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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?
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作者 Giovanni Ribaudo Matteo Giannangeli +1 位作者 Margrate Anyanwu alessandra gianoncelli 《Neural Regeneration Research》 SCIE CAS 2025年第6期1701-1702,共2页
The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect... The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them. 展开更多
关键词 GATEWAY HOMEOSTASIS preserve
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Contamination of Heavy Metals and Nutrients in Sediment, Sludge and Sewage of India 被引量:1
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作者 Shobhana Ramteke Khageshwar Singh Patel +5 位作者 Yogita Nayak Nitin Kumar Jaiswal Vikash Kumar Jain Laura Borgese alessandra gianoncelli Elza Bontempi 《International Journal of Geosciences》 2015年第11期1179-1192,共14页
The stagnant water bodies in India are sink for contaminant i.e. detergent, fertilizer, nutrients, heavy metal, pesticide, microbe, etc. The contamination and sources of elements i.e. Al, K, P, S, Cl, As, Ca, Sr, Ba, ... The stagnant water bodies in India are sink for contaminant i.e. detergent, fertilizer, nutrients, heavy metal, pesticide, microbe, etc. The contamination and sources of elements i.e. Al, K, P, S, Cl, As, Ca, Sr, Ba, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn and Pb in the sediment, sludge and sewage materials of the most industrialized cities of central India i.e. Raipur, Bhilai and Korba is described. The dominated metals i.e. Al, K, Ca, Ti, Fe and Mn in the geowaste materials (n = 20) contributed in the range of 4.8% - 36.3% with mean value of 10.2% ± 2.9%. The ∑4 concentration of nutrients i.e. P, K, S and Cl ranged from 1.2 - 12.5 g/kg with mean value of 7.9 ± 1.3 g/kg. The concentration of other heavy metals (HMs) i.e. As, V, Cr, Ni, Cu, Zn and Pb ranged from 12 - 105, 35 - 175, 88 - 392, 14 - 77, 32 - 185, 38 - 626 and 18 - 228 mg/kg with mean value of 644 ± 78, 83 ± 15, 182 ± 41, 44 ± 7, 68 ± 18, 199 ± 71 and 85 ± 25 mg/kg, respectively. The spatial and vertical distribution, enrichment and sources of the elements in the sediments are discussed. 展开更多
关键词 HEAVY Metal NUTRIENTS CONTAMINATION Sources SEDIMENT
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Cannabidiol preferentially binds TRPV2: a novel mechanism of action
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作者 Elisa Landucci Domenico E.Pellegrini-Giampietro +1 位作者 alessandra gianoncelli Giovanni Ribaudo 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第12期2693-2694,共2页
Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient times.The Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids c... Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient times.The Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids consisting of Δ9-tetrahydrocannabinol(THC),the psychoactive constituent,and cannabidiol(CBD),which does not bear this effect.This paper aims at providing a perspective on the potential therapeutic effects of CBD based on its preferential interaction with transient potential receptor V2(TRPV2).Many formulations based on Cannabis extract have been licensed for therapeutic use in some Western countries.Among these,the most relevant are Sativex(THC+CBD,used mainly for the treatment of spasticity in multiple sclerosis)and Epidyolex(purified plant-derived CBD,used for some rare childhood epilepsies). 展开更多
关键词 EFFECT MECHANISM FORMULATION
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Contamination of Arsenic and Other Heavy Metals in Rhizospheric Soil
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作者 Khageshwar Singh Patel Bharat Lal Sahu +4 位作者 Shobhana Ramteke Nitin Kumar Jaiswal Laura Borgese alessandra gianoncelli Elza Bontempi 《American Journal of Analytical Chemistry》 2015年第10期822-829,共8页
The contamination of arsenic (As) and other heavy metal (HMs) in soil causes serious health hazard to the ecosystem. In this work, the contamination of As and other heavy metals (i.e. Ti, V, Cr, Mn, Fe, Ni, Cu, Zn and... The contamination of arsenic (As) and other heavy metal (HMs) in soil causes serious health hazard to the ecosystem. In this work, the contamination of As and other heavy metals (i.e. Ti, V, Cr, Mn, Fe, Ni, Cu, Zn and Pb) in rhizospheric soil of 14 plants of the severely As contaminated area of Central India is described. Among them, high content of As in the rhizospheric soils was observed, ranging from 0.22 to 4.60 g/kg with mean value of 1.6 ± 0.7 g/kg. The concentration variation, enrichment indices and toxicities of the metals in the soil are described. 展开更多
