In this article,an article published in the World Journal of Gastrointestinal Oncology,which focuses on whether the expression of programmed death-ligand 1(PD-L1)affects the effectiveness of chemotherapy regimens,incl...In this article,an article published in the World Journal of Gastrointestinal Oncology,which focuses on whether the expression of programmed death-ligand 1(PD-L1)affects the effectiveness of chemotherapy regimens,including bevacizumab,in treating patients with colorectal cancer(CRC).Through neutralization of vascular endothelial growth factor(VEGF),bevacizumab inhibits tumor angiogenesis,impairing neovascularization and thereby depriving the tumor of essential nutrients and oxygen.Conversely,PD-L1 binding to VEGF receptor 2 promotes angiogenesis,supporting tumor vasculature.The interplay between these pathways complicates the assessment of bevacizumab’s efficacy in cancer therapy,notably in CRC,where VEGF and PD-L1 significantly affect treatment response.This review examines metastatic CRC treatment strategies,focusing on bevacizumab’s mechanism of action and the role of PD-L1 in this therapeutic context.展开更多
In the era of exponential growth of data availability,the architecture of systems has a trend toward high dimensionality,and directly exploiting holistic information for state inference is not always computationally a...In the era of exponential growth of data availability,the architecture of systems has a trend toward high dimensionality,and directly exploiting holistic information for state inference is not always computationally affordable.This paper proposes a novel Bayesian filtering algorithm that considers algorithmic computational cost and estimation accuracy for high-dimensional linear systems.The high-dimensional state vector is divided into several blocks to save computation resources by avoiding the calculation of error covariance with immense dimensions.After that,two sequential states are estimated simultaneously by introducing an auxiliary variable in the new probability space,mitigating the performance degradation caused by state segmentation.Moreover,the computational cost and error covariance of the proposed algorithm are analyzed analytically to show its distinct features compared with several existing methods.Simulation results illustrate that the proposed Bayesian filtering can maintain a higher estimation accuracy with reasonable computational cost when applied to high-dimensional linear systems.展开更多
This survey paper provides a review and perspective on intermediate and advanced reinforcement learning(RL)techniques in process industries. It offers a holistic approach by covering all levels of the process control ...This survey paper provides a review and perspective on intermediate and advanced reinforcement learning(RL)techniques in process industries. It offers a holistic approach by covering all levels of the process control hierarchy. The survey paper presents a comprehensive overview of RL algorithms,including fundamental concepts like Markov decision processes and different approaches to RL, such as value-based, policy-based, and actor-critic methods, while also discussing the relationship between classical control and RL. It further reviews the wide-ranging applications of RL in process industries, such as soft sensors, low-level control, high-level control, distributed process control, fault detection and fault tolerant control, optimization,planning, scheduling, and supply chain. The survey paper discusses the limitations and advantages, trends and new applications, and opportunities and future prospects for RL in process industries. Moreover, it highlights the need for a holistic approach in complex systems due to the growing importance of digitalization in the process industries.展开更多
BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque formation.This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imag...BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque formation.This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imaging(HR-VWI).AIM To investigate the factors of intracranial atherosclerotic remodelling patterns and the relationship between intracranial atherosclerotic remodelling and diabetes mellitus using HR-VWI.METHODS Ninety-four patients diagnosed with middle cerebral artery or basilar artery INTRODUCTION Intracranial atherosclerotic disease is one of the main causes of ischaemic stroke in the world,accounting for approx-imately 10%of transient ischaemic attacks and 30%-50%of ischaemic strokes[1].It is the most common factor among Asian people[2].The adaptive changes in the structure and function of blood vessels that can adapt to changes in the internal and external environment are called vascular remodelling,which is a common and important pathological mechanism in atherosclerotic diseases,and the remodelling mode of atherosclerotic plaques is closely related to the occurrence of stroke.Positive remodelling(PR)is an outwards compensatory remodelling where the arterial wall grows outwards in an attempt to maintain a constant lumen diameter.For a long time,it was believed that the degree of stenosis can accurately reflect the risk of ischaemic stroke[3-5].Previous studies have revealed that lesions without significant luminal stenosis can also lead to acute events[6,7],as summarized in a recent meta-analysis study in which approximately 50%of acute/subacute ischaemic events were due to this type of lesion[6].Research[8,9]has pointed out that the PR of plaques is more dangerous and more likely to cause acute ischaemic stroke.Previous studies[10-13]have found that there are specific vascular remodelling phenomena in the coronary and carotid arteries of diabetic patients.However,due to the deep location and small lumen of intracranial arteries and limitations of imaging techniques,the relationship between intracranial arterial remodelling and diabetes is still unclear.In recent years,with the development of magnetic resonance technology and the emergence of high-resolution(HR)vascular wall imaging,a clear and multidimensional display of the intracranial vascular wall has been achieved.Therefore,in this study,HR wall imaging(HR-VWI)was used to display the remodelling characteristics of bilateral middle cerebral arteries and basilar arteries and to explore the factors of intracranial vascular remodelling and its relationship with diabetes.展开更多
