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基于PBL教学法与实验对照组设计相结合的实验教学探索 被引量:2
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作者 钟山 邱丽娟 +4 位作者 巢雯 孙筱 卢占英 林晓平 朱玉平 《基础医学教育》 2024年第1期35-40,共6页
通过结合问题导向学习(PBL)教学法与实验对照组设计,探索了其在分子医学综合实验课程中的应用效果。研究对象为临床八年制医学生。教师通过将传统教学与PBL结合的教学模式,强调学生的主动学习和团队合作,以实验对照组设计为载体,加深学... 通过结合问题导向学习(PBL)教学法与实验对照组设计,探索了其在分子医学综合实验课程中的应用效果。研究对象为临床八年制医学生。教师通过将传统教学与PBL结合的教学模式,强调学生的主动学习和团队合作,以实验对照组设计为载体,加深学生对实验原理的理解和应用。实验结果显示,采用PBL结合实验对照组设计的教学方法相较于传统教学方法显著提高了学生的实验设计能力、实验操作技能及科研思维能力,同时增强学生的批判性思维和团队合作精神。学生满意度调查显示,多数学生对新教学模式表示认可和满意。因此,PBL结合实验对照组设计的教学法在分子医学实验教学中具有积极的应用前景。 展开更多
关键词 分子医学综合实验 实验教学 教学改革 问题导向学习(PBL) 实验对照组设计 科研能力培养
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High-Precision Doppler Frequency Estimation Based Positioning Using OTFS Modulations by Red and Blue Frequency Shift Discriminator 被引量:1
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作者 Shaojing Wang Xiaomei Tang +3 位作者 Jing Lei Chunjiang Ma chao wen Guangfu Sun 《China Communications》 SCIE CSCD 2024年第2期17-31,共15页
Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Dopple... Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Doppler frequency for positioning is a promising research direction on communication and navigation integration. To tackle the high Doppler frequency and low signal-to-noise ratio(SNR) in satellite communication, this paper proposes a Red and Blue Frequency Shift Discriminator(RBFSD) based on the pseudo-noise(PN) sequence.The paper derives that the cross-correlation function on the Doppler domain exhibits the characteristic of a Sinc function. Therefore, it applies modulation onto the Delay-Doppler domain using PN sequence and adjusts Doppler frequency estimation by red-shifting or blue-shifting. Simulation results show that the performance of Doppler frequency estimation is close to the Cramér-Rao Lower Bound when the SNR is greater than -15dB. The proposed algorithm is about 1/D times less complex than the existing PN pilot sequence algorithm, where D is the resolution of the fractional Doppler. 展开更多
关键词 channel estimation communication and navigation integration Orthogonal Time Frequency and Space pseudo-noise sequence red-blue frequency shift discriminator
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基于隐马尔可夫模型的台风风险评估与巨灾债券定价研究
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作者 巢文 钱晓涛 《绵阳师范学院学报》 2024年第9期7-14,37,共9页
发行与台风风险相关的巨灾债券,将承保的台风风险由保险市场转移到资本市场,是保险公司规避巨灾风险的一条重要途径。台风风险的准确评估预测,是台风巨灾债券成功发行的关键。针对台风风险特征,构建了隐马尔可夫模型,以台风年经济损失... 发行与台风风险相关的巨灾债券,将承保的台风风险由保险市场转移到资本市场,是保险公司规避巨灾风险的一条重要途径。台风风险的准确评估预测,是台风巨灾债券成功发行的关键。针对台风风险特征,构建了隐马尔可夫模型,以台风年经济损失额为观测序列,预测台风登陆时最大风力等级状态,进而采用风险中性测度技术,在CIR随机利率期限结构下,给出了有息巨灾债券定价公式。结合我国1989—2022年台风灾害损失数据进行实证分析,结果表明,隐马尔可夫模型的台风风险评估预测效果优于其他常用机器学习模型,所建立的定价模型具有可行性。 展开更多
关键词 巨灾债券 隐马尔可夫 台风风险 随机利率
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高温高压下扩张式封隔器胶筒非线性流动仿真计算 被引量:3
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作者 岳欠杯 王岗 +5 位作者 刘巨保 孙国昊 王笑笑 刘跃秋 曹文 张强 《计算力学学报》 CAS CSCD 北大核心 2023年第3期411-423,共13页
针对井下温度压力环境下扩张式封隔器的工作状态,本文建立了卡距内管柱及封隔器力学模型,采用网格重划分方法来描述胶筒在环空间隙中的非线性流动,并将重划分前后的网格信息进行映射,解决了封隔器有限元方程矩阵奇异问题.对不同压裂泵... 针对井下温度压力环境下扩张式封隔器的工作状态,本文建立了卡距内管柱及封隔器力学模型,采用网格重划分方法来描述胶筒在环空间隙中的非线性流动,并将重划分前后的网格信息进行映射,解决了封隔器有限元方程矩阵奇异问题.对不同压裂泵压、不同井温和不同环空间隙下封隔器胶筒的位移、剪切应力及接触压力进行仿真计算.压裂泵压为30MPa~80MPa时,胶筒未发生轴向窜动,橡胶基体的剪切应力及接触压力随着压裂泵压的增加而增大;井温为25℃~175℃时,胶筒基体剪切应力随井温的升高而增大,胶筒与套管间接触压力随井温升高而降低;胶筒与套管环空间隙为2.5mm~9.5mm,胶筒剪切应力随间隙增加而增大,胶筒与套管接触压力随间隙增加而降低.通过胶筒网格变形可知,胶筒橡胶在环空间隙中产生非线性流动是引起胶筒剪切应力数值增大、接触压力数值降低的根本原因.综上可得,在压裂作业中,随着压裂泵压的增大、井温的升高和环空间隙的增大,封隔器胶筒更容易发生剪切撕裂破坏,且封隔器的密封效果亦降低. 展开更多
关键词 高温 高压 胶筒 网格重划分 非线性流动
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The Integration Strategy of Class Teacher Management and Mathematics Teaching
