This paper systematically studies the flashover probability of wind turbine blade lightning arrester and the impact of strong electromagnetic pulses on the local and surrounding wind turbines during lightning strikes....This paper systematically studies the flashover probability of wind turbine blade lightning arrester and the impact of strong electromagnetic pulses on the local and surrounding wind turbines during lightning strikes.The research results indicate that the flashover probability of direct lightning strikes by the wind turbine blade lightning arrester is almost negligible,and the strong electromagnetic pulse of wind turbine blade during lightning strikes has a serious impact on the electronic equipment of the machine,while the impact on the surrounding wind turbine is relatively small.At the same time,the calculation formula for the reflection of lightning current on the carbon brush between the wind turbine hub and the engine compartment during the flashing of the wind turbine blades is provided,and the calculation method for calculating the spatial gradient distribution of electromagnetic field intensity using Biot-Savart Law theorem is applied.The limitations of using wind turbine blades for lightning protection are pointed out,and a technical route for achieving wind turbine lightning safety is proposed,which can be used as a reference for wind turbine lightning protection technicians.展开更多
Heat transfer and vacuum in condenser are influenced by the aerodynamic performance of steam turbine exhaust hood. The current research on exhaust hood is mainly focused on analyzing flow loss and optimal design of it...Heat transfer and vacuum in condenser are influenced by the aerodynamic performance of steam turbine exhaust hood. The current research on exhaust hood is mainly focused on analyzing flow loss and optimal design of its structure without consideration of the wet steam condensing flow and the exhaust hood coupled with the front and rear parts. To better understand the aerodynamic performance influenced by the tilt angle of flow guide inside a diffuser, taking a 600 MW steam turbine as an example, a numerical simulator CFX is adopted to solve compressible three-dimensional(3D) Reynolds time-averaged N-S equations and standard k-e turbulence model.And the exhaust hood flow field influenced by different tilt angles of flow guide is investigated with consideration of the wet steam condensing flow and the exhaust hood coupled with the last stage blades and the condenser throat.The result shows that the total pressure loss coefficient and the static pressure recovery coefficient of exhaust hood change regularly and monotonously with the gradual increase of tilt angle of flow guide. When the tilt angle of flow guide is within the range of 30° to 40°, the static pressure recovery coefficient is in the range of 15.27% to 17.03% and the total pressure loss coefficient drops to approximately 51%, the aerodynamic performance of exhaust hood is significantly improved. And the effectiveenthalpy drop in steam turbine increases by 0.228% to 0.274%. It is feasible to obtain a reasonable title angle of flow guide by the method of coupling the last stage and the condenser throat to exhaust hood in combination of the wet steam model, which provides a practical guidance to flow guide transformation and optimal design in exhaust hood.展开更多
Objective:To use high-frequency ultrasound to evaluate the efficacy ofα-lipoic acid combined with traditional Chinese medicine in the treatment of diabetic peripheral neuropathy(DPN),so as to provide a basis for clin...Objective:To use high-frequency ultrasound to evaluate the efficacy ofα-lipoic acid combined with traditional Chinese medicine in the treatment of diabetic peripheral neuropathy(DPN),so as to provide a basis for clinical medication and evaluation of therapeutic effect.Methods:From December 2018 to December 2019,110 patients with DPN who met the inclusion and exclusion criteria were divided into observation group and control group according to different treatment plans.The control group was treated withα-lipoic acid,and the observation group was treated withα-lipoic acid combined with traditional Chinese medicine encapsulation treatment,and used high-frequency ultrasound,nerve conduction velocity and serological examination to comprehensively evaluate the effectiveness of the two treatment methods.Results:The mean amplitude of glycemic excursions(MAGE)value of the observation group and the control group after treatment was significantly lower than before treatment(P<0.05);After treatment,the SCV of the ulnar nerve,median nerve,and common peroneal nerve in the two groups was significantly faster than before treatment(P<0.05).Similar to SCV,the MCV of the three nerves measured after treatment in the two groups was significantly faster than before treatment(P<0.05).Compared between the groups after treatment,the three kinds of nerve SCV and MCV in the observation group were significantly faster than those in the control group(P<0.05).The cross-sectional area(CSA)value of the ulnar nerve,median nerve and common peroneal nerve in the observation group after treatment was significantly lower than before treatment(P<0.05).Compared with the control group after treatment,the three nerves CSA in the observation group was significantly lower than that in the control group(P<0.05).Abnormal ultrasound performance:The proportion of abnormal ultrasound performances of the ulnar nerve,median nerve,and common peroneal nerve in the observation group after treatment was significantly lower than before treatment(P<0.05).The composition ratio of internal echo reduction and ambiguity in the observation group after three nerve treatments was significantly lower than that in the control group after treatment(P<0.05).In the correlation analysis,the three kinds of nerve CSA before and after treatment were negatively correlated with SCV and amplitude(P<0.05),and positively correlated with latency(P<0.05).Conclusion:The combination ofα-lipoic acid and Chinese medicine encapsulation technology has a good effect on the treatment and repair of DPN nerve damage,and can be routinely applied in clinical treatment.High-frequency ultrasound can intuitively observe changes in peripheral nerves and can be used to evaluate the prognosis of DPN.展开更多