Branch identification technology is a key technology to achieve automated pruning of fruit tree branches, and one of its technical bottlenecks lies in the stitching of branch images. To this end, we propose a set of b...Branch identification technology is a key technology to achieve automated pruning of fruit tree branches, and one of its technical bottlenecks lies in the stitching of branch images. To this end, we propose a set of branch image stitching technology algorithms. The algorithm is based on the grey-scale prime centroid method to determine the detection feature points, and uses the coordinate transformation matrix H of the corresponding points of the image to carry out the image geometric transformation, and realises the feature matching through sample comparison and classification methods. The experimental results show that the matched point images are more correct and less time-consuming.展开更多
Pepsinogen,secreted from the gastric mucosa,is the precursor of pepsin.It is categorized as pepsinogen 1 and pepsinogen 2 based on its immunogenicity.The pepsinogen content that can enter the blood circulation through...Pepsinogen,secreted from the gastric mucosa,is the precursor of pepsin.It is categorized as pepsinogen 1 and pepsinogen 2 based on its immunogenicity.The pepsinogen content that can enter the blood circulation through the capillaries of the gastric mucosa is approximately 1%and remains stable all the time.The pepsinogen content in serum will change with the pathological changes of gastric mucosa.Therefore,the level of pepsinogen in serum can play a role in serologic biopsy to reflect the function and morphology of different regions of gastric mucosa and serve as an indicator of gastric disease.This study conducts relevant research on serum pepsinogen 1,pepsinogen 2,and the ratio of pepsinogen 1 to pepsinogen 2,and reviews their important value in clinical diagnosis of Helicobacter pylori infection,gastric ulcer,and even gastric carcinoma,providing ideas for other researchers.展开更多
Considering that we still do not fully understand the behavior of air pockets trapped in rainstorm systems and water flow changes inside pipes,the study of actual geysers presents many challenges.In this study,three-d...Considering that we still do not fully understand the behavior of air pockets trapped in rainstorm systems and water flow changes inside pipes,the study of actual geysers presents many challenges.In this study,three-dimensional numerical models were developed to investigate the mechanisms of geyser events triggered by rapid filling flows at different scales.The results showed that,in the first stage of the water–air mixture of the prototype model,a large amount of air was released quickly,and the subsequent overflow lasted for a more extended period.The transport capacity of the downstream pipe,as a critical factor,significantly influenced the water–air interaction of the geyser.Restricting the outlet area and increasing the outlet pressure simultaneously resulted in a stronger geyser.The equivalent density of the water–air mixture increased as the scale decreased during the geyser event.展开更多
BACKGROUND Primary central nervous system lymphoma(PCNSL)is a rare malignant tumor originating from the lymphatic hematopoietic system.It exhibits unique imaging manifestations due to its biological characteristics.CA...BACKGROUND Primary central nervous system lymphoma(PCNSL)is a rare malignant tumor originating from the lymphatic hematopoietic system.It exhibits unique imaging manifestations due to its biological characteristics.CASE SUMMARY Magnetic resonance imaging(MRI)with diffusion-weighted imaging(DWI),perfusion-weighted imaging(PWI),and magnetic resonance spectroscopy was performed.The imaging findings showed multiple space-occupying lesions with low signal on T1-weighted imaging,uniform high signal on T2-weighted imaging,and obvious enhancement on contrast-enhanced scans.DWI revealed diffusion restriction,PWI demonstrated hypoperfusion,and spectroscopy showed elevated choline peak and decreased N-acetylaspartic acid.The patient's condition significantly improved after hormone shock therapy.CONCLUSION This case highlights the distinctive imaging features of PCNSL and their importance in accurate diagnosis and management.展开更多
The dynamic stall problem for blades is related to the general performance of wind turbines,where a varying flow field is introduced with a rapid change of the effective angle of attack (AOA).The objective of this wor...The dynamic stall problem for blades is related to the general performance of wind turbines,where a varying flow field is introduced with a rapid change of the effective angle of attack (AOA).The objective of this work is to study the aerodynamic performance of a sinusoidally oscillating NACA0012 airfoil.The coupled k-ω Menter's shear stress transport (SST) turbulence model and γ-Reθ transition model were used for turbulence closure.Lagrangian coherent structures (LCS) were utilized to analyze the dynamic behavior of the flow structures.The computational results were supported by the experiments.The results indicated that this numerical method can well describe the dynamic stall process.For the case with reduced frequency K =0.1,the lift and drag coefficients increase constantly with increasing angle prior to dynamic stall.When the AOA reaches the stall angle,the lift and drag coefficients decline suddenly due to the interplay between the first leading-and trailing-edge vortex.With further increase of the AOA,both the lift and drag coefficients experience a secondary rise and fall process because of formation and shedding of the secondary vortex.The results also reveal that the dynamic behavior of the flow structures can be effectively identified using the finite-time Lyapunov exponent (FTLE) field.The influence of the reduced frequency on the flow structures and energy extraction efficiency in the dynamic stall process is further discussed.When the reduced frequency increases,the dynamic stall is delayed and the total energy extraction efficiency is enhanced.With K =0.05,the amplitude of the dynamic coefficients fluctuates more significantly in the poststall process than in the case of K =0.1.展开更多
Cavitation–structure interaction has become one of the major issues for most engineering applications. The present work reviews recent progress made toward developing experimental and numerical investigation for unst...Cavitation–structure interaction has become one of the major issues for most engineering applications. The present work reviews recent progress made toward developing experimental and numerical investigation for unsteady turbulent cavitating flow and cavitation–structure interaction. The goal of our overall efforts is to（1） summarize the progress made in the experimental and numerical modeling and approaches for unsteady cavitating flow and cavitation–structure interaction,（2） discuss the global multiphase structures for different cavitation regimes, with special emphasis on the unsteady development of cloud cavitation and corresponding cavitating flow-induced vibrations,with a high-speed visualization system and a structural vibration measurement system, as well as a simultaneous sampling system,（3） improve the understanding of the hydroelastic response in cavitating flows via combined physical and numerical analysis, with particular emphasis on the interaction between unsteady cavitation development and structural deformations. Issues including unsteady cavitating flow structures and cavitation–structure interaction mechanism are discussed.展开更多
