Based on the inter-provincial panel data for 31 provinces in China from 2000 to 2019,and incorporating geospatial factors,a spatial panel vector autoregressive(SPVAR)model consisting of population mobility,industrial ...Based on the inter-provincial panel data for 31 provinces in China from 2000 to 2019,and incorporating geospatial factors,a spatial panel vector autoregressive(SPVAR)model consisting of population mobility,industrial structure upgrading,and economic growth is constructed.The space-time impulse response function is used to analyze the space-time conduction of exogenous variables on the impact of three endogenous variables.The study found that first,the population influx barely benefited the industrial structure upgrading and economic growth.Second,the upgrading of the industrial structure would aggravate the population mobility in the province,causing low-level laborers to leave the province in shortterm,but in long-term,there would be influx of talents.Third,the economic growth in developed regions plays a significant role in promoting the industrial development of their province and population-rich provinces,but it has less impact on provinces with high-level industrial structure.Finally,policy recommendations are provided in regard to the benign interaction among population mobility,industrial structure upgrading,and economic growth in addition to clarifying the idea of economic development,implementing correct population policies,and promoting the coordinated regional development.展开更多
Scanning electron microscope(SEM)metrology is critical in semiconductor manufacturing for patterning process quality assessment and monitoring.Besides feature width and feature-feature space dimension measurements fro...Scanning electron microscope(SEM)metrology is critical in semiconductor manufacturing for patterning process quality assessment and monitoring.Besides feature width and feature-feature space dimension measurements from critical dimension SEM(CDSEM)images,visual inspection of SEM image also offers rich information on the quality of patterning.However,visual inspection alone leaves considerable room of ambiguity regarding patterning quality.To narrow the room of ambiguity and to obtain more statistically quantitative information on patterning quality,SEM-image contours are often extracted to serve such purposes.From contours,important information such as critical dimension and resist sidewall angle at any location can be estimated.Those geometrical information can be used for optical proximity correction(OPC)model verification and lithography hotspot detection,etc.Classical contour extraction algorithms based on local information have insufficient capability in dealing with noisy and low contrast images.To achieve reliable contours from noisy and low contrast images,information beyond local should be made use of as much as possible.In this regard,deep convolutional neural network(DCNN)has proven its great capability,as manifested in various computer vision tasks.Taking the full advantages of this maturing technology,we have designed a DCNN network and applied it to the task of extracting contours from noisy and low contrast SEM images.It turns out that the model is capable of separating the resist top and bottom contours reliably.In addition,the model does not generate false contours,it also can suppress the generation of broken contours when ambiguous area for contour extraction is small and non-detrimental.With advanced image alignment algorithm with sub-pixel accuracy,contours from different exposure fields of same process condition can be superposed to estimate process variation band,furthermore,stochastic effect induced edge placement variation statistics can easily be inferred from the extracted contours.展开更多
This paper presents MBITP, a novel method for an indoor target prediction through the sensor data which may be the Big Data. To predict target, a probability model is presented. In addition, a real-time error correcti...This paper presents MBITP, a novel method for an indoor target prediction through the sensor data which may be the Big Data. To predict target, a probability model is presented. In addition, a real-time error correction technique based on map feature is designed to enhance the estimation accuracy. Based on it, we propose an effective prediction algorithm. The practice evaluation shows that the method introduced in this paper has an acceptable performance in real-time target prediction.展开更多
The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulu...The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum.However,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum stress.Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins.The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored.Therefore,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.展开更多
Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of age.The initiatio...Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of age.The initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic process.Cartilage degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte metabolism.Therefore,maintaining mitochondrial homeostasis is an important strategy to mitigate OA.Mitophagy is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial homeostasis.Cumulative studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for OA.By reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.展开更多