Objective: High frequency ultrasound combined with policy thermal perception testing (QTT) was used to analyze the characteristics of nerve damage in diabetic peripheral neuropathy (DPN), and then provided the basis f...Objective: High frequency ultrasound combined with policy thermal perception testing (QTT) was used to analyze the characteristics of nerve damage in diabetic peripheral neuropathy (DPN), and then provided the basis for the clinical prevention, diagnosis and treatment of DPN. Methods: A total of 110 DPN patients admitted to the hospital from December 2015 to May 2018 were selected, and the characteristics of nerve damage in diabetic peripheral neuropathy were analyzed by ultrasound and QTT. Results: In the results of QTT, the abnormal proportion of the CDT, WDT, CPT and HPT of the lower limbs in DPN's were all higher than the upper limbs;The difference of WDT and HPT in the age and course groups of patients in the upper limbs was statistically significant, the abnormal proportion of WDT and HPT in patients aged 60 years or above or with a course of 10 years or more were all above 45%, higher than those in other groups. The patients with larger mean amplitude of glycemic excursions (MAGE) were significantly higher than those with smaller MAGE, regardless of the abnormal proportion of WDT and HPT observed in upper limbs, lower limbs or upper and lower limbs;The results of ultrasonic measurement of nerve cross sectional area showed: the proportion of patients with ulnar nerve and median nerve abnormally thickened in the high age group (≥45 years) and the long course group (>10 years) was significantly higher than that in the low age group (<45 years) and the short course group (<10 years), the proportion of patients with larger MAGE with abnormal enlargement of median nerve was significantly higher than those with smaller MAGE. The thickening of ulnar nerve, median nerve and peroneal nerve was obvious in the patients of MAGE > 4 mmol/L. Conclusion: (1) The main nerve damage in DPN patients was thermal sensation damage, and the lower limb nerve was more vulnerable than the upper limb nerve. (2) The incidence of ulnar and median nerve damage was higher in patients aged 45 years and older or over 10 years of course. (3) Patients with large MAGE (> 4 mmo/L) had higher incidence of median nerve damage. The above characteristics of nerve damage can provide basis for clinical prevention, diagnosis and treatment of DPN.展开更多
Parkinson's disease(PD), characterized by the loss of dopaminergic(DA) neurons in the substantia nigra pars compacta(SNpc) of the midbrain, is a prototype neurological disease that is suitable for cellular replace...Parkinson's disease(PD), characterized by the loss of dopaminergic(DA) neurons in the substantia nigra pars compacta(SNpc) of the midbrain, is a prototype neurological disease that is suitable for cellular replacement therapy. Levodopa has been utilized to replace the insufficient dopamine released by degenerating DA neurons since the 1960s and it remains the cornerstone of PD treatment. However, as the disease progresses.展开更多
Coal and gas outburst is a complex dynamic disaster during coal underground mining.Revealing the disaster mechanism is of great signifcance for accurate prediction and prevention of coal and gas outburst.The geo-dynam...Coal and gas outburst is a complex dynamic disaster during coal underground mining.Revealing the disaster mechanism is of great signifcance for accurate prediction and prevention of coal and gas outburst.The geo-dynamic system of coal and gas outburst is proposed.The framework of geo-dynamic system is composed of gassy coal mass,geological dynamic environment and mining disturbance.Equations of stress–damage–seepage interaction for gassy coal mass is constructed to resolve the outburst elimination process by gas extraction with boreholes through layer in foor roadway.The results show the occurrence of outburst is divided into the evolution process of gestation,formation,development and termination of geo-dynamic system.The scale range of outburst occurrence is determined,which provides a spatial basis for the prevention and control of outburst.The formation criterion and instability criterion of coal and gas outburst are established.The formation criterion F1 is defned as the scale of the geo-dynamic system,and the instability criterion F2 is defned as the scale of the outburst geo-body.According to the geo-dynamic system,the elimination mechanism of coal and gas outburst—‘unloading+depressurization’is established,and the gas extraction by boreholes through layer in foor roadway for outburst elimination is given.For the research case,when the gas extraction is 120 days,the gas pressure of the coal seam is reduced to below 0.4 MPa,and the outburst danger is eliminated efectively.展开更多
