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Fast and Sensitive Chiral Analysis of Amphetamines and Cathinones in Equine Urine and Plasma Using Liquid Chromatography Tandem Mass Spectrometry 被引量:1
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作者 Caroline C. Wang Petra Hartmann-Fischbach +5 位作者 Tim R. Krueger Alisha Lester aaron simonson Terry L. Wells Max O. Wolk Nick J. Hidlay 《American Journal of Analytical Chemistry》 2015年第13期995-1003,共9页
A simple, rapid, sensitive and reproducible method for enantiomer analysis of methamphetamine, amphetamine, cathinone and methcathinone was developed and validated. The compounds were extracted from equine plasma and ... A simple, rapid, sensitive and reproducible method for enantiomer analysis of methamphetamine, amphetamine, cathinone and methcathinone was developed and validated. The compounds were extracted from equine plasma and urine using a fast liquid-liquid extraction procedure. Only one milliliter plasma and one hundred microliter urine sample is needed for analysis. The extraction procedure had good recovery (>70%) and the matrix effect was negligible. Enantiomer differentiation and confirmation were achieved using liquid chromatography with chiral stationary phase and mass spectrometry detection. The method demonstrated excellent reproducibility with intra-day and inter-day precision of lower than 5%. The lower limits of detection for all of the compounds studied here were at low pg/mL level for both plasma and urine. This is the first report of the analysis of four chiral compounds in equine plasma and urine. Routine application was demonstrated for (S)- and (R)-enantiomer differentiation. 展开更多
关键词 AMPHETAMINES and CATHINONES EQUINE PLASMA and URINE Chiral Analysis Liquid Chromatography Tandem Mass SPECTROMETRY
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