Recently, perpendicular shocks have been generated in laboratory experiments by the interaction between a laser-produced supersonic plasma flow and a magnetized ambient plasma. Here, we explore the ion dynamics and th...Recently, perpendicular shocks have been generated in laboratory experiments by the interaction between a laser-produced supersonic plasma flow and a magnetized ambient plasma. Here, we explore the ion dynamics and the formation of such kinds of shock with a one-dimensional(1D)particle-in-cell simulation model using achievable parameters for laser experiments. A small part of the ambient ions is first reflected by the laser-driven piston. These piston-reflected ions interact with the upstream plasma and form a shock then. By analyzing the contribution of the electric force and the Lorentz force during the reflection, shock-reflected ions are found to be accelerated by two different mechanisms: shock drift acceleration and shock surfing acceleration,where shock drift acceleration is the dominant one. Very few ions are reflected twice by the shock and accelerated to a large velocity, implying that a more energetic population of ions can be observed in future experiments.展开更多
Osteoarthritis(OA)is considered to be a highly heterogeneous disease with progressive cartilage loss,subchondral bone remodeling,and low-grade inflammation.It is one of the world's leading causes of disability.Mos...Osteoarthritis(OA)is considered to be a highly heterogeneous disease with progressive cartilage loss,subchondral bone remodeling,and low-grade inflammation.It is one of the world's leading causes of disability.Most conventional clinical treatments for OA are palliative drugs,which cannot fundamentally cure this disease.The stromal vascular fraction(SVF)from adipose tissues is a heterogeneous cell population.According to previous studies,it contains a large number of mesenchymal stem cells,which have been used to treat OA with good therapeutic results.This safe,simple,and effective therapy is expected to be applied and promoted in the future.In this paper,the detailed pathogenesis,diagnosis,and current clinical treatments for OA are introduced.Then,clinical studies and the therapeutic mechanism of SVF for the treatment of OA are summarized.展开更多
Dear Editor,Haploid embryonic stem cells（ha ESCs）hold great potential for genetic screening and the analysis of recessive phenotypes.Several studies have recently reported the generation of mammalian ha ESCs through...Dear Editor,Haploid embryonic stem cells（ha ESCs）hold great potential for genetic screening and the analysis of recessive phenotypes.Several studies have recently reported the generation of mammalian ha ESCs through gamete manipulation,and evaluated the benefits of using them for studying functional genomics in different mammals[1–4].展开更多
基金funded by the Strategic Priority Research Program of Chinese Academy of Sciences (No. XDB41000000)National Natural Science Foundation of China(NSFC)(Nos. 42174181 ,12205298)the Key Research Program of Frontier Sciences CAS (No. QYZDJ-SSWDQC010)。
文摘Recently, perpendicular shocks have been generated in laboratory experiments by the interaction between a laser-produced supersonic plasma flow and a magnetized ambient plasma. Here, we explore the ion dynamics and the formation of such kinds of shock with a one-dimensional(1D)particle-in-cell simulation model using achievable parameters for laser experiments. A small part of the ambient ions is first reflected by the laser-driven piston. These piston-reflected ions interact with the upstream plasma and form a shock then. By analyzing the contribution of the electric force and the Lorentz force during the reflection, shock-reflected ions are found to be accelerated by two different mechanisms: shock drift acceleration and shock surfing acceleration,where shock drift acceleration is the dominant one. Very few ions are reflected twice by the shock and accelerated to a large velocity, implying that a more energetic population of ions can be observed in future experiments.
基金Supported by National Natural Science Foundation of China,No.82070801,No.82100858,No.82073227China Postdoctoral Science Foundation,No.2020M671661+1 种基金Jiangsu Province Science Foundation for Youths,No.BK20200569Jiangsu Province Research Founding for Postdoctoral,No.1412000016.
文摘Osteoarthritis(OA)is considered to be a highly heterogeneous disease with progressive cartilage loss,subchondral bone remodeling,and low-grade inflammation.It is one of the world's leading causes of disability.Most conventional clinical treatments for OA are palliative drugs,which cannot fundamentally cure this disease.The stromal vascular fraction(SVF)from adipose tissues is a heterogeneous cell population.According to previous studies,it contains a large number of mesenchymal stem cells,which have been used to treat OA with good therapeutic results.This safe,simple,and effective therapy is expected to be applied and promoted in the future.In this paper,the detailed pathogenesis,diagnosis,and current clinical treatments for OA are introduced.Then,clinical studies and the therapeutic mechanism of SVF for the treatment of OA are summarized.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01010201)the National Key Basic Research and Development Program of China(2015CB964500 and 2014CB964804)the National Natural Science Foundation of China(91219303,31430058,and 31401261)
文摘Dear Editor,Haploid embryonic stem cells（ha ESCs）hold great potential for genetic screening and the analysis of recessive phenotypes.Several studies have recently reported the generation of mammalian ha ESCs through gamete manipulation,and evaluated the benefits of using them for studying functional genomics in different mammals[1–4].
