Objective:To compare the efficacy of anal adenectomy with virtual hanging wire and anal fistulotomy in the treatment of low anal fistula in infants and children.Methods:60 children with low anal fistula who were admit...Objective:To compare the efficacy of anal adenectomy with virtual hanging wire and anal fistulotomy in the treatment of low anal fistula in infants and children.Methods:60 children with low anal fistula who were admitted to our hospital from October 2021 to March 2022 and met the inclusion criteria were randomly divided into two groups of 30 cases each;the treatment group was treated with anal adenectomy and virtual hanging wire surgery,and the control group was treated with anal fistula resection.The clinical efficacy after treatment was compared.Results:The total effective rate of both groups was 96.67%and the difference between the two groups was not statistically significant(P>0.05).The postoperative pain score of the treatment group was lower than that of the control group(P<0.05).The length of hospitalization and healing time of the treatment group was lower than that of the control group(P<0.05).The anal function of the patients in both groups was normal,and there was no adverse reaction.Conclusion:Anal gland excision and virtual hanging surgery for the treatment of low anal fistula in infants and children have the advantages of mild pain,reduced length of hospitalization,short healing time,and better patient experience as compared to anal fistula excision.展开更多
Blockchain technology promotes the development of the Internet of medical things(IoMT)from the centralized form to distributed trust mode as blockchain-based Internet of medical things(BIoMT).Although blockchain impro...Blockchain technology promotes the development of the Internet of medical things(IoMT)from the centralized form to distributed trust mode as blockchain-based Internet of medical things(BIoMT).Although blockchain improves the cross-institution data sharing ability,there still exist the problems of authentication difficulty and privacy leakage.This paper first describes the architecture of the BIoMT system and designs an anonymous authentication model for medical data sharing.This BIoMT system is divided into four layers:perceptual,network,platform,and application.The model integrates an anonymous authentication scheme to guarantee secure data sharing in the network ledger.Utilizing the untampered blockchain ledger can protect the privacy of medical data and system users.Then,an anonymous authentication scheme called the group blind signature(GBS)scheme is designed.This scheme can provide anonymity for the signer as that one member can represent the group to sign without exposing his identity.The blind property also can protect the message from being signed as it is anonymous to the signer.More-over,this GBS scheme is created with the lattice assumption,which makes it more secure against quantum attacks.In addition,the security proof shows that this GBS scheme can achieve the security properties of dynamical-almost-full anonymity,blindness,traceability,and non-frameability.The comparison analysis and performance evaluation of key size show that this GBS scheme is more efficient than similar schemes in other literature.展开更多
Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is hampered by a lack of resources. Amongst the most important resources for biological study are mo...Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is hampered by a lack of resources. Amongst the most important resources for biological study are monoclonal antibodies. Here, we characterize a panel of monoclonal antibodies specific for cellular prion protein by enzyme-linked immunosorbent assay(ELISA), immunofluorescent staining, flow cytometry, and western blotting. We identify several antibodies that can be used for specific applications and we demonstrate that there is no prion protein expression in human pancreatic ductal epithelial cells(HPDC).展开更多
Blockchain technology has become a research hotspot in recent years with the prominent characteristics as public,distributed and decentration.And blockchain-enabled internet of things(BIoT)has a tendency to make a rev...Blockchain technology has become a research hotspot in recent years with the prominent characteristics as public,distributed and decentration.And blockchain-enabled internet of things(BIoT)has a tendency to make a revolutionary change for the internet of things(IoT)which requires distributed trustless consensus.However,the scalability and security issues become particularly important with the dramatically increasing number of IoT devices.Especially,with the development of quantum computing,many extant cryptographic algorithms applied in blockchain or BIoT systems are vulnerable to the quantum attacks.In this paper,an anti-quantum proxy blind signature scheme based on the lattice cryptography has been proposed,which can provide user anonymity and untraceability in the distributed applications of BIoT.Then,the security proof of the proposed scheme can derive that it is secure in random oracle model,and the efficiency analysis can indicate it is efficient than other similar literatures.展开更多
Cold-chain logistics system(CCLS)plays the role of collecting and managing the logistics data of frozen food.However,there always exist problems of information loss,data tampering,and privacy leakage in traditional ce...Cold-chain logistics system(CCLS)plays the role of collecting and managing the logistics data of frozen food.However,there always exist problems of information loss,data tampering,and privacy leakage in traditional centralized systems,which influence frozen food security and people’s health.The centralized management form impedes the development of the cold-chain logistics industry and weakens logistics data availability.This paper first introduces a distributed CCLS based on blockchain technology to solve the centralized management problem.This system aggregates the production base,storage,transport,detection,processing,and consumer to form a cold-chain logistics union.The blockchain ledger guarantees that the logistics data cannot be tampered with and establishes a traceability mechanism for food safety incidents.Meanwhile,to improve the value of logistics data,a Stackelberg game-based resource allocation model has been proposed between the logistics data resource provider and the consumer.The competition between resource price and volume balances the resource supplement and consumption.This model can help to achieve an optimal resource price when the Stackelberg game obtains Nash equilibrium.The two participants also can maximize their revenues with the optimal resource price and volume by utilizing the backward induction method.Then,the performance evaluations of transaction throughput and latency show that the proposed distributed CCLS is more secure and stable.The simulations about the variation trend of data price and amount,optimal benefits,and total benefits comparison of different forms show that the resource allocation model is more efficient and practical.Moreover,the blockchain-based CCLS and Stackelberg game-based resource allocation model also can promote the value of logistic data and improve social benefits.展开更多
