The coronavirus disease 2019(COVID-19)is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Within a matter of months,this highly contagious novel virus has led to a g...The coronavirus disease 2019(COVID-19)is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Within a matter of months,this highly contagious novel virus has led to a global outbreak and is still spreading rapidly across continents.In patients with COVID-19,underlying chronic diseases and comorbidities are associated with dismal treatment outcomes.Owing to their immunosuppressive status,patients with hematological malignancies(HMs)are at an increased risk of infection and have a worse prognosis than patients without HMs.Accordingly,intensive attention should be paid to this cohort.In this review,we summarize and analyze specific clinical manifestations for patients with coexisting COVID-19 and HMs.Furthermore,we briefly de-scribe customized management strategies and interventions for this susceptible cohort.This review is intended to guide clinical practice.展开更多
Severe aplastic anemia(SAA)is a lethal disease that has been shown to be cured by allogeneic hematopoietic stem cell transplantation(HSCT)dating back to the transplant’s early days[1].It is also the prototype of tran...Severe aplastic anemia(SAA)is a lethal disease that has been shown to be cured by allogeneic hematopoietic stem cell transplantation(HSCT)dating back to the transplant’s early days[1].It is also the prototype of transplantation in its original means,as in HSCT for SAA the malfunctioning organ—the hematopoietic system in the bone marrow is replaced by a functional organ similarly to any other organ transplantation process.展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.81770201 , 81730008)。
文摘The coronavirus disease 2019(COVID-19)is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Within a matter of months,this highly contagious novel virus has led to a global outbreak and is still spreading rapidly across continents.In patients with COVID-19,underlying chronic diseases and comorbidities are associated with dismal treatment outcomes.Owing to their immunosuppressive status,patients with hematological malignancies(HMs)are at an increased risk of infection and have a worse prognosis than patients without HMs.Accordingly,intensive attention should be paid to this cohort.In this review,we summarize and analyze specific clinical manifestations for patients with coexisting COVID-19 and HMs.Furthermore,we briefly de-scribe customized management strategies and interventions for this susceptible cohort.This review is intended to guide clinical practice.
文摘Severe aplastic anemia(SAA)is a lethal disease that has been shown to be cured by allogeneic hematopoietic stem cell transplantation(HSCT)dating back to the transplant’s early days[1].It is also the prototype of transplantation in its original means,as in HSCT for SAA the malfunctioning organ—the hematopoietic system in the bone marrow is replaced by a functional organ similarly to any other organ transplantation process.
