This paper studies the preparation method of As_2O_3 nanoparticles and theirantitumor effect on human liver cancer cells. As_2O_3 nanoparticles were prepared by sol-gel method.As_2O_3 nanoparticles were characterized ...This paper studies the preparation method of As_2O_3 nanoparticles and theirantitumor effect on human liver cancer cells. As_2O_3 nanoparticles were prepared by sol-gel method.As_2O_3 nanoparticles were characterized by transmission electron microscope ( TEM), energydispersive spectrometer ( EDS) and computer color magic image analysis system (CMIAS). A methylthiazolyl tetrazolium (MTT) assay and a flow cytometry (FCM) assay were performed to examine theantitumor effect of As_2O_3 nanoparticlesat various concentrations(1, 2, 5, 10 mumol/L). We alsocompared the antitumor effect of As_2O_3 nanoparticles with that of As_2O_3 solution. The averagediameters of two kinds of As_2O_3 nanoparticles prepared were about 80 nm and 40 nm. It wasidentified that the prepared nanoparticles were As_2O_3 and there were no other components by EDS.After 48 h of treatment with As_2O_3 nanoparticles, the survival ratio of cells was significantlylower than that of the As2O3 solution with the same concentration(P < 0. 05). Experimental resultsdemonstrate that by sol-gel method As_2O_3 can be prepared into nanoparticles. As_2O_3 nanoparticlescan produce a better cytotoxic effect on tumor cells than the As_2O_3 solution.展开更多
目的分析1990—2019年中国女性高血糖相关卵巢癌的疾病负担及其变化趋势,并对2020—2029年情况做出相应预测。方法利用全球疾病负担研究(Global Burden of Disease Study 2019,GBD 2019)公开的数据,从发病、死亡、伤残调整寿命年(disabi...目的分析1990—2019年中国女性高血糖相关卵巢癌的疾病负担及其变化趋势,并对2020—2029年情况做出相应预测。方法利用全球疾病负担研究(Global Burden of Disease Study 2019,GBD 2019)公开的数据,从发病、死亡、伤残调整寿命年(disability adjusted life years,DALY)等多个维度分析1990—2019年中国女性高血糖相关卵巢癌疾病负担及其变化情况,并与全球人群进行比较,预测2020—2029年国内高血糖相关卵巢癌的发病与死亡趋势。结果2019年中国人群高血糖相关卵巢癌的发病数、死亡数、DALY数分别为2751、1758、44615人年,较1990年分别增长352.5%、356.6%、329.0%,增幅均高于全球水平(189.7%、184.2%及180.9%);2019年的标化发病率、死亡率、DALY率分别为0.270/10万、0.164/10万、4.103/10万,平均年度变化百分比(average annual percentage change,AAPC)分别为2.3%、2.0%、2.0%,均高于全球平均水平(1.3%、1.1%及1.1%)。高血糖相关卵巢癌的疾病负担在25~44岁间均处于相对较低水平,45岁后开始快速上升,整体在55~74岁间达到高峰。神经网络模型预测显示,该病的发病与死亡在下一个10年周期仍处于高位上升趋势。结论1990—2019年中国女性高血糖相关卵巢癌导致的疾病负担占全球人群相应比重较大,且标化发病率、死亡率、DALY率逐年上升。应持续关注高血糖等代谢因素在卵巢癌发生发展中的作用,做好三级预防,努力减少健康损失。展开更多
文摘This paper studies the preparation method of As_2O_3 nanoparticles and theirantitumor effect on human liver cancer cells. As_2O_3 nanoparticles were prepared by sol-gel method.As_2O_3 nanoparticles were characterized by transmission electron microscope ( TEM), energydispersive spectrometer ( EDS) and computer color magic image analysis system (CMIAS). A methylthiazolyl tetrazolium (MTT) assay and a flow cytometry (FCM) assay were performed to examine theantitumor effect of As_2O_3 nanoparticlesat various concentrations(1, 2, 5, 10 mumol/L). We alsocompared the antitumor effect of As_2O_3 nanoparticles with that of As_2O_3 solution. The averagediameters of two kinds of As_2O_3 nanoparticles prepared were about 80 nm and 40 nm. It wasidentified that the prepared nanoparticles were As_2O_3 and there were no other components by EDS.After 48 h of treatment with As_2O_3 nanoparticles, the survival ratio of cells was significantlylower than that of the As2O3 solution with the same concentration(P < 0. 05). Experimental resultsdemonstrate that by sol-gel method As_2O_3 can be prepared into nanoparticles. As_2O_3 nanoparticlescan produce a better cytotoxic effect on tumor cells than the As_2O_3 solution.
文摘目的分析1990—2019年中国女性高血糖相关卵巢癌的疾病负担及其变化趋势,并对2020—2029年情况做出相应预测。方法利用全球疾病负担研究(Global Burden of Disease Study 2019,GBD 2019)公开的数据,从发病、死亡、伤残调整寿命年(disability adjusted life years,DALY)等多个维度分析1990—2019年中国女性高血糖相关卵巢癌疾病负担及其变化情况,并与全球人群进行比较,预测2020—2029年国内高血糖相关卵巢癌的发病与死亡趋势。结果2019年中国人群高血糖相关卵巢癌的发病数、死亡数、DALY数分别为2751、1758、44615人年,较1990年分别增长352.5%、356.6%、329.0%,增幅均高于全球水平(189.7%、184.2%及180.9%);2019年的标化发病率、死亡率、DALY率分别为0.270/10万、0.164/10万、4.103/10万,平均年度变化百分比(average annual percentage change,AAPC)分别为2.3%、2.0%、2.0%,均高于全球平均水平(1.3%、1.1%及1.1%)。高血糖相关卵巢癌的疾病负担在25~44岁间均处于相对较低水平,45岁后开始快速上升,整体在55~74岁间达到高峰。神经网络模型预测显示,该病的发病与死亡在下一个10年周期仍处于高位上升趋势。结论1990—2019年中国女性高血糖相关卵巢癌导致的疾病负担占全球人群相应比重较大,且标化发病率、死亡率、DALY率逐年上升。应持续关注高血糖等代谢因素在卵巢癌发生发展中的作用,做好三级预防,努力减少健康损失。