Internet of Medical Things(IoMT)plays an essential role in collecting and managing personal medical data.In recent years,blockchain technology has put power in traditional IoMT systems for data sharing between differe...Internet of Medical Things(IoMT)plays an essential role in collecting and managing personal medical data.In recent years,blockchain technology has put power in traditional IoMT systems for data sharing between different medical institutions and improved the utilization of medical data.However,some problems in the information transfer process between wireless medical devices and mobile medical apps,such as information leakage and privacy disclosure.This paper first designs a cross-device key agreement model for blockchain-enabled IoMT.This model can establish a key agreement mechanism for secure medical data sharing.Meanwhile,a certificateless authenticated key agreement(KA)protocol has been proposed to strengthen the information transfer security in the cross-device key agreement model.The proposed KA protocol only requires one exchange of messages between the two parties,which can improve the protocol execution efficiency.Then,any unauthorized tampering of the transmitted signed message sent by the sender can be detected by the receiver,so this can guarantee the success of the establishment of a session key between the strange entities.The blockchain ledger can ensure that the medical data cannot be tampered with,and the certificateless mechanism can weaken the key escrow problem.Moreover,the security proof and performance analysis are given,which show that the proposed model and KA protocol are more secure and efficient than other schemes in similar literature.展开更多
Data security and user privacy are two main security concerns in the cold-chain logistics system(CCLS).Many security issues exist in traditional CCLS,destroying data security and user privacy.The digital signature can...Data security and user privacy are two main security concerns in the cold-chain logistics system(CCLS).Many security issues exist in traditional CCLS,destroying data security and user privacy.The digital signature can provide data verification and identity authentication based on the mathematical difficulty problem for logistics data sharing in CCLS.This paper first established a blockchain-enabled cold-chain logistics system(BCCLS)based on union blockchain technology,which can provide secure data sharing among different logistics nodes and guarantee logistics data security with the untampered blockchain ledger.Meanwhile,a lattice-based undeniable signature scheme is designed to strengthen the security of logistics data and user privacy against quantum attacks.This scheme is based on the lattice assumption,which can provide anti-quantum security for BCCLS in the future quantum computer age.It also establishes the undeniable mechanism that guarantees that the actual signer cannot deny a valid signature.Then,security proof shows that this undeniable signature scheme is correct and safe,and an efficiency comparison shows that it is more efficient than other schemes in similar literature.The performance evaluations of transaction throughput and latency show that the proposed BCCLS is efficient and practical.This work can improve the security and efficiency of logistics data management and promote the reform and development of the logistics industry.展开更多
With the continuous improvement of urban residents’lives,the demand for of urban infrastructure construction increases,requiring more and more advanced engineering technology.We should not only speed up the progress ...With the continuous improvement of urban residents’lives,the demand for of urban infrastructure construction increases,requiring more and more advanced engineering technology.We should not only speed up the progress of the project,but also reduce the impact of the construction on the surrounding environment.Our company has had several achievements in this regard,and prefabricated open caisson construction process is one of them.In this paper,the application of prefabricated caisson construction method is analyzed in depth according to the actual situation of the rain sewage reconstruction treatment project of Minghe ecological water system in Dancheng County.Through practice,it is concluded that this construction method greatly improves the construction efficiency,shortens the overall construction process,reduces the construction cost,and effectively improves environmental quality of the construction site,which has good reference value.展开更多
The measurement of impurity distribution in the divertor region of tokamaks is key to studying edge impurity transport.Therefore,a space-resolved vacuum-ultraviolet(VUV)spectrometer is designed to measure impurity emi...The measurement of impurity distribution in the divertor region of tokamaks is key to studying edge impurity transport.Therefore,a space-resolved vacuum-ultraviolet(VUV)spectrometer is designed to measure impurity emission in the divertor region on EAST.For good spectral resolution,an eagle-type VUV spectrometer with 1 m long focal length with spherical holograph grating is used in the system.For light collection,a collimating mirror is installed between the EAST plasma and the VUV spectrometer to extend the observing range to cover the upper divertor region.Two types of detectors,i.e.a back-illuminated charge-coupled device detector and a photomultiplier-tube detector,are adopted for the spectral measurement and high-frequency intensity measurement for feedback control,respectively.The angle between the entrance and exit optical axis is fixed at 15°.The detector can be moved along the exit axis to maintain a good focusing position when the wavelength is scanned by rotating the grating.The profile of impurity emissions is projected through the space-resolved slit,which is set horizontally.The spectrometer is equipped with two gratings with 2400 grooves/mm and2160 grooves/mm,respectively.The overall aberration of the system is reduced by accurate detector positioning.As a result,the total spectral broadening can be reduced to about 0.013 nm.The simulated performance of the system is found to satisfy the requirement of measurement of impurity emissions from the divertor area of the EAST tokamak.展开更多