To investigate the enhancing effect of Mn on the performance of simultaneous catalytic oxidation of AsH_(3)and PH_(3)by CuO-Al_(2)O_(3)in a reducing atmosphere under micro-oxygen conditions,Cu-Mn modifiedγ-Al_(2)O_(3...To investigate the enhancing effect of Mn on the performance of simultaneous catalytic oxidation of AsH_(3)and PH_(3)by CuO-Al_(2)O_(3)in a reducing atmosphere under micro-oxygen conditions,Cu-Mn modifiedγ-Al_(2)O_(3)catalysts were prepared.The characteristics of the catalysts showed that Mn reduced the crystallinity of the active CuO component,increased the number of oxygen vacancies and acidic sites on the catalyst surface,enhanced the mobility of surface oxygen,and the interaction between copper and manganese promoted the redox cycling ability of the catalysts and improved their oxidation performance,which increased the conversion frequency(TOF)by 2.54×10^(-2)to 3.07×10^(-2)sec^(-1).On the other hand,the introduction of Mn reduced the production of phosphate and As_(2)O_(3)on the catalyst surface by30.96%and 44.9%,which reduced the coverage and inerting of the active sites by phosphate and As_(2)O_(3),resulting in an 8 hr(6 hr)improvement in the stability of PH_(3)(AsH_(3))removal.展开更多
To the Editor:The shortage of deceased donor(DD)kidneys for transplantation remains a persistent concern.Despite the potential reversibility of acute kidney injury(AKI)lesions,kidneys from pediatric donors with AKI ar...To the Editor:The shortage of deceased donor(DD)kidneys for transplantation remains a persistent concern.Despite the potential reversibility of acute kidney injury(AKI)lesions,kidneys from pediatric donors with AKI are often underutilized,especially in the context of pediatric transplantation.By implementing single kidney transplantation(SKT)from pediatric donors to pediatric recipients(PTP),we can optimize the utilization of available kidneys and increase the number of pediatric recipients.展开更多
Kawasaki disease(KD) is an acute and self-limited febrile disease characterized by fever, polymorphic rash, bulbar conjunctival congestion, redness of the lip mucosa, unilateral cervical lymphadenopathy, erythema, and...Kawasaki disease(KD) is an acute and self-limited febrile disease characterized by fever, polymorphic rash, bulbar conjunctival congestion, redness of the lip mucosa, unilateral cervical lymphadenopathy, erythema, and edema of the extremities. KD was reported first by Tomisaku Kawasaki, a Japanese scholar, in 1967[1]. Since then, the disease has been reported worldwide, with significant differences observed in its incidence in different regions.展开更多
The traction drive system is the“heart”of rail transit vehicles.The development of sustainable,secure,economic,reliable,efficient,and comfortable contemporary rail transportation has led to increasingly stringent re...The traction drive system is the“heart”of rail transit vehicles.The development of sustainable,secure,economic,reliable,efficient,and comfortable contemporary rail transportation has led to increasingly stringent requirements for traction drive systems.The interest in such systems is constantly growing,supported by advancements such as permanent magnet(PM)motors,advanced electronic devices such as those using silicon carbide(SiC),new-generation insulating materials such as organic silicon,and advanced magnetic materials such as rare-earth magnets and amorphous materials.Progress has also been made in control methods,manufacturing technology,artificial intelligence(AI),and other advanced technologies.In this paper,we briefly review the state-of-the-art critical global trends in rail transit traction drive technology in recent years.Potential areas for research and the main obstacles hindering the development of the next-generation rail transit traction drive systems are also discussed.Finally,we describe some advanced traction drive technologies used in actual engineering applications.展开更多
Evidence indicates that improvement of thermal performance of building envelope has the potential for aggravating the indoor overheating risk in summer. On the other hand, evolving building standards continue to stren...Evidence indicates that improvement of thermal performance of building envelope has the potential for aggravating the indoor overheating risk in summer. On the other hand, evolving building standards continue to strengthen the requirements for thermal performance to achieve the energy-saving target. Therefore, this study quantifies the interaction effect between building standards-oriented building design, heating energy demand in winter, and indoor overheating risk in summer. Building databases with different energy efficiency levels are generated using a randomly generated method. Uncertain variables include not only 13 design parameters but also the running state of natural ventilation and external shading. The indoor overheating risk is assessed in terms of severity and duration. Finally, a multi-objective optimization model integrating metamodels and the non-dominated sorting genetic algorithm is proposed to balance heating energy demand in winter and indoor overheating risk in summer. Results indicate that building standards tend to aggravate overheating risk in summer: the duration and severity of high-performance buildings increased by 40.6% and 24.2% than that of conventional-performance buildings. However, window ventilation could offset the adverse effect, and mitigation of duration and severity can be up to 85.2% and 62.1% for high-performance buildings. Window ventilation can weaken the conflict between heating energy demand in winter and overheating risk in summer. As heating energy demand increased from 6.1 to 67.3 kWh/m^(2), the overheating risk changes little that the duration of overheating risk decreased from 17.5% to 15.6% and severity decreased from 8.7 ℃ to 8.3 ℃.展开更多
