目的:使用三维运动分析系统观察不同严重程度的膝骨关节炎(Knee Osteoarthritis,KOA)恐动症(低KOA恐动症、高KOA恐动症)患者与年龄匹配的无KOA症状人群在登梯过程中姿势稳定性和下肢关节角度的差异。方法:运用三维运动分析系统检测低KO...目的:使用三维运动分析系统观察不同严重程度的膝骨关节炎(Knee Osteoarthritis,KOA)恐动症(低KOA恐动症、高KOA恐动症)患者与年龄匹配的无KOA症状人群在登梯过程中姿势稳定性和下肢关节角度的差异。方法:运用三维运动分析系统检测低KOA恐动症患者、高KOA恐动症患者和无KOA症状人群共78例受试者在登梯过程中的姿势稳定性(Mar‐gin of Stability,MoS)和关节角度等生物力学因素的差异。结果:低、高KOA恐动症患者在登梯过程中在矢状面和冠状面MoS较差,上梯时髋屈曲和内收最大角度及膝屈伸活动范围均增加;低KOA恐动症患者踝背屈和膝屈曲最大角度均减小;低KOA恐动症患者膝屈曲最大角度低于高KOA恐动症患者。下梯时,低、高KOA恐动症患者髋屈曲最大角度增加,低KOA恐动症患者踝内外翻活动范围增加,高KOA恐动症患者髋内收最大角度增加。结论:低、高KOA恐动症患者在登梯时矢状面和冠状面稳定性较差,但未发现恐动症对KOA患者的显著影响。展开更多
Objective:To investigate the anti-diabetic effect of the root extract of Annona muricata(AME)in streptozotocin-nicotinamide-induced type 2 diabetic(T2DM)mice.Methods:After 4 weeks of high-fat diet,ICR mice were given ...Objective:To investigate the anti-diabetic effect of the root extract of Annona muricata(AME)in streptozotocin-nicotinamide-induced type 2 diabetic(T2DM)mice.Methods:After 4 weeks of high-fat diet,ICR mice were given 1 g/kg nicotine and 120 mg/kg streptozotocin(STZ)orally to construct a T2DM model.The T2DM mice were randomly divided into five groups:model group,200 mg/kg metformin group and 50,100,200 mg/kg AME groups.Drugs were oral administered continuously for 4 weeks.Fasting blood glucose and body weight were measured weekly.Oral glucose tolerance test(OGTT)and detection of serum glycated hemoglobin(HbA1c)level were performed one week before the end of the experiment.At the end of drug administration,serum total cholesterol(TG),triglycerides(TC),low-density lipoprotein levels(LDL-C)and insulin levels were tested by lipid detection kits;homeostasis model assessment-estimated insulin resistance(HOMA-IR)and HOMA-βindexes were calculated.Liver and kidney tissues were weighed to calculate organ indices and pathological tests were performed.Western blot was performed in the liver to detect adenosine monophosphate-activated protein kinase(AMPK),acetyl coenzyme A carboxylase(ACC),glucose-6-phosphate carboxylase(G6Pase),and phosphoenolpyruvate carboxykinase(PCK1)protein expression.Results:with 200 mg/kg AME significantly reduced fasting blood glucose,HbA1c,TG and LDL-C levels,protected liver and kindey in diabetic mice,decreased the area under the OGTT curve,inhibited ACC and G6Pase protein expressions,and activated AMPK protein expression.Conclusion:AME showed good therapeutic activity against T2DM,and the mechanism may be related to the activation of AMPK and inhibition of ACC and G6Pase proteins.展开更多
目的系统认识国际范围内情感化设计研究的全局特征,把握当前情感化设计的研究热点及理论基础,并根据当前研究热点探究未来发展新趋势。方法以Web of Science收录的情感化设计相关文献作为数据源,以科学文献计量的方法综合运用VOSviewer...目的系统认识国际范围内情感化设计研究的全局特征,把握当前情感化设计的研究热点及理论基础,并根据当前研究热点探究未来发展新趋势。方法以Web of Science收录的情感化设计相关文献作为数据源,以科学文献计量的方法综合运用VOSviewer和CiteSpace从文献的年份产出分布、国家、研究机构、作者、参考文献共被引情况和关键词聚类等方面绘制科学知识图谱,进行可视化分析以梳理研究脉络。结论结果表明检索范围内文献数量整体呈上升趋势,中美等国处于研究的领先地位,研究热点主要集中在情感计算、感性工学、人机多通道交互、用户体验和设计评估等方面。研究现状较为成熟,形成了以三层次理论、感性工学和情感计算为主的理论体系。用户个性化、差异化情绪的识别与表达成为未来发展的新趋势。研究机构与作者合作不紧密,以及高产量作者不多是现阶段研究的主要局限。展开更多
目的为了更好地了解和把握国内外社会创新设计研究进展,对相关文献产出分布、研究热点、基础知识及前沿趋势进行分析。方法以CNKI数据库及Web of Science核心合集数据库作为国内外数据来源,通过可视化文献分析软件VOSviewer及Citespace...目的为了更好地了解和把握国内外社会创新设计研究进展,对相关文献产出分布、研究热点、基础知识及前沿趋势进行分析。方法以CNKI数据库及Web of Science核心合集数据库作为国内外数据来源,通过可视化文献分析软件VOSviewer及Citespace对国内外相关文献进行分析。结论国内外研究基本同步,主要以DESIS网络中的院校合作为主,国外研究热点集中于以社区为对象,设计管理、社会创新设计方法、生态设计、可持续设计;国内主要以城市和乡村社区服务设计、设计教育、设计战略、社会创新设计方法为主要对象。社会创新设计的演进经历了设计思维的发展及设计对象的转变两个阶段。国外研究前沿趋势为以社区为对象的可持续设计,国内前沿趋势为以乡村为对象的社会创新设计、可持续设计、服务设计等。在突发的全球疫情背景下,医疗健康、公共卫生也是国内外的前沿趋势。展开更多