Along with the increase of wearable medical device,the privacy leakage problem in the process of transmission between these edge medical devices.The blockchain-enabled Internet of Medical Things(BIoMT)has been develop...Along with the increase of wearable medical device,the privacy leakage problem in the process of transmission between these edge medical devices.The blockchain-enabled Internet of Medical Things(BIoMT)has been developed to reform traditional centralized medical system in recent years.This paper first introduces a data anonymous authentication model to protect user privacy and medical data in BIoMT.Then,a proxy group signature(PGS)scheme has been proposed based on lattice assumption.This scheme can well satisfy the anonymous authentication demand for the proposed model,and provide anti-quantum attack security for BIoMT in the future general quantum computer age.Moreover,the security analysis shows this PGS scheme is secure against the dynamical-almost-full anonymous and traceability.The efficiency comparison shows the proposed model and PGS scheme is more efficient and practical.展开更多
Aiming at coherence degradation during target detection,a suppressing method based on frequency-modulated continuous wave coherent lidar is proposed.Combined with a random iteration algorithm,a long-pulse echo signal ...Aiming at coherence degradation during target detection,a suppressing method based on frequency-modulated continuous wave coherent lidar is proposed.Combined with a random iteration algorithm,a long-pulse echo signal with coherent degradation is matched with random phase noise of a certain frequency and achieves coherence restoration.Simulation and field experiment results show that this proposed method can recover the intrapulse coherence in long-pulse echo signals.In addition,for the real target echo signal at 4.2 and 19.8 km,the peak signal-to-noise ratio processed by this method is increased by 0.35 times and 4 times after pulse compression,respectively.展开更多
A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has...A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has been considered as an infectious disease in the past decades as it shows strain specificity and transmission potential.Although it remains elusive how protein aggregation leads to AD,it is becoming clear that cellular prion protein(PrP^c)plays an important role in AD pathogenesis.Here,we briefly reviewed AD pathogenesis and focused on recent progresses how PrP^c contributed to AD development.In addition,we proposed a potential mechanism to explain why infectious agents,such as viruses,conduce AD pathogenesis.Microbe infections cause AD deposition and upregulation of PrP^c,which lead to high affinity binding between AD oligomers and PrP^c.The interaction between PrP^c and AP oligomers in turn activates the Fyn signaling cascade,resulting in neuron death in the central nervous system(CNS).Thus,silencing PrP^c expression may turn out be an effective treatment for PrP^c dependent AD.展开更多
Hepatitis C virus(HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is compl...Hepatitis C virus(HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is complex and not completely understood. Here, we found that the expression of host prion protein(Pr P) was induced in an HCV replication cell model. We then showed that increased Pr P expression facilitated HCV genomic replication. Finally, we demonstrated that the KKRPK motif on the N-terminus of Pr P bound nucleic acids and facilitated HCV genomic replication. Our results provided important insights into how viruses may harness cellular protein to achieve propagation.展开更多
The spin Hall effect of light(SHEL) is a photonic version of the spin Hall effect in electronic systems and has been studied for more than 10 years. However, the lack of effective methods for dynamic modulation of spi...The spin Hall effect of light(SHEL) is a photonic version of the spin Hall effect in electronic systems and has been studied for more than 10 years. However, the lack of effective methods for dynamic modulation of spin-dependent splitting may hinder its applications. By introducing additional spin-orbit coupling of photons or nonreciprocal phase shift(NRPS), the magneto-optical Kerr effect may be one of the methods to alleviate the situation. Here, we experimentally reveal an enhanced and tunable SHEL in magneto-optical oxide thin films under the transverse magneto-optical Kerr effect configuration for the first time, to the best of our knowledge, which can be regarded as the magneto-optical SHEL(MOSHEL). We study the magneto-optical response of the multilayer structure and select the optimal structural parameters by the magneto-optical transfer matrix method. With a transverse magnetic field along opposite directions, an obvious SHEL shift difference of H-polarized light caused by NRPS is observed via a weak measurement method. With optimal parameters, the maximum measured shift difference of the SHEL achieves about 70 μm. The demonstrated MOSHEL phenomenon may accelerate the application of the SHEL in the field of spin photonics devices and precision metrology.展开更多
Purpose A charged particle detector(CPD)is one of two main detectors on the GECAM satellite.It was designed to detect charged particles.Electrons and protons are space’s mainly charged particles.So,a research on the ...Purpose A charged particle detector(CPD)is one of two main detectors on the GECAM satellite.It was designed to detect charged particles.Electrons and protons are space’s mainly charged particles.So,a research on the proton detection ability of a CPD and deriving the energy response to charged particles of the CPD in the two designed operating modes is important.Method The proton calibration tests of the CPD under diferent working modes were carried out at the Heavy Ion Research Facility in Lanzhou.Result and conclusion Through testing and analysis,it was concluded that when CPD works in semi-component mode,it can detect the maximum energy,and when working in full-component mode,it can provide better energy resolution.展开更多
