Objective:To investigate the prevalence,clinical and bacteriological features and outcome of extrapulmonary tuberculosis in patients attending a tertiary care hospital at Kota Bharu,Kelantan.Methods:All culture positi...Objective:To investigate the prevalence,clinical and bacteriological features and outcome of extrapulmonary tuberculosis in patients attending a tertiary care hospital at Kota Bharu,Kelantan.Methods:All culture positive tuberculosis cases recorded in Hospital Universiti Sains Malaysia at Kota Bharu during five years period from 2003-2007 were included in the study.Mycobacterium detected in samples originating from sites other than lungs was considered as a case of extrapulmonary tuberculosis.Age,site of infection,bacteriological findings and outcomes were analyzed.Results:Out of 437 tuberculosis cases recorded from 2002-2006,59 cases had culture positive extrapulmonary tuberculosis.Their mean age was 37 years and 44%were between the ages of 20-40 years.About 63%were negative for acid-fast bacilli by Z-N stain.Of the 59,97%was Mycobacterium tuberculosisc(M.tuberculosis) while two(3%) were atypical Mycobacterium Runyon Group-Ⅳ.Only 3 (5%) were isoniazid resistant.Extrapulmonary sites involved were lymph nodes 19(31%),central nervous system 12(20%),pleural 11(19%) spine 8(14%).,renal 3(5.1%) and others 6(10.2%).In this series, 11(18%) were positive for HIV.There was no significant association between extrapulmonary tuberculosis and HIV status.The outcome of CNS tuberculosis was the poorest with a mortality rate of 25%.Conclusion: M.tuberculosis is the predominant organism in extrapulmonary tuberculosis and culture is the most effective method for its diagnosis.展开更多
文摘Objective:To investigate the prevalence,clinical and bacteriological features and outcome of extrapulmonary tuberculosis in patients attending a tertiary care hospital at Kota Bharu,Kelantan.Methods:All culture positive tuberculosis cases recorded in Hospital Universiti Sains Malaysia at Kota Bharu during five years period from 2003-2007 were included in the study.Mycobacterium detected in samples originating from sites other than lungs was considered as a case of extrapulmonary tuberculosis.Age,site of infection,bacteriological findings and outcomes were analyzed.Results:Out of 437 tuberculosis cases recorded from 2002-2006,59 cases had culture positive extrapulmonary tuberculosis.Their mean age was 37 years and 44%were between the ages of 20-40 years.About 63%were negative for acid-fast bacilli by Z-N stain.Of the 59,97%was Mycobacterium tuberculosisc(M.tuberculosis) while two(3%) were atypical Mycobacterium Runyon Group-Ⅳ.Only 3 (5%) were isoniazid resistant.Extrapulmonary sites involved were lymph nodes 19(31%),central nervous system 12(20%),pleural 11(19%) spine 8(14%).,renal 3(5.1%) and others 6(10.2%).In this series, 11(18%) were positive for HIV.There was no significant association between extrapulmonary tuberculosis and HIV status.The outcome of CNS tuberculosis was the poorest with a mortality rate of 25%.Conclusion: M.tuberculosis is the predominant organism in extrapulmonary tuberculosis and culture is the most effective method for its diagnosis.
