The system of SiO2-CaO-P2O5 bioactive glasses （BG） were successfully synthesized by microemulsion approach. X-ray diffraction （XRD）,scanning electron micro scopy（SEM） and energy dispersive X-ray （EDX） analyses...The system of SiO2-CaO-P2O5 bioactive glasses （BG） were successfully synthesized by microemulsion approach. X-ray diffraction （XRD）,scanning electron micro scopy（SEM） and energy dispersive X-ray （EDX） analyses, transmission electron microscopy（TEM）,Fourier transform infrared spectroscopy （FTIR）, BET N2 gas adsorption analysis techniques were utilized in order to evaluate the phase composition, dimension, morphology, interconnectivity of pores and particle size of the synthesized BG respectiveely. The biocompatibility of BG was assessed by using dimethylthiazol diphenyl tetrazolium bromide （MTT）.The BG scaffolds were implanted in rabbit mandibles and studied histologically.The results showed that the BG with a particle size less than 100 nm was prepared successfully. The measured BET specific surface area and pore volume was 113.9 m2/g and 0.28 cm3/g respectively. Cell cultures revealed that BG has been shown to have good biocompatibility and is also beneficial to the survival of Schwann cells, which can promote cell proliferation in vivo assay indicating that the BG can promote osteoconductivity.展开更多
基金Funded by Guangdong Science and Technology Tackling Project(No.2010B031100002)the Orientation of Lu'an Commissioned the West Anhui University Municipal Research Project(No.2011LW009)
文摘The system of SiO2-CaO-P2O5 bioactive glasses （BG） were successfully synthesized by microemulsion approach. X-ray diffraction （XRD）,scanning electron micro scopy（SEM） and energy dispersive X-ray （EDX） analyses, transmission electron microscopy（TEM）,Fourier transform infrared spectroscopy （FTIR）, BET N2 gas adsorption analysis techniques were utilized in order to evaluate the phase composition, dimension, morphology, interconnectivity of pores and particle size of the synthesized BG respectiveely. The biocompatibility of BG was assessed by using dimethylthiazol diphenyl tetrazolium bromide （MTT）.The BG scaffolds were implanted in rabbit mandibles and studied histologically.The results showed that the BG with a particle size less than 100 nm was prepared successfully. The measured BET specific surface area and pore volume was 113.9 m2/g and 0.28 cm3/g respectively. Cell cultures revealed that BG has been shown to have good biocompatibility and is also beneficial to the survival of Schwann cells, which can promote cell proliferation in vivo assay indicating that the BG can promote osteoconductivity.