In this paper,the Pt/SnO2 nanostructures were prepared via a facile one-step microwave assisted hydrothermal route.The structure of the introduced Pt/SnO2 and its gas-sensing properties toward CO were investigated.The...In this paper,the Pt/SnO2 nanostructures were prepared via a facile one-step microwave assisted hydrothermal route.The structure of the introduced Pt/SnO2 and its gas-sensing properties toward CO were investigated.The results from the TEM test reveal that Pt grows on the SnO2 nanostructure,which was not found for bulk in this situ method,constructing Pt/SnO2.The results indicated that the sensor using 3.0 wt%Pt/SnO2 to 100 ppm carbon monoxide performed a superior sensing properties compared to 1.5 wt%and 4.5 wt%Pt/SnO2 at 225℃.The response time of 3.0 wt%sensor is 16 s to 100 ppm CO at225℃.Such enhanced gas sensing performances could be attributed to the chemical and electrical factors.In view of chemical factors,the presence of Pt facilitates the surface reaction,which will improve the gas sensing properties.With respect to the electrical factors,the Pt/SnO2 plays roles in increasing the sensor’s response due to its characteristic configuration.In addition,the one-step in situ microwave assisted process provides a promising and versatile choice for the preparation of gas sensing materials.展开更多
Unfolded protein response(UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum(ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, cancer cells may harness ER stress to f...Unfolded protein response(UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum(ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, cancer cells may harness ER stress to facilitate their survival and growth. Prion protein(PrP) is a glycosylated cell surface protein that has been shown to be up-regulated in many cancer cells. Since PrP is a protein prone to misfolding, ER stress can result in under-glycosylated PrP, which in turn may activate ER stress. To assess whether ER stress leads to the production of under-glycosylated PrP and whether underglycosylated PrP may contribute to ER stress thus leading to cancer cell apoptosis, we treated different cancer cells with brefeldin A(BFA), thapsigargin(Thps), and tunicamycin(TM). We found that although BFA, Thps, and TM treatment activated UPR, only ATF4 was consistently activated by these reagents, but not other branches of ER stress. However, the canonical PERK-eIF2α-ATF4 did not account for the observed activation of ATF4 in lung cancer cells. In addition, BFA,but neither Thps nor TM, significantly stimulated the expression of cytosolic PrP. Finally, we found that the levels of PrP contributed to anti-apoptosis activity of BFA-induced cancer cell death. Thus, the pathway of BFA-induced persistent ER stress may be targeted for lung and pancreatic cancer treatment.展开更多
Converting CO_(2)into carbonaceous fuels via photocatalysis represents an appealing strategy to simultaneously alleviate the energy crisis and associated environmental problems,yet designing with high photoreduction a...Converting CO_(2)into carbonaceous fuels via photocatalysis represents an appealing strategy to simultaneously alleviate the energy crisis and associated environmental problems,yet designing with high photoreduction activity catalysts remains a compelling challenge.Here,combining the merits of highly porous structure and maximum atomic efficiency,we rationally constructed covalent triazine-based frameworks(CTFs)anchoring copper single atoms(Cu-SA/CTF)photocatalysts for efficient CO_(2)conversion.The Cu single atoms were visualized by high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)images and coordination structure of Cu-N-C2 sites was revealed by extended X-ray absorption fine structure(EXAFS)analyses.The as-prepared Cu-SA/CTF photocatalysts exhibited superior photocatalytic CO_(2)conversion to CH4 performance associated with a high selectivity of 98.31%.Significantly,the introduction of Cu single atoms endowed the CuSA/CTF catalysts with increased CO_(2)adsorption capacity,strengthened visible light responsive ability,and improved the photogenerated carriers separation efficiency,thus enhancing the photocatalytic activity.This work provides useful guidelines for designing robust visible light responsive photoreduction CO_(2)catalysts on the atomic scale.展开更多
An optical phase locking method based on direct phase control is proposed.The core of this method is to synchronize the carrier by directly changing the phase of the local beam.The corresponding experimental device an...An optical phase locking method based on direct phase control is proposed.The core of this method is to synchronize the carrier by directly changing the phase of the local beam.The corresponding experimental device and the supporting algorithm were configured to verify the feasibility of this method.Phase locking can be completed without cycle skipping,and the acquisition time is 530 ns.Without an optical preamplifier,a sensitivity of-34.4 d Bm is obtained,and the bit error rate is 10^(-9) for 2.5 Gbit/s binary phase-shift keying modulation.The measured standard deviation of the phase error is 5.2805°.展开更多
基金Xi’an Municipal Bureau of Science and Technology,No.21YXYJ0060。
文摘Objective:To compare the efficacy of anal adenectomy with virtual hanging wire and anal fistulotomy in the treatment of low anal fistula in infants and children.Methods:60 children with low anal fistula who were admitted to our hospital from October 2021 to March 2022 and met the inclusion criteria were randomly divided into two groups of 30 cases each;the treatment group was treated with anal adenectomy and virtual hanging wire surgery,and the control group was treated with anal fistula resection.The clinical efficacy after treatment was compared.Results:The total effective rate of both groups was 96.67%and the difference between the two groups was not statistically significant(P>0.05).The postoperative pain score of the treatment group was lower than that of the control group(P<0.05).The length of hospitalization and healing time of the treatment group was lower than that of the control group(P<0.05).The anal function of the patients in both groups was normal,and there was no adverse reaction.Conclusion:Anal gland excision and virtual hanging surgery for the treatment of low anal fistula in infants and children have the advantages of mild pain,reduced length of hospitalization,short healing time,and better patient experience as compared to anal fistula excision.