Background: The protein encoded by ring finger protein 157 (RNF157) is known to function as an E3 ubiquitinligase. However, whether the level of RNF157 expression in breast cancer correlates with prognosis and immune ...Background: The protein encoded by ring finger protein 157 (RNF157) is known to function as an E3 ubiquitinligase. However, whether the level of RNF157 expression in breast cancer correlates with prognosis and immune cellinfiltration among breast cancer patients remains to be further explored. Methods: In this study, publicly availabledatasets were used for evaluating RNF157 expression in different tumors compared with normal samples. Severalindependent datasets were screened for investigating the relationship between RNF157 and breast cancer survival,different mutation profiles, and tumor immune cell infiltration. We conducted a pathway enrichment analysis toidentify signaling pathways associated with RNF157. Results: Analysis of public and online databases revealed thatRNF157 expression markedly decreased in breast cancer tissue samples compared to non-carcinoma counterparts.Consistently, immunohistochemistry assays also demonstrated this RNF157 down-regulation in breast cancer samples.RNF157 up-regulation could predict the improved survival of breast cancer cases. Further, different RNF157expression level groups exhibited different mutational profiles. Pathway enrichment profiling of RNF157-related genessuggested its possible involvement in regulating breast cancer via the mitogen-activated protein kinase (MAPK)pathway. RNA sequencing (RNA-seq) data and genomic enrichment analysis showed that RNF157 downregulatedseveral genes positively associated with the MAPK signaling pathway. We also explored RNF157 expression andimmune cell infiltration in breast cancer and found that RNF157 mRNA levels were negatively related to non-Timmune cell infiltration. Conclusion: According to our work, RNF157 may be a promising diagnostic biomarker andtherapeutic target for breast cancer.展开更多
Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications.Most recent researches have focused on the health aspects of flavonoids for humans.Especially,d...Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications.Most recent researches have focused on the health aspects of flavonoids for humans.Especially,different flavonoids have been investigated for their potential antiviral activities,and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo.This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids,highlights the cellular and molecular mechanisms of natural flavonoids on viruses,and presents the details of most reported flavonoids.Meanwhile,future perspectives on therapeutic applications of flavonoids against viral infections were discussed.展开更多
Neurocognitive dysfunction is a common postoperative complication,especially in older adult patients.Fingolimod(FTY720)is a sphingosine-1-phosphate receptor modulator that has been found to be neuroprotective in sever...Neurocognitive dysfunction is a common postoperative complication,especially in older adult patients.Fingolimod(FTY720)is a sphingosine-1-phosphate receptor modulator that has been found to be neuroprotective in several animal models of central nervous system disease.However,few reports have examined whether FTY720 could mitigate postoperative cognitive dysfunction.In this study,we investigated whether FTY720 could prevent postoperative neurocognitive impairment in mice subjected to D-galactose-induced aging.We induced an accelerated model of aging by administering an intraperitoneal injection of D-galactose.Subsequently,we performed a partial hepatolobectomy under sevoflurane anesthesia.FTY720(1 mg/kg)was administered intraperitoneally 3 hours before and 24 hours after anesthesia and surgery.Our results indicated that anesthesia and surgery significantly impaired spatial memory in the Y-maze test 6 hours after surgery.We also found that problem solving ability and long-term memory in the puzzle box test on postoperative days 2–4 were significantly improved by FTY720 treatment.Immunohistochemical staining and western blot assay demonstrated that FTY720 significantly inhibited microglial activation in the hippocampal CA1 region of mice 6 hours and 3 days after anesthesia,and down-regulated the expression of synaptic-related proteins postsynaptic density protein 95 and GluR2 in the hippocampus.These results indicate that FTY720 improved postoperative neurocognitive dysfunction in mice subjected to D-galactose-induced aging.This study was approved by the Experimental Animal Ethics Committee of the Third Xiangya Hospital of Central South University of China(approval No.LLSC(LA)2016-025)on September 27,2016.展开更多
