The Cambrian Period is the first period of the Phanerozoic Eon and witnessed the explosive appearance of the metazoans, representing the beginning of the modern earth-life system characterized by animals in contrary t...The Cambrian Period is the first period of the Phanerozoic Eon and witnessed the explosive appearance of the metazoans, representing the beginning of the modern earth-life system characterized by animals in contrary to the Precambrian earth-life system dominated by microbial life. However, understanding Cambrian earth-life system evolution is hampered by regional and global stratigraphic correlations due to an incomplete chronostratigraphy and consequent absence of a highresolution timescale. Here we briefly review the historical narrative of the present international chronostratigraphic framework of the Cambrian System and summarize recent advances and problems of the undefined Cambrian stage GSSPs, in particular we challenge the global correlation of the GSSP for the Cambrian base, in addition to Cambrian chemostratigraphy and geochronology. Based on the recent advances of the international Cambrian chronostratigraphy, revisions to the Cambrian chronostratigraphy of China, which are largely based on the stratigraphic record of South China, are suggested, and the Xiaotanian Stage is newly proposed for the Cambrian Stage 2 of China. We further summarize the integrative stratigraphy of South China, North China and Tarim platforms respectively with an emphasis on the facies variations of the Precambrian-Cambrian boundary successions and problems for identification of the Cambrian base in the different facies and areas of China. Moreover, we discuss stratigraphic complications that are introduced by poorly fossiliferous dolomite successions in the upper Cambrian System which are widespread in South China, North China and Tarim platforms.展开更多
Accumulation and aggregation of β-amyloid（Aβ） peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer＇s disease. The self-assembled Aβ molecules form various intermediate aggregates incl...Accumulation and aggregation of β-amyloid（Aβ） peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer＇s disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic Caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity.展开更多
A method is proposed to optimize the recording structure of the photorefractive volume grating to compensate high spatial frequency in the distorted wavefront by optical phase conjugation.Based on the coupled-wave equ...A method is proposed to optimize the recording structure of the photorefractive volume grating to compensate high spatial frequency in the distorted wavefront by optical phase conjugation.Based on the coupled-wave equation, the diffraction efficiency of the recorded grating formed by the scattered beams in different recording structures is simulated.The theoretical results show that the recorded modulations with high spatial frequency can be significantly improved in the small recording angle.In the experiment, three recording structures with the recording angles of 7.5°, 30°, and 45° are chosen to verify the compensation effect.Compared with the reconstructed image in the large recording angle of 45°, the signal to noise ratio of the image recorded at 7.5° increases to 3.2 times of that at 45°.展开更多
A direct prejudgement strategy that takes the diffraction ring as the analysis target is put forward to predict hot images induced by defects of tens of microns in the main amplifier section of high power laser system...A direct prejudgement strategy that takes the diffraction ring as the analysis target is put forward to predict hot images induced by defects of tens of microns in the main amplifier section of high power laser systems. Analysis of hot-image formation process shows that the hot image can be precisely calculated with the extracted intensity oscillation of the diffraction ring on the front surface of the nonlinear plate. The gradient direction matching （GDM） method is adopted to detect diffraction tings. Recognition of simulated diffraction rings shows that it is feasible to directly prejudge hot images induced by those closely spaced defects and the defects that are far apart from each other. Image compression and cluster analysis are utilized to optimize the performance of the GDM method in recognizing actually collected diffraction images. Results show that hot images induced by defects of tens of microns can be directly prejudged without redundant information.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 41672029, 41661134048)the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (Grant Nos. XDB18000000, XDB10010101)
文摘The Cambrian Period is the first period of the Phanerozoic Eon and witnessed the explosive appearance of the metazoans, representing the beginning of the modern earth-life system characterized by animals in contrary to the Precambrian earth-life system dominated by microbial life. However, understanding Cambrian earth-life system evolution is hampered by regional and global stratigraphic correlations due to an incomplete chronostratigraphy and consequent absence of a highresolution timescale. Here we briefly review the historical narrative of the present international chronostratigraphic framework of the Cambrian System and summarize recent advances and problems of the undefined Cambrian stage GSSPs, in particular we challenge the global correlation of the GSSP for the Cambrian base, in addition to Cambrian chemostratigraphy and geochronology. Based on the recent advances of the international Cambrian chronostratigraphy, revisions to the Cambrian chronostratigraphy of China, which are largely based on the stratigraphic record of South China, are suggested, and the Xiaotanian Stage is newly proposed for the Cambrian Stage 2 of China. We further summarize the integrative stratigraphy of South China, North China and Tarim platforms respectively with an emphasis on the facies variations of the Precambrian-Cambrian boundary successions and problems for identification of the Cambrian base in the different facies and areas of China. Moreover, we discuss stratigraphic complications that are introduced by poorly fossiliferous dolomite successions in the upper Cambrian System which are widespread in South China, North China and Tarim platforms.
基金supported by the National Natural Science Foundation of China(91127043,31600803,and 21273051)
文摘Accumulation and aggregation of β-amyloid（Aβ） peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer＇s disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic Caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity.
基金supported by the National Natural Science Foundation of China(No.11774364)the Shanghai Sailing Program(No.18YF1425900)
文摘A method is proposed to optimize the recording structure of the photorefractive volume grating to compensate high spatial frequency in the distorted wavefront by optical phase conjugation.Based on the coupled-wave equation, the diffraction efficiency of the recorded grating formed by the scattered beams in different recording structures is simulated.The theoretical results show that the recorded modulations with high spatial frequency can be significantly improved in the small recording angle.In the experiment, three recording structures with the recording angles of 7.5°, 30°, and 45° are chosen to verify the compensation effect.Compared with the reconstructed image in the large recording angle of 45°, the signal to noise ratio of the image recorded at 7.5° increases to 3.2 times of that at 45°.
基金supported by the International Partnership Program of Chinese Academy Of Sciences(No.181231KYSB20170022)the National Natural Science Foundation of China(No.11774364)the Shanghai Sailing Program(No.18YF1425900)
文摘A direct prejudgement strategy that takes the diffraction ring as the analysis target is put forward to predict hot images induced by defects of tens of microns in the main amplifier section of high power laser systems. Analysis of hot-image formation process shows that the hot image can be precisely calculated with the extracted intensity oscillation of the diffraction ring on the front surface of the nonlinear plate. The gradient direction matching （GDM） method is adopted to detect diffraction tings. Recognition of simulated diffraction rings shows that it is feasible to directly prejudge hot images induced by those closely spaced defects and the defects that are far apart from each other. Image compression and cluster analysis are utilized to optimize the performance of the GDM method in recognizing actually collected diffraction images. Results show that hot images induced by defects of tens of microns can be directly prejudged without redundant information.
