背景:外周神经系统的成功再生依赖于损伤的神经元轴突和非神经元细胞,包括施万细胞和免疫细胞。促进或限制轴突再生的细胞过程对改善外周神经损伤后的预后具有指导意义。目的:综述沃勒变性过程中周围神经轴突退化与再生的机制及最新治...背景:外周神经系统的成功再生依赖于损伤的神经元轴突和非神经元细胞,包括施万细胞和免疫细胞。促进或限制轴突再生的细胞过程对改善外周神经损伤后的预后具有指导意义。目的:综述沃勒变性过程中周围神经轴突退化与再生的机制及最新治疗进展。方法:利用计算机检索Web of Science核心数据库、万方数据库和中国知网2004-2024年期间发表的相关文献。中文检索词为“周围神经,外周神经,轴突损伤,沃勒氏变性,华勒氏变性,瓦勒变性,许旺细胞,雪旺细胞,施万细胞”,英文检索词为“peripheral nerve injury,axoninjury,axondegeneration,Walleriandegeneration,cells,mechanism”。最终对108篇文献展开综述。结果与结论:沃勒变性是一种动态的细胞过程,在细胞和分子水平上受到严格的调控。通过揭示沃勒变性的主要作用和细胞分子生物学机制,为理解沃勒变性和沃勒样变性提供一个有用的框架,并为开发新的治疗策略奠定基础,以治疗神经损伤和神经退行性疾病的轴突变性。展开更多
目的:通过查阅预防性使用万古霉素粉末手术比较的文献,对该方法在脊柱手术后降低感染率的效果做出系统评价,为以后的临床工作提供依据。方法:通过Pubmed,Medline,Elseveir,万方,CNKI等数据库,以“vancomycin”,“local/intraoperative/t...目的:通过查阅预防性使用万古霉素粉末手术比较的文献,对该方法在脊柱手术后降低感染率的效果做出系统评价,为以后的临床工作提供依据。方法:通过Pubmed,Medline,Elseveir,万方,CNKI等数据库,以“vancomycin”,“local/intraoperative/topical/intra-wound”,“spine/spinal/lumbar/cervical/thoracolumbar surgery”,“infection”,“SSI”,“脊柱”,“腰椎”,“颈椎”,“手术”,“万古霉素”,“感染”等关键词查找相关术中预防性应用万古霉素粉末对术后感染发生率影响方面的病例对照研究论文,并利用Revman5.3荟萃分析软件比较文献中总体感染率,并按不同亚组分析是否应用万古霉素对不同部位、不同类型的脊柱手术的感染率的影响。结果:共查出论文1713篇,其中病例对照试验有38篇,最后筛选出符合要求的文献25篇;有25个研究比较了预防性使用万古霉素粉末对脊柱手术后感染率的影响。总病例16,688例,其中预防性使用万古霉素组7048例,对照组9640例。其荟萃分析结果提示术中预防性使用万古霉素粉末后术后出现感染的可能性为不使用万古霉素时的0.38倍,二者之间的差异有显著性(P Objective: To systematically evaluate the effect of this method in reducing the infection rate after spinal surgery by reviewing the comparative literature of prophylactic vancomycin powder surgery, so as to provide a basis for future clinical work. Methods: Pubmed, Medline, Elseveir, Wanfang, CNKI and other databases, with the following methods: “vancomycin”, “local/intraoperative/topical/intra-wound”, “spine/spinal/lumbar/cervical/thoracolumbar surgery”, “infection”, “SSI”, “spine”, “lumbar spine”, “cervical spine”, “surgery”, “vancomycin”, “infection” and other keywords were used to find case-control research papers on the effect of intraoperative prophylactic vancomycin powder on the incidence of postoperative infection, and the Revman5.3 meta-analysis software was used to compare the overall infection rate in the literature, and the effect of vancomycin application on the infection rate of different parts and different types of spine surgery was analyzed according to different subgroups. Results: A total of 1713 papers were identified, including 38 case-control trials, and 25 papers were screened to meet the requirements. Twenty-five studies compared the effect of prophylactic use of vancomycin powder on infection rates after spinal surgery. The total number of cases was 16,688, including 7048 cases in the prophylactic vancomycin group and 9640 cases in the control group. The results of meta-analysis showed that the probability of postoperative infection after intraoperative prophylactic use of vancomycin powder was 0.38 times higher than that of vancomycin without vancomycin, and the difference between the two was significant (P < 0.01). At the same time, the incidence of infection after vancomycin was 0.28 times higher (0.17, 0.45) than that of vancomycin in patients treated with internal fixation (P < 0.01). However, vancomycin utilization in patients without internal fixation had no significant effect on postoperative infection (P = 0.61). Conclusion: The local prophylactic use of vancomycin powder in spine surgery can significantly reduce the incidence of postoperative infection, and this effect is more obvious in patients with internal fixation, which can be popularized and applied in clinical practice of spine surgery.展开更多