1 The unique ocean forecasting system (OFS) based on FIO-COM The OFS is based on the surface wave-tide-circulation coupled ocean model developed by the First Institute of Oceanography (FIO-COM), Ministry of Natural Re...1 The unique ocean forecasting system (OFS) based on FIO-COM The OFS is based on the surface wave-tide-circulation coupled ocean model developed by the First Institute of Oceanography (FIO-COM), Ministry of Natural Resources, China. The half-century challenge that ocean circulation models must address is that the forecasting/simulated sea surface temperature overheats while the sub-surface temperature is too cold, especially during the summer. Qiao et al.(2004, 2010, 2016) found that the non-breaking surface wave can generate turbulence through wave-turbulence interaction, and they developed the wave-induced mixing theory, which has been confirmed by observations, laboratory experiments and model numerical simulations. As validated by ocean circulation models from various research groups, including Geophysical Fluid Dynamics Laboratory (GFDL) in the US (Fan and Griffies, 2014), Uppsala University of Sweden (Wu et al., 2015), Laboratoire d’Etudes en Geophysique et Oceanographie Spatiale (LEGOS) in France (Malek and Babanin, 2014), Budapest University of Technology and Economics in Hungary (Peter and Kramer, 2016) and the Ocean University of China (Lin et al., 2006), the non-breaking surface waveinduced vertical mixing (Bv) can always dramatically improve the simulation capacity of various ocean circulation models. The First Institute of Oceanography (FIO) research group found that tidal-induced mixing plays a key role in the formation of coastal upwelling, in the bottom mixed layer and in areas with sea mounts (Lv et al., 2006, 2008). With the above breakthroughs, the first surface wavetide-circulation coupled model of FIO-COM was developed in 2013. It was adopted to produce a reanalysis dataset for the period of January 2014 to April 2016, and it has been used for the operational OFS since May 2016. A highly efficient parallel scheme was designed to use the full capacity of Taihu Light with 10 649 600 CPU cores (Qiao et al., 2016), which earned a finalist nomination for the international Association for Computing Machinery (ACM) Gordon Bell Prize.展开更多
In this paper,we first derive two types of transformed Franklin polynomial:substituted and weighted radial Franklin polynomials.Two radial orthogonal moments are proposed based on these two types of polynomials,namely...In this paper,we first derive two types of transformed Franklin polynomial:substituted and weighted radial Franklin polynomials.Two radial orthogonal moments are proposed based on these two types of polynomials,namely substituted Franklin-Fourier moments and weighted Franklin-Fourier moments(SFFMs and WFFMs),which are orthogonal in polar coordinates.The radial kernel functions of SFFMs and WFFMs are transformed Franklin functions and Franklin functions are composed of a class of complete orthogonal splines function system of degree one.Therefore,it provides the possibility of avoiding calculating high order polynomials,and thus the accurate values of SFFMs and WFFMs can be obtained directly with little computational cost.Theoretical and experimental results show that Franklin functions are not well suited for constructing higher-order moments of SFFMs and WFFMs,but compared with traditional orthogonal moments(e.g.,BFMs,OFMs and ZMs)in polar coordinates,the proposed two types of Franklin-Fourier Moments have better performance respectively in lower-order moments.展开更多
Chinese medicine originated in China and has taken root all over the world.In the United States,Chinese medicine belongs to the category of complementary and alternative medicine and has a history of over 50 years as ...Chinese medicine originated in China and has taken root all over the world.In the United States,Chinese medicine belongs to the category of complementary and alternative medicine and has a history of over 50 years as a recognized profession.The education of Chinese medicine is undoubtedly the foundation for the development and growth of Chinese medicine practice.In this article,we briefly introduced the history of acupuncture profession and its development in the United States.Pacific College of Health and Science New York and Eastern School of Acupuncture and Traditional Medicine were discussed and analyzed.This article aims to discuss two examples of acupuncture schools in the United States to provide an overview of the history and current development of Chinese medicine education in the United States.展开更多
Taiji studies are a field of study that has its roots in the philosophical thought of the Yi Jing or Book of changes.It integrates the self‑cultivation traditions of Confucianism,Buddhism,and Daoism,and centers its ac...Taiji studies are a field of study that has its roots in the philosophical thought of the Yi Jing or Book of changes.It integrates the self‑cultivation traditions of Confucianism,Buddhism,and Daoism,and centers its academic system mostly on the perspective of the“states view”(jing jie guan).From the standpoint of its philosophical theory,Taiji studies divide the understanding of Dao into three theoretical states:the state of existence(you jie),the state of existence‑nonexistence(you wu jie),and the state of nonexistence(wu jie).It also establishes a theoretical structure that mainly includes“three states and nine axioms,”“One Dao and Nine theory sections,”and“Three practice levels and Nine secrets.”Based on traditional Chinese culture and philosophy,Taiji studies are continuously integrating the essence of them for better understanding and raising,and finally set up a rational school of Taiji Da Dao。展开更多
基金Research Project on Lightning Protection Technology for 35 kV Collector Lines in Wuxuan Qinglan Wind Farm(SFC/WXY-ZX-FW-23-008)Strong Electromagnetic Pulse Protection(Lightning)Effect in Guangdong Yuedian Zhuhai Biqing Bay Sea Wind Field and Real-time Monitoring Technology Research and Development Project of Grounding ResistanceResearch and Application Demonstration Project of Lightning Protection Technology for Offshore and Island Wind Field of China General Nuclear New Energy South China Branch.