基金supported by the National Natural Science Foundation of China under Grant 61962009the Doctor Scientific Research Fund of Zhengzhou University of Light Industry under Grant 2021BSJJ033+2 种基金the Key Scientific Research Project of Colleges and Universities in Henan Province(CN)underGrant No.22A413010the Foundation and Cutting-Edge Technologies Research Program of Henan Province(CN)under Grant No.222102210161the Natural Science Foundation of Henan Province(CN)under Grant No.222300420582.
文摘Blockchain technology promotes the development of the Internet of medical things(IoMT)from the centralized form to distributed trust mode as blockchain-based Internet of medical things(BIoMT).Although blockchain improves the cross-institution data sharing ability,there still exist the problems of authentication difficulty and privacy leakage.This paper first describes the architecture of the BIoMT system and designs an anonymous authentication model for medical data sharing.This BIoMT system is divided into four layers:perceptual,network,platform,and application.The model integrates an anonymous authentication scheme to guarantee secure data sharing in the network ledger.Utilizing the untampered blockchain ledger can protect the privacy of medical data and system users.Then,an anonymous authentication scheme called the group blind signature(GBS)scheme is designed.This scheme can provide anonymity for the signer as that one member can represent the group to sign without exposing his identity.The blind property also can protect the message from being signed as it is anonymous to the signer.More-over,this GBS scheme is created with the lattice assumption,which makes it more secure against quantum attacks.In addition,the security proof shows that this GBS scheme can achieve the security properties of dynamical-almost-full anonymity,blindness,traceability,and non-frameability.The comparison analysis and performance evaluation of key size show that this GBS scheme is more efficient than similar schemes in other literature.
基金the National Natural Sciences Foundation of China(81172376,31270209)the 100 talent-program of the Chinese Academy of Sciencesthe State Key Laboratory of Virology for financial support
文摘Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is hampered by a lack of resources. Amongst the most important resources for biological study are monoclonal antibodies. Here, we characterize a panel of monoclonal antibodies specific for cellular prion protein by enzyme-linked immunosorbent assay(ELISA), immunofluorescent staining, flow cytometry, and western blotting. We identify several antibodies that can be used for specific applications and we demonstrate that there is no prion protein expression in human pancreatic ductal epithelial cells(HPDC).
文摘Blockchain technology has become a research hotspot in recent years with the prominent characteristics as public,distributed and decentration.And blockchain-enabled internet of things(BIoT)has a tendency to make a revolutionary change for the internet of things(IoT)which requires distributed trustless consensus.However,the scalability and security issues become particularly important with the dramatically increasing number of IoT devices.Especially,with the development of quantum computing,many extant cryptographic algorithms applied in blockchain or BIoT systems are vulnerable to the quantum attacks.In this paper,an anti-quantum proxy blind signature scheme based on the lattice cryptography has been proposed,which can provide user anonymity and untraceability in the distributed applications of BIoT.Then,the security proof of the proposed scheme can derive that it is secure in random oracle model,and the efficiency analysis can indicate it is efficient than other similar literatures.
基金supported by the National Natural Science Foundation of China under Grant 92046001,61962009the Doctor Scientific Research Fund of Zhengzhou University of Light Industry underGrant 2021BSJJ033Key ScientificResearch Project of Colleges andUniversities in Henan Province(CN)under Grant No.22A413010.
文摘Cold-chain logistics system(CCLS)plays the role of collecting and managing the logistics data of frozen food.However,there always exist problems of information loss,data tampering,and privacy leakage in traditional centralized systems,which influence frozen food security and people’s health.The centralized management form impedes the development of the cold-chain logistics industry and weakens logistics data availability.This paper first introduces a distributed CCLS based on blockchain technology to solve the centralized management problem.This system aggregates the production base,storage,transport,detection,processing,and consumer to form a cold-chain logistics union.The blockchain ledger guarantees that the logistics data cannot be tampered with and establishes a traceability mechanism for food safety incidents.Meanwhile,to improve the value of logistics data,a Stackelberg game-based resource allocation model has been proposed between the logistics data resource provider and the consumer.The competition between resource price and volume balances the resource supplement and consumption.This model can help to achieve an optimal resource price when the Stackelberg game obtains Nash equilibrium.The two participants also can maximize their revenues with the optimal resource price and volume by utilizing the backward induction method.Then,the performance evaluations of transaction throughput and latency show that the proposed distributed CCLS is more secure and stable.The simulations about the variation trend of data price and amount,optimal benefits,and total benefits comparison of different forms show that the resource allocation model is more efficient and practical.Moreover,the blockchain-based CCLS and Stackelberg game-based resource allocation model also can promote the value of logistic data and improve social benefits.
基金supported by the National Natural Science Foundation of China under Grant 92046001,61962009,the JSPS KAKENHI Grant Numbers JP19K20250,JP20H04174,JP22K11989Leading Initiative for Excellent Young Researchers (LEADER),MEXT,Japan,and JST,PRESTO Grant Number JPMJPR21P3+1 种基金Japan.Mianxiong Dong is the corresponding author,the Doctor Scientific Research Fund of Zhengzhou University of Light Industry under Grant 2021BSJJ033Key Scientific Research Project of Colleges and Universities in Henan Province (CN)under Grant No.22A413010.