背景:外科模拟训练使外科医生能够在模拟环境中获得临床经验或技能。因为它随着科学和技术的进步而变化,而且以往没有研究从文献计量分析的角度分析这一领域,本研究旨在通过文献计量软件回顾全球外科模拟训练的变化。方法:在核心集成数...背景:外科模拟训练使外科医生能够在模拟环境中获得临床经验或技能。因为它随着科学和技术的进步而变化,而且以往没有研究从文献计量分析的角度分析这一领域,本研究旨在通过文献计量软件回顾全球外科模拟训练的变化。方法:在核心集成数据库Web of Science上进行了搜索,时间段为2000年到2024年8月,使用了四个主题词(外科、训练,模拟和机器人)以进行热点探索。数据主要通过文献计量软件按出版日期、国家、作者和关键词进行分析。结果:初步分析了1562篇文章,结果显示在这些研究时期内,腹腔镜技能、三维打印和虚拟现实是主要关注点。随后,确定了348篇关于机器人外科训练的出版物。结论:本研究系统地总结了外科模拟训练领域的现状,并提供了全球背景下的研究重点和未来热点的见解。Background: Surgical simulation training enables surgeons to gain clinical experience or skills in simulated environments. Because it changes with the advancement of science and technology, and there have been no previous studies analyzing this field from the perspective of bibliometric analysis, this study aims to review the changes in global surgical simulation training through bibliometric software. Methods: A search was conducted on the core integrated database Web of Science from 2000 to August 2024, using four keywords (surgery, training, simulation, and robotics) to explore hot topics. The data were mainly analyzed by publication date, country, author, and keywords through bibliometric software. Result: A preliminary analysis of 1562 articles showed that laparoscopic skills, 3D printing, and virtual reality were the main focus during these research periods. Subsequently, 348 publications on robot surgical training were identified. Conclusion: This study systematically summarizes the current status of surgical simulation training and provides insights into research priorities and future hotspots in the global context.展开更多
丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一,研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法,对国内外有关丹参酮IIA的研究进行分析,发现...丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一,研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法,对国内外有关丹参酮IIA的研究进行分析,发现丹参酮IIA的研究是基于2000年至2024年间发表的13,681篇有关丹参酮IIA的文献的计量学分析;该领域发表研究论文最多的国家是中国,美国和澳大利亚,而发表论文最多的机构为中国医科大学,中国科学院和中山大学。丹参酮IIA在心血管疾病和神经系统疾病中的研究文献占比最高,研究类型主要以应用基础研究,临床研究和技术开发为主,出现频率最多的关键词为凋亡,表达,激活,氧化应激,炎症反应等,体现了其在这些领域的研究热度和临床应用价值。丹参酮IIA作为一种具有多重药理活性的中药成分,显示出广泛的临床应用前景,而当前研究的局限性和挑战需要我们在未来的研究中予以重视,通过多学科合作和创新研究方法,共同推动丹参酮IIA在疾病治疗中的进一步应用与发展。Tanshinone IIA (TanIIA) is one of the main active ingredients extracted from the traditional Chinese medicine Danshen, and studies have shown that it has significant pharmacological activities in anti-inflammatory, antioxidant, anti-tumor, cardioprotective and nervous system protection. In this paper, bibliometric methods were used to analyze the studies on tanshinone IIA at home and abroad, and found that the research on tanshinone IIA was based on quantitative analysis of 13,681 articles on tanshinone IIA published between 2000 and 2024. The countries with the most published research papers in this field are China, United States and Australia, while the institutions with the most published