Electrocatalytic water splitting is crucial for H2generation via hydrogen evolution reaction(HER)but subject to the sluggish dynamics of oxygen evolution reaction(OER).In this work,single Fe atomdoped MoS_(2)nanosheet...Electrocatalytic water splitting is crucial for H2generation via hydrogen evolution reaction(HER)but subject to the sluggish dynamics of oxygen evolution reaction(OER).In this work,single Fe atomdoped MoS_(2)nanosheets(SFe-DMNs)were prepared based on the high-throughput density functional theory(DFT)calculation screening.Due to the synergistic effect between Fe atom and MoS_(2)and optimized intermediate binding energy,the SFe-DMNs could deliver outstanding activity for both HER and OER.When assembled into a two-electrode electrolytic cell,the SFe-DMNs could achieve the current density of 50 mA cm^(-2)at a low cell voltage of 1.55 V under neutral condition.These results not only confirmed the effectiveness of high-throughput screening,but also revealed the excellent activity and thus the potential applications in fuel cells of SFe-DMNs.展开更多
Dietary polyphenols are the most abundant antioxidants in daily diet and widely distributed in plants and plant-based foods,including vegetables,fruits,cereals,nuts,and beverages(e.g.,tea,coffee,red wine).Over the pas...Dietary polyphenols are the most abundant antioxidants in daily diet and widely distributed in plants and plant-based foods,including vegetables,fruits,cereals,nuts,and beverages(e.g.,tea,coffee,red wine).Over the past decades,there has been rising scientific interest in their diverse benefits to human health,since dietary polyphenols display various bioactivities,such as antioxidant activity,anti-inflammatory activity,anticancer,anti-microbial activity,neuro-protective activity,among others.Various studies have demonstrated that diet with polyphenols is strongly related to decrease the risk of chronic diseases.In this review,firstly,we systematically summarize classification and sources of dietary polyphenols,and focus on the current evidences defining their function and mechanism on improving chronic diseases,including diabetes,obesity,hypertension,hyperuricemia.Then,future directions of dietary polyphenols are discussed.Noteworthy,despite the physiological effects of dietary polyphenols have been widely convinced in vitro and in vivo,human trials show inconsistent evidence with their beneficial effects in chronic diseases administration,so as to their unclear molecular mechanism.More clinical studies are needed to provide clear evidence on dietary polyphenols against chronic diseases.In general,this paper provides comprehensive review of the sources and compositions of dietary polyphenols from plant materials,and presents an overview of the evidence on dietary polyphenols against chronic diseases,which may offer some constructive inspirations for further research on dietary polyphenols and industrial application in the food and medicine industry.展开更多
Gut microbiome(GM)is closely related to the overall health status for the human being.The dysfunction of microbiome can lead to many diseases such as inflammation,cancer and neurodegenerative disease.Therefore,it'...Gut microbiome(GM)is closely related to the overall health status for the human being.The dysfunction of microbiome can lead to many diseases such as inflammation,cancer and neurodegenerative disease.Therefore,it's of great importance to develop effective strategy to regulate GM.Gut lumen-targeted oral delivery system(GLT-ODS)has been extensively investigated and widely used in food science and engineering in these years,due to the targeted delivery property,controlled release profile,high biocompatibility and enhanced bioavailability of cargos.Herein,we comprehensively summarized the current advances in GLT-ODS for bioactive agent.Specifically,we systematically summarize the GLT-ODS for pre-agents(prebiotics and probiotics)and anti-agents(antibiotics and bacteriophages)according to the type of cargos.Through in-depth discussion of representative researches,we refined the limitations of existing research in carrier material and target selection,and drew a blueprint for the future technological research and development.We believe that GLT-ODS will become a safe,efficient,simple and precise GM management strategy for improvement of health and shine in the development of precision food and pharmaceutical engineering in future.展开更多
Diet plays an important role in diabetes development.The effect of ketogenic diet on type 2 diabetes remains elusive.In this study,we collect diabetes related physiological parameters and abdominal MRI images to evalu...Diet plays an important role in diabetes development.The effect of ketogenic diet on type 2 diabetes remains elusive.In this study,we collect diabetes related physiological parameters and abdominal MRI images to evaluate the effect of ketogenic diet after 3-months of consecutive treatment.Ketogenic diet mitigates the diabetes symptom inferring from the statistically significant reduction of key diabetic physiological parameters such as Hemoglobin A1c(HbA1c)concentration,Triglyceride(TG),Fasting blood glucose(FBG),Body Mass Index(BMI),and adipose tissue volume.Moreover,we propose a new parameter to quantify the treating effect of ketogenic diet since Slope and Offset of Oral Glucose Tolerance Test(SOOGTT)incorporate more sampling points by fitting OGTT(Oral Glucose Tolerance Test)curve.SOOGTT shows statistically significant(P<0.001)treating effect of ketogenic diet on type 2 diabetes.We use artificial intelligence to segment adipose tissue for treatment evaluation,which shows that ketogenic diet reduces the amount of adipose tissue.展开更多
基金supported by the Research Funds of Institute of Zhejiang University-Quzhou(IZQ2023RCZX032)the Natural Science Foundation of Guangdong Province(2022A1515010185)+1 种基金the Fundamental Research Funds for the Central Universities(FRF-TP-20-005A3)partially supported by the Special Funds for Postdoctoral Research at Tsinghua University(100415017)。
文摘Electrocatalytic water splitting is crucial for H2generation via hydrogen evolution reaction(HER)but subject to the sluggish dynamics of oxygen evolution reaction(OER).In this work,single Fe atomdoped MoS_(2)nanosheets(SFe-DMNs)were prepared based on the high-throughput density functional theory(DFT)calculation screening.Due to the synergistic effect between Fe atom and MoS_(2)and optimized intermediate binding energy,the SFe-DMNs could deliver outstanding activity for both HER and OER.When assembled into a two-electrode electrolytic cell,the SFe-DMNs could achieve the current density of 50 mA cm^(-2)at a low cell voltage of 1.55 V under neutral condition.These results not only confirmed the effectiveness of high-throughput screening,but also revealed the excellent activity and thus the potential applications in fuel cells of SFe-DMNs.
