Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney disease.The gut microbiota of patients with gout and HUA is significantly ...Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney disease.The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people.This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder.Some studies have suggested that changes in the composition,diversity,and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis.Therefore,we discussed how the gut microbiota contributes to HUA through purine metabolism,UA excretion,and intestinal inflammatory responses.We examined specific changes in the composition of the gut microbiota associated with gout and HUA,highlighting key bacterial taxa and the metabolic pathways involved.Additionally,we discussed the effect of conventional gout treatments on the gut microbiota composition,along with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and prebiotics.We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.展开更多
In this editorial,we examine a paper by Koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the inte...In this editorial,we examine a paper by Koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the intestinal barrier and reduced liver fibrosis in a mouse model of ALD.The study also underlines the role of PPARs in intestinal barrier function and lipid homeostasis,which are both affected by ALD.Effective therapies are necessary for ALD because it is a critical health issue that affects people worldwide.This editorial analyzes the possibility of PPAR agonists as treatments for ALD.As key factors of inflammation and metabolism,PPARs offer multiple methods for managing the complex etiology of ALD.We assess the abilities of PPARα,PPARγ,and PPARβ/δagonists to prevent steatosis,inflammation,and fibrosis due to liver diseases.Recent research carried out in preclinical and clinical settings has shown that PPAR agonists can reduce the severity of liver disease.This editorial discusses the data analyzed and the obstacles,advantages,and mechanisms of action of PPAR agonists for ALD.Further research is needed to understand the efficacy,safety,and mechanisms of PPAR agonists for treating ALD.展开更多
In the present work,we study the time evolution,significance of the N-S asymmetry excesses presented as a function of the solar cycle and prominent rotational periods(~27 d)separately for the northern and southern hem...In the present work,we study the time evolution,significance of the N-S asymmetry excesses presented as a function of the solar cycle and prominent rotational periods(~27 d)separately for the northern and southern hemispheres.We have investigated short-term variations of the hemispheric solar activity(sunspot numbers and sunspot areas)during the time period 2010-2015,which covers the ascending and the maximum phase of solar cycle 24.We have implemented the Lomb-Scargle periodogram and continuous wavelet transform power spectrum techniques to study the time evolution and dominant rotational periods separately for the northern and southern hemispheres,and whole solar disk.Our results showed that the northern hemisphere exhibited longer solar synodic periods than the southern hemisphere,indicating that the northern hemisphere has a lower rotation rate.Moreover,the northern hemisphere was found to be dominant before transferring to the southern hemisphere during mid-2013.Also,the sunspot areas clearly demonstrated a two-peak structure of solar activity in the northern and southern hemispheres respectively during 2012 and 2014.The statistical significance of the southern hemisphere affirmed enhanced excess during the maximum phase of solar cycle 24.展开更多
We have theoretically studied the modal dispersion equation and effective refractive index of one-dimensional plasma photonic crystals (1-D PPCs) having different materials in one unit cell. The dispersion relations r...We have theoretically studied the modal dispersion equation and effective refractive index of one-dimensional plasma photonic crystals (1-D PPCs) having different materials in one unit cell. The dispersion relations related for such structure is derived by solving Maxwell’s equation using the transfer matrix method. It is found that the presence of plasma in a unit cell enhanced the phase matching ability and provides additional degree of freedom to control phase matching condition compared to the conventional one-dimensional photonic crystals (1-D PCs).展开更多
In this paper,we discuss the DNA construction of general length over the finite ring =Z4+vZ4,with v2=v,which plays a very significant role in DNA computing.We discuss the GC weight of DNA codes over R.Several examples...In this paper,we discuss the DNA construction of general length over the finite ring =Z4+vZ4,with v2=v,which plays a very significant role in DNA computing.We discuss the GC weight of DNA codes over R.Several examples of reversible cyclic codes over R are provided,whose Z4-images are Z4-1inear codes with good parameters.展开更多
The composition-dependent microstructural morphology variations of Se89Zn2Te5In4 and Se87Zn2Te5In6 chalcogenide alloys are investigated. Glassy and nanophase surfaces and structural morphologies of these alloys have b...The composition-dependent microstructural morphology variations of Se89Zn2Te5In4 and Se87Zn2Te5In6 chalcogenide alloys are investigated. Glassy and nanophase surfaces and structural morphologies of these alloys have been described with help of scanning electron microscope (SEM) and transmission electron microscope (TEM), and their elemental concentrations are confirmed from the energy dispersive X-ray spectroscopy (EDX). Experimental results demonstrate that the microstructure of Se89Zn2Te5In4 alloy belongs to pure glassy state, while the Se87Zn2Te5In6 alloy is with nanophase structure.展开更多
In this paper, our main objective is to find out the necessary and sufficient conditions for a cyclic code of arbitrary length over the ring of four elements R1 = F2 ＋ u2 （u^2 = 1） to be a reversible cyclic code. W...In this paper, our main objective is to find out the necessary and sufficient conditions for a cyclic code of arbitrary length over the ring of four elements R1 = F2 ＋ u2 （u^2 = 1） to be a reversible cyclic code. We also obtain the structure of cyclic DNA codes of odd length over the ring R = F2 [u, v]/（u^2 -1, v^3 -v, uv- vu）, which plays an important role in Computational Biology. Furthermore, we establish a direct link between the elements of ring /{ and 64 codons used in the amino acids of living organisms by introducing a Gray map from R to R1. Among others, binary images of cyclic codes over R are also investigated. As applications, some cyclic DNA codes over R using the Gray map are provided.展开更多
文摘Hyperuricemia(HUA)is a condition associated with a high concentration of uric acid(UA)in the bloodstream and can cause gout and chronic kidney disease.The gut microbiota of patients with gout and HUA is significantly altered compared to that of healthy people.This article focused on the complex interconnection between alterations in the gut microbiota and the development of this disorder.Some studies have suggested that changes in the composition,diversity,and activity of microbes play a key role in establishing and progressing HUA and gout pathogenesis.Therefore,we discussed how the gut microbiota contributes to HUA through purine metabolism,UA excretion,and intestinal inflammatory responses.We examined specific changes in the composition of the gut microbiota associated with gout and HUA,highlighting key bacterial taxa and the metabolic pathways involved.Additionally,we discussed the effect of conventional gout treatments on the gut microbiota composition,along with emerging therapeutic approaches that target the gut microbiome,such as the use of probiotics and prebiotics.We also provided insights into a study regarding the gut microbiota as a possible novel therapeutic intervention for gout treatment and dysbiosis-related diagnosis.
