Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we in...Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.展开更多
Recently,van der Waals heterostructures(vdWHs)constructed by transition-metal dichalcogenides(TMDCs)have come under the research spotlight owing to their excellent capabilities,multiple functionalities,and innovative ...Recently,van der Waals heterostructures(vdWHs)constructed by transition-metal dichalcogenides(TMDCs)have come under the research spotlight owing to their excellent capabilities,multiple functionalities,and innovative architecture for advanced optoelectronic devices.Herein,novel heterojunction photodetectors composed of monolayer molybdenum disulfide(MoS2)and few-layer rhenium selenide(ReSe_(2))are explored for ultra-fast and polarization detection.Owing to the enhanced light-matter interactions and type-II band alignment of the ReSe_(2)/MoS_(2) heterostructure,the photodetector exhibits impressive performances at 638 nm in terms of a high on/off ratio~104,large photoresponsivity~3.52 A/W,high specific detectivity~1011 Jones,and large 3 dB frequency of 65.7 kHz.In addition,ultrafast rise/decay times(5.0/9.1 ms)are obtained under pulsed incident light contributed to the built-in electric field at the heterointerface,demonstrating a result one or two orders of magnitude faster than the currently reported values of group VII-TMDCs based photodetectors.Beyond the conventional photodetection,this photodetector also displays polarization detection capability with sensitivity 1.35.Such Re-based vdWHs provide superior platforms for the realization of ultra-fast and polarization-sensitive photodetection in broadband spectrum.展开更多
基金supported by Natural Science Foundation of Guangdong basic and applied basic research foundation(2021A1515010965)General project of Basic and applied basic Research in Guangzhou(202102080241)+3 种基金Laboratory opening project of Guangzhou Medical University(PX-1020423)Natural Science Foundation of Guangdong basic and applied basic research foundation([2018]105)Guangdong Provincial Department of Education(S202010570042)Communist Youth League Committee of Guangzhou Medical University(2019A060).
文摘Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.
基金supported by the National Natural Science Foundation of China(61804086)National Natural Science Foundation of Shandong Province(ZR2021MA033).
文摘Recently,van der Waals heterostructures(vdWHs)constructed by transition-metal dichalcogenides(TMDCs)have come under the research spotlight owing to their excellent capabilities,multiple functionalities,and innovative architecture for advanced optoelectronic devices.Herein,novel heterojunction photodetectors composed of monolayer molybdenum disulfide(MoS2)and few-layer rhenium selenide(ReSe_(2))are explored for ultra-fast and polarization detection.Owing to the enhanced light-matter interactions and type-II band alignment of the ReSe_(2)/MoS_(2) heterostructure,the photodetector exhibits impressive performances at 638 nm in terms of a high on/off ratio~104,large photoresponsivity~3.52 A/W,high specific detectivity~1011 Jones,and large 3 dB frequency of 65.7 kHz.In addition,ultrafast rise/decay times(5.0/9.1 ms)are obtained under pulsed incident light contributed to the built-in electric field at the heterointerface,demonstrating a result one or two orders of magnitude faster than the currently reported values of group VII-TMDCs based photodetectors.Beyond the conventional photodetection,this photodetector also displays polarization detection capability with sensitivity 1.35.Such Re-based vdWHs provide superior platforms for the realization of ultra-fast and polarization-sensitive photodetection in broadband spectrum.
