目的对心房颤动(AF)患者导管射频消融(RFCA)术后复发的风险预测模型进行系统评价,为临床治疗AF提供依据。方法检索中国知网数据库、万方数据库、维普数据库、中国生物医学文献数据库以及PubMed、CINAHL、Web of Science、Embase、Cochra...目的对心房颤动(AF)患者导管射频消融(RFCA)术后复发的风险预测模型进行系统评价,为临床治疗AF提供依据。方法检索中国知网数据库、万方数据库、维普数据库、中国生物医学文献数据库以及PubMed、CINAHL、Web of Science、Embase、Cochrane Library数据库中“AF患者RFCA术后复发的风险预测模型”相关文献,检索年限为建库至2024年5月11日,提取文献数据,用预测模型偏倚风险评估工具评价所纳入模型的偏倚风险和适用性。结果最终纳入文献19篇,发表于2021—2024年,全部来源于中国。11篇文献为模型建立,8篇文献为模型建立与验证。最终纳入19个模型,样本总量为136~6127例,复发率为8.70%~48.57%。19篇文献报告了模型预测AF患者RFCA术后复发的曲线下面积,为0.723~0.938。模型重复报告的前6位预测变量为左心房内径、年龄、AF类型、AF病程、性别和BMI。1篇文献偏倚风险评估为“不清楚”,其余18篇文献均为“高偏倚风险”;5篇文献适用性“不清楚”,其余14篇文献适用性风险较低。结论AF患者RFCA术后复发风险预测模型研究开展较晚,建模方式多数基于Logistic回归分析构建列线图模型,纳入的19个模型预测效能较高,预测因子可从临床资料、影像学资料、电生理检查中筛选,模型整体偏倚风险较高。展开更多
目的:本研究旨在探讨阿戈美拉汀对阿尔茨海默症(AD)患者认知功能及炎性因子水平的影响,并初步分析其可能的作用机制,为AD的临床治疗提供新的理论依据。方法:选择2023年1月至2023年12月在青岛市精神卫生中心接受治疗的AD患者,共40例。通...目的:本研究旨在探讨阿戈美拉汀对阿尔茨海默症(AD)患者认知功能及炎性因子水平的影响,并初步分析其可能的作用机制,为AD的临床治疗提供新的理论依据。方法:选择2023年1月至2023年12月在青岛市精神卫生中心接受治疗的AD患者,共40例。通过口服阿戈美拉汀治疗8周,使用蒙特利尔认知评估量表(MoCA)和简易精神状态量表(MMSE)评估治疗前后认知功能变化。同时,测定血清IL-6、IL-8、IL-1β和TNF-α水平,分析炎性因子变化及其与认知功能的关系。结果:治疗后,AD患者的MoCA和MMSE评分显著提高(P β和TNF-α水平显著高于健康组(P P P Objective: This study aimed to explore the effects of agomelatine on cognitive function and inflammatory factor levels in patients with Alzheimer’s disease (AD), and preliminarily analyze its potential mechanisms, providing new theoretical support for AD clinical treatment. Methods: Forty AD patients treated at Qingdao Mental Health Center from January to December 2023 were included. After 8 weeks of oral agomelatine treatment, changes in cognitive function before and after treatment were assessed using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). Meanwhile, serum levels of IL-6, IL-8, IL-1β, and TNF-α were measured to analyze changes in inflammatory factors and their relationship with cognitive function. Results: After treatment, MoCA and MMSE scores of AD patients significantly improved (P β, and TNF-α were significantly higher in the AD group compared to the healthy control group (P P P < 0.001), with higher inflammatory levels associated with more severe AD. Conclusion: Agomelatine significantly improves cognitive function and reduces inflammatory factor levels, exerting a neuroprotective effect. The elevation of inflammatory factors is closely related to cognitive impairment in AD patients, suggesting that neuroinflammation may be a key driver of cognitive decline in AD. This study provides new theoretical support and clinical evidence for the application of agomelatine in the treatment of Alzheimer’s disease.展开更多