This paper proposes the application of high-voltage stator-cable windings in superconducting machines,based on the characteristics of strong magnetic fields and large air gaps.Cross-linked polyethylene cable winding c...This paper proposes the application of high-voltage stator-cable windings in superconducting machines,based on the characteristics of strong magnetic fields and large air gaps.Cross-linked polyethylene cable winding can be employed to achieve a rated voltage of 35 kV in direct-current(DC)-field superconducting machines,thereby enabling a direct connection between the superconducting machine and the power grid,eliminating the need for transformers.We first,through finite element analysis,demonstrate that the proposed high-voltage high-temperature superconducting machine not only meets the requirement of a 35 kV-rated voltage,but also exhibits minimal flux leakage,torque fluctuation,and harmonic distortion.We then compare three candidate types to discuss the tradeoff between the multi-group superconducting field winding arrangement and machine performances.We propose inverted trapezoidal superconducting field winding as a promising candidate,because it has minimal superconductivity material usage,the largest safety margin for the superconducting coils(SCs),low thrust ripple,and low total harmonic distortion with the desired 35 kV-rated voltage.Finally,through large-scale design parameter sweeping,we show how we selected the optimal parameters for field winding and validated them by the finite element method.展开更多
基金This work was supported by 2021 Jiangxi University of Finance and Economics Student Innovation Training Program(No.202110421068).
文摘Based on the inter-provincial panel data for 31 provinces in China from 2000 to 2019,and incorporating geospatial factors,a spatial panel vector autoregressive(SPVAR)model consisting of population mobility,industrial structure upgrading,and economic growth is constructed.The space-time impulse response function is used to analyze the space-time conduction of exogenous variables on the impact of three endogenous variables.The study found that first,the population influx barely benefited the industrial structure upgrading and economic growth.Second,the upgrading of the industrial structure would aggravate the population mobility in the province,causing low-level laborers to leave the province in shortterm,but in long-term,there would be influx of talents.Third,the economic growth in developed regions plays a significant role in promoting the industrial development of their province and population-rich provinces,but it has less impact on provinces with high-level industrial structure.Finally,policy recommendations are provided in regard to the benign interaction among population mobility,industrial structure upgrading,and economic growth in addition to clarifying the idea of economic development,implementing correct population policies,and promoting the coordinated regional development.
文摘Scanning electron microscope(SEM)metrology is critical in semiconductor manufacturing for patterning process quality assessment and monitoring.Besides feature width and feature-feature space dimension measurements from critical dimension SEM(CDSEM)images,visual inspection of SEM image also offers rich information on the quality of patterning.However,visual inspection alone leaves considerable room of ambiguity regarding patterning quality.To narrow the room of ambiguity and to obtain more statistically quantitative information on patterning quality,SEM-image contours are often extracted to serve such purposes.From contours,important information such as critical dimension and resist sidewall angle at any location can be estimated.Those geometrical information can be used for optical proximity correction(OPC)model verification and lithography hotspot detection,etc.Classical contour extraction algorithms based on local information have insufficient capability in dealing with noisy and low contrast images.To achieve reliable contours from noisy and low contrast images,information beyond local should be made use of as much as possible.In this regard,deep convolutional neural network(DCNN)has proven its great capability,as manifested in various computer vision tasks.Taking the full advantages of this maturing technology,we have designed a DCNN network and applied it to the task of extracting contours from noisy and low contrast SEM images.It turns out that the model is capable of separating the resist top and bottom contours reliably.In addition,the model does not generate false contours,it also can suppress the generation of broken contours when ambiguous area for contour extraction is small and non-detrimental.With advanced image alignment algorithm with sub-pixel accuracy,contours from different exposure fields of same process condition can be superposed to estimate process variation band,furthermore,stochastic effect induced edge placement variation statistics can easily be inferred from the extracted contours.
