目的:分析急性冠脉综合征(ACS)患者ApoE基因多态性的临床分布特征及与血脂的关系。方式:入选2023年4月~2024年3月在空军军医大学唐都医院住院的ACS患者共134例,采用PCR-芯片杂交法进行ApoE基因多态性检测,同时检测总胆固醇(TC)、甘油三...目的:分析急性冠脉综合征(ACS)患者ApoE基因多态性的临床分布特征及与血脂的关系。方式:入选2023年4月~2024年3月在空军军医大学唐都医院住院的ACS患者共134例,采用PCR-芯片杂交法进行ApoE基因多态性检测,同时检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)水平。结果:所有纳入的ACS患者其ApoE基因型在不同性别组间的分布差异无统计学意义(X2 = 5.0,P = 0.42);所有纳入的ACS患者其ApoE表现型在不同性别组间的分布差异无统计学意义(X2 = 1.46,P = 0.48)。ACS患者其ApoE基因多态性在各年龄组间的分布差异无统计学意义(X2 = 15.68,P = 0.11;X2 = 8.06,P = 0.09)。不同ApoE基因型的ACS患者在总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)和低密度脂蛋白胆固醇(LDL)浓度水平上的差异均具有统计学意义(P Objective: analyze the clinical distribution characteristics of ApoE gene polymorphism in patients with acute coronary syndrome (ACS) and its relationship with blood lipid. Methods: A total of 134 patients with ACS who were hospitalized in Tangdu Hospital of Air Force Military Medical University from April 2023 to March 2024 were selected and ApoE gene polymorphism was detected by PCR-chip hybridization. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and low density lipoprotein cholesterol (LDL) were also measured. Results: There was no statistically significant difference in the distribution of ApoE genotypes in all the included ACS patients between different sex groups (X2 = 5.0, P = 0.42). There was no statistically significant difference in the distribution of ApoE phenotypes among all the included ACS patients between different sex groups (X2 = 1.46, P = 0.48). There was no significant difference in the distribution of ApoE gene polymorphism in ACS patients among different age groups (X2 = 15.68, P = 0.11;X2 = 8.06, P = 0.09). The concentration levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and low density lipoprotein cholesterol (LDL) in ACS patients with different ApoE genotypes were statistically significant (P < 0.05). Conclusion: ApoE gene shows polymorphic distribution in ACS patients, and its polymorphic distribution is not related to gender and age. There are differences in ApoE genotypes and phenotypes and individual blood lipid levels in ACS patients. Clinically, individualized lipid-lowering regimens and appropriate lipid-lowering drugs can be formulated accordingly.展开更多
目的:探讨白细胞计数(WBC)、降钙素原(procalcitonin, PCT)和白细胞介素-6 (interleukin-6, IL-6)水平对肾综合征出血热患者病情严重程度的预测价值。方法:本研究选取2021年至2023年在空军军医大学第二附属医院急诊科确诊为HFRS患者为...目的:探讨白细胞计数(WBC)、降钙素原(procalcitonin, PCT)和白细胞介素-6 (interleukin-6, IL-6)水平对肾综合征出血热患者病情严重程度的预测价值。方法:本研究选取2021年至2023年在空军军医大学第二附属医院急诊科确诊为HFRS患者为研究对象,共118例。参照《肾综合征出血热诊疗陕西省专家共识》(2019),将患者分为轻型、中型、重型和危重型,其中将轻型与中型定义为轻症组(n = 50),重型与危重型定义为重症组(n = 68)。比较WBC、PCT和IL-6水平在不同组间的表达差异;分析WBC、PCT和IL-6预测HFRS病情严重程度的敏感度及特异度。结果:重症组血清WBC、PCT和IL-6水平均高于轻症组,差异均有统计学意义(P P AUC)分别为0.872,0.768,最佳阈值分别为8.220 ng/ml、42.670 pg/ml,联合检测AUC为0.883,敏感度为36.8%,特异度为90.0%,优于单个实验室检查指标的检测。结论:WBC、PCT和IL-6能早期预测HFRS病情严重程度,其中的PCT和IL-6水平为独立危险因素,其联合指标有更好的特异度。Objective: To investigate the value of leukocyte count (WBC), procalcitonin (PCT) and interleukin-6 (IL-6) levels in predicting the severity of hemorrhagic fever with renal syndrome. Methods: A total of 118 patients diagnosed with HFRS in the emergency Department of the Second Affiliated Hospital of Air Force Med Prediction value of WBC, PCT and IL-6 levels in the severity of hemorrhagic fever with renal syndromeical University from 2021 to 2023 were selected as the study objects. According to the Expert Consensus on the Diagnosis and Treatment of hemorrhagic fever with renal Syndrome in Shaanxi Province (2019), the patients were divided into mild, medium, severe and critical types, in which the mild and medium types were defined as the mild group (n = 50), and the severe and critical types as the severe group (n = 68). The expression of WBC, PCT and IL-6 in different groups were compared. The sensitivity and specificity of WBC, PCT and IL-6 in predicting the severity of HFRS were analyzed. Results: The levels of serum WBC, PCT and IL-6 in severe group were higher than those in mild group, with statistical significance (P P AUC) of PCT, IL-6 and their combined indicators for warning severe HFRS was 0.872 and 0.768, respectively, and the optimal threshold was 8.220 ng/ml and 42.670 pg/ml, respectively, and the AUC of combined detection was 0.883. The sensitivity was 36.8%, and the specificity was 90.0%, which was better than that of a single laboratory test index. Conclusion: WBC, PCT and IL-6 can predict the severity of HFRS early. PCT and IL-6 levels are independent risk factors, and their combined indexes have better specificity.展开更多
