Objective:To explore the clinical therapeutic effect of Qianggan Capsule(QGC)in treating chronic hepatitis B with liver fibrosis from the pathological aspect.Methods:Sixty three patients of chronic hepatitis B with li...Objective:To explore the clinical therapeutic effect of Qianggan Capsule(QGC)in treating chronic hepatitis B with liver fibrosis from the pathological aspect.Methods:Sixty three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group(n=45)and the control group(n=18).Both groups were treated with general liver protective drugs,such as Glucurone and vitamins B complex for 6 months.To the treated group,QGC was used additionally.The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid(HA),collagen typeⅣ(CⅣ)and laminin(LN)as well as the pathological examination of liver biopsy were observed before and after treatment.Results:The liver cirrhosis indexes,HA,CⅣand LN,were improved significantly in the treated group after treatment,P<0.05.The liver function improvement rate in the treated group and the control group was 90.3%and 66.7%respectively,comparison of the two groups showed insignificant difference,P>0.05.Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57.8%and that on liver fibrosis stage was 75.6%,which were significantly improved as compared with those before treatment(P<0.05 and P<0.01),while in the control group,no significant improvement was found after treatment(P>0.05).Conclusion:QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis,and could lower the serum liver fibrosis related indexes effectively.展开更多
基金Item of the key program of Science and Technique of Zhanjiang City(No.200068)
文摘Objective:To explore the clinical therapeutic effect of Qianggan Capsule(QGC)in treating chronic hepatitis B with liver fibrosis from the pathological aspect.Methods:Sixty three patients of chronic hepatitis B with liver fibrosis were randomly divided into the treated group(n=45)and the control group(n=18).Both groups were treated with general liver protective drugs,such as Glucurone and vitamins B complex for 6 months.To the treated group,QGC was used additionally.The levels of serum alanine transaminase and liver fibrosis indexes including hyaluronic acid(HA),collagen typeⅣ(CⅣ)and laminin(LN)as well as the pathological examination of liver biopsy were observed before and after treatment.Results:The liver cirrhosis indexes,HA,CⅣand LN,were improved significantly in the treated group after treatment,P<0.05.The liver function improvement rate in the treated group and the control group was 90.3%and 66.7%respectively,comparison of the two groups showed insignificant difference,P>0.05.Pathological examination showed that the effective rate of treatment on liver inflammatory necrosis activity grade in the treated group was 57.8%and that on liver fibrosis stage was 75.6%,which were significantly improved as compared with those before treatment(P<0.05 and P<0.01),while in the control group,no significant improvement was found after treatment(P>0.05).Conclusion:QGC has marked effects in reversing liver fibrosis and alleviating hepatic inflammatory necrosis in patients of chronic hepatitis B with liver fibrosis,and could lower the serum liver fibrosis related indexes effectively.
