<b>Objective:</b> Almost all year round occurrence of typhoid fever remains a major public health issue in Bangladesh. In recent years, there has been a significant rise in the prevalence of multi-drug res...<b>Objective:</b> Almost all year round occurrence of typhoid fever remains a major public health issue in Bangladesh. In recent years, there has been a significant rise in the prevalence of multi-drug resistance <i>Salmonella typhi</i> in Dhaka city. The major objective of this study was to observe the prevalence of multi-drug and Extended drug-resistant patterns of typhoidal <i>Salmonella typhi</i> among the patients attending a tertiary medical center by conventional culture and serologic test. <b>Materials and Methods:</b> Blood was collected by syringe and equally divided between aerobic & anaerobic BacT Alert bottle, 10 mL for paediatrics. Post isolation <i>Salmonella</i> strains were identified and were tested for antibiotic resistance. <b>Results:</b> A total of 600 blood samples of typhoid suspected patients were tested, where 32.5% came out positive, which were identified as <i>Salmonella typhi</i>. These isolates were susceptible to carbapenem drugs but highly resistant to Fluoroquinolones and Aminoglycosides antibiotics. <b>Discussion:</b> It was seen that 73.23% of isolates among male patients were extensively drug-resistant (XDR) meaning that isolates were sensitive against only one or two antibiotics while in the female it was 58.46%. Isolates from Female patients showed higher multi-drug resistant (MDR) (26.15%) isolates resistance to multiple antibiotics in comparison to isolates from the male (16.54%). 87.19% of the strains showed high drug resistance (XDR and MDR). <b>Conclusion:</b> The emergence of XDR and MDR strains of <i>S. typhi</i> in recent years is becoming a significant threat. Although no PAN-Drug resistance (resistant against all tested drugs) was observed in the current study, a high level of XDR and MDR isolates are indicating that the scenario might take place sooner than later.展开更多
文摘<b>Objective:</b> Almost all year round occurrence of typhoid fever remains a major public health issue in Bangladesh. In recent years, there has been a significant rise in the prevalence of multi-drug resistance <i>Salmonella typhi</i> in Dhaka city. The major objective of this study was to observe the prevalence of multi-drug and Extended drug-resistant patterns of typhoidal <i>Salmonella typhi</i> among the patients attending a tertiary medical center by conventional culture and serologic test. <b>Materials and Methods:</b> Blood was collected by syringe and equally divided between aerobic & anaerobic BacT Alert bottle, 10 mL for paediatrics. Post isolation <i>Salmonella</i> strains were identified and were tested for antibiotic resistance. <b>Results:</b> A total of 600 blood samples of typhoid suspected patients were tested, where 32.5% came out positive, which were identified as <i>Salmonella typhi</i>. These isolates were susceptible to carbapenem drugs but highly resistant to Fluoroquinolones and Aminoglycosides antibiotics. <b>Discussion:</b> It was seen that 73.23% of isolates among male patients were extensively drug-resistant (XDR) meaning that isolates were sensitive against only one or two antibiotics while in the female it was 58.46%. Isolates from Female patients showed higher multi-drug resistant (MDR) (26.15%) isolates resistance to multiple antibiotics in comparison to isolates from the male (16.54%). 87.19% of the strains showed high drug resistance (XDR and MDR). <b>Conclusion:</b> The emergence of XDR and MDR strains of <i>S. typhi</i> in recent years is becoming a significant threat. Although no PAN-Drug resistance (resistant against all tested drugs) was observed in the current study, a high level of XDR and MDR isolates are indicating that the scenario might take place sooner than later.