A local vortical cavitation（LVC） model for the computation of unsteady cavitation is proposed.The model is derived from the Rayleigh–Plesset equations,and takes into account the relations between the cavitation bub...A local vortical cavitation（LVC） model for the computation of unsteady cavitation is proposed.The model is derived from the Rayleigh–Plesset equations,and takes into account the relations between the cavitation bubble radius and local vortical effects.Calculations of unsteady cloud cavitating fows around a Clark-Y hydrofoil are performed to assess the predictive capability of the LVC model using well-documented experimental data.Compared with the conventional Zwart＇s model,better agreement is observed between the predictions of the LVC model and experimental data,including measurements of time-averaged fl w structures,instantaneous cavity shapes and the frequency of the cloud cavity shedding process.Based on the predictions of the LVC model,it is demonstrated that the evaporation process largely concentrates in the core region of the leading edge vorticity in accordance with the growth in the attached cavity,and the condensation process concentrates in the core region of the trailing edge vorticity,which corresponds to the spread of the rear component of the attached cavity.When the attached cavity breaks up and moves downstream,the condensation area fully transports to the wake region,which is in accordance with the dissipation of the detached cavity.Furthermore,using vorticity transport equations,we also fin that the periodic formation,breakup,and shedding of the sheet/cloud cavities,along with the associated baroclinic torque,are important mechanisms for vorticity production and modification When the attached cavity grows,the liquid–vapour interface that moves towards the trailing edge enhances the vorticity in the attached cav-ity closure region.As the re-entrant jet moves upstream,the wavy/bubbly cavity interface enhances the vorticity near the trailing edge.At the end of the cycle,the break-up of the stable attached cavity is the main reason for the vorticity enhancement near the suction surface.展开更多
The objective of this paper is to address the transient flow structures around a pitching hydrofoil by com- bining physical and numerical studies. In order to predict the dynamic behavior of the flow structure effecti...The objective of this paper is to address the transient flow structures around a pitching hydrofoil by com- bining physical and numerical studies. In order to predict the dynamic behavior of the flow structure effectively, the Lagrangian coherent structures （LCS） defined by the ridges of the finite-time Lyapunov exponent （FTLE） are utilized under the framework of Navier-Stokes flow computations. In the numerical simulations, the k-w shear stress trans- port （SST） turbulence model, coupled with a two-equation F-Reo transition model, is used for the turbulence closure. Results are presented for a NACA66 hydrofoil undergoing slowly and rapidly pitching motions from 0° to 15° then back to 0° at a moderate Reynolds number Re = 7.5 × 105. The results reveal that the transient flow structures can be observed by the LCS method. For the slowly pitching case, it consists of five stages： quasi-steady and laminar, transition from laminar to turbulent, vortex development, large-scale vortex shedding, and reverting to laminar. The observation of LCS and Lagrangian particle tracers elucidates that the trailing edge vortex is nearly attached and stable during the vortex development stage and the interaction between the leading and trailing edge vortex caused by the adverse pres- sure gradient forces the vortexes to shed downstream during the large-scale vortex shedding stage, which corresponds to obvious fluctuations of the hydrodynamic response. For the rapidly pitching case, the inflection is hardly to be observed and the stall is delayed. The vortex formation, interaction, and shedding occurred once instead of being repeated three times, which is responsible for just one fluctuation in the hydrody- namic characteristics. The numerical results also show that the FTLE field has the potential to identify the transient flows, and the LCS can represent the divergence extent of infinite neighboring particles and capture the interface of the vortex region.展开更多
Wood has no inherent natural resistance against agents of biodegradation. We evaluated the effects of metal bath heat treatment(MBHT) on decay resistance and dimensional stability of Chinese parasol(Firmiana simplex) ...Wood has no inherent natural resistance against agents of biodegradation. We evaluated the effects of metal bath heat treatment(MBHT) on decay resistance and dimensional stability of Chinese parasol(Firmiana simplex) and Chinese fir(Cunninghamia lanceolata) wood. A low melting point alloy was used as heating medium in the treatment of the wood samples at 150, 180, and 210 °C for2, 4, and 8 h. Heat-treated and control samples were exposed to brown rot fungus(Poria placenta) and white rot fungus(Coriolus versicolor) for decay resistance testing and anti-swelling efficiency(ASE). The improved decay resistance with increase temperatures with low mass losses of 7.3 and 7.3% for F. simplex, and 3.9 and 3.6% for C.lanceolata at 210 °C for 8 h against Coriolus versicolor and Poria placenta, respectively. ASE indicated that MBHT contributed to improved dimensional stability of both wood species after treatment. Scanning electron micrograph results indicate that metal bath-treated samples showed strong decay resistance. Therefore, our approach to thermally modify wood should be explored to overcome the energy utilization by using low melting point alloy for the heat treatment of wood.展开更多
Pinus massoniana L. was thermally treated with low melting point alloy as heating medium to investigate the strength properties changes. Contact angle, color and scanning electron microscopy were recorded to assess th...Pinus massoniana L. was thermally treated with low melting point alloy as heating medium to investigate the strength properties changes. Contact angle, color and scanning electron microscopy were recorded to assess the effectiveness of the treatment. Samples were pre-treated in a micro-wave for 5 min followed by metal bath heat treatment at 150, 180, and 210 °C for 2, 4, and 8 h,respectively. Strength properties of metal bath treated wood were decreased with increase temperature and time.Density, modulus of rupture, impact bending, modulus of elasticity were reduced for all treatments. Maximum compressive strength slightly increased at 150 °C for 4 h followed by gradual reduction. The Janka hardness was reduced in the tangential and radial directions. Treatment of the wood at 210 °C for 8 h caused the wood to become brittle and rupture. The contact angle was considerably higher after thermal treatment. The color of the wood became darker with increasing temperature of thermal treatment. Micrographs of the heat-treated samples showed damage to the cell wall with increase in temperature. Metal bath heat treatment of wood was carried out successfully and some strength properties were reduced.展开更多
