BACKGROUND An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer(CRC).However,no work is currently available to synthesize the field through bibliometr...BACKGROUND An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer(CRC).However,no work is currently available to synthesize the field through bibliometrics.AIM To analyze the development in the field of“glucose metabolism”(GM),“amino acid metabolism”(AM),“lipid metabolism”(LM),and“nucleotide metabolism”(NM)in CRC by visualization.METHODS Articles within the abovementioned areas of GM,AM,LM and NM in CRC,which were published from January 1,1991,to December 31,2022,are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6.2.R4 and VOSviewer 1.6.19.RESULTS The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three fields.Meanwhile,China and the United States were two of the most prominent contri-butors in these four areas.In addition,Gang Wang,Wei Jia,Maria Notar-nicola,and Cornelia Ulrich ranked first in publication numbers,while Jing-Yuan Fang,Senji Hirasawa,Wei Jia,and Charles Fuchs were the most cited authors on average in these four fields,respectively.“Gut microbiota”and“epithelial-mesenchymal transition”emerged as the newest burst words in GM,“gut microbiota”was the latest outburst word in AM,“metastasis”,“tumor microenvironment”,“fatty acid metabolism”,and“metabolic reprogramming”were the up-to-date outbreaking words in LM,while“epithelial-mesenchymal transition”and“apoptosis”were the most recently occurring words in NM.CONCLUSION Research in“cellular metabolism in CRC”is all the rage at the moment,and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in CRC.Targeting metabolic vulnerability appears to be a promising direction in CRC therapy.展开更多
AIM:To evaluate the diagnostic accuracy of magnetic resonance cholangiopancreatography(MRCP) in patients with choledocholithiasis.METHODS:We systematically searched MEDLINE,EMBASE,Web of Science,and Cochrane databases...AIM:To evaluate the diagnostic accuracy of magnetic resonance cholangiopancreatography(MRCP) in patients with choledocholithiasis.METHODS:We systematically searched MEDLINE,EMBASE,Web of Science,and Cochrane databases for studies reporting on the sensitivity,specificity and other accuracy measures of diagnostic effectiveness of MRCP for detection of common bile duct(CBD) stones.Pooled analysis was performed using random effects models,and receiver operating characteristic curves were generated to summarize overall test performance.Two reviewers independently assessed the methodological quality of studies using standards for reporting diagnostic accuracy and quality assessment for studies of diagnostic accuracy tools.RESULTS:A total of 25 studies involving 2310 patients with suspected choledocholithiasis and 738 patients with CBD stones met the inclusion criteria.The average inter-rater agreement on the methodological quality checklists was 0.96.Pooled analysis of the ability of MRCP to detect CBD stones showed the following effect estimates:sensitivity,0.90(95%CI:0.88-0.92,χ2 = 65.80; P < 0.001); specificity,0.95(95%CI:0.93-1.0,χ2 = 110.51; P < 0.001); positive likelihood ratio,13.28(95%CI:8.85-19.94,χ2 = 78.95; P < 0.001); negative likelihood ratio,0.13(95%CI:0.09-0.18,χ2 = 6.27; P < 0.001); and diagnostic odds ratio,143.82(95%CI:82.42-250.95,χ2 = 44.19; P < 0.001).The area under the receiver operating characteristic curve was 0.97.Significant publication bias was not detected(P = 0.266).CONCLUSION:MRCP has high diagnostic accuracy for the detection of choledocholithiasis.MRCP should be the method of choice for suspected cases of CBD stones.展开更多
Objective:Empathy can help establish harmonious nurse-patient relationships.We aimed to assess the status of empathy,and explore the relationship between learning burnout,parental rearing patterns and empathy amongst ...Objective:Empathy can help establish harmonious nurse-patient relationships.We aimed to assess the status of empathy,and explore the relationship between learning burnout,parental rearing patterns and empathy amongst nursing students.Method:A questionnaire survey that employed the Learning Burnout Scale,the Short-Form Egna Minnenav Barndoms Uppfostran(s-EMBU)and the Jefferson Scale of Empathy was conducted amongst 562 nursing students.The data were analysed on the basis of descriptive statistic and correlation analysis was used.Results:Empathy is negatively correlated with learning burnout,parental rejection and overprotection and showed no positive correlation with parental emotional warmth.Conclusions:Educators should pay attention to nursing students'feelings and learning burnout status and take positive measures to improve the empathy level of the students.Positive parental rearing patterns also help cultivate empathy.展开更多
基金National Natural Science Foundation of China,No.82173063 and No.81972220Wuxi Taihu Lake Talent Plan Supporting for Leading Talents in Medical and Health Profession+2 种基金Wuxi Medical Key Discipline,No.ZDXK2021002China Postdoctoral Science Foundation,No.2022M711370Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX23_2573.
