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Implication of gut microbiome in immunotherapy for colorectal cancer
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作者 Evangelos Koustas Eleni-Myrto Trifylli +8 位作者 Panagiotis Sarantis Nikolaos Papadopoulos Georgios Aloizos ariadne tsagarakis Christos Damaskos Nikolaos Garmpis Anna Garmpi Athanasios G Papavassiliou Michalis V Karamouzis 《World Journal of Gastrointestinal Oncology》 SCIE 2022年第9期1665-1674,共10页
Colorectal cancer(CRC) constitutes the third most frequently reported malignancy in the male population and the second most common in women in the last two decades. Colon carcinogenesis is a complex, multifactorial ev... Colorectal cancer(CRC) constitutes the third most frequently reported malignancy in the male population and the second most common in women in the last two decades. Colon carcinogenesis is a complex, multifactorial event, resulting from genetic and epigenetic aberrations, the impact of environmental factors, as well as the disturbance of the gut microbial ecosystem. The relationship between the intestinal microbiome and carcinogenesis was relatively undervalued in the last decade. However, its remarkable effect on metabolic and immune functions on the host has been in the spotlight as of recent years. There is a strong relationship between gut microbiome dysbiosis, bowel pathogenicity and responsiveness to anti-cancer treatment;including immunotherapy. Modifications of bacteriome consistency are closely associated with the immunologic response to immunotherapeutic agents. This condition that implies the necessity of gut microbiome manipulation. Thus, creatingan optimal response for CRC patients to immunotherapeutic agents. In this paper, we will review the current literature observing how gut microbiota influence the response of immunotherapy on CRC patients. 展开更多
关键词 Colorectal cancer Gut microbiome IMMUNOTHERAPY Checkpoint inhibitors Tumor micro-environment
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