Various peptide toxins in animal venom inhibit voltage-gated sodium ion channel Nav1.7, including Nav-targeting spider toxin(NaSpTx) Family I. Toxins in NaSpTx Family I share a similar structure, i.e., Nterminal, loop...Various peptide toxins in animal venom inhibit voltage-gated sodium ion channel Nav1.7, including Nav-targeting spider toxin(NaSpTx) Family I. Toxins in NaSpTx Family I share a similar structure, i.e., Nterminal, loops 1–4, and C-terminal. Here, we used Mu-theraphotoxin-Ca2a(Ca2a), a peptide isolated from Cyriopagopus albostriatus, as a template to investigate the general properties of toxins in NaSpTx Family I. The toxins interacted with the cell membrane prior to binding to Nav1.7 via similar hydrophobic residues. Residues in loop 1, loop 4,and the C-terminal primarily interacted with the S3–S4 linker of domain II, especially basic amino acids binding to E818. We also identified the critical role of loop 2 in Ca2a regarding its affinity to Nav1.7.Our results provide further evidence that NaSpTx Family I toxins share similar structures and mechanisms of binding to Nav1.7.展开更多
This paper synchronizes control theory with computer vision by formalizing object tracking as a sequential decision-making process.A reinforcement learning(RL)agent successfully tracks an interface between two liquids...This paper synchronizes control theory with computer vision by formalizing object tracking as a sequential decision-making process.A reinforcement learning(RL)agent successfully tracks an interface between two liquids,which is often a critical variable to track in many chemical,petrochemical,metallurgical,and oil industries.This method utilizes less than 100 images for creating an environment,from which the agent generates its own data without the need for expert knowledge.Unlike supervised learning(SL)methods that rely on a huge number of parameters,this approach requires far fewer parameters,which naturally reduces its maintenance cost.Besides its frugal nature,the agent is robust to environmental uncertainties such as occlusion,intensity changes,and excessive noise.From a closed-loop control context,an interface location-based deviation is chosen as the optimization goal during training.The methodology showcases RL for real-time object-tracking applications in the oil sands industry.Along with a presentation of the interface tracking problem,this paper provides a detailed review of one of the most effective RL methodologies:actor–critic policy.展开更多
Continuous-variable quantum key distribution (CVQKD) with the local local oscillator (LLO) is confronted with new security problems due to the reference pulses transmitted together with quantum signals over the insecu...Continuous-variable quantum key distribution (CVQKD) with the local local oscillator (LLO) is confronted with new security problems due to the reference pulses transmitted together with quantum signals over the insecure quantum channel. In this paper, we propose a method of phase attack on reference pulses of the LLO-CVQKD with time-multiplexing. Under this phase attack, the phase drifts of reference pulses are manipulated by eavesdroppers, and then the phase compensation error is increased. Consequently, the secret key rate is reduced due to the imperfect phase compensation for quantum signals. Based on the noise model of imperfect phase compensation, the practical security of LLO-CVQKD under phase attack is analyzed. The simulation results show that the practical security is reduced due to the phase attack, yet it is still tight when system parameters are estimated by training signals.展开更多
pHKCl and pHH2O are two basic necessary indexes to reflect the acidity of asoil. Predicting pHKCl?directly from pHH2O?could save the cost of laboratory work. In this study, the values of pHKCl and of 442 and 310 horiz...pHKCl and pHH2O are two basic necessary indexes to reflect the acidity of asoil. Predicting pHKCl?directly from pHH2O?could save the cost of laboratory work. In this study, the values of pHKCl and of 442 and 310 horizon samples from 126 and 98 soil profiles (0 - 120 cm in depth) surveyed from 2014 to 2015 in Guangxi and Yunnan were used to establish the optimal correlation model between pHKCl and pHH2O. The results showed that: 1) pHKCl is lower than pHH2O, pHKCl?was 0.07 - 1.99 units with a mean of 0.99 units lower than for Guangxi, while 0.03 - 1.90 units with a mean of 0.89 lower than pHH2O?for Yunan. 2) There is significant positive correlation between pHKCl?and pHH2O, the optimal correlation models between pHKCl?(y) and pHH2O?(x) for Guangxi and Yunnan are y = 0.1963x2 −1.0512x + 4.338, R2 = 0.836, p 0.1859x, R2 = 0.769, p pHKCl?with exchangeable H+ and Al3+ (R2 = 0.487, 0.716, p pHKCl?is dominated by exchangeable Al3+, followed by exchangeable H+, and their contribution to pHKCl?were 71.1% and 28.7%, respectively.展开更多
In order to satisfy the spectrum requirements of the future international mobile telecommunication (IMT) systems, to realize scientific allocation and usage of spectrum resources and to avoid spectrum waste brought by...In order to satisfy the spectrum requirements of the future international mobile telecommunication (IMT) systems, to realize scientific allocation and usage of spectrum resources and to avoid spectrum waste brought by allocation in advanced, there is a need to make a reasonable estimation for the spectrum demands of future IMT systems. The estimation results can also provide guidelines for the subsequent spectrum planning and assignment work. This paper gives a description of study progress of related spectrum estimation for future IMT systems. From the analysis of current work and practical situation, the key factors in the estimation methodology are summarized to provide a reference for the following work.展开更多
基金The Natural Science Foundation of Zhejiang Province,No.LQ23H050005The Scientific Research Project of Zhejiang Provincial Education Department,No.Y202250731 and No.Y202353130+1 种基金China Students’Innovation and Entrepreneurship Training Program,No.202310338044China Postdoctoral Science Foundation,No.2022M721720.