文摘In this editorial,we examine a paper by Koizumi et al,on the role of peroxisome proliferator-activated receptor(PPAR)agonists in alcoholic liver disease(ALD).The study determined whether elafibranor protected the intestinal barrier and reduced liver fibrosis in a mouse model of ALD.The study also underlines the role of PPARs in intestinal barrier function and lipid homeostasis,which are both affected by ALD.Effective therapies are necessary for ALD because it is a critical health issue that affects people worldwide.This editorial analyzes the possibility of PPAR agonists as treatments for ALD.As key factors of inflammation and metabolism,PPARs offer multiple methods for managing the complex etiology of ALD.We assess the abilities of PPARα,PPARγ,and PPARβ/δagonists to prevent steatosis,inflammation,and fibrosis due to liver diseases.Recent research carried out in preclinical and clinical settings has shown that PPAR agonists can reduce the severity of liver disease.This editorial discusses the data analyzed and the obstacles,advantages,and mechanisms of action of PPAR agonists for ALD.Further research is needed to understand the efficacy,safety,and mechanisms of PPAR agonists for treating ALD.
文摘In the present work,we study the time evolution,significance of the N-S asymmetry excesses presented as a function of the solar cycle and prominent rotational periods(~27 d)separately for the northern and southern hemispheres.We have investigated short-term variations of the hemispheric solar activity(sunspot numbers and sunspot areas)during the time period 2010-2015,which covers the ascending and the maximum phase of solar cycle 24.We have implemented the Lomb-Scargle periodogram and continuous wavelet transform power spectrum techniques to study the time evolution and dominant rotational periods separately for the northern and southern hemispheres,and whole solar disk.Our results showed that the northern hemisphere exhibited longer solar synodic periods than the southern hemisphere,indicating that the northern hemisphere has a lower rotation rate.Moreover,the northern hemisphere was found to be dominant before transferring to the southern hemisphere during mid-2013.Also,the sunspot areas clearly demonstrated a two-peak structure of solar activity in the northern and southern hemispheres respectively during 2012 and 2014.The statistical significance of the southern hemisphere affirmed enhanced excess during the maximum phase of solar cycle 24.
文摘We have theoretically studied the modal dispersion equation and effective refractive index of one-dimensional plasma photonic crystals (1-D PPCs) having different materials in one unit cell. The dispersion relations related for such structure is derived by solving Maxwell’s equation using the transfer matrix method. It is found that the presence of plasma in a unit cell enhanced the phase matching ability and provides additional degree of freedom to control phase matching condition compared to the conventional one-dimensional photonic crystals (1-D PCs).
文摘In this paper,we discuss the DNA construction of general length over the finite ring =Z4+vZ4,with v2=v,which plays a very significant role in DNA computing.We discuss the GC weight of DNA codes over R.Several examples of reversible cyclic codes over R are provided,whose Z4-images are Z4-1inear codes with good parameters.
文摘The composition-dependent microstructural morphology variations of Se89Zn2Te5In4 and Se87Zn2Te5In6 chalcogenide alloys are investigated. Glassy and nanophase surfaces and structural morphologies of these alloys have been described with help of scanning electron microscope (SEM) and transmission electron microscope (TEM), and their elemental concentrations are confirmed from the energy dispersive X-ray spectroscopy (EDX). Experimental results demonstrate that the microstructure of Se89Zn2Te5In4 alloy belongs to pure glassy state, while the Se87Zn2Te5In6 alloy is with nanophase structure.
文摘In this paper, our main objective is to find out the necessary and sufficient conditions for a cyclic code of arbitrary length over the ring of four elements R1 = F2 ＋ u2 （u^2 = 1） to be a reversible cyclic code. We also obtain the structure of cyclic DNA codes of odd length over the ring R = F2 [u, v]/（u^2 -1, v^3 -v, uv- vu）, which plays an important role in Computational Biology. Furthermore, we establish a direct link between the elements of ring /{ and 64 codons used in the amino acids of living organisms by introducing a Gray map from R to R1. Among others, binary images of cyclic codes over R are also investigated. As applications, some cyclic DNA codes over R using the Gray map are provided.