文摘This paper systematically studies the flashover probability of wind turbine blade lightning arrester and the impact of strong electromagnetic pulses on the local and surrounding wind turbines during lightning strikes.The research results indicate that the flashover probability of direct lightning strikes by the wind turbine blade lightning arrester is almost negligible,and the strong electromagnetic pulse of wind turbine blade during lightning strikes has a serious impact on the electronic equipment of the machine,while the impact on the surrounding wind turbine is relatively small.At the same time,the calculation formula for the reflection of lightning current on the carbon brush between the wind turbine hub and the engine compartment during the flashing of the wind turbine blades is provided,and the calculation method for calculating the spatial gradient distribution of electromagnetic field intensity using Biot-Savart Law theorem is applied.The limitations of using wind turbine blades for lightning protection are pointed out,and a technical route for achieving wind turbine lightning safety is proposed,which can be used as a reference for wind turbine lightning protection technicians.
基金Supported by National Natural Science Foundation of China(Grant Nos.51576036,51476192)Science and Technology Development Planning Foundation of Jilin Province of China(Grant No.20140204040SF)
文摘Heat transfer and vacuum in condenser are influenced by the aerodynamic performance of steam turbine exhaust hood. The current research on exhaust hood is mainly focused on analyzing flow loss and optimal design of its structure without consideration of the wet steam condensing flow and the exhaust hood coupled with the front and rear parts. To better understand the aerodynamic performance influenced by the tilt angle of flow guide inside a diffuser, taking a 600 MW steam turbine as an example, a numerical simulator CFX is adopted to solve compressible three-dimensional(3D) Reynolds time-averaged N-S equations and standard k-e turbulence model.And the exhaust hood flow field influenced by different tilt angles of flow guide is investigated with consideration of the wet steam condensing flow and the exhaust hood coupled with the last stage blades and the condenser throat.The result shows that the total pressure loss coefficient and the static pressure recovery coefficient of exhaust hood change regularly and monotonously with the gradual increase of tilt angle of flow guide. When the tilt angle of flow guide is within the range of 30° to 40°, the static pressure recovery coefficient is in the range of 15.27% to 17.03% and the total pressure loss coefficient drops to approximately 51%, the aerodynamic performance of exhaust hood is significantly improved. And the effectiveenthalpy drop in steam turbine increases by 0.228% to 0.274%. It is feasible to obtain a reasonable title angle of flow guide by the method of coupling the last stage and the condenser throat to exhaust hood in combination of the wet steam model, which provides a practical guidance to flow guide transformation and optimal design in exhaust hood.
基金National natural science foundation of China(No.81701891)Guided scientific research project of Shiyan science and technology bureau(No.18Y63)。
文摘Objective:To use high-frequency ultrasound to evaluate the efficacy ofα-lipoic acid combined with traditional Chinese medicine in the treatment of diabetic peripheral neuropathy(DPN),so as to provide a basis for clinical medication and evaluation of therapeutic effect.Methods:From December 2018 to December 2019,110 patients with DPN who met the inclusion and exclusion criteria were divided into observation group and control group according to different treatment plans.The control group was treated withα-lipoic acid,and the observation group was treated withα-lipoic acid combined with traditional Chinese medicine encapsulation treatment,and used high-frequency ultrasound,nerve conduction velocity and serological examination to comprehensively evaluate the effectiveness of the two treatment methods.Results:The mean amplitude of glycemic excursions(MAGE)value of the observation group and the control group after treatment was significantly lower than before treatment(P<0.05);After treatment,the SCV of the ulnar nerve,median nerve,and common peroneal nerve in the two groups was significantly faster than before treatment(P<0.05).Similar to SCV,the MCV of the three nerves measured after treatment in the two groups was significantly faster than before treatment(P<0.05).Compared between the groups after treatment,the three kinds of nerve SCV and MCV in the observation group were significantly faster than those in the control group(P<0.05).The cross-sectional area(CSA)value of the ulnar nerve,median nerve and common peroneal nerve in the observation group after treatment was significantly lower than before treatment(P<0.05).Compared with the control group after treatment,the three nerves CSA in the observation group was significantly lower than that in the control group(P<0.05).Abnormal ultrasound performance:The proportion of abnormal ultrasound performances of the ulnar nerve,median nerve,and common peroneal nerve in the observation group after treatment was significantly lower than before treatment(P<0.05).The composition ratio of internal echo reduction and ambiguity in the observation group after three nerve treatments was significantly lower than that in the control group after treatment(P<0.05).In the correlation analysis,the three kinds of nerve CSA before and after treatment were negatively correlated with SCV and amplitude(P<0.05),and positively correlated with latency(P<0.05).Conclusion:The combination ofα-lipoic acid and Chinese medicine encapsulation technology has a good effect on the treatment and repair of DPN nerve damage,and can be routinely applied in clinical treatment.High-frequency ultrasound can intuitively observe changes in peripheral nerves and can be used to evaluate the prognosis of DPN.
