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国家婴儿喂养推荐方案变更前后乳糜泻患病率的变化
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作者 Carlsson A. agardh d. +1 位作者 Borulf S. 张诗峰 《世界核心医学期刊文摘(胃肠病学分册)》 2006年第11期47-48,共2页
Objective. A national change in infant feeding recommendations was proposed in 1996 in Sweden: a slow introduction to gluten during weaning was stressed, the recommendation being introduction at 4 instead of 6 months ... Objective. A national change in infant feeding recommendations was proposed in 1996 in Sweden: a slow introduction to gluten during weaning was stressed, the recommendation being introduction at 4 instead of 6 months of age. The aim of the present study was to compare the prevalence of celiac disease in healthy young children born before and after the new feeding recommendations in 1996. Material and methods. Sera from 679 children at a median age of 2.9 years (range 2.5-4.2 years) born between January 1996 and November 1997 were investigated with IgA-antigliadin antibodies (AGA) and IgA-endomysial autoantibodies (EMA) and compared with 690 age-matched children born between July 1992 and June 1993. Children with a positive test for EMA and AGA or EMA only were re-tested, and if positive at follow-up, investigated with intestinal biopsy. Results. At baseline, 2.2%(15/679) children were positive for EMA and another 0.6%(4/679) for both EMA and AGA. One child refused to be re-tested and eight children were still EMA positive at follow-up. Intestinal biopsy was performed in seven children (one declined biopsy), of whom three showed total villous atrophy. Two children with EMA titers 1∶640, respectively, refused further participation in the study, but were strongly suspected to have celiac disease. In total, 0.7%(5/679) (95%confidence interval (CI) = 0.1-1.4%)were considered to have celiac disease compared with 1.3%(9/690) (95%CI = 0.4-2.2%) in the control group (p = 0.4217). In addition, 0.3%of the children were diagnosed with symptomatic celiac disease compared with 0.7%in controls (p = 0.0134). Conclusions. The prevalence of symptomatic celiac disease declined after the infant dietary recommendations were introduced in 1996, but we could not find any difference in undiagnosed celiac disease between the screened children born before and those born after 1996. 展开更多
关键词 婴儿喂养 乳糜泻 黏膜活检 麸质 自身抗体 清抗 肌内膜 断奶期 滴度
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采用放射性配体结合测定法检测幼儿组织谷氨酰胺转移酶自身抗体
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作者 agardh d. Carlsson A. +1 位作者 Lynch K. 李开 《世界核心医学期刊文摘(儿科学分册)》 2005年第3期9-10,共2页
目的:前瞻性筛查腹腔疾病(CD)易感性幼儿,测定其体内抗组织谷氨酰胺转移酶(tTG)自身抗体水平。方法:共有652名幼儿被纳入试验,其平均年龄为2.9岁(2.5-4.2岁),采用放射性配体结合测定法,检测抗组织谷氨酰胺转移酶免疫球蛋白A(IgA-tTG)和G... 目的:前瞻性筛查腹腔疾病(CD)易感性幼儿,测定其体内抗组织谷氨酰胺转移酶(tTG)自身抗体水平。方法:共有652名幼儿被纳入试验,其平均年龄为2.9岁(2.5-4.2岁),采用放射性配体结合测定法,检测抗组织谷氨酰胺转移酶免疫球蛋白A(IgA-tTG)和G (IgA-tTG);采用间接荧光免疫测定法,检测肌内膜抗体免疫球蛋白A(EMA)。对于自身抗体阳性儿童,平均1.2年(0.2-1.9年)后再次进行检测。对于自身抗体水平持续偏高的儿童,进行肠组织活检。结果:试验基准, 全部625名受试儿童中,3.2%(95%CI 1.9%-4.6%) 至少有1种自身抗体呈阳性:2.5%(95%CI 1.3%- 3.7%)出现IgA-tTG,1.7%(95%C1 0.7%-2.7%) 展开更多
关键词 自身抗体 谷氨酰胺转移酶 配体结合 肠组织活检 荧光免疫测定法 免疫球蛋白 肌内膜 IgG 上皮内淋巴细胞
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