Articular cartilage repair is one of the most challenging issues which remains to be resolved in clinic work. Discovering of bone marrow stromal cells (BMSC) and its application in tissue engineering provide new metho...Articular cartilage repair is one of the most challenging issues which remains to be resolved in clinic work. Discovering of bone marrow stromal cells (BMSC) and its application in tissue engineering provide new methods for the treatment of cartilage defects. High seeding density, appropriate cytokines and three-dimensional culture play important roles in the process of inducing BMSC differentiating into chondrocytes, suitable scaffold is also essential in reconstructing cartilage in vitro by methods of tissue engineering.展开更多
目的探讨新生儿先天性甲状腺功能低下症与出生体重及胎龄的关系。方法用时间分辨荧光免疫分析法测定2010年1月~2015年7月佛山市(顺德区除外)各产科医院新生儿干血片促甲状腺激素(TSH)值,凡TSH>10.0 m IU/L者予以召回,进行甲状腺功能...目的探讨新生儿先天性甲状腺功能低下症与出生体重及胎龄的关系。方法用时间分辨荧光免疫分析法测定2010年1月~2015年7月佛山市(顺德区除外)各产科医院新生儿干血片促甲状腺激素(TSH)值,凡TSH>10.0 m IU/L者予以召回,进行甲状腺功能检查。分别按照出生体重和胎龄进行分组,并对出生体重、胎龄与TSH初筛阳性率及发病率进行相关性分析。结果共筛查标本466 078例,统计有效信息456 094例。确诊先天性甲状腺功能低下症236例,总患病率为1/1 975。其中,低出生体重儿发病率为1/744,正常出生体重儿发病率为1/2 218,巨大儿发病率为1/1 535(χ2=153.45,P=0.004)。早产儿发病率为1/975,足月儿患病率为1/1903,过期产儿患病率为1/5666(χ2=169.63,P=0.003)。不同出生体重和胎龄的患病率差异有统计学意义(P<0.05)。结论新生儿先天性甲状腺功能低下症的发病与新生儿出生时的体重、胎龄等因素有关,早产、低出生体重的新生儿甲状腺功能低下症的患病率最高。因此,加强孕期保健和管理、防止早产和减少低出生体重的发生是降低新生儿先天性甲状腺功能低下症患病率的关键。展开更多
文摘Articular cartilage repair is one of the most challenging issues which remains to be resolved in clinic work. Discovering of bone marrow stromal cells (BMSC) and its application in tissue engineering provide new methods for the treatment of cartilage defects. High seeding density, appropriate cytokines and three-dimensional culture play important roles in the process of inducing BMSC differentiating into chondrocytes, suitable scaffold is also essential in reconstructing cartilage in vitro by methods of tissue engineering.