文摘In this article,an article published in the World Journal of Gastrointestinal Oncology,which focuses on whether the expression of programmed death-ligand 1(PD-L1)affects the effectiveness of chemotherapy regimens,including bevacizumab,in treating patients with colorectal cancer(CRC).Through neutralization of vascular endothelial growth factor(VEGF),bevacizumab inhibits tumor angiogenesis,impairing neovascularization and thereby depriving the tumor of essential nutrients and oxygen.Conversely,PD-L1 binding to VEGF receptor 2 promotes angiogenesis,supporting tumor vasculature.The interplay between these pathways complicates the assessment of bevacizumab’s efficacy in cancer therapy,notably in CRC,where VEGF and PD-L1 significantly affect treatment response.This review examines metastatic CRC treatment strategies,focusing on bevacizumab’s mechanism of action and the role of PD-L1 in this therapeutic context.
基金supported in part by the National Key R&D Program of China(2022YFC3401303)the Natural Science Foundation of Jiangsu Province(BK20211528)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KFCX22_2300)。
文摘In the era of exponential growth of data availability,the architecture of systems has a trend toward high dimensionality,and directly exploiting holistic information for state inference is not always computationally affordable.This paper proposes a novel Bayesian filtering algorithm that considers algorithmic computational cost and estimation accuracy for high-dimensional linear systems.The high-dimensional state vector is divided into several blocks to save computation resources by avoiding the calculation of error covariance with immense dimensions.After that,two sequential states are estimated simultaneously by introducing an auxiliary variable in the new probability space,mitigating the performance degradation caused by state segmentation.Moreover,the computational cost and error covariance of the proposed algorithm are analyzed analytically to show its distinct features compared with several existing methods.Simulation results illustrate that the proposed Bayesian filtering can maintain a higher estimation accuracy with reasonable computational cost when applied to high-dimensional linear systems.
基金supported in part by the Natural Sciences Engineering Research Council of Canada (NSERC)。
文摘This survey paper provides a review and perspective on intermediate and advanced reinforcement learning(RL)techniques in process industries. It offers a holistic approach by covering all levels of the process control hierarchy. The survey paper presents a comprehensive overview of RL algorithms,including fundamental concepts like Markov decision processes and different approaches to RL, such as value-based, policy-based, and actor-critic methods, while also discussing the relationship between classical control and RL. It further reviews the wide-ranging applications of RL in process industries, such as soft sensors, low-level control, high-level control, distributed process control, fault detection and fault tolerant control, optimization,planning, scheduling, and supply chain. The survey paper discusses the limitations and advantages, trends and new applications, and opportunities and future prospects for RL in process industries. Moreover, it highlights the need for a holistic approach in complex systems due to the growing importance of digitalization in the process industries.
基金Supported by National Natural Science Foundation of China,No.82071871Guangdong Basic and Applied Basic Research Foundation,No.2021A1515220131+1 种基金Guangdong Medical Science and Technology Research Fund Project,No.2022111520491834Clinical Research Project of Shenzhen Second People's Hospital,No.20223357022。
文摘BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque formation.This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imaging(HR-VWI).AIM To investigate the factors of intracranial atherosclerotic remodelling patterns and the relationship between intracranial atherosclerotic remodelling and diabetes mellitus using HR-VWI.METHODS Ninety-four patients diagnosed with middle cerebral artery or basilar artery INTRODUCTION Intracranial atherosclerotic disease is one of the main causes of ischaemic stroke in the world,accounting for approx-imately 10%of transient ischaemic attacks and 30%-50%of ischaemic strokes[1].It is the most common factor among Asian people[2].The adaptive changes in the structure and function of blood vessels that can adapt to changes in the internal and external environment are called vascular remodelling,which is a common and important pathological mechanism in atherosclerotic diseases,and the remodelling mode of atherosclerotic plaques is closely related to the occurrence of stroke.Positive remodelling(PR)is an outwards compensatory remodelling where the arterial wall grows outwards in an attempt to maintain a constant lumen diameter.For a long time,it was believed that the degree of stenosis can accurately reflect the risk of ischaemic stroke[3-5].Previous studies have revealed that lesions without significant luminal stenosis can also lead to acute events[6,7],as summarized in a recent meta-analysis study in which approximately 50%of acute/subacute ischaemic events were due to this type of lesion[6].Research[8,9]has pointed out that the PR of plaques is more dangerous and more likely to cause acute ischaemic stroke.Previous studies[10-13]have found that there are specific vascular remodelling phenomena in the coronary and carotid arteries of diabetic patients.However,due to the deep location and small lumen of intracranial arteries and limitations of imaging techniques,the relationship between intracranial arterial remodelling and diabetes is still unclear.In recent years,with the development of magnetic resonance technology and the emergence of high-resolution(HR)vascular wall imaging,a clear and multidimensional display of the intracranial vascular wall has been achieved.Therefore,in this study,HR wall imaging(HR-VWI)was used to display the remodelling characteristics of bilateral middle cerebral arteries and basilar arteries and to explore the factors of intracranial vascular remodelling and its relationship with diabetes.