文摘BACKGROUND An increasing number of studies have focused on the role of cellular metabolism in the development of colorectal cancer(CRC).However,no work is currently available to synthesize the field through bibliometrics.AIM To analyze the development in the field of“glucose metabolism”(GM),“amino acid metabolism”(AM),“lipid metabolism”(LM),and“nucleotide metabolism”(NM)in CRC by visualization.METHODS Articles within the abovementioned areas of GM,AM,LM and NM in CRC,which were published from January 1,1991,to December 31,2022,are retrieved from the Web of Science Core Collection and analyzed by CiteSpace 6.2.R4 and VOSviewer 1.6.19.RESULTS The field of LM in CRC presented the largest number of annual publications and the fastest increase in the last decade compared with the other three fields.Meanwhile,China and the United States were two of the most prominent contri-butors in these four areas.In addition,Gang Wang,Wei Jia,Maria Notar-nicola,and Cornelia Ulrich ranked first in publication numbers,while Jing-Yuan Fang,Senji Hirasawa,Wei Jia,and Charles Fuchs were the most cited authors on average in these four fields,respectively.“Gut microbiota”and“epithelial-mesenchymal transition”emerged as the newest burst words in GM,“gut microbiota”was the latest outburst word in AM,“metastasis”,“tumor microenvironment”,“fatty acid metabolism”,and“metabolic reprogramming”were the up-to-date outbreaking words in LM,while“epithelial-mesenchymal transition”and“apoptosis”were the most recently occurring words in NM.CONCLUSION Research in“cellular metabolism in CRC”is all the rage at the moment,and researchers are particularly interested in exploring the mechanism to explain the metabolic alterations in CRC.Targeting metabolic vulnerability appears to be a promising direction in CRC therapy.
文摘AIM:To evaluate the diagnostic accuracy of magnetic resonance cholangiopancreatography(MRCP) in patients with choledocholithiasis.METHODS:We systematically searched MEDLINE,EMBASE,Web of Science,and Cochrane databases for studies reporting on the sensitivity,specificity and other accuracy measures of diagnostic effectiveness of MRCP for detection of common bile duct(CBD) stones.Pooled analysis was performed using random effects models,and receiver operating characteristic curves were generated to summarize overall test performance.Two reviewers independently assessed the methodological quality of studies using standards for reporting diagnostic accuracy and quality assessment for studies of diagnostic accuracy tools.RESULTS:A total of 25 studies involving 2310 patients with suspected choledocholithiasis and 738 patients with CBD stones met the inclusion criteria.The average inter-rater agreement on the methodological quality checklists was 0.96.Pooled analysis of the ability of MRCP to detect CBD stones showed the following effect estimates:sensitivity,0.90(95%CI:0.88-0.92,χ2 = 65.80; P < 0.001); specificity,0.95(95%CI:0.93-1.0,χ2 = 110.51; P < 0.001); positive likelihood ratio,13.28(95%CI:8.85-19.94,χ2 = 78.95; P < 0.001); negative likelihood ratio,0.13(95%CI:0.09-0.18,χ2 = 6.27; P < 0.001); and diagnostic odds ratio,143.82(95%CI:82.42-250.95,χ2 = 44.19; P < 0.001).The area under the receiver operating characteristic curve was 0.97.Significant publication bias was not detected(P = 0.266).CONCLUSION:MRCP has high diagnostic accuracy for the detection of choledocholithiasis.MRCP should be the method of choice for suspected cases of CBD stones.
文摘Objective:Empathy can help establish harmonious nurse-patient relationships.We aimed to assess the status of empathy,and explore the relationship between learning burnout,parental rearing patterns and empathy amongst nursing students.Method:A questionnaire survey that employed the Learning Burnout Scale,the Short-Form Egna Minnenav Barndoms Uppfostran(s-EMBU)and the Jefferson Scale of Empathy was conducted amongst 562 nursing students.The data were analysed on the basis of descriptive statistic and correlation analysis was used.Results:Empathy is negatively correlated with learning burnout,parental rejection and overprotection and showed no positive correlation with parental emotional warmth.Conclusions:Educators should pay attention to nursing students'feelings and learning burnout status and take positive measures to improve the empathy level of the students.Positive parental rearing patterns also help cultivate empathy.
