Background:The study aimed to evaluate the efficacy of postoperative short-term therapy(for 2 weeks)of topical bevacizumab in recurrent pterygium surgery regarding to corneal vascularization and pterygium recurrence.M...Background:The study aimed to evaluate the efficacy of postoperative short-term therapy(for 2 weeks)of topical bevacizumab in recurrent pterygium surgery regarding to corneal vascularization and pterygium recurrence.Methods:This prospective randomized comparative study included two groups of patients with recurrent pterygium,all eyes were subjected to pterygium excision with conjunctiva auto graft,and group A(30 eyes of 30 patients)was treated with postoperative topical tobramycine and dexamethazone for 2 weeks.Group B(30 eyes of 30 patients)was treated also with postoperative topical tobramycine and dexamethazone in addition to topical bevacizumab 5 mg/mL 4 times daily for 2 weeks.Follow-up of cases up to 6 months was performed recording corneal vascularization and pterygium recurrence.Results:The results revealed that after 6 months,group A treated with postoperative tobramycine and dexamethazone reported 5 eyes of recurrence(16.7%)which not significantly(P=0.44726)(P>0.05)different from group B treated with the addition of topical bevacizumab which reported 3 eyes of recurrence(10%).But group B showed significantly different in decreasing corneal neovascularization than group A(P=0.000805)(P<0.05).Conclusions:Postoperative short-term therapy of topical bevacizumab in recurrent pterygium surgery by conjunctiva auto graft showed lower recurrence rate but not statistically significant,But it reduced significantly corneal neovascularization.展开更多
文摘Background:The study aimed to evaluate the efficacy of postoperative short-term therapy(for 2 weeks)of topical bevacizumab in recurrent pterygium surgery regarding to corneal vascularization and pterygium recurrence.Methods:This prospective randomized comparative study included two groups of patients with recurrent pterygium,all eyes were subjected to pterygium excision with conjunctiva auto graft,and group A(30 eyes of 30 patients)was treated with postoperative topical tobramycine and dexamethazone for 2 weeks.Group B(30 eyes of 30 patients)was treated also with postoperative topical tobramycine and dexamethazone in addition to topical bevacizumab 5 mg/mL 4 times daily for 2 weeks.Follow-up of cases up to 6 months was performed recording corneal vascularization and pterygium recurrence.Results:The results revealed that after 6 months,group A treated with postoperative tobramycine and dexamethazone reported 5 eyes of recurrence(16.7%)which not significantly(P=0.44726)(P>0.05)different from group B treated with the addition of topical bevacizumab which reported 3 eyes of recurrence(10%).But group B showed significantly different in decreasing corneal neovascularization than group A(P=0.000805)(P<0.05).Conclusions:Postoperative short-term therapy of topical bevacizumab in recurrent pterygium surgery by conjunctiva auto graft showed lower recurrence rate but not statistically significant,But it reduced significantly corneal neovascularization.