文摘Branch identification technology is a key technology to achieve automated pruning of fruit tree branches, and one of its technical bottlenecks lies in the stitching of branch images. To this end, we propose a set of branch image stitching technology algorithms. The algorithm is based on the grey-scale prime centroid method to determine the detection feature points, and uses the coordinate transformation matrix H of the corresponding points of the image to carry out the image geometric transformation, and realises the feature matching through sample comparison and classification methods. The experimental results show that the matched point images are more correct and less time-consuming.
基金Supported by the National Natural Science Foundation of China,No.82172336“Pioneer”and“Leading Goose”R&D Program of Zhejiang,No.2022C03118 and No.2023C03075+1 种基金Natural Science Foundation of Zhejiang Province,No.LQ23H050005Scientific Research Project of Zhejiang Provincial Education Department,No.Y202250731.
文摘Pepsinogen,secreted from the gastric mucosa,is the precursor of pepsin.It is categorized as pepsinogen 1 and pepsinogen 2 based on its immunogenicity.The pepsinogen content that can enter the blood circulation through the capillaries of the gastric mucosa is approximately 1%and remains stable all the time.The pepsinogen content in serum will change with the pathological changes of gastric mucosa.Therefore,the level of pepsinogen in serum can play a role in serologic biopsy to reflect the function and morphology of different regions of gastric mucosa and serve as an indicator of gastric disease.This study conducts relevant research on serum pepsinogen 1,pepsinogen 2,and the ratio of pepsinogen 1 to pepsinogen 2,and reviews their important value in clinical diagnosis of Helicobacter pylori infection,gastric ulcer,and even gastric carcinoma,providing ideas for other researchers.
基金supported by the National Key Laboratory of Water Disaster Prevention(Grant No.2021492011)the Natural Science Foundation of Zhejiang Province(Grant No.LQ22E090002).
文摘Considering that we still do not fully understand the behavior of air pockets trapped in rainstorm systems and water flow changes inside pipes,the study of actual geysers presents many challenges.In this study,three-dimensional numerical models were developed to investigate the mechanisms of geyser events triggered by rapid filling flows at different scales.The results showed that,in the first stage of the water–air mixture of the prototype model,a large amount of air was released quickly,and the subsequent overflow lasted for a more extended period.The transport capacity of the downstream pipe,as a critical factor,significantly influenced the water–air interaction of the geyser.Restricting the outlet area and increasing the outlet pressure simultaneously resulted in a stronger geyser.The equivalent density of the water–air mixture increased as the scale decreased during the geyser event.
基金Supported by National Natural Science Foundation of China,No.82071871Guangdong Basic and Applied Basic Research Foundation,No.2021A1515220131+1 种基金Guangdong Medical Science and Technology Research Fund Project,No.2022111520491834and Clinical Research Project of Shenzhen Second People's Hospital,China,No.20223357022。
文摘BACKGROUND Primary central nervous system lymphoma(PCNSL)is a rare malignant tumor originating from the lymphatic hematopoietic system.It exhibits unique imaging manifestations due to its biological characteristics.CASE SUMMARY Magnetic resonance imaging(MRI)with diffusion-weighted imaging(DWI),perfusion-weighted imaging(PWI),and magnetic resonance spectroscopy was performed.The imaging findings showed multiple space-occupying lesions with low signal on T1-weighted imaging,uniform high signal on T2-weighted imaging,and obvious enhancement on contrast-enhanced scans.DWI revealed diffusion restriction,PWI demonstrated hypoperfusion,and spectroscopy showed elevated choline peak and decreased N-acetylaspartic acid.The patient's condition significantly improved after hormone shock therapy.CONCLUSION This case highlights the distinctive imaging features of PCNSL and their importance in accurate diagnosis and management.
基金the National Postdoctoral Program for Innovative Talents(Grant BX201700126)the China Postdoctoral Science Foundation(Grant 2017M620043)+1 种基金the National Natural Science Foundation of China(Grants 51679005 and 91752105)the National Natural Science Foundation of Beijing(Grant 3172029).
文摘The dynamic stall problem for blades is related to the general performance of wind turbines,where a varying flow field is introduced with a rapid change of the effective angle of attack (AOA).The objective of this work is to study the aerodynamic performance of a sinusoidally oscillating NACA0012 airfoil.The coupled k-ω Menter's shear stress transport (SST) turbulence model and γ-Reθ transition model were used for turbulence closure.Lagrangian coherent structures (LCS) were utilized to analyze the dynamic behavior of the flow structures.The computational results were supported by the experiments.The results indicated that this numerical method can well describe the dynamic stall process.For the case with reduced frequency K =0.1,the lift and drag coefficients increase constantly with increasing angle prior to dynamic stall.When the AOA reaches the stall angle,the lift and drag coefficients decline suddenly due to the interplay between the first leading-and trailing-edge vortex.With further increase of the AOA,both the lift and drag coefficients experience a secondary rise and fall process because of formation and shedding of the secondary vortex.The results also reveal that the dynamic behavior of the flow structures can be effectively identified using the finite-time Lyapunov exponent (FTLE) field.The influence of the reduced frequency on the flow structures and energy extraction efficiency in the dynamic stall process is further discussed.When the reduced frequency increases,the dynamic stall is delayed and the total energy extraction efficiency is enhanced.With K =0.05,the amplitude of the dynamic coefficients fluctuates more significantly in the poststall process than in the case of K =0.1.