基金This work is supported in part by the National Natural Science Foundation of China (NSFC) under Grant No.61370222 and No.61070193, Heilongjiang Province Founds for Distinguished Young Scientists under Grant No.JC201104, Technology Innovation of Heilongjiang Educational Committee under grant No.2013TD012, Program for Group of Science Harbin technological innovation found under grant No.2011RFXXG014.
文摘This paper presents MBITP, a novel method for an indoor target prediction through the sensor data which may be the Big Data. To predict target, a probability model is presented. In addition, a real-time error correction technique based on map feature is designed to enhance the estimation accuracy. Based on it, we propose an effective prediction algorithm. The practice evaluation shows that the method introduced in this paper has an acceptable performance in real-time target prediction.
基金This work was supported by the National Natural Science Foundation of China(No.82071762)the Shanghai Key Lab of Human Performance(Shanghai University of Sport)(No.11DZ2261100)the 2021 Capacity Building of Shanghai Universities(No.21010503600),China。
文摘The endoplasmic reticulum is a key site for protein production and quality control.More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum.However,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum stress.Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins.The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored.Therefore,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.
基金This work was supported by the National Natural Science Foundation of China(No.82071762)the Shanghai Key Lab of Human Performance(Shanghai University of Sport)(No.11DZ2261100)the 2021 Capacity Building of Shanghai Universities(No.21010503600),China。
文摘Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of age.The initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic process.Cartilage degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte metabolism.Therefore,maintaining mitochondrial homeostasis is an important strategy to mitigate OA.Mitophagy is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial homeostasis.Cumulative studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for OA.By reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.
基金supported by the National Natural Science Foundation of China (Nos.51868030,52070090,52100122,22266019,and 21876071)the Science and Technology Planning Project of Yunnan Province (Nos.202001AU070031,202101BE070001-030,and 202101BC070001-009)Applied Basic Research Program of Yunnan Province (No.2019FD043)。
文摘To investigate the enhancing effect of Mn on the performance of simultaneous catalytic oxidation of AsH_(3)and PH_(3)by CuO-Al_(2)O_(3)in a reducing atmosphere under micro-oxygen conditions,Cu-Mn modifiedγ-Al_(2)O_(3)catalysts were prepared.The characteristics of the catalysts showed that Mn reduced the crystallinity of the active CuO component,increased the number of oxygen vacancies and acidic sites on the catalyst surface,enhanced the mobility of surface oxygen,and the interaction between copper and manganese promoted the redox cycling ability of the catalysts and improved their oxidation performance,which increased the conversion frequency(TOF)by 2.54×10^(-2)to 3.07×10^(-2)sec^(-1).On the other hand,the introduction of Mn reduced the production of phosphate and As_(2)O_(3)on the catalyst surface by30.96%and 44.9%,which reduced the coverage and inerting of the active sites by phosphate and As_(2)O_(3),resulting in an 8 hr(6 hr)improvement in the stability of PH_(3)(AsH_(3))removal.
基金supported by funding from the National Natural Science Foundation of China(Nos.81870511,82170770,and 82200848)Natural Science Foundation of Guangdong Province(No.2023A1515010139)+6 种基金Science and Technology Planning Project of Guangzhou City(No.202201011318)Key Clinical Technique of Guangzhou(No.2023P-ZD15)Elite Talent Project of Guangdong Province(No.R09002)Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010884)Guangdong Provincial Key Laboratory on Organ Donation and Transplant Immunology(No.2020B1212060026)Guangdong Provincial International Cooperation Base of Science and Technology(No.2020A0505020003)Science Research Cultivation Program of Stomatological Hospital,Southern Medical University(No.PY2021026)
文摘To the Editor:The shortage of deceased donor(DD)kidneys for transplantation remains a persistent concern.Despite the potential reversibility of acute kidney injury(AKI)lesions,kidneys from pediatric donors with AKI are often underutilized,especially in the context of pediatric transplantation.By implementing single kidney transplantation(SKT)from pediatric donors to pediatric recipients(PTP),we can optimize the utilization of available kidneys and increase the number of pediatric recipients.