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作者 chao wen 《Journal of Contemporary Educational Research》 2024年第6期142-147,共6页
The professional and moral education of high school mathematics teachers will make classroom management work better,but their work pressure will also lead to classroom management problems.To do a good job in high scho... The professional and moral education of high school mathematics teachers will make classroom management work better,but their work pressure will also lead to classroom management problems.To do a good job in high school class teacher management and organically integrate it with mathematics teaching,we need to start from two aspects:mathematics teaching class teachers and class teacher work teaching,and penetrate mathematical thinking into daily classroom management,moral education,and classroom culture construction.Based on the attributes of the subject,we guide high school students to reflect after class to stimulate their self-management initiative through the cultivation of qualified class representatives.In addition,it is necessary to skillfully resolve classroom generative problems,change the roles of teachers and students,and integrate classroom management with mathematics teaching. 展开更多
关键词 High school class teacher Class teacher management Mathematics teaching Integration strategies
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Speech Encryption in Linear Canonical Transform Domain Based on Chaotic Dynamic Modulation
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作者 Liyun Xu Tong Zhang chao wen 《Journal of Beijing Institute of Technology》 EI CAS 2021年第3期295-304,共10页
In order to transmit the speech information safely in the channel,a new speech encryp-tion algorithm in linear canonical transform(LCT)domain based on dynamic modulation of chaot-ic system is proposed.The algorithm fi... In order to transmit the speech information safely in the channel,a new speech encryp-tion algorithm in linear canonical transform(LCT)domain based on dynamic modulation of chaot-ic system is proposed.The algorithm first uses a chaotic system to obtain the number of sampling points of the grouped encrypted signal.Then three chaotic systems are used to modulate the corres-ponding parameters of the LCT,and each group of transform parameters corresponds to a group of encrypted signals.Thus,each group of signals is transformed by LCT with different parameters.Fi-nally,chaotic encryption is performed on the LCT domain spectrum of each group of signals,to realize the overall encryption of the speech signal.The experimental results show that the proposed algorithm is extremely sensitive to the keys and has a larger key space.Compared with the original signal,the waveform and LCT domain spectrum of obtained encrypted signal are distributed more uniformly and have less correlation,which can realize the safe transmission of speech signals. 展开更多
关键词 communication security linear canonical transform transform domain encryption chaotic system
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基于藤Copula-Monte Carlo方法的多事件巨灾债券触发概率模拟 被引量:1
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作者 巢文 钱晓涛 《中央民族大学学报(自然科学版)》 2023年第1期66-70,共5页
当前全球自然灾害频发,传统的保险业已经无法承担日益严峻的巨灾风险。巨灾债券作为一种新型的金融创新产品,可以为巨灾风险提供更有效的分散方式。文章采用藤Copula模型来刻画多巨灾损失变量间的相关关系,在此基础上,将多巨灾损失变量... 当前全球自然灾害频发,传统的保险业已经无法承担日益严峻的巨灾风险。巨灾债券作为一种新型的金融创新产品,可以为巨灾风险提供更有效的分散方式。文章采用藤Copula模型来刻画多巨灾损失变量间的相关关系,在此基础上,将多巨灾损失变量的条件分位数估计应用到多事件触发巨灾债券的触发值设定。结合全球洪灾数据进行实证分析,通过Monte Carlo方法模拟多事件巨灾债券的触发概率,验证了所构建模型的可行性和优越性。 展开更多
关键词 藤Copula模型 Monte Carlo方法 多事件触发 巨灾债券 条件分位数
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Prediction of high-speed train delay propagation based on causal text information