基金supported by the National Natural Science Foundation of China (Grant 51679005)the Natural Science Foundation of Beijing Municipality (Grant 3172029)the Ph.D. Programs Foundation of Ministry of Education of China (Grant 20131101120014)
文摘Cavitation–structure interaction has become one of the major issues for most engineering applications. The present work reviews recent progress made toward developing experimental and numerical investigation for unsteady turbulent cavitating flow and cavitation–structure interaction. The goal of our overall efforts is to（1） summarize the progress made in the experimental and numerical modeling and approaches for unsteady cavitating flow and cavitation–structure interaction,（2） discuss the global multiphase structures for different cavitation regimes, with special emphasis on the unsteady development of cloud cavitation and corresponding cavitating flow-induced vibrations,with a high-speed visualization system and a structural vibration measurement system, as well as a simultaneous sampling system,（3） improve the understanding of the hydroelastic response in cavitating flows via combined physical and numerical analysis, with particular emphasis on the interaction between unsteady cavitation development and structural deformations. Issues including unsteady cavitating flow structures and cavitation–structure interaction mechanism are discussed.
基金supported by the National Natural Science Foundation of China (Grants 11172040,51239005)
文摘A local vortical cavitation（LVC） model for the computation of unsteady cavitation is proposed.The model is derived from the Rayleigh–Plesset equations,and takes into account the relations between the cavitation bubble radius and local vortical effects.Calculations of unsteady cloud cavitating fows around a Clark-Y hydrofoil are performed to assess the predictive capability of the LVC model using well-documented experimental data.Compared with the conventional Zwart＇s model,better agreement is observed between the predictions of the LVC model and experimental data,including measurements of time-averaged fl w structures,instantaneous cavity shapes and the frequency of the cloud cavity shedding process.Based on the predictions of the LVC model,it is demonstrated that the evaporation process largely concentrates in the core region of the leading edge vorticity in accordance with the growth in the attached cavity,and the condensation process concentrates in the core region of the trailing edge vorticity,which corresponds to the spread of the rear component of the attached cavity.When the attached cavity breaks up and moves downstream,the condensation area fully transports to the wake region,which is in accordance with the dissipation of the detached cavity.Furthermore,using vorticity transport equations,we also fin that the periodic formation,breakup,and shedding of the sheet/cloud cavities,along with the associated baroclinic torque,are important mechanisms for vorticity production and modification When the attached cavity grows,the liquid–vapour interface that moves towards the trailing edge enhances the vorticity in the attached cav-ity closure region.As the re-entrant jet moves upstream,the wavy/bubbly cavity interface enhances the vorticity near the trailing edge.At the end of the cycle,the break-up of the stable attached cavity is the main reason for the vorticity enhancement near the suction surface.
基金project was supported by the National Natural Science Foundation of China (Grants 51306020, 11172040)the Natural Science Foundation of Beijing (Grant 3144034)the Excellent Young Scholars Research Fund of Beijing Institute of Technology
文摘The objective of this paper is to address the transient flow structures around a pitching hydrofoil by com- bining physical and numerical studies. In order to predict the dynamic behavior of the flow structure effectively, the Lagrangian coherent structures （LCS） defined by the ridges of the finite-time Lyapunov exponent （FTLE） are utilized under the framework of Navier-Stokes flow computations. In the numerical simulations, the k-w shear stress trans- port （SST） turbulence model, coupled with a two-equation F-Reo transition model, is used for the turbulence closure. Results are presented for a NACA66 hydrofoil undergoing slowly and rapidly pitching motions from 0° to 15° then back to 0° at a moderate Reynolds number Re = 7.5 × 105. The results reveal that the transient flow structures can be observed by the LCS method. For the slowly pitching case, it consists of five stages： quasi-steady and laminar, transition from laminar to turbulent, vortex development, large-scale vortex shedding, and reverting to laminar. The observation of LCS and Lagrangian particle tracers elucidates that the trailing edge vortex is nearly attached and stable during the vortex development stage and the interaction between the leading and trailing edge vortex caused by the adverse pres- sure gradient forces the vortexes to shed downstream during the large-scale vortex shedding stage, which corresponds to obvious fluctuations of the hydrodynamic response. For the rapidly pitching case, the inflection is hardly to be observed and the stall is delayed. The vortex formation, interaction, and shedding occurred once instead of being repeated three times, which is responsible for just one fluctuation in the hydrody- namic characteristics. The numerical results also show that the FTLE field has the potential to identify the transient flows, and the LCS can represent the divergence extent of infinite neighboring particles and capture the interface of the vortex region.
基金financially supported by the Special Scientific Research Fund for Public Service Sectors of Forestry(Grant No.201504603)Science and Technology Projects of Fujian Province(2014NZ003)the National Natural Science Foundation of China(Grant Nos.31370560,31170520)
文摘Wood has no inherent natural resistance against agents of biodegradation. We evaluated the effects of metal bath heat treatment(MBHT) on decay resistance and dimensional stability of Chinese parasol(Firmiana simplex) and Chinese fir(Cunninghamia lanceolata) wood. A low melting point alloy was used as heating medium in the treatment of the wood samples at 150, 180, and 210 °C for2, 4, and 8 h. Heat-treated and control samples were exposed to brown rot fungus(Poria placenta) and white rot fungus(Coriolus versicolor) for decay resistance testing and anti-swelling efficiency(ASE). The improved decay resistance with increase temperatures with low mass losses of 7.3 and 7.3% for F. simplex, and 3.9 and 3.6% for C.lanceolata at 210 °C for 8 h against Coriolus versicolor and Poria placenta, respectively. ASE indicated that MBHT contributed to improved dimensional stability of both wood species after treatment. Scanning electron micrograph results indicate that metal bath-treated samples showed strong decay resistance. Therefore, our approach to thermally modify wood should be explored to overcome the energy utilization by using low melting point alloy for the heat treatment of wood.