papers are China Medical University, Chinese Academy of Sciences and Sun Yat-sen University. Tanshinone IIA has the highest proportion of research literature in cardiovascular diseases and nervous system diseases, and the research types are mainly applied basic research, clinical research and technology development, and the most frequent keywords are apoptosis, expression, activation, oxidative stress, inflammatory response, etc., reflecting its research enthusiasm and clinical application value in these fields. As a traditional Chinese medicine ingredient with multiple pharmacological activities, tanshinone IIA has shown a wide range of clinical application prospects, but the limitations and challenges of current research need to be paid attention to in future research, and jointly promote the further application and development of tanshinone IIA in disease treatment through multidisciplinary cooperation and innovative research methods.展开更多
背景:随着元宇宙的出现,虚拟现实作为一种数字技术,必定变得越来越热门。高质量的虚拟现实相关护理知识场景学习正逐渐取代传统的教育和干预技能。目标:本系统研究旨在深入了解虚拟现实技术在护理研究中的整体应用情况。方法:研究使用了...背景:随着元宇宙的出现,虚拟现实作为一种数字技术,必定变得越来越热门。高质量的虚拟现实相关护理知识场景学习正逐渐取代传统的教育和干预技能。目标:本系统研究旨在深入了解虚拟现实技术在护理研究中的整体应用情况。方法:研究使用了从Web of Science核心合集数据库下载的关于2000年1月1日至2024年7月期间发布的虚拟现实在护理领域应用的引用文献信息。信息检索分析工具包括https://bibliometric.com/app和VOS viewer。结果:共498个机构来自95个地区贡献了相关出版物,其中美国是该研究领域最具影响力的国家。从引用的文献中获得了被引文献的聚类标签。虚拟仿真、虚拟学习、临床技能和痴呆症是共同被引文献的聚类标签。结论:虚拟护理对护士和患者都产生了影响。随着元宇宙概念的出现,虚拟现实技术在护理中的研究和应用将逐渐增加。Background: With the advent of the metaverse, virtual reality is bound to become more and more popular as a digital technology. High-quality virtual reality-related nursing knowledge and scenario-based learning is gradually replacing traditional education and intervention skills. Objective: This systematic study aims to gain insight into the overall application of virtual reality technology in nursing research. Methods: The study used citation information on the use of virtual reality in nursing published between January 1, 2000 and July 2024 from the Web of Science Core Collection database. Information retrieval and analysis tools include https://bibliometric.com/app and VOS viewer. Results: A total of 498 institutions from 95 regions contributed relevant publications, with United States being the most influential country in this research field. Clustering tags of cited documents were obtained from the cited documents. Virtual simulation, virtual learning, clinical skills, and dementia are cluster labels for co-cited articles. Conclusion: Virtual care has had an impact on both nurses and patients. With the advent of the metaverse concept, the research and application of virtual reality technology in nursing will gradually increase.展开更多
丹参酮IIA,也称为TanIIA,在生物体内代谢过程中扮演着多重角色,其产物能够影响多种生物化学反应。这些反应中,TanIIA有时作为辅酶参与,有时则可能促进或干扰这些反应过程,从而展现出多样的药理特性。尽管在脊髓损伤等神经系统疾病的治疗...丹参酮IIA,也称为TanIIA,在生物体内代谢过程中扮演着多重角色,其产物能够影响多种生物化学反应。这些反应中,TanIIA有时作为辅酶参与,有时则可能促进或干扰这些反应过程,从而展现出多样的药理特性。尽管在脊髓损伤等神经系统疾病的治疗中,TanIIA已经显示出了一定的疗效,但其具体的作用机制尚未完全阐明。基于现有的研究成果,我们推测TanIIA可能通过多种药理途径,包括抗炎、抗氧化、抗细胞凋亡以及保护血管,来促进脊髓损伤后的神经细胞存活和修复。