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作者 Qianyi Liu Shengjie Wang +3 位作者 Zhongcan Li Li Li Jun Zhang chao wen 《Railway Engineering Science》 2023年第1期89-106,共18页
The delay-causing text data contain valuable information such as the specific reasons for the delay,location and time of the disturbance,which can provide an efficient support for the prediction of train delays and im... The delay-causing text data contain valuable information such as the specific reasons for the delay,location and time of the disturbance,which can provide an efficient support for the prediction of train delays and improve the guidance of train control efficiency.Based on the train operation data and delay-causing data of the Wuhan-Guangzhou high-speed railway,the relevant algorithms in the natural language processing field are used to process the delay-causing text data.It also integrates the train operatingenvironment information and delay-causing text information so as to develop a cause-based train delay propagation prediction model.The Word2vec model is first used to vectorize the delay-causing text description after word segmentation.The mean model or the term frequency-inverse document frequency-weighted model is then used to generate the delay-causing sentence vector based on the original word vector.Afterward,the train operating-environment features and delay-causing sentence vector are input into the extreme gradient boosting(XGBoost)regression algorithm to develop a delay propagation prediction model.In this work,4 text feature processing methods and 8 regression algorithms are considered.The results demonstrate that the XGBoost regression algorithm has the highest prediction accuracy using the test features processed by the continuous bag of words and the mean models.Compared with the prediction model that only considers the train-operating-environment features,the results show that the prediction accuracy of the model is significantly improved with multi-ple regression algorithms after integrating the delay-causing feature. 展开更多
关键词 High-speed rail Delay propagation Cause of delay Word2vec Natural language processing
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破产概率视角下的巨灾保险偿付能力分析——基于混合分布模型
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作者 巢文 钱晓涛 《保险职业学院学报》 2023年第5期51-57,共7页
破产概率是分析保险公司巨灾风险偿付能力的一个重要数量指标,而巨灾损失数据的拟合模型则是准确估计破产概率的关键。选取我国1990-2018年震级5级以上地震灾害为研究样本,用非参数核密度估计方法和广义帕累托分布构建了地震造成的直接... 破产概率是分析保险公司巨灾风险偿付能力的一个重要数量指标,而巨灾损失数据的拟合模型则是准确估计破产概率的关键。选取我国1990-2018年震级5级以上地震灾害为研究样本,用非参数核密度估计方法和广义帕累托分布构建了地震造成的直接经济损失的混合分布模型,并用峰度法确定该模型中的阈值,进而给出保险公司破产概率的尾渐近估计。实证结果表明,所构建的混合分布模型对巨灾损失数据的拟合效果良好,可以为我国保险公司经营巨灾风险提供一种新的精算模型。 展开更多
关键词 巨灾保险 广义帕累托分布 核密度估计 破产概率 偿付能力
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一种深空天文测角导航中的星历误差抑制方法 被引量:5
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作者 宁晓琳 晁雯 杨雨青 《宇航学报》 EI CAS CSCD 北大核心 2019年第12期1412-1421,共10页
以火星探测器为例,提出一种以星光角距/时间差分星光角距作为量测量的星历误差抑制方法,分析了火卫一星历误差对导航精度的影响,建立了火卫一时间差分星光角距的量测模型。通过将火星星光角距和火卫一星光角距相结合,发挥了两种量测的优... 以火星探测器为例,提出一种以星光角距/时间差分星光角距作为量测量的星历误差抑制方法,分析了火卫一星历误差对导航精度的影响,建立了火卫一时间差分星光角距的量测模型。通过将火星星光角距和火卫一星光角距相结合,发挥了两种量测的优势,实现了对火卫一星历误差的抑制。仿真结果表明,基于星光角距/时间差分星光角距天文导航方法的位置误差是传统基于星光角距天文导航方法的64%,是基于时间差分星光角距导航方法的58%。此外,还分析了导航恒星个数、火星敏感器精度、火卫一敏感器精度、星历误差大小和滤波周期对导航性能的影响。 展开更多
关键词 深空探测器 天文测角导航 星历误差 时间差分
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High-Speed Railway Train Timetable Conflict Prediction Based on Fuzzy Temporal Knowledge Reasoning 被引量:3
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作者 He Zhuang Liping Feng +2 位作者 chao wen Qiyuan peng Qizhi Tang 《Engineering》 SCIE EI 2016年第3期366-373,共8页
