We investigated the effect of aging on the mechanism of erctile dysfunction (ED) in rats and the posibility of NO release from rat penile cavernous smooth muscle cells (RPCSMC). NOS activity in penile tissue (2 , 8 an...We investigated the effect of aging on the mechanism of erctile dysfunction (ED) in rats and the posibility of NO release from rat penile cavernous smooth muscle cells (RPCSMC). NOS activity in penile tissue (2 , 8 and 16 months rats) and NO contents in RPCSMC were detected. Immunocytochemistry was used to deterimne NOS activity. The results showed that NOS activity (23±5,11±2 ,4±1) kU·g -1 and NO contents (138±9, 76±4, 22±1) mmol·L -1 decreased significantly with aging ( P <0.01). So we conclude that NO can be released from RPCSMC and NOS probably relates to aging dependent ED.展开更多
文摘We investigated the effect of aging on the mechanism of erctile dysfunction (ED) in rats and the posibility of NO release from rat penile cavernous smooth muscle cells (RPCSMC). NOS activity in penile tissue (2 , 8 and 16 months rats) and NO contents in RPCSMC were detected. Immunocytochemistry was used to deterimne NOS activity. The results showed that NOS activity (23±5,11±2 ,4±1) kU·g -1 and NO contents (138±9, 76±4, 22±1) mmol·L -1 decreased significantly with aging ( P <0.01). So we conclude that NO can be released from RPCSMC and NOS probably relates to aging dependent ED.