Tanshinone IIA, also known as TanIIA, plays multiple roles in the metabolic process of living organisms, and its products can affect a variety of biochemical reactions. In these reactions, TanIIA is sometimes involved as a coenzyme, and sometimes it may facilitate or interfere with these reaction processes, thus exhibiting diverse pharmacological properties. Although TanIIA has shown some efficacy in the treatment of neurological diseases such as spinal cord injury, its specific mechanism of action has not been fully elucidated. Based on the existing research results, we speculate that TanIIA may promote the survival and repair of nerve cells after spinal cord injury through multiple pharmacological pathways, including anti-inflammatory, antioxidant, anti-apoptosis, and vascular protection.展开更多
目的:本研究采用文献计量学方法,分析了关于间充质干细胞在脊髓损伤修复中的研究热点以及未来发展趋势。方法:我们通过在Web of Science数据库中使用关键词TS = (“Mesenchymal stem cells” AND “Spinal cord injury”) OR TS = (“Me...目的:本研究采用文献计量学方法,分析了关于间充质干细胞在脊髓损伤修复中的研究热点以及未来发展趋势。方法:我们通过在Web of Science数据库中使用关键词TS = (“Mesenchymal stem cells” AND “Spinal cord injury”) OR TS = (“Mesenchymal stem cells” AND “Spinal cord injury repair”)进行筛选,收集了从2014年01月01日到2024年04月30日之间发表的相关文章数据。随后,我们利用可视化分析软件VOS viewer,从文献的发表数量、作者、所属国家、机构、关键词、以及热门研究主题等多个角度进行了综合评估。结果:在本研究中,我们广泛检索了Web of Science数据库,总计获取了1193篇相关文献。这些文献是由来自70个国家的6565名合作作者撰写的,他们分布在1520个不同的研究机构中。这些合作作者将其研究成果发表在424个不同期刊上,并引用59,798篇文献。此外,我们还分析了文献的年度发表量、国家分布、发表量前十的作者、被引用次数最多的十篇文章,以及发表量前十的机构,以更全面地了解最近十年脊髓损伤修复方面研究的现状和趋势。结论:近10年来,有关间充质干细胞在脊髓损伤修复领域的研究发表数量和被引次数呈总体上升趋势。这反映出该领域的迅速发展,国际社会对其关注程度逐渐增加。尽管在脊髓损伤修复领域取得了很多成绩,关于间充质干细胞的研究起步较晚,相关文献数量相对较少,但这个领域具有巨大的发展潜力。干细胞治疗脊髓损伤已成为当今一个备受关注的研究领域,特别是间充质干细胞疗法,在脊髓损伤治疗修复中拥有巨大的潜力,可能为患者提供更好的治疗和康复机会,同时也为医学领域的进步和创新做出重要贡献。展开更多
目的采用文献计量学的方法分析2005-2022年腰椎管狭窄症的研究热点和研究结果,为后续相关研究提供参考。方法Web of Science数据库中采集数据,包括2005-2022年发表的所有学术文献。文献采用关键词[TS=(lumbar canal stenosis)]AND TS=(t...目的采用文献计量学的方法分析2005-2022年腰椎管狭窄症的研究热点和研究结果,为后续相关研究提供参考。方法Web of Science数据库中采集数据,包括2005-2022年发表的所有学术文献。文献采用关键词[TS=(lumbar canal stenosis)]AND TS=(treatment)进行筛选收集。可视化分析分别使用CiteSpace和VOSviever软件,从文献的作者、所属国家、关键词等方面进行评估。结果从Web of Science数据库中收集到646篇文献,通过筛选最终纳入研究的文献有375篇。本研究所用的375篇文献来自18个国家,99个机构的246名作者发表在78篇期刊上。引用了来自1314期刊的6583篇引用文献。本研究列出了每年文献发表量、国家分布、发文量前5的作者名字、发文量最多的期刊和被引的前5篇文章。结论腰椎管狭窄症治疗领域的发展起步较晚。论文数量相对较少。研究方向主要集中在外科手术领域。而我国的文献缺乏国际影响力,期待未来能发表高质量的文章,对该领域的发展作出贡献。展开更多
目的:周围神经损伤(PNI)是最常见的一种临床疾病。本研究通过文献计量学方法分析微RNA(miRNA)在周围神经后轴突再生中的治疗作用的当今研究热点和未来发展趋势,从而为后来相关研究提供可靠的参考。方法:应用Web of Science数据库,通过...目的:周围神经损伤(PNI)是最常见的一种临床疾病。本研究通过文献计量学方法分析微RNA(miRNA)在周围神经后轴突再生中的治疗作用的当今研究热点和未来发展趋势,从而为后来相关研究提供可靠的参考。方法:应用Web of Science数据库,通过关键词TS=microRNA OR TS=miRNA AND TS=peripheral nerve injury OR TS=microRNA OR TS=miRNA AND TS=axonal regeneration筛检采集从2009年到2024年间发表的相关文章数据。并用可视化分析软件CiteSpace,从文献的作者、所属国家、关键词、爆发词和机构等方面进行评估。结果:从Web of Science数据库中共检索到301篇文献,通过剔除和筛选最终符合研究的文献有288篇。本研究所用的288篇文章共有1513名作者,他们分别来自34个国家,358个机构的1513名作者发表在148篇期刊上。引用了来自2038期刊的13941篇文献。另外本研究列出了文献年发表量、国家分布、发文量前5的作者、被引次数最多的5篇文章和发文量前十的机构,其中中国是发文量最多的国家,但在文章质量上跟欧美地区有着显著的差距。对机构的分析发现,国内机构在该领域的研究中占比最多,相互之间的合作密切,与国外机构缺乏合作。研究引用次数最多的文章是Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor被引用了34次。发文量最多的机构是南通大学31篇。结论:虽然miRNA在周围神经损伤后轴突再生中的治疗作用研究起步较晚,论文数量相对较少,但有着极大的发展潜力。miRNA作为当今最热门的话题,它在神经炎症、神经细胞修复再生、神经保护和功能恢复等领域的作用机制已经成为当前的研究热点。随着对该领域科研研究的投入,将会有更多高质量的文章发表在国内外优秀期刊上,使得周围神经损伤的治疗迎来新的纪元。展开更多