Trains are prone to delays and deviations from train operation plans during their operation because of internal or external disturbances. Delays may develop into operational conflicts between adjacent trains as a resu... Trains are prone to delays and deviations from train operation plans during their operation because of internal or external disturbances. Delays may develop into operational conflicts between adjacent trains as a result of delay propagation, which may disturb the arrangement of the train operation plan and threaten the operational safety of trains. Therefore, reliable conflict prediction results can be valuable references for dispatchers in making more efficient train operation adjustments when conflicts occur. In contrast to the traditional approach to conflict prediction that involves introducing random disturbances, this study addresses the issue of the fuzzification of time intervals in a train timetable based on historical statistics and the modeling of a high-speed railway train timetable based on the concept of a timed Petri net. To measure conflict prediction results more comprehensively, we divided conflicts into potential conflicts and certain conflicts and defined the judgment conditions for both. Two evaluation indexes, one for the deviation of a single train and one for the possibility of conflicts between adjacent train operations, were developed using a formalized computation method. Based on the temporal fuzzy reasoning method, with some adjustment, a new conflict prediction method is proposed, and the results of a simulation example for two scenarios are presented. The results prove that conflict prediction after fuzzy processing of the time intervals of a train timetable is more reliable and practical and can provide helpful information for use in train operation adjustment, train timetable improvement, and other purposes. 展开更多
关键词 High-speed railway Train timetable Conflict prediction Fuzzy temporal knowledge reasoning
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基于Copula-POT模型的条件VaR估计——以洪灾风险为例 被引量:5
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作者 巢文 钱晓涛 《华南理工大学学报(社会科学版)》 2020年第4期88-97,共10页
针对巨灾损失具有尖峰厚尾的特征,采用极值理论中的POT模型拟合巨灾损失变量的边缘分布,利用二元阿基米德Copula函数来刻画巨灾损失变量之间的相关结构,构建了Copula-POT模型来估算巨灾损失的条件VaR值。结合全球洪水事件的损失数据进... 针对巨灾损失具有尖峰厚尾的特征,采用极值理论中的POT模型拟合巨灾损失变量的边缘分布,利用二元阿基米德Copula函数来刻画巨灾损失变量之间的相关结构,构建了Copula-POT模型来估算巨灾损失的条件VaR值。结合全球洪水事件的损失数据进行实证分析和比较,结果表明:损失变量的厚尾性与相关关系的刻画是估计条件VaR的关键,且Copula-POT模型能够提供准确的巨灾损失条件VaR估计。本研究能为巨灾风险评估及其应对提供一定的参考。 展开更多
关键词 阿基米德Copula函数 极值理论 巨灾风险 CVAR
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基于POT模型的巨灾损失VaR和CVaR估计 被引量:2
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作者 巢文 邹辉文 《北京化工大学学报(社会科学版)》 2020年第2期18-22,39,共6页
自2008年汶川地震发生以来,巨灾风险越来越受到人们的关注。开展巨灾损失评估方面的相关研究,对减少我国巨灾经济损失、促进灾区经济发展具有重大意义。针对巨灾损失发生频率低、损失严重的厚尾性特点,利用对数正态分布和POT模型对我国1... 自2008年汶川地震发生以来,巨灾风险越来越受到人们的关注。开展巨灾损失评估方面的相关研究,对减少我国巨灾经济损失、促进灾区经济发展具有重大意义。针对巨灾损失发生频率低、损失严重的厚尾性特点,利用对数正态分布和POT模型对我国1990年至2013年间的地震直接经济损失数据进行实证分析。回测检验结果表明,POT模型对巨灾损失的VaR和CVaR的估计和预测效果要优于对数正态分布,更能提高巨灾损失估计的精度。 展开更多
关键词 巨灾风险 POT模型 VAR CVAR 回测检验
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硬脂酸单甘油酯协同卡泊芬净的体外抗念珠菌活性研究 被引量:1
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作者 邱丽娟 巢雯 +3 位作者 石安喆 阎澜 吕权真 姜远英 《中国真菌学杂志》 CSCD 2021年第3期145-149,165,共6页
目的通过化合物体外筛选,获得与临床常用抗真菌药物卡泊芬净具有协同作用的化合物,增强卡泊芬净的抗菌效果。方法采用棋盘式微量液基稀释法考察硬脂酸单甘油酯(glyceryl monostearate,GMS)与卡泊芬净(CAS)、氟康唑(FCZ)对多种念珠菌的... 目的通过化合物体外筛选,获得与临床常用抗真菌药物卡泊芬净具有协同作用的化合物,增强卡泊芬净的抗菌效果。方法采用棋盘式微量液基稀释法考察硬脂酸单甘油酯(glyceryl monostearate,GMS)与卡泊芬净(CAS)、氟康唑(FCZ)对多种念珠菌的最低抑菌浓度(MIC)和协同指数(FICI);考察硬脂酸单甘油酯与卡泊芬净单用及联合使用时,在RPMI 1640和Spider培养基中抑制白念珠菌菌丝形成的抑菌浓度。结果在考察的绝大多数致病念珠菌中,硬脂酸单甘油酯与卡泊芬净具有协同抗菌作用,协同指数FICI≤0.5;联用硬脂酸单甘油酯后,卡泊芬净抑制菌丝形成的浓度降低。结论硬脂酸单甘油酯可以增强卡泊芬净的体外抗真菌效果,二者具有较强的协同抗念珠菌活性。 展开更多
关键词 念珠菌 卡泊芬净 硬脂酸单甘油酯 协同作用