文摘Internet of Medical Things(IoMT)plays an essential role in collecting and managing personal medical data.In recent years,blockchain technology has put power in traditional IoMT systems for data sharing between different medical institutions and improved the utilization of medical data.However,some problems in the information transfer process between wireless medical devices and mobile medical apps,such as information leakage and privacy disclosure.This paper first designs a cross-device key agreement model for blockchain-enabled IoMT.This model can establish a key agreement mechanism for secure medical data sharing.Meanwhile,a certificateless authenticated key agreement(KA)protocol has been proposed to strengthen the information transfer security in the cross-device key agreement model.The proposed KA protocol only requires one exchange of messages between the two parties,which can improve the protocol execution efficiency.Then,any unauthorized tampering of the transmitted signed message sent by the sender can be detected by the receiver,so this can guarantee the success of the establishment of a session key between the strange entities.The blockchain ledger can ensure that the medical data cannot be tampered with,and the certificateless mechanism can weaken the key escrow problem.Moreover,the security proof and performance analysis are given,which show that the proposed model and KA protocol are more secure and efficient than other schemes in similar literature.
基金This work was supported by the National Natural Science Foundation of China under Grant 92046001,61962009the Doctor Scientific Research Fund of Zhengzhou University of Light Industry underGrant 2021BSJJ033Key ScientificResearch Project of Colleges andUniversities in Henan Province(CN)under Grant No.22A413010.
文摘Data security and user privacy are two main security concerns in the cold-chain logistics system(CCLS).Many security issues exist in traditional CCLS,destroying data security and user privacy.The digital signature can provide data verification and identity authentication based on the mathematical difficulty problem for logistics data sharing in CCLS.This paper first established a blockchain-enabled cold-chain logistics system(BCCLS)based on union blockchain technology,which can provide secure data sharing among different logistics nodes and guarantee logistics data security with the untampered blockchain ledger.Meanwhile,a lattice-based undeniable signature scheme is designed to strengthen the security of logistics data and user privacy against quantum attacks.This scheme is based on the lattice assumption,which can provide anti-quantum security for BCCLS in the future quantum computer age.It also establishes the undeniable mechanism that guarantees that the actual signer cannot deny a valid signature.Then,security proof shows that this undeniable signature scheme is correct and safe,and an efficiency comparison shows that it is more efficient than other schemes in similar literature.The performance evaluations of transaction throughput and latency show that the proposed BCCLS is efficient and practical.This work can improve the security and efficiency of logistics data management and promote the reform and development of the logistics industry.
文摘With the continuous improvement of urban residents’lives,the demand for of urban infrastructure construction increases,requiring more and more advanced engineering technology.We should not only speed up the progress of the project,but also reduce the impact of the construction on the surrounding environment.Our company has had several achievements in this regard,and prefabricated open caisson construction process is one of them.In this paper,the application of prefabricated caisson construction method is analyzed in depth according to the actual situation of the rain sewage reconstruction treatment project of Minghe ecological water system in Dancheng County.Through practice,it is concluded that this construction method greatly improves the construction efficiency,shortens the overall construction process,reduces the construction cost,and effectively improves environmental quality of the construction site,which has good reference value.
基金the National Magnetic Confinement Fusion Science Program of China(Nos.2017YFE0301300,2019YFE03030002 and 2018YFE0303103)National Natural Science Foundation of China(No.12175278)+7 种基金Anhui Province Key Research and Development Program(No.202104a06020021)ASIPP Science and Research Grant(No.DSJJ-2020-02)Anhui Provincial Natural Science Foundation(No.1908085J01)Distinguished Young Scholar of Anhui Provincial Natural Science Foundation(No.2008085QA39)Instrument Developing Project of the Chinese Academy of Sciences(No.YJKYYQ20180013)the Comprehensive Research Facility for Fusion Technology Program of China(No.2018-000052-73-01-001228)the University Synergy Innovation Program of Anhui Province(No.GXXT-2021-029)CAS President’s International Fellowship Initiative(No.2022VMB0007)。
文摘The measurement of impurity distribution in the divertor region of tokamaks is key to studying edge impurity transport.Therefore,a space-resolved vacuum-ultraviolet(VUV)spectrometer is designed to measure impurity emission in the divertor region on EAST.For good spectral resolution,an eagle-type VUV spectrometer with 1 m long focal length with spherical holograph grating is used in the system.For light collection,a collimating mirror is installed between the EAST plasma and the VUV spectrometer to extend the observing range to cover the upper divertor region.Two types of detectors,i.e.a back-illuminated charge-coupled device detector and a photomultiplier-tube detector,are adopted for the spectral measurement and high-frequency intensity measurement for feedback control,respectively.The angle between the entrance and exit optical axis is fixed at 15°.The detector can be moved along the exit axis to maintain a good focusing position when the wavelength is scanned by rotating the grating.The profile of impurity emissions is projected through the space-resolved slit,which is set horizontally.The spectrometer is equipped with two gratings with 2400 grooves/mm and2160 grooves/mm,respectively.The overall aberration of the system is reduced by accurate detector positioning.As a result,the total spectral broadening can be reduced to about 0.013 nm.The simulated performance of the system is found to satisfy the requirement of measurement of impurity emissions from the divertor area of the EAST tokamak.