文摘背景:外周神经系统的成功再生依赖于损伤的神经元轴突和非神经元细胞,包括施万细胞和免疫细胞。促进或限制轴突再生的细胞过程对改善外周神经损伤后的预后具有指导意义。目的:综述沃勒变性过程中周围神经轴突退化与再生的机制及最新治疗进展。方法:利用计算机检索Web of Science核心数据库、万方数据库和中国知网2004-2024年期间发表的相关文献。中文检索词为“周围神经,外周神经,轴突损伤,沃勒氏变性,华勒氏变性,瓦勒变性,许旺细胞,雪旺细胞,施万细胞”,英文检索词为“peripheral nerve injury,axoninjury,axondegeneration,Walleriandegeneration,cells,mechanism”。最终对108篇文献展开综述。结果与结论:沃勒变性是一种动态的细胞过程,在细胞和分子水平上受到严格的调控。通过揭示沃勒变性的主要作用和细胞分子生物学机制,为理解沃勒变性和沃勒样变性提供一个有用的框架,并为开发新的治疗策略奠定基础,以治疗神经损伤和神经退行性疾病的轴突变性。
文摘目的:通过查阅预防性使用万古霉素粉末手术比较的文献,对该方法在脊柱手术后降低感染率的效果做出系统评价,为以后的临床工作提供依据。方法:通过Pubmed,Medline,Elseveir,万方,CNKI等数据库,以“vancomycin”,“local/intraoperative/topical/intra-wound”,“spine/spinal/lumbar/cervical/thoracolumbar surgery”,“infection”,“SSI”,“脊柱”,“腰椎”,“颈椎”,“手术”,“万古霉素”,“感染”等关键词查找相关术中预防性应用万古霉素粉末对术后感染发生率影响方面的病例对照研究论文,并利用Revman5.3荟萃分析软件比较文献中总体感染率,并按不同亚组分析是否应用万古霉素对不同部位、不同类型的脊柱手术的感染率的影响。结果:共查出论文1713篇,其中病例对照试验有38篇,最后筛选出符合要求的文献25篇;有25个研究比较了预防性使用万古霉素粉末对脊柱手术后感染率的影响。总病例16,688例,其中预防性使用万古霉素组7048例,对照组9640例。其荟萃分析结果提示术中预防性使用万古霉素粉末后术后出现感染的可能性为不使用万古霉素时的0.38倍,二者之间的差异有显著性(P Objective: To systematically evaluate the effect of this method in reducing the infection rate after spinal surgery by reviewing the comparative literature of prophylactic vancomycin powder surgery, so as to provide a basis for future clinical work. Methods: Pubmed, Medline, Elseveir, Wanfang, CNKI and other databases, with the following methods: “vancomycin”, “local/intraoperative/topical/intra-wound”, “spine/spinal/lumbar/cervical/thoracolumbar surgery”, “infection”, “SSI”, “spine”, “lumbar spine”, “cervical spine”, “surgery”, “vancomycin”, “infection” and other keywords were used to find case-control research papers on the effect of intraoperative prophylactic vancomycin powder on the incidence of postoperative infection, and the Revman5.3 meta-analysis software was used to compare the overall infection rate in the literature, and the effect of vancomycin application on the infection rate of different parts and different types of spine surgery was analyzed according to different subgroups. Results: A total of 1713 papers were identified, including 38 case-control trials, and 25 papers were screened to meet the requirements. Twenty-five studies compared the effect of prophylactic use of vancomycin powder on infection rates after spinal surgery. The total number of cases was 16,688, including 7048 cases in the prophylactic vancomycin group and 9640 cases in the control group. The results of meta-analysis showed that the probability of postoperative infection after intraoperative prophylactic use of vancomycin powder was 0.38 times higher than that of vancomycin without vancomycin, and the difference between the two was significant (P < 0.01). At the same time, the incidence of infection after vancomycin was 0.28 times higher (0.17, 0.45) than that of vancomycin in patients treated with internal fixation (P < 0.01). However, vancomycin utilization in patients without internal fixation had no significant effect on postoperative infection (P = 0.61). Conclusion: The local prophylactic use of vancomycin powder in spine surgery can significantly reduce the incidence of postoperative infection, and this effect is more obvious in patients with internal fixation, which can be popularized and applied in clinical practice of spine surgery.