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Pathogenesis of Secretory Otitis Media 被引量:3
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作者 chao wen Xiaoyu Wang +2 位作者 Taisheng Chen Hongying Ruan Peng Lin 《国际感染病学(电子版)》 CAS 2015年第1期10-15,共6页
关键词 Secretory otitis media INFECTION IMMUNE PATHOGENESIS
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Delay recovery model for high-speed trains with compressed train dwell time and running time 被引量:1
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作者 Yafei Hou chao wen +2 位作者 Ping Huang Liping Fu chaozhe Jiang 《Railway Engineering Science》 2020年第4期424-434,共11页
Modeling the application of train operation adjustment actions to recover from delays is of great importance to supporting the decision-making of dispatchers.In this study,the effects of two train operation adjustment... Modeling the application of train operation adjustment actions to recover from delays is of great importance to supporting the decision-making of dispatchers.In this study,the effects of two train operation adjustment actions on train delay recovery were explored using train operation records from scheduled and actual train timetables.First,the modeling data were sorted to extract the possible influencing factors under two typical train operation adjustment actions,namely the compression of the train dwell time at stations and the compression of the train running time in sections.Stepwise regression methods were then employed to determine the importance of the influencing factors corresponding to the train delay recovery time,namely the delay time,the scheduled supplement time,the running interval,the occurrence time,and the place where the delay occurred,under the two train operation adjustment actions.Finally,the gradient-boosted regression tree(GBRT)algorithm was applied to construct a delay recovery model to predict the delay recovery effects of the train operation adjustment actions.A comparison of the prediction results of the GBRT model with those of a random forest model confirmed the better performance of the GBRT prediction model. 展开更多
关键词 High-speed train Delay recovery Train operation adjustment actions Gradient-boosted regression tree
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基于路线布设与路基设计的公路工程设计及应用分析 被引量:3
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作者 巢文 乐欢 《中国高新科技》 2020年第10期117-118,共2页
公路设计要根据当地的地形、地貌、地质等条件,选择科学合理的设计方案。施工时还需要使用合理的工程建筑法,降低对周边环境的破坏力,达到绿色的建筑工程要求,在保证公路安全的前提下,努力实现人与自然可持续性和谐发展。文章通过对路... 公路设计要根据当地的地形、地貌、地质等条件,选择科学合理的设计方案。施工时还需要使用合理的工程建筑法,降低对周边环境的破坏力,达到绿色的建筑工程要求,在保证公路安全的前提下,努力实现人与自然可持续性和谐发展。文章通过对路线布设和路基设计工程设计的应用进行探索和分析,为相关人员提供一些参考和经验。 展开更多
关键词 路线布设 路基设计 工程设计
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随机利率下基于蒙特卡洛算法的巨灾保险破产概率模拟 被引量:1
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作者 巢文 钱晓涛 《中央民族大学学报(自然科学版)》 2021年第2期47-51,共5页
巨灾保险是分散巨灾风险的一种重要手段,而破产概率则是评估保险公司巨灾风险偿付能力的一个关键数量指标。在利率服从CIR随机利率模型且巨灾索赔服从对数正态分布的假设下,本文采用经典更新风险模型描述保险公司盈余过程,并应用蒙特卡... 巨灾保险是分散巨灾风险的一种重要手段,而破产概率则是评估保险公司巨灾风险偿付能力的一个关键数量指标。在利率服从CIR随机利率模型且巨灾索赔服从对数正态分布的假设下,本文采用经典更新风险模型描述保险公司盈余过程,并应用蒙特卡洛算法估计保险公司经营巨灾风险的破产概率,利用Matlab软件进行了模拟,所得结果验证了基于蒙特卡洛算法估计随机利率下巨灾保险破产概率方案的有效性和可行性。 展开更多
关键词 巨灾保险 随机利率 蒙特卡洛算法 破产概率
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Statistical delay distribution analysis on high-speed railway trains
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作者 Yuxiang Yang Ping Huang +2 位作者 Qiyuan Peng Jie LI chao wen 《Journal of Modern Transportation》 2019年第3期188-197,共10页