基金National Natural Science Foundation(81701891)Shiyan Municipal Leading Scientific Research Project in 2018(18Y63).
文摘Objective: High frequency ultrasound combined with policy thermal perception testing (QTT) was used to analyze the characteristics of nerve damage in diabetic peripheral neuropathy (DPN), and then provided the basis for the clinical prevention, diagnosis and treatment of DPN. Methods: A total of 110 DPN patients admitted to the hospital from December 2015 to May 2018 were selected, and the characteristics of nerve damage in diabetic peripheral neuropathy were analyzed by ultrasound and QTT. Results: In the results of QTT, the abnormal proportion of the CDT, WDT, CPT and HPT of the lower limbs in DPN's were all higher than the upper limbs;The difference of WDT and HPT in the age and course groups of patients in the upper limbs was statistically significant, the abnormal proportion of WDT and HPT in patients aged 60 years or above or with a course of 10 years or more were all above 45%, higher than those in other groups. The patients with larger mean amplitude of glycemic excursions (MAGE) were significantly higher than those with smaller MAGE, regardless of the abnormal proportion of WDT and HPT observed in upper limbs, lower limbs or upper and lower limbs;The results of ultrasonic measurement of nerve cross sectional area showed: the proportion of patients with ulnar nerve and median nerve abnormally thickened in the high age group (≥45 years) and the long course group (>10 years) was significantly higher than that in the low age group (<45 years) and the short course group (<10 years), the proportion of patients with larger MAGE with abnormal enlargement of median nerve was significantly higher than those with smaller MAGE. The thickening of ulnar nerve, median nerve and peroneal nerve was obvious in the patients of MAGE > 4 mmol/L. Conclusion: (1) The main nerve damage in DPN patients was thermal sensation damage, and the lower limb nerve was more vulnerable than the upper limb nerve. (2) The incidence of ulnar and median nerve damage was higher in patients aged 45 years and older or over 10 years of course. (3) Patients with large MAGE (> 4 mmo/L) had higher incidence of median nerve damage. The above characteristics of nerve damage can provide basis for clinical prevention, diagnosis and treatment of DPN.
基金the Singapore Ministry of Health's National Medical Research Council (Open Fund Large Collaborative Grant (MOH-000207)Singapore Translational Research (STaR) Investigator A word (NMRC/STaR/0030/2018) to EKT,CS-IRG-NIG,OF-YIRG and TA award to BX) for their support。
文摘Parkinson's disease(PD), characterized by the loss of dopaminergic(DA) neurons in the substantia nigra pars compacta(SNpc) of the midbrain, is a prototype neurological disease that is suitable for cellular replacement therapy. Levodopa has been utilized to replace the insufficient dopamine released by degenerating DA neurons since the 1960s and it remains the cornerstone of PD treatment. However, as the disease progresses.
基金supported by the National Natural Science Foundation of China(52004117,52174117 and 51674132)the Postdoctoral Science Foundation of China(2021T140290 and 2020M680975)the Discipline Innovation Team of Liaoning Technical University(LNTU20TD-03 and LNTU20TD-30).
文摘Coal and gas outburst is a complex dynamic disaster during coal underground mining.Revealing the disaster mechanism is of great signifcance for accurate prediction and prevention of coal and gas outburst.The geo-dynamic system of coal and gas outburst is proposed.The framework of geo-dynamic system is composed of gassy coal mass,geological dynamic environment and mining disturbance.Equations of stress–damage–seepage interaction for gassy coal mass is constructed to resolve the outburst elimination process by gas extraction with boreholes through layer in foor roadway.The results show the occurrence of outburst is divided into the evolution process of gestation,formation,development and termination of geo-dynamic system.The scale range of outburst occurrence is determined,which provides a spatial basis for the prevention and control of outburst.The formation criterion and instability criterion of coal and gas outburst are established.The formation criterion F1 is defned as the scale of the geo-dynamic system,and the instability criterion F2 is defned as the scale of the outburst geo-body.According to the geo-dynamic system,the elimination mechanism of coal and gas outburst—‘unloading+depressurization’is established,and the gas extraction by boreholes through layer in foor roadway for outburst elimination is given.For the research case,when the gas extraction is 120 days,the gas pressure of the coal seam is reduced to below 0.4 MPa,and the outburst danger is eliminated efectively.