文摘Kawasaki disease(KD) is an acute and self-limited febrile disease characterized by fever, polymorphic rash, bulbar conjunctival congestion, redness of the lip mucosa, unilateral cervical lymphadenopathy, erythema, and edema of the extremities. KD was reported first by Tomisaku Kawasaki, a Japanese scholar, in 1967[1]. Since then, the disease has been reported worldwide, with significant differences observed in its incidence in different regions.
基金supported by the National Key Research and Development Program of China(No.2018YFB1201804)the Science and Technology Research and Development Plan of China State Railway Group Co.,Ltd.(No.N2021J049).
文摘The traction drive system is the“heart”of rail transit vehicles.The development of sustainable,secure,economic,reliable,efficient,and comfortable contemporary rail transportation has led to increasingly stringent requirements for traction drive systems.The interest in such systems is constantly growing,supported by advancements such as permanent magnet(PM)motors,advanced electronic devices such as those using silicon carbide(SiC),new-generation insulating materials such as organic silicon,and advanced magnetic materials such as rare-earth magnets and amorphous materials.Progress has also been made in control methods,manufacturing technology,artificial intelligence(AI),and other advanced technologies.In this paper,we briefly review the state-of-the-art critical global trends in rail transit traction drive technology in recent years.Potential areas for research and the main obstacles hindering the development of the next-generation rail transit traction drive systems are also discussed.Finally,we describe some advanced traction drive technologies used in actual engineering applications.
基金This research has been supported by the“National Key R&D Program of China”(Grant No.2016YFC0700100)The U.S.authors recognize Lawrence Berkeley National Laboratory’s support from the U.S.Department of Energy under Contract No.DE-AC02-05CH11231 and support from the Energy FoundationThe U.S.Government retains a non-exclusive,paid-up,irrevocable,world-wide license to publish or reproduce the published form of this manuscript,or allow others to do so,for U.S.Government purposes.
文摘Evidence indicates that improvement of thermal performance of building envelope has the potential for aggravating the indoor overheating risk in summer. On the other hand, evolving building standards continue to strengthen the requirements for thermal performance to achieve the energy-saving target. Therefore, this study quantifies the interaction effect between building standards-oriented building design, heating energy demand in winter, and indoor overheating risk in summer. Building databases with different energy efficiency levels are generated using a randomly generated method. Uncertain variables include not only 13 design parameters but also the running state of natural ventilation and external shading. The indoor overheating risk is assessed in terms of severity and duration. Finally, a multi-objective optimization model integrating metamodels and the non-dominated sorting genetic algorithm is proposed to balance heating energy demand in winter and indoor overheating risk in summer. Results indicate that building standards tend to aggravate overheating risk in summer: the duration and severity of high-performance buildings increased by 40.6% and 24.2% than that of conventional-performance buildings. However, window ventilation could offset the adverse effect, and mitigation of duration and severity can be up to 85.2% and 62.1% for high-performance buildings. Window ventilation can weaken the conflict between heating energy demand in winter and overheating risk in summer. As heating energy demand increased from 6.1 to 67.3 kWh/m^(2), the overheating risk changes little that the duration of overheating risk decreased from 17.5% to 15.6% and severity decreased from 8.7 ℃ to 8.3 ℃.
基金State Grid Corporation of China R&D Project(No.5500-202319193A-1-1-ZN).
文摘This paper proposes the application of high-voltage stator-cable windings in superconducting machines,based on the characteristics of strong magnetic fields and large air gaps.Cross-linked polyethylene cable winding can be employed to achieve a rated voltage of 35 kV in direct-current(DC)-field superconducting machines,thereby enabling a direct connection between the superconducting machine and the power grid,eliminating the need for transformers.We first,through finite element analysis,demonstrate that the proposed high-voltage high-temperature superconducting machine not only meets the requirement of a 35 kV-rated voltage,but also exhibits minimal flux leakage,torque fluctuation,and harmonic distortion.We then compare three candidate types to discuss the tradeoff between the multi-group superconducting field winding arrangement and machine performances.We propose inverted trapezoidal superconducting field winding as a promising candidate,because it has minimal superconductivity material usage,the largest safety margin for the superconducting coils(SCs),low thrust ripple,and low total harmonic distortion with the desired 35 kV-rated voltage.Finally,through large-scale design parameter sweeping,we show how we selected the optimal parameters for field winding and validated them by the finite element method.