The focus of this study is to explore the statis-tical distribution models of high-speed railway (HSR) train delays. Based on actual HSR operational data, the delay causes and their classification, delay frequency, nu... The focus of this study is to explore the statis-tical distribution models of high-speed railway (HSR) train delays. Based on actual HSR operational data, the delay causes and their classification, delay frequency, number of affected trains, and space–time delay distributions are discussed. Eleven types of delay events are classified, and a detailed analysis of delay distribution for each classifica-tion is presented. Models of delay probability delay prob-ability distribution for each cause are proposed. Different distribution functions, including the lognormal, exponen-tial, gamma, uniform, logistic, and normal distribution, were selected to estimate and model delay patterns. The most appropriate distribution, which can approximate the delay duration corresponding to each cause, is derived. Subsequently, the Kolmogorov–Smirnov (K–S) test was used to test the goodness of fit of different train delay distribution models and the associated parameter values. The test results show that the distribution of the test data is consistent with that of the selected models. The fitting distribution models show the execution effect of the timetable and help in finding out the potential conflicts in real-time train operations. 展开更多
关键词 High-speed railway TRAIN DELAY CAUSE Actual operation data DISTRIBUTION model
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Bilateral posterior scleritis presenting as acute primary angle closure:A case report
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作者 chao wen Hui Duan 《World Journal of Clinical Cases》 SCIE 2021年第15期3779-3786,共8页
BACKGROUND Scleritis is a rare disease and the incidence of bilateral posterior scleritis is even rarer.Unfortunately,misdiagnosis of the latter is common due to its insidious onset,atypical symptoms,and varied manife... BACKGROUND Scleritis is a rare disease and the incidence of bilateral posterior scleritis is even rarer.Unfortunately,misdiagnosis of the latter is common due to its insidious onset,atypical symptoms,and varied manifestations.We report here a case of bilateral posterior scleritis that presented with acute eye pain and intraocular hypertension,and was initially misdiagnosed as acute primary angle closure.Expanding the literature on such cases will not only increase physicians’awareness but also help to improve accurate diagnosis.CASE SUMMARY A 53-year-old man was referred to our hospital to address a 4-d history of bilateral acute eye pain,headache,and loss of vision,after initial presentation to a local hospital 3 d prior.Our initial examination revealed bilateral cornea edema accompanied by a shallow anterior chamber and visual acuity reduction,with left-eye amblyopia(>30 years).There was bilateral hypertension(by intraocular pressure:28 mmHg in right,34 mmHg in left)and normal fundi.Accordingly,acute primary angle closure was diagnosed.Miotics and ocular hypotensive drugs were prescribed,but the symptoms continued to worsen over the 3-d treatment course.Further imaging examinations(i.e.,anterior segment photography and ultrasonography)indicated a diagnosis of bilateral posterior scleritis.Methylprednisolone,topical atropine,and steroid eye drops were prescribed along with intraocular pressure-lowering agents.Subsequent optical coherence tomography(OCT)showed gradual improvements in subretinal fluid under the sensory retina,thickened sclera,and ciliary body detachment.CONCLUSION Bilateral posterior scleritis can lead to secondary acute angle closure.Diagnosis requires ophthalmic accessory examinations(i.e.,ultrasound biomicroscopy,Bscan,and OCT). 展开更多
关键词 Acute primary angle closure Posterior scleritis Differential diagnosis B-scan Optical coherence tomography Case report
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