目的:分析糖尿病视网膜病变(diabetic retinopathy,DR)患者的生活质量(quality of life,QOL)及其影响因素。方法:分别采用一般情况问卷、视功能损害眼病患者生活质量量表(scale of quality of life in patients with visual impairment,...目的:分析糖尿病视网膜病变(diabetic retinopathy,DR)患者的生活质量(quality of life,QOL)及其影响因素。方法:分别采用一般情况问卷、视功能损害眼病患者生活质量量表(scale of quality of life in patients with visual impairment,SQQL-VI)和社会支持评定量表对103例DR患者进行问卷调查。采用向后逐步多重线性回归分析法分析年龄、性别、文化程度及社会支持度等因素对DR患者生活质量的影响。结果:DR患者的SQQL-VI量表中总生活质量评分为63.59±9.58分,症状与视功能评分为53.13±8.51分,身体机能评分为28.39±3.86分,社会活动评分为27.95±3.63分,精神心理方面评分为27.78±3.85分。单因素分析结果显示,不同年龄、文化程度、职业、家庭月收入、医疗费用负担方式、糖尿病病程和社会支持度DR患者的生活质量评分的差异有统计学意义(P<0.05)。多重线性回归分析显示,年龄、文化程度、医疗费用负担方式、糖尿病病程及社会支持度是DR患者生活质量的独立影响因素。结论:DR患者的生活质量较差,年龄、文化程度、医疗费用负担方式、糖尿病病程及社会支持是其主要影响因素,可通过减少经济负担、增加社会支持改善DR患者的生活质量。展开更多
Objective: To explore the effects of connective tissue growth factor (CTGF) on the pathogenesis of human keloid. Methods: CTGF antisense oligonucleotides (ASODN) conjugated with isothiocyananate fluorescence was encap...Objective: To explore the effects of connective tissue growth factor (CTGF) on the pathogenesis of human keloid. Methods: CTGF antisense oligonucleotides (ASODN) conjugated with isothiocyananate fluorescence was encapsulated by liposome, and then added into the human keloid fibroblasts (HKFs) culture media. The intracellular distribution of CTGF ASODN was observed by fluorescence microscopy in the fixed HKFs. The proliferation of HKFs was measured by MTT test. The collagen synthesis of HKFs was measured by 3H-proline incorporation method. Results: Compared with control group, the CTGF ASODN can inhibit the proliferation and collagen synthesis of the HKFs (P<0.01). Conclusion: CTGF ASODN has anti-fibrotic effects on keloid in vitro, and CTGF play an important role in promoting the fibrosis of keloid.展开更多
文摘目的:分析糖尿病视网膜病变(diabetic retinopathy,DR)患者的生活质量(quality of life,QOL)及其影响因素。方法:分别采用一般情况问卷、视功能损害眼病患者生活质量量表(scale of quality of life in patients with visual impairment,SQQL-VI)和社会支持评定量表对103例DR患者进行问卷调查。采用向后逐步多重线性回归分析法分析年龄、性别、文化程度及社会支持度等因素对DR患者生活质量的影响。结果:DR患者的SQQL-VI量表中总生活质量评分为63.59±9.58分,症状与视功能评分为53.13±8.51分,身体机能评分为28.39±3.86分,社会活动评分为27.95±3.63分,精神心理方面评分为27.78±3.85分。单因素分析结果显示,不同年龄、文化程度、职业、家庭月收入、医疗费用负担方式、糖尿病病程和社会支持度DR患者的生活质量评分的差异有统计学意义(P<0.05)。多重线性回归分析显示,年龄、文化程度、医疗费用负担方式、糖尿病病程及社会支持度是DR患者生活质量的独立影响因素。结论:DR患者的生活质量较差,年龄、文化程度、医疗费用负担方式、糖尿病病程及社会支持是其主要影响因素,可通过减少经济负担、增加社会支持改善DR患者的生活质量。
文摘Objective: To explore the effects of connective tissue growth factor (CTGF) on the pathogenesis of human keloid. Methods: CTGF antisense oligonucleotides (ASODN) conjugated with isothiocyananate fluorescence was encapsulated by liposome, and then added into the human keloid fibroblasts (HKFs) culture media. The intracellular distribution of CTGF ASODN was observed by fluorescence microscopy in the fixed HKFs. The proliferation of HKFs was measured by MTT test. The collagen synthesis of HKFs was measured by 3H-proline incorporation method. Results: Compared with control group, the CTGF ASODN can inhibit the proliferation and collagen synthesis of the HKFs (P<0.01). Conclusion: CTGF ASODN has anti-fibrotic effects on keloid in vitro, and CTGF play an important role in promoting the fibrosis of keloid.