文摘目的:使用三维运动分析系统观察不同严重程度的膝骨关节炎(Knee Osteoarthritis,KOA)恐动症(低KOA恐动症、高KOA恐动症)患者与年龄匹配的无KOA症状人群在登梯过程中姿势稳定性和下肢关节角度的差异。方法:运用三维运动分析系统检测低KOA恐动症患者、高KOA恐动症患者和无KOA症状人群共78例受试者在登梯过程中的姿势稳定性(Mar‐gin of Stability,MoS)和关节角度等生物力学因素的差异。结果:低、高KOA恐动症患者在登梯过程中在矢状面和冠状面MoS较差,上梯时髋屈曲和内收最大角度及膝屈伸活动范围均增加;低KOA恐动症患者踝背屈和膝屈曲最大角度均减小;低KOA恐动症患者膝屈曲最大角度低于高KOA恐动症患者。下梯时,低、高KOA恐动症患者髋屈曲最大角度增加,低KOA恐动症患者踝内外翻活动范围增加,高KOA恐动症患者髋内收最大角度增加。结论:低、高KOA恐动症患者在登梯时矢状面和冠状面稳定性较差,但未发现恐动症对KOA患者的显著影响。
基金Supported by the Foundation of Anhui Province Key Laboratory of Physical Geographic Environment(2022PGE010)The Fundamental Research Funds for the Central Universities,CHD(300102353508)+5 种基金the Key Laboratory of Southeast Coast Marine Information Intelligent Perception and Application,MNR(22101)National Natural Science Foundation of China(61801211)Natural Science Foundation of Jiangsu Province(BK20221478)Hong Kong Scholars Program(XJ2022043)S&T Program of Hebei(21567624H)Open Project Program of Key Laboratory of Meteorology and Ecological Environment of Hebei Province(Z202102YH)。
基金National Natural Science Foundation of China(No.81460591)Hainan Medical University Training Fund(HY2018-09)。
文摘Objective:To investigate the anti-diabetic effect of the root extract of Annona muricata(AME)in streptozotocin-nicotinamide-induced type 2 diabetic(T2DM)mice.Methods:After 4 weeks of high-fat diet,ICR mice were given 1 g/kg nicotine and 120 mg/kg streptozotocin(STZ)orally to construct a T2DM model.The T2DM mice were randomly divided into five groups:model group,200 mg/kg metformin group and 50,100,200 mg/kg AME groups.Drugs were oral administered continuously for 4 weeks.Fasting blood glucose and body weight were measured weekly.Oral glucose tolerance test(OGTT)and detection of serum glycated hemoglobin(HbA1c)level were performed one week before the end of the experiment.At the end of drug administration,serum total cholesterol(TG),triglycerides(TC),low-density lipoprotein levels(LDL-C)and insulin levels were tested by lipid detection kits;homeostasis model assessment-estimated insulin resistance(HOMA-IR)and HOMA-βindexes were calculated.Liver and kidney tissues were weighed to calculate organ indices and pathological tests were performed.Western blot was performed in the liver to detect adenosine monophosphate-activated protein kinase(AMPK),acetyl coenzyme A carboxylase(ACC),glucose-6-phosphate carboxylase(G6Pase),and phosphoenolpyruvate carboxykinase(PCK1)protein expression.Results:with 200 mg/kg AME significantly reduced fasting blood glucose,HbA1c,TG and LDL-C levels,protected liver and kindey in diabetic mice,decreased the area under the OGTT curve,inhibited ACC and G6Pase protein expressions,and activated AMPK protein expression.Conclusion:AME showed good therapeutic activity against T2DM,and the mechanism may be related to the activation of AMPK and inhibition of ACC and G6Pase proteins.
文摘目的系统认识国际范围内情感化设计研究的全局特征,把握当前情感化设计的研究热点及理论基础,并根据当前研究热点探究未来发展新趋势。方法以Web of Science收录的情感化设计相关文献作为数据源,以科学文献计量的方法综合运用VOSviewer和CiteSpace从文献的年份产出分布、国家、研究机构、作者、参考文献共被引情况和关键词聚类等方面绘制科学知识图谱,进行可视化分析以梳理研究脉络。结论结果表明检索范围内文献数量整体呈上升趋势,中美等国处于研究的领先地位,研究热点主要集中在情感计算、感性工学、人机多通道交互、用户体验和设计评估等方面。研究现状较为成熟,形成了以三层次理论、感性工学和情感计算为主的理论体系。用户个性化、差异化情绪的识别与表达成为未来发展的新趋势。研究机构与作者合作不紧密,以及高产量作者不多是现阶段研究的主要局限。
文摘目的为了更好地了解和把握国内外社会创新设计研究进展,对相关文献产出分布、研究热点、基础知识及前沿趋势进行分析。方法以CNKI数据库及Web of Science核心合集数据库作为国内外数据来源,通过可视化文献分析软件VOSviewer及Citespace对国内外相关文献进行分析。结论国内外研究基本同步,主要以DESIS网络中的院校合作为主,国外研究热点集中于以社区为对象,设计管理、社会创新设计方法、生态设计、可持续设计;国内主要以城市和乡村社区服务设计、设计教育、设计战略、社会创新设计方法为主要对象。社会创新设计的演进经历了设计思维的发展及设计对象的转变两个阶段。国外研究前沿趋势为以社区为对象的可持续设计,国内前沿趋势为以乡村为对象的社会创新设计、可持续设计、服务设计等。在突发的全球疫情背景下,医疗健康、公共卫生也是国内外的前沿趋势。