基金funded by the Innovation Team Project of Hainan Natural Science Foundation(820CXTD446)the Technology Program of Qingyuan(No.2022KJJH027 to Linhai Li).
文摘Background: The protein encoded by ring finger protein 157 (RNF157) is known to function as an E3 ubiquitinligase. However, whether the level of RNF157 expression in breast cancer correlates with prognosis and immune cellinfiltration among breast cancer patients remains to be further explored. Methods: In this study, publicly availabledatasets were used for evaluating RNF157 expression in different tumors compared with normal samples. Severalindependent datasets were screened for investigating the relationship between RNF157 and breast cancer survival,different mutation profiles, and tumor immune cell infiltration. We conducted a pathway enrichment analysis toidentify signaling pathways associated with RNF157. Results: Analysis of public and online databases revealed thatRNF157 expression markedly decreased in breast cancer tissue samples compared to non-carcinoma counterparts.Consistently, immunohistochemistry assays also demonstrated this RNF157 down-regulation in breast cancer samples.RNF157 up-regulation could predict the improved survival of breast cancer cases. Further, different RNF157expression level groups exhibited different mutational profiles. Pathway enrichment profiling of RNF157-related genessuggested its possible involvement in regulating breast cancer via the mitogen-activated protein kinase (MAPK)pathway. RNA sequencing (RNA-seq) data and genomic enrichment analysis showed that RNF157 downregulatedseveral genes positively associated with the MAPK signaling pathway. We also explored RNF157 expression andimmune cell infiltration in breast cancer and found that RNF157 mRNA levels were negatively related to non-Timmune cell infiltration. Conclusion: According to our work, RNF157 may be a promising diagnostic biomarker andtherapeutic target for breast cancer.
基金supported by CAMS Innovation Fund for Medical Sciences(Grant No.2017-I2M-1-010)National Key Research and Development Program(Grant No.2018YFC0311005)National Science and Technology Major Projects(Grant No.2018ZX09711001-012).
文摘Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications.Most recent researches have focused on the health aspects of flavonoids for humans.Especially,different flavonoids have been investigated for their potential antiviral activities,and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo.This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids,highlights the cellular and molecular mechanisms of natural flavonoids on viruses,and presents the details of most reported flavonoids.Meanwhile,future perspectives on therapeutic applications of flavonoids against viral infections were discussed.
基金supported by the National Natural Science Foundation of China,No.81500932(YW)
文摘Neurocognitive dysfunction is a common postoperative complication,especially in older adult patients.Fingolimod(FTY720)is a sphingosine-1-phosphate receptor modulator that has been found to be neuroprotective in several animal models of central nervous system disease.However,few reports have examined whether FTY720 could mitigate postoperative cognitive dysfunction.In this study,we investigated whether FTY720 could prevent postoperative neurocognitive impairment in mice subjected to D-galactose-induced aging.We induced an accelerated model of aging by administering an intraperitoneal injection of D-galactose.Subsequently,we performed a partial hepatolobectomy under sevoflurane anesthesia.FTY720(1 mg/kg)was administered intraperitoneally 3 hours before and 24 hours after anesthesia and surgery.Our results indicated that anesthesia and surgery significantly impaired spatial memory in the Y-maze test 6 hours after surgery.We also found that problem solving ability and long-term memory in the puzzle box test on postoperative days 2–4 were significantly improved by FTY720 treatment.Immunohistochemical staining and western blot assay demonstrated that FTY720 significantly inhibited microglial activation in the hippocampal CA1 region of mice 6 hours and 3 days after anesthesia,and down-regulated the expression of synaptic-related proteins postsynaptic density protein 95 and GluR2 in the hippocampus.These results indicate that FTY720 improved postoperative neurocognitive dysfunction in mice subjected to D-galactose-induced aging.This study was approved by the Experimental Animal Ethics Committee of the Third Xiangya Hospital of Central South University of China(approval No.LLSC(LA)2016-025)on September 27,2016.
