The syntheses of three new optically active β-mercaptoalcohols,(R)-1,1-diphenyl-2-mercapto-3-methyl-1-butanol, (R)-1,1-diphenyl-2-mercapto-4-methyl-1-pentanol, and(R)-1,1-diphenyl-2-mercapto-1-benzenepropanol from th...The syntheses of three new optically active β-mercaptoalcohols,(R)-1,1-diphenyl-2-mercapto-3-methyl-1-butanol, (R)-1,1-diphenyl-2-mercapto-4-methyl-1-pentanol, and(R)-1,1-diphenyl-2-mercapto-1-benzenepropanol from the corresponding amino acids are described. Theenantiomeric excesses of these β-mercaptoalcohols were determined by ~1H NMR as their(S)-mandeloyl derivatives.展开更多
Three 2-{(3R,7aS)-1,1-disubstituted-tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-yl}phenols have been synthesized from salicylaldehyde and amino alcohols derived from L-proline,and used as ligands hi enantioselective add...Three 2-{(3R,7aS)-1,1-disubstituted-tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-yl}phenols have been synthesized from salicylaldehyde and amino alcohols derived from L-proline,and used as ligands hi enantioselective addition of diethylzinc to aldehydes,the ee values of obtained secondary alcohols were found in the range of 0-90%.展开更多
文摘The syntheses of three new optically active β-mercaptoalcohols,(R)-1,1-diphenyl-2-mercapto-3-methyl-1-butanol, (R)-1,1-diphenyl-2-mercapto-4-methyl-1-pentanol, and(R)-1,1-diphenyl-2-mercapto-1-benzenepropanol from the corresponding amino acids are described. Theenantiomeric excesses of these β-mercaptoalcohols were determined by ~1H NMR as their(S)-mandeloyl derivatives.
基金Project supported by the Key Laboratory of Organic Syntheses,Jiangsu Province(No.T2109102).
文摘Three 2-{(3R,7aS)-1,1-disubstituted-tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-yl}phenols have been synthesized from salicylaldehyde and amino alcohols derived from L-proline,and used as ligands hi enantioselective addition of diethylzinc to aldehydes,the ee values of obtained secondary alcohols were found in the range of 0-90%.
