目的:利用功能磁共振成像(functional magnetic resonance imaging,fMRI)技术,研究静息状态下重性抑郁症患者经抗抑郁药治疗前后脑局部一致性变化的特点。方法:20例重性抑郁症患者(抑郁症组),以20名在性别、年龄、受教育年限均与之相匹...目的:利用功能磁共振成像(functional magnetic resonance imaging,fMRI)技术,研究静息状态下重性抑郁症患者经抗抑郁药治疗前后脑局部一致性变化的特点。方法:20例重性抑郁症患者(抑郁症组),以20名在性别、年龄、受教育年限均与之相匹配的健康人作为对照(对照组),在抗抑郁治疗前和治疗10周进行静息状态fMRI扫描。结果:与治疗前比较,抑郁症组治疗后大脑左侧黑质、左额中回(BA9,BA10)、左额内侧回(BA10)、左颞中回(BA21)、右额中回(BA11)、右额内侧回(BA25)、右额下回(BA45)及右颞上回(BA38)局部一致性减低。与对照组比较,抑郁症组治疗前双侧楔前叶(BA7)局部一致性增高,而治疗后右前扣带回腹侧(BA31)、右额下回(BA46)、右额内侧回(BA10)及左海马旁回(BA36)局部一致性减低。结论:静息状态下抑郁症患者存在部分脑功能异常,经抗抑郁治疗后可逆转。展开更多
A multichannel matching pursuit（MMP）algorithm is proposed to decompose the one-dimensional multichannel non-stationary magnetoencephalography（MEG）signal at a single-trial level.The single-channel matching pursuit...A multichannel matching pursuit（MMP）algorithm is proposed to decompose the one-dimensional multichannel non-stationary magnetoencephalography（MEG）signal at a single-trial level.The single-channel matching pursuit（MP）linearly decomposes the signal into a set of Gabor atoms,which are adaptively chosen from an overcomplete dictionary with good time-frequency characters.The MMP is the extension of the MP,which represents multichannel signals using linear combination of Gabor atoms with the same occurrence,frequency,phase,and time width,but varying amplitude in all channels.The results demonstrate that the MMP can optimally reconstruct the original signal and automatically remove artifact noises.Moreover,the coherence between the 3D source reconstruction and the prior knowledge of psychology further suggests that the MMP is effective in MEG single-trial processing.展开更多
文摘目的:利用功能磁共振成像(functional magnetic resonance imaging,fMRI)技术,研究静息状态下重性抑郁症患者经抗抑郁药治疗前后脑局部一致性变化的特点。方法:20例重性抑郁症患者(抑郁症组),以20名在性别、年龄、受教育年限均与之相匹配的健康人作为对照(对照组),在抗抑郁治疗前和治疗10周进行静息状态fMRI扫描。结果:与治疗前比较,抑郁症组治疗后大脑左侧黑质、左额中回(BA9,BA10)、左额内侧回(BA10)、左颞中回(BA21)、右额中回(BA11)、右额内侧回(BA25)、右额下回(BA45)及右颞上回(BA38)局部一致性减低。与对照组比较,抑郁症组治疗前双侧楔前叶(BA7)局部一致性增高,而治疗后右前扣带回腹侧(BA31)、右额下回(BA46)、右额内侧回(BA10)及左海马旁回(BA36)局部一致性减低。结论:静息状态下抑郁症患者存在部分脑功能异常,经抗抑郁治疗后可逆转。
基金The National Natural Science Foundation of China(No.30900356,81071135)the National High Technology Research and Development Program of China(863Program)(No.2008AA02Z410)
文摘A multichannel matching pursuit（MMP）algorithm is proposed to decompose the one-dimensional multichannel non-stationary magnetoencephalography（MEG）signal at a single-trial level.The single-channel matching pursuit（MP）linearly decomposes the signal into a set of Gabor atoms,which are adaptively chosen from an overcomplete dictionary with good time-frequency characters.The MMP is the extension of the MP,which represents multichannel signals using linear combination of Gabor atoms with the same occurrence,frequency,phase,and time width,but varying amplitude in all channels.The results demonstrate that the MMP can optimally reconstruct the original signal and automatically remove artifact noises.Moreover,the coherence between the 3D source reconstruction and the prior knowledge of psychology further suggests that the MMP is effective in MEG single-trial processing.
