This paper proposed a high-sensitivity phase imaging eddy current magneto-optical (PI-ECMO) system for carbon fiber reinforced polymer (CFRP) defect detection. In contrast to other eddy current-based detection systems...This paper proposed a high-sensitivity phase imaging eddy current magneto-optical (PI-ECMO) system for carbon fiber reinforced polymer (CFRP) defect detection. In contrast to other eddy current-based detection systems, the proposed system employs a fixed position excitation coil while enabling the detection point to move within the detection region. This configuration effectively mitigates the interference caused by the lift-off effect, which is commonly observed in systems with moving excitation coils. Correspondingly, the relationship between the defect characteristics (orientation and position) and the surface vertical magnetic field distribution (amplitude and phase) is studied in detail by theoretical analysis and numerical simulations. Experiments conducted on woven CFRP plates demonstrate that the designed PI-ECMO system is capable of effectively detecting both surface and internal cracks, as well as impact defects. The excitation current is significantly reduced compared with traditional eddy current magneto-optical (ECMO) systems.展开更多
BACKGROUND Acquired factor V deficiency is a rare secondary hemorrhagic disease,which can lead to a severe bleeding disorder.CASE SUMMARY We report a 47-year-old hemodialysis patient who presented with severe hemorrha...BACKGROUND Acquired factor V deficiency is a rare secondary hemorrhagic disease,which can lead to a severe bleeding disorder.CASE SUMMARY We report a 47-year-old hemodialysis patient who presented with severe hemorrhagic pleural effusion and hemorrhagic pericardial effusion associated with lymphatic leakage.The laboratory examination revealed decreased factor V activity (2% of population average value).With decreased lymphatic leakage,factor V activity increased (to 46%).Lymph drainage correlated with prothrombin time and active partial thrombin time.The cause of the disease favored an acquired disease.The common causes which trigger factor V inhibitors were excluded.An inhibitor was not detected.It is possible that there was a clotting factor inhibitor leaking with the lymph in the drainage.Inhibitor production may be due to immune dysfunction caused by persistent lymphatic drainage,or that coagulation inhibitors were produced,drained with the lymph,and partly cleared by hemodialysis.CONCLUSION In this case,we have firstly reported factor V deficiency associated with lymphatic leakage in a hemodialysis patient.展开更多
AIM: To determine the levels of aquaporin-1(AQP-1) in the lens epithelial cells(LECs) of primary glaucoma and to clarify its correlation with lens thickness.METHODS: This study comprised 64 eyes of 64 patients with pr...AIM: To determine the levels of aquaporin-1(AQP-1) in the lens epithelial cells(LECs) of primary glaucoma and to clarify its correlation with lens thickness.METHODS: This study comprised 64 eyes of 64 patients with primary glaucoma, who were divided into 3 groups: 25 eyes of 25 patients with acute primary angle-closure glaucoma(APACG), 19 eyes of 19 patients with chronic primary angle-closure glaucoma(CPACG) and 20 eyes of 20 patients with primary open angle glaucoma(POAG). This study also included 12 eyes of 12 patients with senile cataract as controls. The levels of AQP-1 in LECs were examined by real-time quantitative polymerase chain reaction(RT-q PCR) and immunohistochemistry. The lens thickness was measured by A-scan ultrasonography. RESULTS: The AQP-1 m RNA levels of LECs were 0.84±0.27, 0.69±0.34, 0.44±0.19 and 0.51±0.21 in APACG, CPACG, POAG and senile cataract group, respectively. The levels of AQP-1m RNA were significantly higher in PACG groups compared with those in senile cataract and POAG group(all P<0.05). The immunohistochemistry showed the AQP-1 expression were strong-positive in PACG groups, but weak-positive in senile cataract and POAG group. A positive correlation was found between AQP-1 m RNA levels and the lens thickness(r=0.645, P<0.001). CONCLUSION: These findings show that the higher expression of AQP-1 in LECs may contribute to increased lens thickness, which might be associated with the occurrence and development of PACG.展开更多
Objective:The aim of the study was to explore the bone morphogenetic protein 4(BMP-4) how to regulate prolactin(PRL) secreting,cell proliferation and invasiveness in human prolactinoma.Methods:Ten patients who diagnos...Objective:The aim of the study was to explore the bone morphogenetic protein 4(BMP-4) how to regulate prolactin(PRL) secreting,cell proliferation and invasiveness in human prolactinoma.Methods:Ten patients who diagnosed as prolactinoma by clinical characteristics and pathology were divided into two groups,one was sensitive to Bromocriptine,the other was insensitive to Bromocriptine.Every case was conducted by primal cell culture then treated by different concentrations of BMP-4.The cell configuration was observed and PRL hormone was measured in different times.The expressions of BMP-4 mRNA and BMP-4 in 37 cases of prolactinoma and 8 cases of normal pituitary tissues samples were detected by immunohistochemical and in situ hybridization technique,and the results were analyzed by statistic methods.Results:BMP-4(5 ng/mL) could accelerate the secreting of PRL in prolactinoma cell,and it could reach the greatest effect in the concentration of 20 ng/mL.BMP-4 could increase prolactinoma cell proliferation,but when the concentration was 50 ng/mL,the BMP-4 effect of increasing secreting decreased.When 100 ng/mL,the cell began to die.The effects of the BMP-4 in sensitive group and insensitive group had no difference.The BMP-4 was highly expressed in the prolactinomas and was positively related with the invasiveness grades.Conclusion:BMP-4 have positive regulation in prolactinoma secreting,proliferation,invasiveness effects.BMP-4 probably has the important role in prolactinoma pathogenesis.展开更多
基金the National Natural Science Foundation of China under Grants No.U2030205,No.62003075,No.61903065,and No.62003074Sichuan Science and Technology Planning Project under Grant No.2022JDJQ0040.
