背景:本研究探讨了内脏肥胖指数与美国高血压患病率之间的关系。研究方法:这项横断面研究使用了美国国家健康与营养调查(national health and nutrition examination survey, NHANES)的数据,该调查在2007年至2018年期间连续进行了六次,...背景:本研究探讨了内脏肥胖指数与美国高血压患病率之间的关系。研究方法:这项横断面研究使用了美国国家健康与营养调查(national health and nutrition examination survey, NHANES)的数据,该调查在2007年至2018年期间连续进行了六次,每次为期两年。研究采用多变量逻辑回归和平滑曲线拟合技术,分别研究了高血压患病率与内脏脂肪指数(visceral adiposity index, VAI)之间的关系。利用亚组分析和交互检验对二者之间关系的稳定性进行了检验。结果:在28,743名参与者中,有12,405人患有高血压,16,338人不患有高血压。在对所有协变量进行调整后,VAI与高血压患病率呈显著正相关[OR = 1.07, 95% CI = 1.06~1.08;P Background: This research examined the connection between the visceral obesity index and the prevalence of hypertension in the United States. Methods: This cross-sectional research used data from the National Health and Nutrition Examination Survey (NHANES), conducted in six consecutive two-year cycles between 2007 and 2018. The study employed multivariable logistic regression and smoothing curve fitting techniques to investigate the relationship between the prevalence of hypertension and the visceral adiposity index (VAI), respectively. The stability of the association between them was tested utilizing subgroup analysis and interaction tests. Results: Of the 28,743 participants, 12,405 had hypertension and 16,338 did not. After adjusting for all covariates, VAI was significantly and positively associated with the prevalence of hypertension [odd ratio (OR) = 1.07, 95% confidence interval (CI) 1.06~1.08;P-value < 0.0001] and remained stable after converting VAI to a categorical variable. Subgroup analyses revealed a greater correlation between VAI and the prevalence of hypertension among participants who were female, aged 20~39, without diabetes, or smoked a small number of cigarettes. Conclusions: Higher VAI scores and a greater prevalence of hypertension seem to be correlated. Reducing visceral fat may help reduce the prevalence of hypertension.展开更多
目的探讨机械通气对重症肺部感染患者的可溶性髓样细胞触发受体-1(soluble triggering receptorexpressed on myeloid cell-1,sTREM-1)及肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)影响及其临床价值。方法选...目的探讨机械通气对重症肺部感染患者的可溶性髓样细胞触发受体-1(soluble triggering receptorexpressed on myeloid cell-1,sTREM-1)及肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)影响及其临床价值。方法选取42例肺部感染并给予有创机械通气的住院患者,观察机械通气前及通气后第1、3、6、9、12天的临床指标变化;同时采用ELISA检测血sTREM-1、TNF-α、IL-6、IL-1β水平。另以健康同龄人作为对照组。结果肺部感染患者血中sTREM-1、TNF-α、IL-6、IL-1β均高于健康对照组(P<0.01),但上述指标在肺部感染患者之间差异无统计学意义(P>0.05)。肺部感染患者机械通气前后24 h sTREM-1差异无统计学意义(P>0.05),TNF-α、IL-6、IL-1β有所升高(P<0.05)。在预后不良者中临床指标好转不明显或有所恶化,且sTREM-1、TNF-α、IL-6、IL-1β有明显上升趋势(P<0.01);在预后良好者中临床指标明显好转,sTREM-1水平稳定或轻度下降,TNF-α、IL-6、IL-1β下降较明显(P<0.05)。结论肺部感染、机械通气可引起TNF-α、IL-6、IL-1β升高,但sTREM-1受肺部感染的影响,机械通气对其无影响。上述炎症介质水平对需机械通气的重症肺部感染患者有相对独立的预后评价意义。展开更多
文摘背景:本研究探讨了内脏肥胖指数与美国高血压患病率之间的关系。研究方法:这项横断面研究使用了美国国家健康与营养调查(national health and nutrition examination survey, NHANES)的数据,该调查在2007年至2018年期间连续进行了六次,每次为期两年。研究采用多变量逻辑回归和平滑曲线拟合技术,分别研究了高血压患病率与内脏脂肪指数(visceral adiposity index, VAI)之间的关系。利用亚组分析和交互检验对二者之间关系的稳定性进行了检验。结果:在28,743名参与者中,有12,405人患有高血压,16,338人不患有高血压。在对所有协变量进行调整后,VAI与高血压患病率呈显著正相关[OR = 1.07, 95% CI = 1.06~1.08;P Background: This research examined the connection between the visceral obesity index and the prevalence of hypertension in the United States. Methods: This cross-sectional research used data from the National Health and Nutrition Examination Survey (NHANES), conducted in six consecutive two-year cycles between 2007 and 2018. The study employed multivariable logistic regression and smoothing curve fitting techniques to investigate the relationship between the prevalence of hypertension and the visceral adiposity index (VAI), respectively. The stability of the association between them was tested utilizing subgroup analysis and interaction tests. Results: Of the 28,743 participants, 12,405 had hypertension and 16,338 did not. After adjusting for all covariates, VAI was significantly and positively associated with the prevalence of hypertension [odd ratio (OR) = 1.07, 95% confidence interval (CI) 1.06~1.08;P-value < 0.0001] and remained stable after converting VAI to a categorical variable. Subgroup analyses revealed a greater correlation between VAI and the prevalence of hypertension among participants who were female, aged 20~39, without diabetes, or smoked a small number of cigarettes. Conclusions: Higher VAI scores and a greater prevalence of hypertension seem to be correlated. Reducing visceral fat may help reduce the prevalence of hypertension.
文摘目的探讨机械通气对重症肺部感染患者的可溶性髓样细胞触发受体-1(soluble triggering receptorexpressed on myeloid cell-1,sTREM-1)及肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)影响及其临床价值。方法选取42例肺部感染并给予有创机械通气的住院患者,观察机械通气前及通气后第1、3、6、9、12天的临床指标变化;同时采用ELISA检测血sTREM-1、TNF-α、IL-6、IL-1β水平。另以健康同龄人作为对照组。结果肺部感染患者血中sTREM-1、TNF-α、IL-6、IL-1β均高于健康对照组(P<0.01),但上述指标在肺部感染患者之间差异无统计学意义(P>0.05)。肺部感染患者机械通气前后24 h sTREM-1差异无统计学意义(P>0.05),TNF-α、IL-6、IL-1β有所升高(P<0.05)。在预后不良者中临床指标好转不明显或有所恶化,且sTREM-1、TNF-α、IL-6、IL-1β有明显上升趋势(P<0.01);在预后良好者中临床指标明显好转,sTREM-1水平稳定或轻度下降,TNF-α、IL-6、IL-1β下降较明显(P<0.05)。结论肺部感染、机械通气可引起TNF-α、IL-6、IL-1β升高,但sTREM-1受肺部感染的影响,机械通气对其无影响。上述炎症介质水平对需机械通气的重症肺部感染患者有相对独立的预后评价意义。
