AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM pat...AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P【0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P【0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P【0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P【0.05)and Imp2.R/Hhigher(53% vs 28%,P【0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P【0.05)and Imp2-R/H higher(47% vs 13%,P【0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P【0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics.展开更多
OBJECTIVE To conduct meta-regression for the identification of clinically meaningful characteristics that can predict successful treatment of intracranial aneurysms(IAs)with the Pipeline Embolization Device(PED).METHO...OBJECTIVE To conduct meta-regression for the identification of clinically meaningful characteristics that can predict successful treatment of intracranial aneurysms(IAs)with the Pipeline Embolization Device(PED).METHODS Using the keyword"Pipeline Embolization Device"and pre-specified eligibility criteria,we searched PubM ed and EMBASE and identified 105 original research articles(10,813 patients)published or in press(April 6,2011-December 31,2016)focused on safety and/or effectiveness of PED.We constructed meta-regression models to identify predictors of three measures of PED treatment success,specifically rates of aneurysm occlusion,modified Rankin score(mRS)and death.Rates were loge-transformed and the adjusted R2 statistic was reported for each model.RESULTS Aneurysm morphology and type accounted for substantial variation in 1-year aneurysm occlusion rate(14 studies with 689 patients;Radj2=88.91%).By contrast,predictors of 6-months aneurysm occlusion rate(aneurysm location,aneurysm type)(24 studies with 1,321 patients;Radj2=31.67%)and aneurysm occlusion rate at unspecified follow-up time(year of publication,mean duration of angiographic follow-up)(34 studies with 1,663 patients,Radj2=42.82%)accounted for less variability.Few predictors were identified for death rate(number of patients,aneurysm morphology;34 studies with 6,463 patients,Radj2=50.69%)or mRS≤2(year of publication,mean age,aneurysm morphology;14 studies with 556 patients,Radj2=100%).CONCLUSIONS:Few clinically meaningful characteristics appear to be relevant as predictors of the selected measures of PED treatment success.Future studies should attempt to identify additional predictors while focusing on aneurysm morphology as a key predictor of PED outcomes.展开更多
Background Previous studies have demonstrated that acupuncture could modulate various brain systems in the resting brain networks. Graph theoretical analysis offers a novel way to investigate the functional organizati...Background Previous studies have demonstrated that acupuncture could modulate various brain systems in the resting brain networks. Graph theoretical analysis offers a novel way to investigate the functional organization of the large-scale cortical networks modulated by acupuncture at whole brain level. In this study, we used wavelets correlation analysis to estimate the pairwise correlations between 90 cortical and subcortical human brain regions in normal human volunteers scanned during the post-stimulus resting state. Methods Thirty-two college students, all right-handed and acupuncture na＇fve, participated in this study. Every participant received only one acupoint stimulation, resulting in 16 subjects in one group. Both structural functional magnetic resonance imaging （fMRI） data （3D sequence with a voxel size of 1 mm3 for anatomical localization） and functional fMRI data （TR=1500 ms, TE=30 ms, flip angle=90°） were collected for each subject. After thresholding the resulting scale-specific wavelet correlation matrices to generate undirected binary graphs, we compared graph metrics of brain organization following verum manual acupuncture （ACU） and sham acupuncture （SHAM） groups. Results The topological parameters of the large-scale brain networks in ACU group were different from those of the SHAM group at multiple scales. There existed distinct modularity functional brain networks during the post-stimulus resting state following ACU and SHAM at multiple scales. Conclusions The distinct modulation patterns of the resting brain attributed to the specific effects evoked by acupuncture. In addition, we also identified that there existed frequency-specific modulation in the post-stimulus resting brain following ACU and SHAM. The modulation may be related to the effects of verum acupuncture on modulating special disorder treatment. This preliminary finding may provide a new clue to understand the relatively function- oriented specificity of acupuncture effects.展开更多
文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P【0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P【0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P【0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P【0.05)and Imp2.R/Hhigher(53% vs 28%,P【0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P【0.05)and Imp2-R/H higher(47% vs 13%,P【0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P【0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics.
文摘OBJECTIVE To conduct meta-regression for the identification of clinically meaningful characteristics that can predict successful treatment of intracranial aneurysms(IAs)with the Pipeline Embolization Device(PED).METHODS Using the keyword"Pipeline Embolization Device"and pre-specified eligibility criteria,we searched PubM ed and EMBASE and identified 105 original research articles(10,813 patients)published or in press(April 6,2011-December 31,2016)focused on safety and/or effectiveness of PED.We constructed meta-regression models to identify predictors of three measures of PED treatment success,specifically rates of aneurysm occlusion,modified Rankin score(mRS)and death.Rates were loge-transformed and the adjusted R2 statistic was reported for each model.RESULTS Aneurysm morphology and type accounted for substantial variation in 1-year aneurysm occlusion rate(14 studies with 689 patients;Radj2=88.91%).By contrast,predictors of 6-months aneurysm occlusion rate(aneurysm location,aneurysm type)(24 studies with 1,321 patients;Radj2=31.67%)and aneurysm occlusion rate at unspecified follow-up time(year of publication,mean duration of angiographic follow-up)(34 studies with 1,663 patients,Radj2=42.82%)accounted for less variability.Few predictors were identified for death rate(number of patients,aneurysm morphology;34 studies with 6,463 patients,Radj2=50.69%)or mRS≤2(year of publication,mean age,aneurysm morphology;14 studies with 556 patients,Radj2=100%).CONCLUSIONS:Few clinically meaningful characteristics appear to be relevant as predictors of the selected measures of PED treatment success.Future studies should attempt to identify additional predictors while focusing on aneurysm morphology as a key predictor of PED outcomes.
基金This work was supported by the National Key Basic Research and Development Program ＂973＂ Project （No. 2007CB512503）, the National Natural Science Foundation of China （No. 81071217）, Fundamental Research Funds for the Central University, Beijing Nova Program （No. Zl11101054511116）, and Beijing Natural Science Foundation （No. 4122082）.
文摘Background Previous studies have demonstrated that acupuncture could modulate various brain systems in the resting brain networks. Graph theoretical analysis offers a novel way to investigate the functional organization of the large-scale cortical networks modulated by acupuncture at whole brain level. In this study, we used wavelets correlation analysis to estimate the pairwise correlations between 90 cortical and subcortical human brain regions in normal human volunteers scanned during the post-stimulus resting state. Methods Thirty-two college students, all right-handed and acupuncture na＇fve, participated in this study. Every participant received only one acupoint stimulation, resulting in 16 subjects in one group. Both structural functional magnetic resonance imaging （fMRI） data （3D sequence with a voxel size of 1 mm3 for anatomical localization） and functional fMRI data （TR=1500 ms, TE=30 ms, flip angle=90°） were collected for each subject. After thresholding the resulting scale-specific wavelet correlation matrices to generate undirected binary graphs, we compared graph metrics of brain organization following verum manual acupuncture （ACU） and sham acupuncture （SHAM） groups. Results The topological parameters of the large-scale brain networks in ACU group were different from those of the SHAM group at multiple scales. There existed distinct modularity functional brain networks during the post-stimulus resting state following ACU and SHAM at multiple scales. Conclusions The distinct modulation patterns of the resting brain attributed to the specific effects evoked by acupuncture. In addition, we also identified that there existed frequency-specific modulation in the post-stimulus resting brain following ACU and SHAM. The modulation may be related to the effects of verum acupuncture on modulating special disorder treatment. This preliminary finding may provide a new clue to understand the relatively function- oriented specificity of acupuncture effects.
