Objective: To investigate the analysis of atrial remodeling, fibrosis, oxidative stress and insulin resistance levels in patients with atrial fibrillation. Methods: 60 patients with atrial fibrillation treated in our ...Objective: To investigate the analysis of atrial remodeling, fibrosis, oxidative stress and insulin resistance levels in patients with atrial fibrillation. Methods: 60 patients with atrial fibrillation treated in our hospital from December 2016 to January 2018 were selected as observation group, and 60 healthy persons in the same period were selected as control group. The expression levels of indexes in atrial remodeling [including osteoprotegerin (OPG), nuclear factor kappa beta receptor activating factor ligand (RANKL)], fibrosis [including transforming growth factor beta (TGF-beta) and tumor necrosis factor alpha (TNF-alpha)], oxidative stress [including reactive oxygen species (ROS) and advanced oxidation protein products (AOPP)] and insulin resistance [including human fibroblast growth factor -21 (FGF-21) and omentin-1 (Omentin-1)] were observed and compared between the two groups. Results: The level of Omentin-1 in observation group [(36.75±4.60) ug/L] was significantly lower than that in control group [(87.98±4.43) ug/L] (P<0.05). And there was no significant difference in AOPP level between the observation group and the control group [(13.75±2.13) micromol/L] (P>0.05). While the levels of atrial remodeling and fibrosis related indexes, ROS and FGF-21 in the observation group were significantly higher than those in the control group (P<0.05). Conclusions: Understanding the mechanism of atrial remodeling in patients with atrial fibrillation contributes to the prevention and treatment of atrial fibrillation. Patients with atrial fibrillation are not only prone to myocardial fibrosis, but also to oxidative stress and insulin resistance. The relevant indicators should be strengthened in clinical practice, so as to provide evidence for early diagnosis and treatment of the disease.展开更多
Enormous LiFePO_(4)(LFP)/graphite batteries retired from the market need urgent rational disposal and reutilization based on the degradation analysis of the evolutional mechanism for electrodes.Typically,Li inventory ...Enormous LiFePO_(4)(LFP)/graphite batteries retired from the market need urgent rational disposal and reutilization based on the degradation analysis of the evolutional mechanism for electrodes.Typically,Li inventory loss is one of the main reasons for the degradation of LFP-based batteries.The reduced portion of lithium in a cathode is inevitably consumed to form solid electrolyte interphase or trapped in the anode.Herein,we propose a comprehensive strategy for battery recycling and conduct the work by simply regenerating the degraded LFP materials directly with the extracted lithium compounds from spent anodes.Moreover,inter-particle three-dimensional(3D)conductive networks are built via an in situ carbonization to reinforce the electronic conductivity of regenerated cathodes.An improved electrochemical performance was achieved in the regenerated LFP materials even compared with the pristine LFP.This integrated recycling strategy not only brings more added value to the recycled materials by leveraging the recycling process but also aims to apply the concept of“treating waste with waste”and spur innovations in battery recycling technologies in the future.展开更多
文摘Objective: To investigate the analysis of atrial remodeling, fibrosis, oxidative stress and insulin resistance levels in patients with atrial fibrillation. Methods: 60 patients with atrial fibrillation treated in our hospital from December 2016 to January 2018 were selected as observation group, and 60 healthy persons in the same period were selected as control group. The expression levels of indexes in atrial remodeling [including osteoprotegerin (OPG), nuclear factor kappa beta receptor activating factor ligand (RANKL)], fibrosis [including transforming growth factor beta (TGF-beta) and tumor necrosis factor alpha (TNF-alpha)], oxidative stress [including reactive oxygen species (ROS) and advanced oxidation protein products (AOPP)] and insulin resistance [including human fibroblast growth factor -21 (FGF-21) and omentin-1 (Omentin-1)] were observed and compared between the two groups. Results: The level of Omentin-1 in observation group [(36.75±4.60) ug/L] was significantly lower than that in control group [(87.98±4.43) ug/L] (P<0.05). And there was no significant difference in AOPP level between the observation group and the control group [(13.75±2.13) micromol/L] (P>0.05). While the levels of atrial remodeling and fibrosis related indexes, ROS and FGF-21 in the observation group were significantly higher than those in the control group (P<0.05). Conclusions: Understanding the mechanism of atrial remodeling in patients with atrial fibrillation contributes to the prevention and treatment of atrial fibrillation. Patients with atrial fibrillation are not only prone to myocardial fibrosis, but also to oxidative stress and insulin resistance. The relevant indicators should be strengthened in clinical practice, so as to provide evidence for early diagnosis and treatment of the disease.
基金supported by the Basic Science Center Project of the National Natural Science Foundation of China under grant no.51788104,the National Key R&D Program of China(grant no.2021YFB2400200)the National Natural Science Foundation of China(grant nos.21905286,21773264,51772301)the“Transformational Technologies for Clean Energy and Demonstration,”Strategic Priority Research Program of the Chinese Academy of Sciences,grant no.XDA21070300.
文摘Enormous LiFePO_(4)(LFP)/graphite batteries retired from the market need urgent rational disposal and reutilization based on the degradation analysis of the evolutional mechanism for electrodes.Typically,Li inventory loss is one of the main reasons for the degradation of LFP-based batteries.The reduced portion of lithium in a cathode is inevitably consumed to form solid electrolyte interphase or trapped in the anode.Herein,we propose a comprehensive strategy for battery recycling and conduct the work by simply regenerating the degraded LFP materials directly with the extracted lithium compounds from spent anodes.Moreover,inter-particle three-dimensional(3D)conductive networks are built via an in situ carbonization to reinforce the electronic conductivity of regenerated cathodes.An improved electrochemical performance was achieved in the regenerated LFP materials even compared with the pristine LFP.This integrated recycling strategy not only brings more added value to the recycled materials by leveraging the recycling process but also aims to apply the concept of“treating waste with waste”and spur innovations in battery recycling technologies in the future.
