Ischemic stro ke occurs when a blood vessel in the brain is occluded.In the immediate aftermath.blood flow becomes deficient in regions supplied by the blocked vessel.This leads to the development of a core region,whe...Ischemic stro ke occurs when a blood vessel in the brain is occluded.In the immediate aftermath.blood flow becomes deficient in regions supplied by the blocked vessel.This leads to the development of a core region,where blood flow is reduced to <30% and injury occurs rapidly,and a penumbral region,where blood flow is reduced to a level that is not capable of supporting neuronal function,but is sufficient to maintain cell viability(Morris et al.,2023).展开更多
The brain has a high metabolic rate and consumes approximately 20% of the total energy in the body at any given time. Although it requires a large amount of energy to function, the brain cannot store significant amoun...The brain has a high metabolic rate and consumes approximately 20% of the total energy in the body at any given time. Although it requires a large amount of energy to function, the brain cannot store significant amounts of energy making it exquisitely dependent on constant nutrient supply via blood flow. When blood flow to the brain is impaired, such as during stroke, there are rapid and severe consequences for the neurons that depend on this constant energy supply.展开更多
Over the last ten years or so,it has become apparent that pericytes have the potential to differentiate into other cell types which may help in the repair and regeneration of tissue after injury.In fact,pericytes have...Over the last ten years or so,it has become apparent that pericytes have the potential to differentiate into other cell types which may help in the repair and regeneration of tissue after injury.In fact,pericytes have been described as a precursor to mesenchymal stem cells.Their location at the interface between the microvasculature and the brain parenchyma means they are ideally positioned to initiate repair and regeneration in response to various factors.In this perspective,we will highlight how pericytes have stem cell potential alongside their role in regulating processes,such as angiogenesis and inflammation,and discuss how pericytes could be harnessed to promote tissue repair in the brain(Figure 1).展开更多
基金funding support from the National Health and Medical Research Council (NHMRCapplication id:2003351) of Australia (to BAS)。
文摘Ischemic stro ke occurs when a blood vessel in the brain is occluded.In the immediate aftermath.blood flow becomes deficient in regions supplied by the blocked vessel.This leads to the development of a core region,where blood flow is reduced to <30% and injury occurs rapidly,and a penumbral region,where blood flow is reduced to a level that is not capable of supporting neuronal function,but is sufficient to maintain cell viability(Morris et al.,2023).
基金supported by the National Health and Medical Research Council(NHMRC,application id:2003351)of Australia。
文摘The brain has a high metabolic rate and consumes approximately 20% of the total energy in the body at any given time. Although it requires a large amount of energy to function, the brain cannot store significant amounts of energy making it exquisitely dependent on constant nutrient supply via blood flow. When blood flow to the brain is impaired, such as during stroke, there are rapid and severe consequences for the neurons that depend on this constant energy supply.
文摘Over the last ten years or so,it has become apparent that pericytes have the potential to differentiate into other cell types which may help in the repair and regeneration of tissue after injury.In fact,pericytes have been described as a precursor to mesenchymal stem cells.Their location at the interface between the microvasculature and the brain parenchyma means they are ideally positioned to initiate repair and regeneration in response to various factors.In this perspective,we will highlight how pericytes have stem cell potential alongside their role in regulating processes,such as angiogenesis and inflammation,and discuss how pericytes could be harnessed to promote tissue repair in the brain(Figure 1).