关键词 ARSENIC HEAVY Metal Rhizospheric SOIL
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Alterations in Low-Z Elements Distribution in Heart Tissue after Treatments to Breast Cancer Using LEXRF Technique
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作者 Andrea Mantuano Regina Cely Barroso +8 位作者 Liebert Parreiras Nogueira Marcos Vinicius Colaço Carla Lemos Mota Arissa Pickler Delson Braz Camila Salata Samara Ferreira-Machado Carlos Eduardo de Almeida alessandra gianoncelli 《American Journal of Analytical Chemistry》 2016年第11期754-771,共18页
Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for ... Data from Global Cancer Statistics show that breast cancer (BC) is the most common type of cancer among women, leading the number of deaths caused by cancer. The developments in diagnosis and treatment techniques for the BC, including chemotherapy and/or radiotherapy, increased the survival rates for this type of cancer. One late complication induced by BC treatment is the cardiotoxicity. This term comprises different cardiotoxic side effects, which include blood pressure alterations, myocardial ischemia, congestive heart failure and other damages. This study aimed to evaluate the cardiac alterations induced by radiotherapy and chemotherapy, simulating a treatment for BC in Wistar rats. It is, therefore, important to understand the mechanisms involved in the cardiotoxicity, in order to prevent women from this late effect, when they undergo BC treatments. The major interests in this work are in Low atomic weight elements as Sodium, because it is strongly related to cardiomyocyte contraction;Magnesium, because it is important in the cardiac metabolism;and Iron, because BC treatment induced cardiotoxicity can be associated to the oxidative stress. Changes that occur in unhealthy tissues in case to cardiovascular damages can be better understood when elemental compounds and structures of healthy tissues are known. Low Energy X-ray Fluorescence (LEXRF) technique was used to obtain elemental maps of low Z-elements providing a semi-quantitative analysis of the tissues evaluated under different conditions. Through the technique LEXRF we obtained elemental and absorption maps. The results showed more damages when associating chemotherapy and radiotherapy in comparison to myocardium healthy. Those images taken together with light microscopy, X-ray absorption and phase contrast images, satisfactorily characterize the cardiac tissue for the first time in the literature, from the structural and morphological points of view. LEXRF was carried out at TwinMic beamline in the ELETTRA Synchrotron Fa-cility, at the beamline TwinMic, in Trieste, Italy. 展开更多
关键词 Micro-X-Ray Fluorescence Low-Z Elements Distribution MYOCARDIAL Cardiac Tissue
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Shedding light on electrodeposition dynamics tracked in situ via soft X-ray coherent diffraction imaging
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作者 George Kourousias Benedetto Bozzini +4 位作者 alessandra gianoncelli Michael W. M. Jones Mark Junker Grant van Riessen Maya Kiskinova 《Nano Research》 SCIE EI CAS CSCD 2016年第7期2046-2056,共11页
The in situ physicochemical analysis of nanostructured functional materials is crucial for advances in their design and production. X-ray coherent diffraction imaging (CDI) methods have recently demonstrated impress... The in situ physicochemical analysis of nanostructured functional materials is crucial for advances in their design and production. X-ray coherent diffraction imaging (CDI) methods have recently demonstrated impressive potential for characterizing such materials with a high spatial resolution and elemental sensitivity; however, moving from the current ex situ static regime to the in situ dynamic one remains a challenge. By combining soft X-ray ptychography and single-shot keyhole CDI, we performed the first in situ spatiotemporal study on an electrodeposition process in a sealed wet environment, employed for the fabrication of oxygen-reduction catalysts, which are key components for alkaline fuel cells and metal-air batteries. The results provide the first experimental demonstration of theoretically predicted Turing-Hopf electrochemical pattern formation resulting from morphochemical coupling, adding a new dimension for the in-depth in situ characterization of electrodeposition processes in space and time. 展开更多
关键词 in situ electrodeposition X-ray coherent diffractionimaging keyhole coherentdiffraction imaging (CDI) X-ray ptychography
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