基金financially supported by Shenzhen agricultural development special fund(Fishery)agricultural high-tech project([2021]735)the Shenzhen Science and Technology Innovation Commission(KCXFZ20201221173207022)Youth Science Foundation Project(32101936).
文摘Dietary polyphenols are the most abundant antioxidants in daily diet and widely distributed in plants and plant-based foods,including vegetables,fruits,cereals,nuts,and beverages(e.g.,tea,coffee,red wine).Over the past decades,there has been rising scientific interest in their diverse benefits to human health,since dietary polyphenols display various bioactivities,such as antioxidant activity,anti-inflammatory activity,anticancer,anti-microbial activity,neuro-protective activity,among others.Various studies have demonstrated that diet with polyphenols is strongly related to decrease the risk of chronic diseases.In this review,firstly,we systematically summarize classification and sources of dietary polyphenols,and focus on the current evidences defining their function and mechanism on improving chronic diseases,including diabetes,obesity,hypertension,hyperuricemia.Then,future directions of dietary polyphenols are discussed.Noteworthy,despite the physiological effects of dietary polyphenols have been widely convinced in vitro and in vivo,human trials show inconsistent evidence with their beneficial effects in chronic diseases administration,so as to their unclear molecular mechanism.More clinical studies are needed to provide clear evidence on dietary polyphenols against chronic diseases.In general,this paper provides comprehensive review of the sources and compositions of dietary polyphenols from plant materials,and presents an overview of the evidence on dietary polyphenols against chronic diseases,which may offer some constructive inspirations for further research on dietary polyphenols and industrial application in the food and medicine industry.
基金This work was financially supported by the Scientific Research Start-up Funds(QD2021020C)at Shenzhen International Graduate School at Tsinghua University,the Research Fund Program of Guangdong Provincial Key Lab of Green Chemical Product Technology(20212779)Shenzhen Science and Technology Innovation Commission(KCXFZ20201221173207022).
文摘Gut microbiome(GM)is closely related to the overall health status for the human being.The dysfunction of microbiome can lead to many diseases such as inflammation,cancer and neurodegenerative disease.Therefore,it's of great importance to develop effective strategy to regulate GM.Gut lumen-targeted oral delivery system(GLT-ODS)has been extensively investigated and widely used in food science and engineering in these years,due to the targeted delivery property,controlled release profile,high biocompatibility and enhanced bioavailability of cargos.Herein,we comprehensively summarized the current advances in GLT-ODS for bioactive agent.Specifically,we systematically summarize the GLT-ODS for pre-agents(prebiotics and probiotics)and anti-agents(antibiotics and bacteriophages)according to the type of cargos.Through in-depth discussion of representative researches,we refined the limitations of existing research in carrier material and target selection,and drew a blueprint for the future technological research and development.We believe that GLT-ODS will become a safe,efficient,simple and precise GM management strategy for improvement of health and shine in the development of precision food and pharmaceutical engineering in future.
基金Part of this work is supported by National Natural Science Foundation of China(31970752)Science and Technology Planning Project of Shenzhen Municipality(JSGG20191129110812708,JCYJ20190809180003689,JSGG20200225150707332)Shenzhen Bay Laboratory Open Funding(SZBL2020090501004).
文摘Diet plays an important role in diabetes development.The effect of ketogenic diet on type 2 diabetes remains elusive.In this study,we collect diabetes related physiological parameters and abdominal MRI images to evaluate the effect of ketogenic diet after 3-months of consecutive treatment.Ketogenic diet mitigates the diabetes symptom inferring from the statistically significant reduction of key diabetic physiological parameters such as Hemoglobin A1c(HbA1c)concentration,Triglyceride(TG),Fasting blood glucose(FBG),Body Mass Index(BMI),and adipose tissue volume.Moreover,we propose a new parameter to quantify the treating effect of ketogenic diet since Slope and Offset of Oral Glucose Tolerance Test(SOOGTT)incorporate more sampling points by fitting OGTT(Oral Glucose Tolerance Test)curve.SOOGTT shows statistically significant(P<0.001)treating effect of ketogenic diet on type 2 diabetes.We use artificial intelligence to segment adipose tissue for treatment evaluation,which shows that ketogenic diet reduces the amount of adipose tissue.