文摘背景:外科模拟训练使外科医生能够在模拟环境中获得临床经验或技能。因为它随着科学和技术的进步而变化,而且以往没有研究从文献计量分析的角度分析这一领域,本研究旨在通过文献计量软件回顾全球外科模拟训练的变化。方法:在核心集成数据库Web of Science上进行了搜索,时间段为2000年到2024年8月,使用了四个主题词(外科、训练,模拟和机器人)以进行热点探索。数据主要通过文献计量软件按出版日期、国家、作者和关键词进行分析。结果:初步分析了1562篇文章,结果显示在这些研究时期内,腹腔镜技能、三维打印和虚拟现实是主要关注点。随后,确定了348篇关于机器人外科训练的出版物。结论:本研究系统地总结了外科模拟训练领域的现状,并提供了全球背景下的研究重点和未来热点的见解。Background: Surgical simulation training enables surgeons to gain clinical experience or skills in simulated environments. Because it changes with the advancement of science and technology, and there have been no previous studies analyzing this field from the perspective of bibliometric analysis, this study aims to review the changes in global surgical simulation training through bibliometric software. Methods: A search was conducted on the core integrated database Web of Science from 2000 to August 2024, using four keywords (surgery, training, simulation, and robotics) to explore hot topics. The data were mainly analyzed by publication date, country, author, and keywords through bibliometric software. Result: A preliminary analysis of 1562 articles showed that laparoscopic skills, 3D printing, and virtual reality were the main focus during these research periods. Subsequently, 348 publications on robot surgical training were identified. Conclusion: This study systematically summarizes the current status of surgical simulation training and provides insights into research priorities and future hotspots in the global context.
文摘丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一,研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法,对国内外有关丹参酮IIA的研究进行分析,发现丹参酮IIA的研究是基于2000年至2024年间发表的13,681篇有关丹参酮IIA的文献的计量学分析;该领域发表研究论文最多的国家是中国,美国和澳大利亚,而发表论文最多的机构为中国医科大学,中国科学院和中山大学。丹参酮IIA在心血管疾病和神经系统疾病中的研究文献占比最高,研究类型主要以应用基础研究,临床研究和技术开发为主,出现频率最多的关键词为凋亡,表达,激活,氧化应激,炎症反应等,体现了其在这些领域的研究热度和临床应用价值。丹参酮IIA作为一种具有多重药理活性的中药成分,显示出广泛的临床应用前景,而当前研究的局限性和挑战需要我们在未来的研究中予以重视,通过多学科合作和创新研究方法,共同推动丹参酮IIA在疾病治疗中的进一步应用与发展。Tanshinone IIA (TanIIA) is one of the main active ingredients extracted from the traditional Chinese medicine Danshen, and studies have shown that it has significant pharmacological activities in anti-inflammatory, antioxidant, anti-tumor, cardioprotective and nervous system protection. In this paper, bibliometric methods were used to analyze the studies on tanshinone IIA at home and abroad, and found that the research on tanshinone IIA was based on quantitative analysis of 13,681 articles on tanshinone IIA published between 2000 and 2024. The countries with the most published research papers in this field are China, United States and Australia, while the institutions with the most published papers are China Medical University, Chinese Academy of Sciences and Sun Yat-sen University. Tanshinone IIA has the highest proportion of research literature in cardiovascular diseases and nervous system diseases, and the research types are mainly applied basic research, clinical research and technology development, and the most frequent keywords are apoptosis, expression, activation, oxidative stress, inflammatory response, etc., reflecting its research enthusiasm and clinical application value in these fields. As a traditional Chinese medicine ingredient with multiple pharmacological activities, tanshinone IIA has shown a wide range of clinical application prospects, but the limitations and challenges of current research need to be paid attention to in future research, and jointly promote the further application and development of tanshinone IIA in disease treatment through multidisciplinary cooperation and innovative research methods.
