The present study reports a case of a patient with choroidal neovascularization(CNV)associated with pseudoxanthoma elasticum(PXE).We observed the functional and anatomical improvement of the patient treated with intra...The present study reports a case of a patient with choroidal neovascularization(CNV)associated with pseudoxanthoma elasticum(PXE).We observed the functional and anatomical improvement of the patient treated with intravitreal vascular endothelial growth factor(VEGF)inhibitor bevacizumab.The study also systematically searched the database for similar cases to provide a literature review.Data concerning the clinical features,treatment strategies and outcomes were extracted and analyzed.Retrospective interventional case report and systematic literature review.A 56-year-old healthy Chinese woman with CNV secondary to PXE was reported.Examinations included best corrected visual acuity(BCVA),biomicroscopy,optical coherence tomography(OCT),fluorescein and indocyanine green angiography and digital fundus photography.The patient managed with intravitreal anti-vascular endothelial growth factor(anti-VEGF)injections(bevacizumab 1.25 mg/0.05 m L).The Cochrane Library,Pub Med,OVID,and Up To Date databases were searched using the term pseudoxanthoma elasticum or Gr?nblad-Strandberg syndrome with the limits English.Articles that predated the databases were gathered from current references.Fundus examination revealed angioid streaks bilaterally and CNV in left eye(LE).After the patient underwent three intravitreal injections of bevacizumab,the LE showed absorption of the subretinal fluid and shrinkage of the CNV.Visual acuity(VA)was improved in her treated LE.Bevacizumab treatment was well tolerated with no adverse events reported.Approximately ten articles about 45 patients(49 eyes)describing CNV secondary to angioid streaks in PXE treated with anti-VEGF were found in the literature search.In the present case,bevacizumab of an initial three injection loading dose,achieved maintenance of visual function in the treatment of CNV associated with angioid streaks in PXE.Literature articles concluded that the intravitreal application of anti-VEGF is highly efficient for improving and stabilizing the lesion as well as the eyesight.So we believe that anti-VEGF therapy can be a great choice of treatment for CNV secondary to angioid streaks related PXE.展开更多
Objective ：To investigate the role the lens dimensions played on the pathogenesis of primary angle-closure glaucoma. Methods：38 eyes of 20 patients with primary angle-closure glaucoma （PACG） and 35 eyes of 22 norm...Objective ：To investigate the role the lens dimensions played on the pathogenesis of primary angle-closure glaucoma. Methods：38 eyes of 20 patients with primary angle-closure glaucoma （PACG） and 35 eyes of 22 normal individuals without ocular abnormalities were examined. The anatomical parameters of the lens and other structures of the anterior segment were calculated using B ultrasound, computer image processing and ultrasound biomicroscopy （UBM）. The parameters were compared between the patients and normal subjects. Correlation analysis was used to determine the relationship between the radii of curvature of the anterior lens surface （RCALS） and the other parameters of the anterior segment. Results：Compared with the normal eyes, the eyes of PACG had thicker lens, steeper curvature of anterior lens surface, decreased depth of the anterior chamber, narrower chamber angle, and more anterior position of the ciliary bodies and lens. All these differences were significant（P 〈 0.05 or P 〈 0.01）. In the PACG group, the RCALS had significantly negative correlation with the central and peripheral lens thickness （P 〈 0.01 and P 〈 0.05 respectively）, and had positive correlation with relative lens position, anterior chamber depth（ACD）, angle-open distance at 500 um（AOD500）, trabecular iris angle （TIA） and trabecular ciliary processes distance（TCPD, P 〈 0.05 or P 〈 0.01 ）. Conclusion：The occurrence of PACG is relevant to the abnormal anatomical structures of the anterior segment. Among all factors, the lens parameters play an important role in the pathogenesis. Increased lens thickness, relative more anterior position of lens, especially steepened curvature of anterior lens surface are predisposing factors of the pathologic phenomenon in PACG including pupillary blockage, shallow anterior chamber, secondary closure of chamber angle and elevation of intraocular pressure.展开更多
This study aimed to determine the infection status,exercise habits,anxiety levels,and sleep quality in Chinese residents who recovered from infection during the period of coronavirus disease 2019(COVID-19)period.It al...This study aimed to determine the infection status,exercise habits,anxiety levels,and sleep quality in Chinese residents who recovered from infection during the period of coronavirus disease 2019(COVID-19)period.It also aimed to investigate the influencing factors of recovery status and aid in improving intervention measures for COVID-19 recovery.This study is a sub-study nested within a cross-sectional investigation of infection and physical and mental health among partially recovered residents in all 34 provincial areas of China during the COVID-19 pandemic.A total of 1013 participants(374 males and 639 females)completed the study.Cardiopulmonary endurance was significantly lower after infection than before infection(p<0.001).Women(3.924.97)exhibited higher levels of anxiety than men(3.334.54,p?0.015).The sleep score was significantly higher after infection(8.277.05)than before infection(4.174.97,p<0.001).The active and regular exercise groups exhibited significantly shorter durations of fever than the sedentary and irregular groups(p?0.033;p?0.021).Additionally,the active group demonstrated significantly fewer recovery days([7.323.24]days)than the sedentary group([7.663.06]days,p?0.035).We found a correlation between age and the recovery time of symptoms after COVID-19.We noted that a greater number of symptoms corresponded to poorer cardiopulmonary fitness and sleep quality.Individuals who engage in sedentary lifestyles and irregular exercise regimens generally require prolonged recovery periods.Therefore,incorporating moderate exercise,psychological support,sleep hygiene and other health interventions into post-COVID-19 recovery measures is imperative.展开更多
