The first asymmetric hydrogenation of acyclic tetrasubstitutedα,β-unsaturated amides has been achieved by using Rh/DuanPhos complex as a catalyst,delivering chiralβ-amino amides with two contiguous chiral centers i...The first asymmetric hydrogenation of acyclic tetrasubstitutedα,β-unsaturated amides has been achieved by using Rh/DuanPhos complex as a catalyst,delivering chiralβ-amino amides with two contiguous chiral centers in excellent yields and high enantioselectivities(up to 99%yield,96%ee),which provides efficient and concise access to valuableβ-amino amide derivatives.The gram-scale reaction and efficient transformation ofβ-amino amide toβ-amino acid andβ-amino cyanide demonstrated the utility of this methodology.展开更多
基金financial support from the National Natural Science Foundation of China(Grant Nos.22071188,22371217)Hubei Provincial Natural Science Foundation of China(2023AFA011).
文摘The first asymmetric hydrogenation of acyclic tetrasubstitutedα,β-unsaturated amides has been achieved by using Rh/DuanPhos complex as a catalyst,delivering chiralβ-amino amides with two contiguous chiral centers in excellent yields and high enantioselectivities(up to 99%yield,96%ee),which provides efficient and concise access to valuableβ-amino amide derivatives.The gram-scale reaction and efficient transformation ofβ-amino amide toβ-amino acid andβ-amino cyanide demonstrated the utility of this methodology.