基金The National Natural Science Foundation of China under contract No.41821004the NSFC-Shandong Joint Fund for Marine Science Research Centers under contract No.U1606405+1 种基金the International Cooperation Project of Indo-Pacific Ocean Environment Variation and Air-Sea Interaction under contract No.GASI-IPOVAI-05the IOC/WESTPAC OFS Project
文摘1 The unique ocean forecasting system (OFS) based on FIO-COM The OFS is based on the surface wave-tide-circulation coupled ocean model developed by the First Institute of Oceanography (FIO-COM), Ministry of Natural Resources, China. The half-century challenge that ocean circulation models must address is that the forecasting/simulated sea surface temperature overheats while the sub-surface temperature is too cold, especially during the summer. Qiao et al.(2004, 2010, 2016) found that the non-breaking surface wave can generate turbulence through wave-turbulence interaction, and they developed the wave-induced mixing theory, which has been confirmed by observations, laboratory experiments and model numerical simulations. As validated by ocean circulation models from various research groups, including Geophysical Fluid Dynamics Laboratory (GFDL) in the US (Fan and Griffies, 2014), Uppsala University of Sweden (Wu et al., 2015), Laboratoire d’Etudes en Geophysique et Oceanographie Spatiale (LEGOS) in France (Malek and Babanin, 2014), Budapest University of Technology and Economics in Hungary (Peter and Kramer, 2016) and the Ocean University of China (Lin et al., 2006), the non-breaking surface waveinduced vertical mixing (Bv) can always dramatically improve the simulation capacity of various ocean circulation models. The First Institute of Oceanography (FIO) research group found that tidal-induced mixing plays a key role in the formation of coastal upwelling, in the bottom mixed layer and in areas with sea mounts (Lv et al., 2006, 2008). With the above breakthroughs, the first surface wavetide-circulation coupled model of FIO-COM was developed in 2013. It was adopted to produce a reanalysis dataset for the period of January 2014 to April 2016, and it has been used for the operational OFS since May 2016. A highly efficient parallel scheme was designed to use the full capacity of Taihu Light with 10 649 600 CPU cores (Qiao et al., 2016), which earned a finalist nomination for the international Association for Computing Machinery (ACM) Gordon Bell Prize.
基金supported by the National Natural Science Foundation of China(61572092,61702403)the Fundamental Research Funds for the Central Universities(JB170308,JBF180301)+2 种基金the Project Funded by China Postdoctoral Science Foundation(2018M633473)the Basic Research Project of Weinan Science and Technology Bureau(ZDYF-JCYJ-17)the Project of Shaanxi Provincial Supports Discipline(Mathematics)
文摘In this paper,we first derive two types of transformed Franklin polynomial:substituted and weighted radial Franklin polynomials.Two radial orthogonal moments are proposed based on these two types of polynomials,namely substituted Franklin-Fourier moments and weighted Franklin-Fourier moments(SFFMs and WFFMs),which are orthogonal in polar coordinates.The radial kernel functions of SFFMs and WFFMs are transformed Franklin functions and Franklin functions are composed of a class of complete orthogonal splines function system of degree one.Therefore,it provides the possibility of avoiding calculating high order polynomials,and thus the accurate values of SFFMs and WFFMs can be obtained directly with little computational cost.Theoretical and experimental results show that Franklin functions are not well suited for constructing higher-order moments of SFFMs and WFFMs,but compared with traditional orthogonal moments(e.g.,BFMs,OFMs and ZMs)in polar coordinates,the proposed two types of Franklin-Fourier Moments have better performance respectively in lower-order moments.
基金the grant from the school of Acupuncture-Moxibustion and Tuina SHUTCM(No.2022SHUTCMKCJS060).
文摘Chinese medicine originated in China and has taken root all over the world.In the United States,Chinese medicine belongs to the category of complementary and alternative medicine and has a history of over 50 years as a recognized profession.The education of Chinese medicine is undoubtedly the foundation for the development and growth of Chinese medicine practice.In this article,we briefly introduced the history of acupuncture profession and its development in the United States.Pacific College of Health and Science New York and Eastern School of Acupuncture and Traditional Medicine were discussed and analyzed.This article aims to discuss two examples of acupuncture schools in the United States to provide an overview of the history and current development of Chinese medicine education in the United States.
文摘Taiji studies are a field of study that has its roots in the philosophical thought of the Yi Jing or Book of changes.It integrates the self‑cultivation traditions of Confucianism,Buddhism,and Daoism,and centers its academic system mostly on the perspective of the“states view”(jing jie guan).From the standpoint of its philosophical theory,Taiji studies divide the understanding of Dao into three theoretical states:the state of existence(you jie),the state of existence‑nonexistence(you wu jie),and the state of nonexistence(wu jie).It also establishes a theoretical structure that mainly includes“three states and nine axioms,”“One Dao and Nine theory sections,”and“Three practice levels and Nine secrets.”Based on traditional Chinese culture and philosophy,Taiji studies are continuously integrating the essence of them for better understanding and raising,and finally set up a rational school of Taiji Da Dao。
