The computation of stable or unstable manifold of two-dimensional is developed, which is an efficient method in studying stable structure analysis of system character geometrically. The Lorentz stable manifold is comp...The computation of stable or unstable manifold of two-dimensional is developed, which is an efficient method in studying stable structure analysis of system character geometrically. The Lorentz stable manifold is computed by the fixed arclength method and the hyperbolic equilibrium is a saddle. The two-dimensional stable structure of Lorentz manifold is significant in people’s usual view. We also introduce the V-function to compute the V-manifold correspondingly. The defined V-function is smooth in the unstable direction of the manifold. Especially, the routh to period-doubling attractor on manifold surface is discussed too.展开更多
Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Her...Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(MoO4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy.展开更多
The experimental study on the volume fraction of retained austenite for QP980CR steel under high-strain-rate tension is briefly described. An interrupted tensile split Hopkinson bar （TSHB） is developed to control th...The experimental study on the volume fraction of retained austenite for QP980CR steel under high-strain-rate tension is briefly described. An interrupted tensile split Hopkinson bar （TSHB） is developed to control the elongation of specimens. The QP980CR steel sam- ples recovered from the interrupted TSt-IB tests are investigated using synchrotron X-ray diffraction （XRD） to analyze the effects of strain and strain rate on the martensitic trans- formation of retained austenite. A constitutive model of QP980CR steel coupling with the transformation-induced plasticity （TRIP） effect is presented based on Delannay＇s mean-field modeling. The stress-strain curves of quasi-static and dynamic tensile tests for QP980CR steel are compared with the results predicted by the presented constitutive model. The dif- fuse necking of QP980CR steel sheet specimens in TSHB tests is analyzed using Batra and Vv＇ei＇s instability criterion and the presented constitutive model. The effects of strain rate and temperature on the dynamic tensile fracture strain of QP980CR steel are also given.展开更多
文摘The computation of stable or unstable manifold of two-dimensional is developed, which is an efficient method in studying stable structure analysis of system character geometrically. The Lorentz stable manifold is computed by the fixed arclength method and the hyperbolic equilibrium is a saddle. The two-dimensional stable structure of Lorentz manifold is significant in people’s usual view. We also introduce the V-function to compute the V-manifold correspondingly. The defined V-function is smooth in the unstable direction of the manifold. Especially, the routh to period-doubling attractor on manifold surface is discussed too.
基金National Key R&D Program of China (No. 2017YFA0208000)the China National Funds for Excellent Young Scientists (No. 21522106)+3 种基金Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine ResearchCollege of Stomatology, Xian Jiaotong University (No. 2018LHM-KFKT004)National Natural Science Foundation of China (Nos. 51502237, 51872224, and U1501245)We also appreciate Dr. Dong Su from the Center for Functional Nanomaterials at Brookhaven National Laboratory for his kind help in Electron Microscopy (EM) work.
文摘Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(MoO4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy.
基金supported by the National Natural Science Foundation of China(nos.11372149 and 11572164)the Zhejiang Provincial Key Science and Technology Innovation Team(2013TD21)programK.C.Wong Magna Fund in Ningbo University
文摘The experimental study on the volume fraction of retained austenite for QP980CR steel under high-strain-rate tension is briefly described. An interrupted tensile split Hopkinson bar （TSHB） is developed to control the elongation of specimens. The QP980CR steel sam- ples recovered from the interrupted TSt-IB tests are investigated using synchrotron X-ray diffraction （XRD） to analyze the effects of strain and strain rate on the martensitic trans- formation of retained austenite. A constitutive model of QP980CR steel coupling with the transformation-induced plasticity （TRIP） effect is presented based on Delannay＇s mean-field modeling. The stress-strain curves of quasi-static and dynamic tensile tests for QP980CR steel are compared with the results predicted by the presented constitutive model. The dif- fuse necking of QP980CR steel sheet specimens in TSHB tests is analyzed using Batra and Vv＇ei＇s instability criterion and the presented constitutive model. The effects of strain rate and temperature on the dynamic tensile fracture strain of QP980CR steel are also given.
