期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus 被引量:6
1
作者 ahmad ghorbani Reza Shafiee-Nick 《World Journal of Diabetes》 SCIE CAS 2015年第1期145-150,共6页
Diabetes is associated with several complications such as retinopathy, nephropathy, neuropathy and cardiovascular diseases. Currently, insulin is the main used medication for management of insulin-dependentdiabetes me... Diabetes is associated with several complications such as retinopathy, nephropathy, neuropathy and cardiovascular diseases. Currently, insulin is the main used medication for management of insulin-dependentdiabetes mellitus(type-1 diabetes). In this metabolic syndrome, in addition to decrease of endogenous insulin, the plasma level of connecting peptide(C-peptide) is also reduced due to beta cell destruction. Studies in the past decade have shown that C-peptide is much more than a byproduct of insulin biosynthesis and possess different biological activities. Therefore, it may be possible that C-peptide deficiency be involved, at least in part, in the development of different complications of diabetes. It has been shown that a small level of remaining C-peptide is associated with significant metabolic benefit. The purpose of this review is to describe beneficial effects of C-peptide replacement on pathological features associated with insulin-dependent diabetes. Also, experimental and clinical findings on the effects of C-peptide on wholebody glucose utilization, adipose tissue metabolism and tissues blood flow are summarized and discussed. The hypoglycemic, antilipolytic and vasodilator effects of C-peptide suggest that it may contribute to fine-tuning of the tissues metabolism under different physiologic or pathologic conditions. Therefore, C-peptide replacement together with the classic insulin therapy may prevent, retard, or ameliorate diabetic complications in patients with type-1 diabetes. 展开更多
关键词 C-PEPTIDE DIABETES INSULIN NEPHROPATHY NEUROPATHY
下载PDF
不同丁香提取物对戊四唑诱导的小鼠癫癎发作的影响(英文) 被引量:1
2
作者 Mahmoud Hosseini Taha Jafarianheris +4 位作者 Navid Seddighi Mohammad Parvaneh ahmad ghorbani Hamid Reza Sadeghnia Hassan Rakhshandeh 《中西医结合学报》 CAS 2012年第12期1476-1481,共6页
目的:研究不同丁香提取物对戊四唑引发小鼠癫癎的作用。方法:实验小鼠被随机分为生理盐水对照组、不同剂量(50、100、250及500mg/kg)丁香水提取物组、不同剂量(50、100、250及500mg/kg)丁香乙醇提取物组、不同剂量(50、100、250及500mg/... 目的:研究不同丁香提取物对戊四唑引发小鼠癫癎的作用。方法:实验小鼠被随机分为生理盐水对照组、不同剂量(50、100、250及500mg/kg)丁香水提取物组、不同剂量(50、100、250及500mg/kg)丁香乙醇提取物组、不同剂量(50、100、250及500mg/kg)丁香三氯甲烷提取物组。给予戊四唑前60min为各组小鼠注射药物。记录并比较各组小鼠阵发性强直性抽搐潜伏期(generalized tonic-clonic seizure,GTCS)、最小阵发性痉挛潜伏期(minimal clonic seizure,MCS)及死亡率。结果:低、中、高三种剂量的丁香水提取物能有效延长MSC和GTCS的潜伏期(P<0.05)。50、100和250mg/kg的丁香乙醇提取物显著增加了小鼠MCS潜伏时间(P<0.05)。与盐水治疗组相比,惊厥小鼠模型经50、100、250和500mg/kg丁香的乙醇提取物治疗后,其GTCS的潜伏期显著高于盐水治疗组,但丁香的三氯甲烷提取物对惊厥小鼠的GTCS和MCS潜伏期没有显著的影响。结论:丁香乙醇和水提取物能抑制由戊四唑诱发的小鼠惊厥,但其确切的作用机制和有效的抗惊厥活性物质还有待进一步的研究。 展开更多
关键词 丁香 戊四唑 癫癎发作 小鼠
下载PDF
Coefficient of consolidation by end of arc method
3
作者 Mohsen Abbaspout Reza Porhoseini +1 位作者 Kazem Barkhordari ahmad ghorbani 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第1期332-337,共6页
One of the most important issues in geotechnical engineering is excess pore pressure caused by clay soil loading and consolidation. Regarding uncertainties and complexities, this issue has long been the subject of att... One of the most important issues in geotechnical engineering is excess pore pressure caused by clay soil loading and consolidation. Regarding uncertainties and complexities, this issue has long been the subject of attention of many researchers. In this work, a one-dimensional consolidation apparatus was equipped in a way that pore water pressure and settlement could be continuously read and recorded during consolidation process under static loading. The end of primary consolidation was obtained using water pressure changes helping to present a new method for determining the end of primary consolidation and consolidation coefficient. This method was then compared with two classical theory methods of lg t and t. Using Terzaghi's theory, the way of pore pressure dissipation for lg t, t and the new method was found and compared with experimental results. It is concluded that the new method has better results. 展开更多
关键词 one-dimensional consolidation of soil excess pore pressure end primary consolidation consolidation coefficient static loading
下载PDF
Clinical and experimental studies on polyherbal formulations for diabetes: current status and future prospective
4
作者 ahmad ghorbani 《Journal of Integrative Medicine》 SCIE CAS CSCD 2014年第4期336-345,共10页
Diabetes is a leading cause of morbidity an active search for antidiabetic drugs with greater and mortality in the world. There is currently effectiveness with fewer and less adverse side effects. Although numerous in... Diabetes is a leading cause of morbidity an active search for antidiabetic drugs with greater and mortality in the world. There is currently effectiveness with fewer and less adverse side effects. Although numerous individual herbs have been experimentally or clinically reported to possess antidiabetic effects, considerably less research has been conducted on polyherbal compounds. It is believed that herbal compounds containing multiple plant products have synergistic antidiabetic effects and could enhance the desired actions. Several polyherbal formulations have been studied as therapeutic agents in diabetes management. To describe the current state of research on polyherbal compounds in the treatment of diabetes, an extensive review of literature was undertaken on several major databases. This paper presents what is known about the efficacy of these polyherbal formulations and compare their antidiabetic effects with those of current oral hypoglycemic drugs as reference. The percent decrease in blood glucose, lipids and other biochemical parameters achieved by each product in diabetic animals and patients is reported. Also, the possible mechanisms responsible for hypoglycemic action of polyherbal formulations are discussed. 展开更多
关键词 diabetes mellitus hypoglycemic agents plants medicinal review
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部