基金This work was supported by the National Natural Science Foundation of China under Grants 92046001,61962009the Doctor Scientific Research Fund of Zhengzhou University of Light Industry under Grant 2021BSJJ033Key Scientific Research Project of Colleges and Universities in Henan Province(CN)under Grant No.22A413010。
文摘Along with the increase of wearable medical device,the privacy leakage problem in the process of transmission between these edge medical devices.The blockchain-enabled Internet of Medical Things(BIoMT)has been developed to reform traditional centralized medical system in recent years.This paper first introduces a data anonymous authentication model to protect user privacy and medical data in BIoMT.Then,a proxy group signature(PGS)scheme has been proposed based on lattice assumption.This scheme can well satisfy the anonymous authentication demand for the proposed model,and provide anti-quantum attack security for BIoMT in the future general quantum computer age.Moreover,the security analysis shows this PGS scheme is secure against the dynamical-almost-full anonymous and traceability.The efficiency comparison shows the proposed model and PGS scheme is more efficient and practical.
基金supported by the National Key Research and Development Program of China(No.2020YFB0408302)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB43030400)。
文摘Aiming at coherence degradation during target detection,a suppressing method based on frequency-modulated continuous wave coherent lidar is proposed.Combined with a random iteration algorithm,a long-pulse echo signal with coherent degradation is matched with random phase noise of a certain frequency and achieves coherence restoration.Simulation and field experiment results show that this proposed method can recover the intrapulse coherence in long-pulse echo signals.In addition,for the real target echo signal at 4.2 and 19.8 km,the peak signal-to-noise ratio processed by this method is increased by 0.35 times and 4 times after pulse compression,respectively.
基金supported by National Natural Science Foundation of China (31670170 and 31270209)by Ministry monomer, GAG facilitates Aβ fibrilization by pulling PrPC monomer to oligomerize
文摘A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has been considered as an infectious disease in the past decades as it shows strain specificity and transmission potential.Although it remains elusive how protein aggregation leads to AD,it is becoming clear that cellular prion protein(PrP^c)plays an important role in AD pathogenesis.Here,we briefly reviewed AD pathogenesis and focused on recent progresses how PrP^c contributed to AD development.In addition,we proposed a potential mechanism to explain why infectious agents,such as viruses,conduce AD pathogenesis.Microbe infections cause AD deposition and upregulation of PrP^c,which lead to high affinity binding between AD oligomers and PrP^c.The interaction between PrP^c and AP oligomers in turn activates the Fyn signaling cascade,resulting in neuron death in the central nervous system(CNS).Thus,silencing PrP^c expression may turn out be an effective treatment for PrP^c dependent AD.
基金supported by the Strategic Priority Research Program A of the Chinese Academy of Sciences(XDA12010309)the National Science Foundation of China(31670170)+1 种基金the Nature Science Foundation of Hubei Province(2015CFA087)the National Basic Research Priorities Program of China(2013CB911102)
文摘Hepatitis C virus(HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is complex and not completely understood. Here, we found that the expression of host prion protein(Pr P) was induced in an HCV replication cell model. We then showed that increased Pr P expression facilitated HCV genomic replication. Finally, we demonstrated that the KKRPK motif on the N-terminus of Pr P bound nucleic acids and facilitated HCV genomic replication. Our results provided important insights into how viruses may harness cellular protein to achieve propagation.
基金Sichuan Science and Technology Program(2019JDJQ0003)Open Project Program of State Key Laboratory of Marine Resource Utilization in South China Sea(2019010)National Natural Science Foundation of China(NSFC)(61505016,61751103,51522204)
文摘The spin Hall effect of light(SHEL) is a photonic version of the spin Hall effect in electronic systems and has been studied for more than 10 years. However, the lack of effective methods for dynamic modulation of spin-dependent splitting may hinder its applications. By introducing additional spin-orbit coupling of photons or nonreciprocal phase shift(NRPS), the magneto-optical Kerr effect may be one of the methods to alleviate the situation. Here, we experimentally reveal an enhanced and tunable SHEL in magneto-optical oxide thin films under the transverse magneto-optical Kerr effect configuration for the first time, to the best of our knowledge, which can be regarded as the magneto-optical SHEL(MOSHEL). We study the magneto-optical response of the multilayer structure and select the optimal structural parameters by the magneto-optical transfer matrix method. With a transverse magnetic field along opposite directions, an obvious SHEL shift difference of H-polarized light caused by NRPS is observed via a weak measurement method. With optimal parameters, the maximum measured shift difference of the SHEL achieves about 70 μm. The demonstrated MOSHEL phenomenon may accelerate the application of the SHEL in the field of spin photonics devices and precision metrology.
基金This work was supported by the National Natural Science Foundation of China(Projects:11975257,12074045,11804335).
文摘Purpose A charged particle detector(CPD)is one of two main detectors on the GECAM satellite.It was designed to detect charged particles.Electrons and protons are space’s mainly charged particles.So,a research on the proton detection ability of a CPD and deriving the energy response to charged particles of the CPD in the two designed operating modes is important.Method The proton calibration tests of the CPD under diferent working modes were carried out at the Heavy Ion Research Facility in Lanzhou.Result and conclusion Through testing and analysis,it was concluded that when CPD works in semi-component mode,it can detect the maximum energy,and when working in full-component mode,it can provide better energy resolution.
