In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor （ASGPR）, four cluster galactosides with different scaffolds were synthesized in this paper. The affinity of these compounds for A...In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor （ASGPR）, four cluster galactosides with different scaffolds were synthesized in this paper. The affinity of these compounds for ASGPR was analyzed by binding study in vitro. The results showed that trivalent cluster galactosides behaved better than divalent analogues and the cluster galactosides with aryl groups on their scaffolds presented better binding affinity than those with aliphatic chain scaffolds.展开更多
基金Project supported by the Program for New Century Excellent Talents in University （No. NCET-04-0649） and the National Natural Science Foundation of China （No. 20475030）.
文摘In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor （ASGPR）, four cluster galactosides with different scaffolds were synthesized in this paper. The affinity of these compounds for ASGPR was analyzed by binding study in vitro. The results showed that trivalent cluster galactosides behaved better than divalent analogues and the cluster galactosides with aryl groups on their scaffolds presented better binding affinity than those with aliphatic chain scaffolds.