文摘The present study reports a case of a patient with choroidal neovascularization(CNV)associated with pseudoxanthoma elasticum(PXE).We observed the functional and anatomical improvement of the patient treated with intravitreal vascular endothelial growth factor(VEGF)inhibitor bevacizumab.The study also systematically searched the database for similar cases to provide a literature review.Data concerning the clinical features,treatment strategies and outcomes were extracted and analyzed.Retrospective interventional case report and systematic literature review.A 56-year-old healthy Chinese woman with CNV secondary to PXE was reported.Examinations included best corrected visual acuity(BCVA),biomicroscopy,optical coherence tomography(OCT),fluorescein and indocyanine green angiography and digital fundus photography.The patient managed with intravitreal anti-vascular endothelial growth factor(anti-VEGF)injections(bevacizumab 1.25 mg/0.05 m L).The Cochrane Library,Pub Med,OVID,and Up To Date databases were searched using the term pseudoxanthoma elasticum or Gr?nblad-Strandberg syndrome with the limits English.Articles that predated the databases were gathered from current references.Fundus examination revealed angioid streaks bilaterally and CNV in left eye(LE).After the patient underwent three intravitreal injections of bevacizumab,the LE showed absorption of the subretinal fluid and shrinkage of the CNV.Visual acuity(VA)was improved in her treated LE.Bevacizumab treatment was well tolerated with no adverse events reported.Approximately ten articles about 45 patients(49 eyes)describing CNV secondary to angioid streaks in PXE treated with anti-VEGF were found in the literature search.In the present case,bevacizumab of an initial three injection loading dose,achieved maintenance of visual function in the treatment of CNV associated with angioid streaks in PXE.Literature articles concluded that the intravitreal application of anti-VEGF is highly efficient for improving and stabilizing the lesion as well as the eyesight.So we believe that anti-VEGF therapy can be a great choice of treatment for CNV secondary to angioid streaks related PXE.
基金This work was supported by Science and Technology Foundation ofShanxi Province [No: 2005K12- G(3)]
文摘Objective ：To investigate the role the lens dimensions played on the pathogenesis of primary angle-closure glaucoma. Methods：38 eyes of 20 patients with primary angle-closure glaucoma （PACG） and 35 eyes of 22 normal individuals without ocular abnormalities were examined. The anatomical parameters of the lens and other structures of the anterior segment were calculated using B ultrasound, computer image processing and ultrasound biomicroscopy （UBM）. The parameters were compared between the patients and normal subjects. Correlation analysis was used to determine the relationship between the radii of curvature of the anterior lens surface （RCALS） and the other parameters of the anterior segment. Results：Compared with the normal eyes, the eyes of PACG had thicker lens, steeper curvature of anterior lens surface, decreased depth of the anterior chamber, narrower chamber angle, and more anterior position of the ciliary bodies and lens. All these differences were significant（P 〈 0.05 or P 〈 0.01）. In the PACG group, the RCALS had significantly negative correlation with the central and peripheral lens thickness （P 〈 0.01 and P 〈 0.05 respectively）, and had positive correlation with relative lens position, anterior chamber depth（ACD）, angle-open distance at 500 um（AOD500）, trabecular iris angle （TIA） and trabecular ciliary processes distance（TCPD, P 〈 0.05 or P 〈 0.01 ）. Conclusion：The occurrence of PACG is relevant to the abnormal anatomical structures of the anterior segment. Among all factors, the lens parameters play an important role in the pathogenesis. Increased lens thickness, relative more anterior position of lens, especially steepened curvature of anterior lens surface are predisposing factors of the pathologic phenomenon in PACG including pupillary blockage, shallow anterior chamber, secondary closure of chamber angle and elevation of intraocular pressure.
文摘This study aimed to determine the infection status,exercise habits,anxiety levels,and sleep quality in Chinese residents who recovered from infection during the period of coronavirus disease 2019(COVID-19)period.It also aimed to investigate the influencing factors of recovery status and aid in improving intervention measures for COVID-19 recovery.This study is a sub-study nested within a cross-sectional investigation of infection and physical and mental health among partially recovered residents in all 34 provincial areas of China during the COVID-19 pandemic.A total of 1013 participants(374 males and 639 females)completed the study.Cardiopulmonary endurance was significantly lower after infection than before infection(p<0.001).Women(3.924.97)exhibited higher levels of anxiety than men(3.334.54,p?0.015).The sleep score was significantly higher after infection(8.277.05)than before infection(4.174.97,p<0.001).The active and regular exercise groups exhibited significantly shorter durations of fever than the sedentary and irregular groups(p?0.033;p?0.021).Additionally,the active group demonstrated significantly fewer recovery days([7.323.24]days)than the sedentary group([7.663.06]days,p?0.035).We found a correlation between age and the recovery time of symptoms after COVID-19.We noted that a greater number of symptoms corresponded to poorer cardiopulmonary fitness and sleep quality.Individuals who engage in sedentary lifestyles and irregular exercise regimens generally require prolonged recovery periods.Therefore,incorporating moderate exercise,psychological support,sleep hygiene and other health interventions into post-COVID-19 recovery measures is imperative.