文摘目的对心房颤动(AF)患者导管射频消融(RFCA)术后复发的风险预测模型进行系统评价,为临床治疗AF提供依据。方法检索中国知网数据库、万方数据库、维普数据库、中国生物医学文献数据库以及PubMed、CINAHL、Web of Science、Embase、Cochrane Library数据库中“AF患者RFCA术后复发的风险预测模型”相关文献,检索年限为建库至2024年5月11日,提取文献数据,用预测模型偏倚风险评估工具评价所纳入模型的偏倚风险和适用性。结果最终纳入文献19篇,发表于2021—2024年,全部来源于中国。11篇文献为模型建立,8篇文献为模型建立与验证。最终纳入19个模型,样本总量为136~6127例,复发率为8.70%~48.57%。19篇文献报告了模型预测AF患者RFCA术后复发的曲线下面积,为0.723~0.938。模型重复报告的前6位预测变量为左心房内径、年龄、AF类型、AF病程、性别和BMI。1篇文献偏倚风险评估为“不清楚”,其余18篇文献均为“高偏倚风险”;5篇文献适用性“不清楚”,其余14篇文献适用性风险较低。结论AF患者RFCA术后复发风险预测模型研究开展较晚,建模方式多数基于Logistic回归分析构建列线图模型,纳入的19个模型预测效能较高,预测因子可从临床资料、影像学资料、电生理检查中筛选,模型整体偏倚风险较高。
文摘目的:本研究旨在探讨阿戈美拉汀对阿尔茨海默症(AD)患者认知功能及炎性因子水平的影响,并初步分析其可能的作用机制,为AD的临床治疗提供新的理论依据。方法:选择2023年1月至2023年12月在青岛市精神卫生中心接受治疗的AD患者,共40例。通过口服阿戈美拉汀治疗8周,使用蒙特利尔认知评估量表(MoCA)和简易精神状态量表(MMSE)评估治疗前后认知功能变化。同时,测定血清IL-6、IL-8、IL-1β和TNF-α水平,分析炎性因子变化及其与认知功能的关系。结果:治疗后,AD患者的MoCA和MMSE评分显著提高(P β和TNF-α水平显著高于健康组(P P P Objective: This study aimed to explore the effects of agomelatine on cognitive function and inflammatory factor levels in patients with Alzheimer’s disease (AD), and preliminarily analyze its potential mechanisms, providing new theoretical support for AD clinical treatment. Methods: Forty AD patients treated at Qingdao Mental Health Center from January to December 2023 were included. After 8 weeks of oral agomelatine treatment, changes in cognitive function before and after treatment were assessed using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). Meanwhile, serum levels of IL-6, IL-8, IL-1β, and TNF-α were measured to analyze changes in inflammatory factors and their relationship with cognitive function. Results: After treatment, MoCA and MMSE scores of AD patients significantly improved (P β, and TNF-α were significantly higher in the AD group compared to the healthy control group (P P P < 0.001), with higher inflammatory levels associated with more severe AD. Conclusion: Agomelatine significantly improves cognitive function and reduces inflammatory factor levels, exerting a neuroprotective effect. The elevation of inflammatory factors is closely related to cognitive impairment in AD patients, suggesting that neuroinflammation may be a key driver of cognitive decline in AD. This study provides new theoretical support and clinical evidence for the application of agomelatine in the treatment of Alzheimer’s disease.
文摘差分全球卫星导航系统(GNSS)技术辅助空中三角测量技术可实现无人机影像元素的高精度绝对定位.机载GNSS模块采样频率一般不超过50 Hz,更高的采样频率对GNSS模块软硬件提出更高的要求.本文基于三次样条函数实现无人机高动态定位的三维坐标插值,并通过实测数据检验三次样条函数的适用性,实验结果表明,固支样条更适用于无人机高动态运动轨迹坐标插值,当采样频率高于5 Hz时,平面插值精度优于1.0 cm,高程插值精度优于2.2 cm.