文摘背景:随着元宇宙的出现,虚拟现实作为一种数字技术,必定变得越来越热门。高质量的虚拟现实相关护理知识场景学习正逐渐取代传统的教育和干预技能。目标:本系统研究旨在深入了解虚拟现实技术在护理研究中的整体应用情况。方法:研究使用了从Web of Science核心合集数据库下载的关于2000年1月1日至2024年7月期间发布的虚拟现实在护理领域应用的引用文献信息。信息检索分析工具包括https://bibliometric.com/app和VOS viewer。结果:共498个机构来自95个地区贡献了相关出版物,其中美国是该研究领域最具影响力的国家。从引用的文献中获得了被引文献的聚类标签。虚拟仿真、虚拟学习、临床技能和痴呆症是共同被引文献的聚类标签。结论:虚拟护理对护士和患者都产生了影响。随着元宇宙概念的出现,虚拟现实技术在护理中的研究和应用将逐渐增加。Background: With the advent of the metaverse, virtual reality is bound to become more and more popular as a digital technology. High-quality virtual reality-related nursing knowledge and scenario-based learning is gradually replacing traditional education and intervention skills. Objective: This systematic study aims to gain insight into the overall application of virtual reality technology in nursing research. Methods: The study used citation information on the use of virtual reality in nursing published between January 1, 2000 and July 2024 from the Web of Science Core Collection database. Information retrieval and analysis tools include https://bibliometric.com/app and VOS viewer. Results: A total of 498 institutions from 95 regions contributed relevant publications, with United States being the most influential country in this research field. Clustering tags of cited documents were obtained from the cited documents. Virtual simulation, virtual learning, clinical skills, and dementia are cluster labels for co-cited articles. Conclusion: Virtual care has had an impact on both nurses and patients. With the advent of the metaverse concept, the research and application of virtual reality technology in nursing will gradually increase.
文摘丹参酮IIA,也称为TanIIA,在生物体内代谢过程中扮演着多重角色,其产物能够影响多种生物化学反应。这些反应中,TanIIA有时作为辅酶参与,有时则可能促进或干扰这些反应过程,从而展现出多样的药理特性。尽管在脊髓损伤等神经系统疾病的治疗中,TanIIA已经显示出了一定的疗效,但其具体的作用机制尚未完全阐明。基于现有的研究成果,我们推测TanIIA可能通过多种药理途径,包括抗炎、抗氧化、抗细胞凋亡以及保护血管,来促进脊髓损伤后的神经细胞存活和修复。Tanshinone IIA, also known as TanIIA, plays multiple roles in the metabolic process of living organisms, and its products can affect a variety of biochemical reactions. In these reactions, TanIIA is sometimes involved as a coenzyme, and sometimes it may facilitate or interfere with these reaction processes, thus exhibiting diverse pharmacological properties. Although TanIIA has shown some efficacy in the treatment of neurological diseases such as spinal cord injury, its specific mechanism of action has not been fully elucidated. Based on the existing research results, we speculate that TanIIA may promote the survival and repair of nerve cells after spinal cord injury through multiple pharmacological pathways, including anti-inflammatory, antioxidant, anti-apoptosis, and vascular protection.