文摘目的:分析急性冠脉综合征(ACS)患者ApoE基因多态性的临床分布特征及与血脂的关系。方式:入选2023年4月~2024年3月在空军军医大学唐都医院住院的ACS患者共134例,采用PCR-芯片杂交法进行ApoE基因多态性检测,同时检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)水平。结果:所有纳入的ACS患者其ApoE基因型在不同性别组间的分布差异无统计学意义(X2 = 5.0,P = 0.42);所有纳入的ACS患者其ApoE表现型在不同性别组间的分布差异无统计学意义(X2 = 1.46,P = 0.48)。ACS患者其ApoE基因多态性在各年龄组间的分布差异无统计学意义(X2 = 15.68,P = 0.11;X2 = 8.06,P = 0.09)。不同ApoE基因型的ACS患者在总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL)和低密度脂蛋白胆固醇(LDL)浓度水平上的差异均具有统计学意义(P Objective: analyze the clinical distribution characteristics of ApoE gene polymorphism in patients with acute coronary syndrome (ACS) and its relationship with blood lipid. Methods: A total of 134 patients with ACS who were hospitalized in Tangdu Hospital of Air Force Military Medical University from April 2023 to March 2024 were selected and ApoE gene polymorphism was detected by PCR-chip hybridization. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and low density lipoprotein cholesterol (LDL) were also measured. Results: There was no statistically significant difference in the distribution of ApoE genotypes in all the included ACS patients between different sex groups (X2 = 5.0, P = 0.42). There was no statistically significant difference in the distribution of ApoE phenotypes among all the included ACS patients between different sex groups (X2 = 1.46, P = 0.48). There was no significant difference in the distribution of ApoE gene polymorphism in ACS patients among different age groups (X2 = 15.68, P = 0.11;X2 = 8.06, P = 0.09). The concentration levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and low density lipoprotein cholesterol (LDL) in ACS patients with different ApoE genotypes were statistically significant (P < 0.05). Conclusion: ApoE gene shows polymorphic distribution in ACS patients, and its polymorphic distribution is not related to gender and age. There are differences in ApoE genotypes and phenotypes and individual blood lipid levels in ACS patients. Clinically, individualized lipid-lowering regimens and appropriate lipid-lowering drugs can be formulated accordingly.
文摘目的:探讨白细胞计数(WBC)、降钙素原(procalcitonin, PCT)和白细胞介素-6 (interleukin-6, IL-6)水平对肾综合征出血热患者病情严重程度的预测价值。方法:本研究选取2021年至2023年在空军军医大学第二附属医院急诊科确诊为HFRS患者为研究对象,共118例。参照《肾综合征出血热诊疗陕西省专家共识》(2019),将患者分为轻型、中型、重型和危重型,其中将轻型与中型定义为轻症组(n = 50),重型与危重型定义为重症组(n = 68)。比较WBC、PCT和IL-6水平在不同组间的表达差异;分析WBC、PCT和IL-6预测HFRS病情严重程度的敏感度及特异度。结果:重症组血清WBC、PCT和IL-6水平均高于轻症组,差异均有统计学意义(P P AUC)分别为0.872,0.768,最佳阈值分别为8.220 ng/ml、42.670 pg/ml,联合检测AUC为0.883,敏感度为36.8%,特异度为90.0%,优于单个实验室检查指标的检测。结论:WBC、PCT和IL-6能早期预测HFRS病情严重程度,其中的PCT和IL-6水平为独立危险因素,其联合指标有更好的特异度。Objective: To investigate the value of leukocyte count (WBC), procalcitonin (PCT) and interleukin-6 (IL-6) levels in predicting the severity of hemorrhagic fever with renal syndrome. Methods: A total of 118 patients diagnosed with HFRS in the emergency Department of the Second Affiliated Hospital of Air Force Med Prediction value of WBC, PCT and IL-6 levels in the severity of hemorrhagic fever with renal syndromeical University from 2021 to 2023 were selected as the study objects. According to the Expert Consensus on the Diagnosis and Treatment of hemorrhagic fever with renal Syndrome in Shaanxi Province (2019), the patients were divided into mild, medium, severe and critical types, in which the mild and medium types were defined as the mild group (n = 50), and the severe and critical types as the severe group (n = 68). The expression of WBC, PCT and IL-6 in different groups were compared. The sensitivity and specificity of WBC, PCT and IL-6 in predicting the severity of HFRS were analyzed. Results: The levels of serum WBC, PCT and IL-6 in severe group were higher than those in mild group, with statistical significance (P P AUC) of PCT, IL-6 and their combined indicators for warning severe HFRS was 0.872 and 0.768, respectively, and the optimal threshold was 8.220 ng/ml and 42.670 pg/ml, respectively, and the AUC of combined detection was 0.883. The sensitivity was 36.8%, and the specificity was 90.0%, which was better than that of a single laboratory test index. Conclusion: WBC, PCT and IL-6 can predict the severity of HFRS early. PCT and IL-6 levels are independent risk factors, and their combined indexes have better specificity.