文摘This paper proposed a high-sensitivity phase imaging eddy current magneto-optical (PI-ECMO) system for carbon fiber reinforced polymer (CFRP) defect detection. In contrast to other eddy current-based detection systems, the proposed system employs a fixed position excitation coil while enabling the detection point to move within the detection region. This configuration effectively mitigates the interference caused by the lift-off effect, which is commonly observed in systems with moving excitation coils. Correspondingly, the relationship between the defect characteristics (orientation and position) and the surface vertical magnetic field distribution (amplitude and phase) is studied in detail by theoretical analysis and numerical simulations. Experiments conducted on woven CFRP plates demonstrate that the designed PI-ECMO system is capable of effectively detecting both surface and internal cracks, as well as impact defects. The excitation current is significantly reduced compared with traditional eddy current magneto-optical (ECMO) systems.
文摘BACKGROUND Acquired factor V deficiency is a rare secondary hemorrhagic disease,which can lead to a severe bleeding disorder.CASE SUMMARY We report a 47-year-old hemodialysis patient who presented with severe hemorrhagic pleural effusion and hemorrhagic pericardial effusion associated with lymphatic leakage.The laboratory examination revealed decreased factor V activity (2% of population average value).With decreased lymphatic leakage,factor V activity increased (to 46%).Lymph drainage correlated with prothrombin time and active partial thrombin time.The cause of the disease favored an acquired disease.The common causes which trigger factor V inhibitors were excluded.An inhibitor was not detected.It is possible that there was a clotting factor inhibitor leaking with the lymph in the drainage.Inhibitor production may be due to immune dysfunction caused by persistent lymphatic drainage,or that coagulation inhibitors were produced,drained with the lymph,and partly cleared by hemodialysis.CONCLUSION In this case,we have firstly reported factor V deficiency associated with lymphatic leakage in a hemodialysis patient.
基金Supported by the Science and Technology Planning Project of Guangdong Province(No.2012B050600032)the Science and Technology Planning Project of Guangzhou(No.1515000176)
文摘AIM: To determine the levels of aquaporin-1(AQP-1) in the lens epithelial cells(LECs) of primary glaucoma and to clarify its correlation with lens thickness.METHODS: This study comprised 64 eyes of 64 patients with primary glaucoma, who were divided into 3 groups: 25 eyes of 25 patients with acute primary angle-closure glaucoma(APACG), 19 eyes of 19 patients with chronic primary angle-closure glaucoma(CPACG) and 20 eyes of 20 patients with primary open angle glaucoma(POAG). This study also included 12 eyes of 12 patients with senile cataract as controls. The levels of AQP-1 in LECs were examined by real-time quantitative polymerase chain reaction(RT-q PCR) and immunohistochemistry. The lens thickness was measured by A-scan ultrasonography. RESULTS: The AQP-1 m RNA levels of LECs were 0.84±0.27, 0.69±0.34, 0.44±0.19 and 0.51±0.21 in APACG, CPACG, POAG and senile cataract group, respectively. The levels of AQP-1m RNA were significantly higher in PACG groups compared with those in senile cataract and POAG group(all P<0.05). The immunohistochemistry showed the AQP-1 expression were strong-positive in PACG groups, but weak-positive in senile cataract and POAG group. A positive correlation was found between AQP-1 m RNA levels and the lens thickness(r=0.645, P<0.001). CONCLUSION: These findings show that the higher expression of AQP-1 in LECs may contribute to increased lens thickness, which might be associated with the occurrence and development of PACG.
文摘Objective:The aim of the study was to explore the bone morphogenetic protein 4(BMP-4) how to regulate prolactin(PRL) secreting,cell proliferation and invasiveness in human prolactinoma.Methods:Ten patients who diagnosed as prolactinoma by clinical characteristics and pathology were divided into two groups,one was sensitive to Bromocriptine,the other was insensitive to Bromocriptine.Every case was conducted by primal cell culture then treated by different concentrations of BMP-4.The cell configuration was observed and PRL hormone was measured in different times.The expressions of BMP-4 mRNA and BMP-4 in 37 cases of prolactinoma and 8 cases of normal pituitary tissues samples were detected by immunohistochemical and in situ hybridization technique,and the results were analyzed by statistic methods.Results:BMP-4(5 ng/mL) could accelerate the secreting of PRL in prolactinoma cell,and it could reach the greatest effect in the concentration of 20 ng/mL.BMP-4 could increase prolactinoma cell proliferation,but when the concentration was 50 ng/mL,the BMP-4 effect of increasing secreting decreased.When 100 ng/mL,the cell began to die.The effects of the BMP-4 in sensitive group and insensitive group had no difference.The BMP-4 was highly expressed in the prolactinomas and was positively related with the invasiveness grades.Conclusion:BMP-4 have positive regulation in prolactinoma secreting,proliferation,invasiveness effects.BMP-4 probably has the important role in prolactinoma pathogenesis.