基金financially supported by the Special Scientific Research Fund for Public Service Sectors of Forestry(Grant No.201504603)Science and Technology Projects of Fujian Province(2014NZ003)the National Natural Science Foundation of China(Grant Nos.31370560,31170520)
文摘Pinus massoniana L. was thermally treated with low melting point alloy as heating medium to investigate the strength properties changes. Contact angle, color and scanning electron microscopy were recorded to assess the effectiveness of the treatment. Samples were pre-treated in a micro-wave for 5 min followed by metal bath heat treatment at 150, 180, and 210 °C for 2, 4, and 8 h,respectively. Strength properties of metal bath treated wood were decreased with increase temperature and time.Density, modulus of rupture, impact bending, modulus of elasticity were reduced for all treatments. Maximum compressive strength slightly increased at 150 °C for 4 h followed by gradual reduction. The Janka hardness was reduced in the tangential and radial directions. Treatment of the wood at 210 °C for 8 h caused the wood to become brittle and rupture. The contact angle was considerably higher after thermal treatment. The color of the wood became darker with increasing temperature of thermal treatment. Micrographs of the heat-treated samples showed damage to the cell wall with increase in temperature. Metal bath heat treatment of wood was carried out successfully and some strength properties were reduced.
基金supported by the National Natural Science Foundation of China (31971190)Science Fund for Distinguished Young Scholars of Hunan Province (2021JJ10035)Education Department of Hunan Province (19A321)。
文摘Various peptide toxins in animal venom inhibit voltage-gated sodium ion channel Nav1.7, including Nav-targeting spider toxin(NaSpTx) Family I. Toxins in NaSpTx Family I share a similar structure, i.e., Nterminal, loops 1–4, and C-terminal. Here, we used Mu-theraphotoxin-Ca2a(Ca2a), a peptide isolated from Cyriopagopus albostriatus, as a template to investigate the general properties of toxins in NaSpTx Family I. The toxins interacted with the cell membrane prior to binding to Nav1.7 via similar hydrophobic residues. Residues in loop 1, loop 4,and the C-terminal primarily interacted with the S3–S4 linker of domain II, especially basic amino acids binding to E818. We also identified the critical role of loop 2 in Ca2a regarding its affinity to Nav1.7.Our results provide further evidence that NaSpTx Family I toxins share similar structures and mechanisms of binding to Nav1.7.
文摘This paper synchronizes control theory with computer vision by formalizing object tracking as a sequential decision-making process.A reinforcement learning(RL)agent successfully tracks an interface between two liquids,which is often a critical variable to track in many chemical,petrochemical,metallurgical,and oil industries.This method utilizes less than 100 images for creating an environment,from which the agent generates its own data without the need for expert knowledge.Unlike supervised learning(SL)methods that rely on a huge number of parameters,this approach requires far fewer parameters,which naturally reduces its maintenance cost.Besides its frugal nature,the agent is robust to environmental uncertainties such as occlusion,intensity changes,and excessive noise.From a closed-loop control context,an interface location-based deviation is chosen as the optimization goal during training.The methodology showcases RL for real-time object-tracking applications in the oil sands industry.Along with a presentation of the interface tracking problem,this paper provides a detailed review of one of the most effective RL methodologies:actor–critic policy.
文摘Continuous-variable quantum key distribution (CVQKD) with the local local oscillator (LLO) is confronted with new security problems due to the reference pulses transmitted together with quantum signals over the insecure quantum channel. In this paper, we propose a method of phase attack on reference pulses of the LLO-CVQKD with time-multiplexing. Under this phase attack, the phase drifts of reference pulses are manipulated by eavesdroppers, and then the phase compensation error is increased. Consequently, the secret key rate is reduced due to the imperfect phase compensation for quantum signals. Based on the noise model of imperfect phase compensation, the practical security of LLO-CVQKD under phase attack is analyzed. The simulation results show that the practical security is reduced due to the phase attack, yet it is still tight when system parameters are estimated by training signals.
文摘pHKCl and pHH2O are two basic necessary indexes to reflect the acidity of asoil. Predicting pHKCl?directly from pHH2O?could save the cost of laboratory work. In this study, the values of pHKCl and of 442 and 310 horizon samples from 126 and 98 soil profiles (0 - 120 cm in depth) surveyed from 2014 to 2015 in Guangxi and Yunnan were used to establish the optimal correlation model between pHKCl and pHH2O. The results showed that: 1) pHKCl is lower than pHH2O, pHKCl?was 0.07 - 1.99 units with a mean of 0.99 units lower than for Guangxi, while 0.03 - 1.90 units with a mean of 0.89 lower than pHH2O?for Yunan. 2) There is significant positive correlation between pHKCl?and pHH2O, the optimal correlation models between pHKCl?(y) and pHH2O?(x) for Guangxi and Yunnan are y = 0.1963x2 −1.0512x + 4.338, R2 = 0.836, p 0.1859x, R2 = 0.769, p pHKCl?with exchangeable H+ and Al3+ (R2 = 0.487, 0.716, p pHKCl?is dominated by exchangeable Al3+, followed by exchangeable H+, and their contribution to pHKCl?were 71.1% and 28.7%, respectively.
文摘In order to satisfy the spectrum requirements of the future international mobile telecommunication (IMT) systems, to realize scientific allocation and usage of spectrum resources and to avoid spectrum waste brought by allocation in advanced, there is a need to make a reasonable estimation for the spectrum demands of future IMT systems. The estimation results can also provide guidelines for the subsequent spectrum planning and assignment work. This paper gives a description of study progress of related spectrum estimation for future IMT systems. From the analysis of current work and practical situation, the key factors in the estimation methodology are summarized to provide a reference for the following work.