基金supported by the National Natural Science Foundation of China (No.61803172)the Start-up Research Foundation of Hainan University (No.KYQD(ZR)1910)。
文摘In this paper,the Pt/SnO2 nanostructures were prepared via a facile one-step microwave assisted hydrothermal route.The structure of the introduced Pt/SnO2 and its gas-sensing properties toward CO were investigated.The results from the TEM test reveal that Pt grows on the SnO2 nanostructure,which was not found for bulk in this situ method,constructing Pt/SnO2.The results indicated that the sensor using 3.0 wt%Pt/SnO2 to 100 ppm carbon monoxide performed a superior sensing properties compared to 1.5 wt%and 4.5 wt%Pt/SnO2 at 225℃.The response time of 3.0 wt%sensor is 16 s to 100 ppm CO at225℃.Such enhanced gas sensing performances could be attributed to the chemical and electrical factors.In view of chemical factors,the presence of Pt facilitates the surface reaction,which will improve the gas sensing properties.With respect to the electrical factors,the Pt/SnO2 plays roles in increasing the sensor’s response due to its characteristic configuration.In addition,the one-step in situ microwave assisted process provides a promising and versatile choice for the preparation of gas sensing materials.
基金supported by the Strategic Priority Research Program A of the Chinese Academy of Sciences (XDA12010309)the National Natural Science Foundation of China (31670170 and 31270209)+1 种基金the National Key R&D program of China (2018YFA0507201)the National Basic Research Priorities Program of China (2013CB911102) from the Ministry of Science and Technology of China
文摘Unfolded protein response(UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum(ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, cancer cells may harness ER stress to facilitate their survival and growth. Prion protein(PrP) is a glycosylated cell surface protein that has been shown to be up-regulated in many cancer cells. Since PrP is a protein prone to misfolding, ER stress can result in under-glycosylated PrP, which in turn may activate ER stress. To assess whether ER stress leads to the production of under-glycosylated PrP and whether underglycosylated PrP may contribute to ER stress thus leading to cancer cell apoptosis, we treated different cancer cells with brefeldin A(BFA), thapsigargin(Thps), and tunicamycin(TM). We found that although BFA, Thps, and TM treatment activated UPR, only ATF4 was consistently activated by these reagents, but not other branches of ER stress. However, the canonical PERK-eIF2α-ATF4 did not account for the observed activation of ATF4 in lung cancer cells. In addition, BFA,but neither Thps nor TM, significantly stimulated the expression of cytosolic PrP. Finally, we found that the levels of PrP contributed to anti-apoptosis activity of BFA-induced cancer cell death. Thus, the pathway of BFA-induced persistent ER stress may be targeted for lung and pancreatic cancer treatment.
基金the National Natural Science Foundation of China(Nos.51672047,21707173,and 21701168)Dalian high level talent innovation project(No.2019RQ063)+2 种基金the National Natural Science Foundation of Fujian Province(Nos.2019J01648 and 2019J01226)Open project Foundation of State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences(No.20200021)the Youth Talent Support Program of Fujian Province(No.00387077).
文摘Converting CO_(2)into carbonaceous fuels via photocatalysis represents an appealing strategy to simultaneously alleviate the energy crisis and associated environmental problems,yet designing with high photoreduction activity catalysts remains a compelling challenge.Here,combining the merits of highly porous structure and maximum atomic efficiency,we rationally constructed covalent triazine-based frameworks(CTFs)anchoring copper single atoms(Cu-SA/CTF)photocatalysts for efficient CO_(2)conversion.The Cu single atoms were visualized by high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)images and coordination structure of Cu-N-C2 sites was revealed by extended X-ray absorption fine structure(EXAFS)analyses.The as-prepared Cu-SA/CTF photocatalysts exhibited superior photocatalytic CO_(2)conversion to CH4 performance associated with a high selectivity of 98.31%.Significantly,the introduction of Cu single atoms endowed the CuSA/CTF catalysts with increased CO_(2)adsorption capacity,strengthened visible light responsive ability,and improved the photogenerated carriers separation efficiency,thus enhancing the photocatalytic activity.This work provides useful guidelines for designing robust visible light responsive photoreduction CO_(2)catalysts on the atomic scale.
基金supported by the National Key R&D Program of China(No.2020YFB0408302)Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB43030400)+1 种基金National Natural Science Foundation of China(No.91938302)Key Project of Chinese Academy of Sciences(No.ZDRWKT-2019-1-01-0302)。
文摘An optical phase locking method based on direct phase control is proposed.The core of this method is to synchronize the carrier by directly changing the phase of the local beam.The corresponding experimental device and the supporting algorithm were configured to verify the feasibility of this method.Phase locking can be completed without cycle skipping,and the acquisition time is 530 ns.Without an optical preamplifier,a sensitivity of-34.4 d Bm is obtained,and the bit error rate is 10^(-9) for 2.5 Gbit/s binary phase-shift keying modulation.The measured standard deviation of the phase error is 5.2805°.