文摘目的:本研究采用文献计量学方法,分析了关于间充质干细胞在脊髓损伤修复中的研究热点以及未来发展趋势。方法:我们通过在Web of Science数据库中使用关键词TS = (“Mesenchymal stem cells” AND “Spinal cord injury”) OR TS = (“Mesenchymal stem cells” AND “Spinal cord injury repair”)进行筛选,收集了从2014年01月01日到2024年04月30日之间发表的相关文章数据。随后,我们利用可视化分析软件VOS viewer,从文献的发表数量、作者、所属国家、机构、关键词、以及热门研究主题等多个角度进行了综合评估。结果:在本研究中,我们广泛检索了Web of Science数据库,总计获取了1193篇相关文献。这些文献是由来自70个国家的6565名合作作者撰写的,他们分布在1520个不同的研究机构中。这些合作作者将其研究成果发表在424个不同期刊上,并引用59,798篇文献。此外,我们还分析了文献的年度发表量、国家分布、发表量前十的作者、被引用次数最多的十篇文章,以及发表量前十的机构,以更全面地了解最近十年脊髓损伤修复方面研究的现状和趋势。结论:近10年来,有关间充质干细胞在脊髓损伤修复领域的研究发表数量和被引次数呈总体上升趋势。这反映出该领域的迅速发展,国际社会对其关注程度逐渐增加。尽管在脊髓损伤修复领域取得了很多成绩,关于间充质干细胞的研究起步较晚,相关文献数量相对较少,但这个领域具有巨大的发展潜力。干细胞治疗脊髓损伤已成为当今一个备受关注的研究领域,特别是间充质干细胞疗法,在脊髓损伤治疗修复中拥有巨大的潜力,可能为患者提供更好的治疗和康复机会,同时也为医学领域的进步和创新做出重要贡献。
文摘目的 3D打印是广泛应用于医学教育中的一项新兴技术,但其在人体解剖学教学中的作用有尚需进一步研究。本研究通过汇总分析目前已经发表的3D打印在人体解剖学教学中的作用方面的研究,探讨其在人体解剖学教学中的作用。方法 系统检索PubMed, Web of Science,万方,CNKI等数据库,收集2011年1月—2022年10月发表的中英文研究。使用ReviewManeger 5.3对其中提取的数据进行了Meta分析,探讨3D打印技术在人体解剖学教学中的作用。结果 通过对比训练后神经解剖、心脏解剖、腹部解剖测试,3D打印模型组与常规组的标准化平均差(SMD)分别为0.65,0.60,1.86(P<0.01)。对于3D相比尸体和2D,SMD分别为1.27和1.10(P<0.01)。结论 本研究通过汇总分析包含1 395名学生的22项研究结果后提出,3D打印模型技术在人体解剖学教学中应用的教学效果优于传统的教学手段,值得在解剖教学中推广应用。
文摘目的采用文献计量学的方法分析2005-2022年腰椎管狭窄症的研究热点和研究结果,为后续相关研究提供参考。方法Web of Science数据库中采集数据,包括2005-2022年发表的所有学术文献。文献采用关键词[TS=(lumbar canal stenosis)]AND TS=(treatment)进行筛选收集。可视化分析分别使用CiteSpace和VOSviever软件,从文献的作者、所属国家、关键词等方面进行评估。结果从Web of Science数据库中收集到646篇文献,通过筛选最终纳入研究的文献有375篇。本研究所用的375篇文献来自18个国家,99个机构的246名作者发表在78篇期刊上。引用了来自1314期刊的6583篇引用文献。本研究列出了每年文献发表量、国家分布、发文量前5的作者名字、发文量最多的期刊和被引的前5篇文章。结论腰椎管狭窄症治疗领域的发展起步较晚。论文数量相对较少。研究方向主要集中在外科手术领域。而我国的文献缺乏国际影响力,期待未来能发表高质量的文章,对该领域的发展作出贡献。
文摘目的:周围神经损伤(PNI)是最常见的一种临床疾病。本研究通过文献计量学方法分析微RNA(miRNA)在周围神经后轴突再生中的治疗作用的当今研究热点和未来发展趋势,从而为后来相关研究提供可靠的参考。方法:应用Web of Science数据库,通过关键词TS=microRNA OR TS=miRNA AND TS=peripheral nerve injury OR TS=microRNA OR TS=miRNA AND TS=axonal regeneration筛检采集从2009年到2024年间发表的相关文章数据。并用可视化分析软件CiteSpace,从文献的作者、所属国家、关键词、爆发词和机构等方面进行评估。结果:从Web of Science数据库中共检索到301篇文献,通过剔除和筛选最终符合研究的文献有288篇。本研究所用的288篇文章共有1513名作者,他们分别来自34个国家,358个机构的1513名作者发表在148篇期刊上。引用了来自2038期刊的13941篇文献。另外本研究列出了文献年发表量、国家分布、发文量前5的作者、被引次数最多的5篇文章和发文量前十的机构,其中中国是发文量最多的国家,但在文章质量上跟欧美地区有着显著的差距。对机构的分析发现,国内机构在该领域的研究中占比最多,相互之间的合作密切,与国外机构缺乏合作。研究引用次数最多的文章是Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor被引用了34次。发文量最多的机构是南通大学31篇。结论:虽然miRNA在周围神经损伤后轴突再生中的治疗作用研究起步较晚,论文数量相对较少,但有着极大的发展潜力。miRNA作为当今最热门的话题,它在神经炎症、神经细胞修复再生、神经保护和功能恢复等领域的作用机制已经成为当前的研究热点。随着对该领域科研研究的投入,将会有更多高质量的文章发表在国内外优秀期刊上,使得周围神经损伤的治疗迎来新的纪元。
