院后完成肺炎支原体血清学检测的患者纳入研究,分为合并支原体感染组(MP组)和...目的:探讨分析新型冠状病毒肺炎(COVID-19)成人患者合并肺炎支原体感染的临床特征。方法:回顾性分析2020年1月至3月,鄂州市中心医院收治的COVID-19患者,将入院后完成肺炎支原体血清学检测的患者纳入研究,分为合并支原体感染组(MP组)和未合并肺炎支原体感染组(MONO组),比较两组一般情况、发病时症状、实验室检查结果、胸部CT影像、主要治疗及预后情况。结果:共纳入了符合条件的356例患者,80例(22.5%)合并肺炎支原体感染,与MONO组相比,MP组平均年龄明显小于MONO组(47 vs.55岁,P=0.003),且女性明显多于男性(65%vs.35%,P=0.001),肌肉酸痛症状发生率高(OR=2.46,95%CI:1.02~5.91,P=0.044),两组患者的基础疾病、胸部CT影像、临床分型和预后方面差异无统计学意义;对年龄≥65岁的老年患者亚组分析显示,与MONO组相比,MP组D-二聚体水平升高(P=0.04)、应用机械通气的比例增加(P=0.031)、住院时间明显延长(28 d vs.21.5 d,P=0.045)。结论:COVID-19合并肺炎支原体感染不少见,年轻者、女性易合并感染,合并感染会延长老年患者的住院时间。展开更多
Intravenous and intratracheal implantation of mesenchymal stem cells (MSCs) may offer ameliorating effects on pulmonary hypertension (PH) induced by monocrotaline (MCT) in rats. The aim of this study was to examine th...Intravenous and intratracheal implantation of mesenchymal stem cells (MSCs) may offer ameliorating effects on pulmonary hypertension (PH) induced by monocrotaline (MCT) in rats. The aim of this study was to examine the anti-remodeling effect of intravenous MSCs (VMSCs) and intratracheal MSCs (TMSCs) in rats with PH, and the underlying mechanisms. MSCs were isolated from rat bone marrow and cultured. PH was induced in rats by intraperitoneal injection of MCT. One week after MCT administration, the rats were divided into 3 groups in terms of different treatments: VMSCs group (intravenous injection of MSCs), TMSCs group (intratracheal injection of MSCs), PH group (no treatment given). Those receiving saline instead of MCT served as negative control (control group). Pulmonary arterial structure was pathologically observed, pulmonary arterial dynamics measured, and remodeling-associated cytokines Smad2 and Smad3 detected in the lungs, three weeks after MCT injection. The results showed that PH group versus control group had higher pulmonary arterial pressure (PAP) and wall thickness index (WTI) 21 days after MCT treatment. The expression of phosphorylated (p)-Smad2 and the ratio of p-Smad2/Smad2 were much higher in PH group than in control group. Fluorescence-labeled MSCs were extensively distributed in rats' lungs in VMSCs and TMSCs groups 3 and 14 days after transplantation, but not found in the media of the pulmonary artery. WTI and PAP were significantly lower in both VMSCs and TMSCs groups than in PH group three weeks after MCT injection. The p-Smad2 expression and the ratio of p-Smad2/Smad2 were obviously reduced in VMSCs and TMSCs groups as compared with those in PH group. In conclusion, both intravenous and intratracheal transplantation of MSCs can attenuate PAP and pulmonary artery remodeling in MCT-induced PH rats, which may be associated with the early suppression of Smad2 phosphorylation via paracrine pathways.展开更多
Objective To analyze the effects of proton pump inhibitors (PPIs) on the prevention of stress ulcers (SU)in elderly patients with acute respiratory distress syndrome (ARDS),and to analyze related factors for the risk ...Objective To analyze the effects of proton pump inhibitors (PPIs) on the prevention of stress ulcers (SU)in elderly patients with acute respiratory distress syndrome (ARDS),and to analyze related factors for the risk of short-term death.Methods This study was amulticenter retrospective cohort study.展开更多
文摘目的:探讨分析新型冠状病毒肺炎(COVID-19)成人患者合并肺炎支原体感染的临床特征。方法:回顾性分析2020年1月至3月,鄂州市中心医院收治的COVID-19患者,将入院后完成肺炎支原体血清学检测的患者纳入研究,分为合并支原体感染组(MP组)和未合并肺炎支原体感染组(MONO组),比较两组一般情况、发病时症状、实验室检查结果、胸部CT影像、主要治疗及预后情况。结果:共纳入了符合条件的356例患者,80例(22.5%)合并肺炎支原体感染,与MONO组相比,MP组平均年龄明显小于MONO组(47 vs.55岁,P=0.003),且女性明显多于男性(65%vs.35%,P=0.001),肌肉酸痛症状发生率高(OR=2.46,95%CI:1.02~5.91,P=0.044),两组患者的基础疾病、胸部CT影像、临床分型和预后方面差异无统计学意义;对年龄≥65岁的老年患者亚组分析显示,与MONO组相比,MP组D-二聚体水平升高(P=0.04)、应用机械通气的比例增加(P=0.031)、住院时间明显延长(28 d vs.21.5 d,P=0.045)。结论:COVID-19合并肺炎支原体感染不少见,年轻者、女性易合并感染,合并感染会延长老年患者的住院时间。
文摘Intravenous and intratracheal implantation of mesenchymal stem cells (MSCs) may offer ameliorating effects on pulmonary hypertension (PH) induced by monocrotaline (MCT) in rats. The aim of this study was to examine the anti-remodeling effect of intravenous MSCs (VMSCs) and intratracheal MSCs (TMSCs) in rats with PH, and the underlying mechanisms. MSCs were isolated from rat bone marrow and cultured. PH was induced in rats by intraperitoneal injection of MCT. One week after MCT administration, the rats were divided into 3 groups in terms of different treatments: VMSCs group (intravenous injection of MSCs), TMSCs group (intratracheal injection of MSCs), PH group (no treatment given). Those receiving saline instead of MCT served as negative control (control group). Pulmonary arterial structure was pathologically observed, pulmonary arterial dynamics measured, and remodeling-associated cytokines Smad2 and Smad3 detected in the lungs, three weeks after MCT injection. The results showed that PH group versus control group had higher pulmonary arterial pressure (PAP) and wall thickness index (WTI) 21 days after MCT treatment. The expression of phosphorylated (p)-Smad2 and the ratio of p-Smad2/Smad2 were much higher in PH group than in control group. Fluorescence-labeled MSCs were extensively distributed in rats' lungs in VMSCs and TMSCs groups 3 and 14 days after transplantation, but not found in the media of the pulmonary artery. WTI and PAP were significantly lower in both VMSCs and TMSCs groups than in PH group three weeks after MCT injection. The p-Smad2 expression and the ratio of p-Smad2/Smad2 were obviously reduced in VMSCs and TMSCs groups as compared with those in PH group. In conclusion, both intravenous and intratracheal transplantation of MSCs can attenuate PAP and pulmonary artery remodeling in MCT-induced PH rats, which may be associated with the early suppression of Smad2 phosphorylation via paracrine pathways.
文摘Objective To analyze the effects of proton pump inhibitors (PPIs) on the prevention of stress ulcers (SU)in elderly patients with acute respiratory distress syndrome (ARDS),and to analyze related factors for the risk of short-term death.Methods This study was amulticenter retrospective cohort study.
