To investigate the relationship between food insecurity(FI)and overweight/obesity(OW/OB)or corresponding chronic diseases in adolescents,33 studies with 181135 individuals were included in this meta-analysis.Six studi...To investigate the relationship between food insecurity(FI)and overweight/obesity(OW/OB)or corresponding chronic diseases in adolescents,33 studies with 181135 individuals were included in this meta-analysis.Six studies and 10 studies,reported a higher risk of overweight and obesity in adolescents experiencing FI,respectively(OR 1.38,95%CI 1.20‒1.58,P<0.0001;OR 1.11,95%CI 1.01‒1.22,P=0.035,respectively).Based on the pooled results,adolescents with severe FI had the highest risk of OW/OB(OR 1.45,95%CI 1.20‒1.75,P<0.0001).The pooled OR indicated no signifi cant association between FI and OW/OB,when the adolescents were stratifi ed into those under 6 years old and those between 6 and 18 years old.Eleven studies assessed the relationship between FI and the risk of chronic diseases.The anemia subgroup was significantly associated with FI(OR 1.67,95%CI 1.30‒2.13,P<0.0001).Severe FI was reported to increase the risk of hypertension(OR 1.59,95%CI 1.28‒1.98,P<0.0001).Furthermore,a pooled analysis revealed a signifi cant association between FI and the risk of chronic diseases in both 6 and 6-18-year-old subgroups.展开更多
Taking construction of the online and offline integrated first-class undergraduate curriculum teaching modes of Histology and Embryology in Guangxi as an opportunity,under the guidance of student-centered teaching con...Taking construction of the online and offline integrated first-class undergraduate curriculum teaching modes of Histology and Embryology in Guangxi as an opportunity,under the guidance of student-centered teaching concept,efforts were made to innovate online and offline integrated teaching mode to overcome the shortcomings and dilemma of traditional Histology and Embryology teaching,with attention paid to the competence education in students including schematic knowledge,professional techniques,analytical thinking,and ideological and political theories,which would be of great significance for the cultivation of high-quality professionals specialized in traditional Chinese medicine.展开更多
Polycystic ovary syndrome(PCOS)is a reproductive endocrine disease characterized by ovulation disorder,hyperandrogenism and/or polycystic ovary.Follicular development disorder caused by PCOS accounts for up to 75%of a...Polycystic ovary syndrome(PCOS)is a reproductive endocrine disease characterized by ovulation disorder,hyperandrogenism and/or polycystic ovary.Follicular development disorder caused by PCOS accounts for up to 75%of anovulatory infertility,which is a common cause of infertility and affects up to 15%of reproductive aged women worldwide.Oxidative stress,chronic inflammation,endoplasmic reticulum stress and other pathological conditions coexist in the ovarian microenvironment of PCOS,which are further aggravated under the action of high levels of androgens,synergistically deteriorating the follicular microenvironment,leading to ovulation disorders in PCOS patients.This paper briefly reviewed the research on the mechanism of PCOS ovulation disorder in recent years.展开更多
The molten salt leakage accident is an important issue in the nuclear safety analysis of molten salt reactors.While the molten salt leaks from the pipeline or storage tank,it will contact the insulation layer outside;...The molten salt leakage accident is an important issue in the nuclear safety analysis of molten salt reactors.While the molten salt leaks from the pipeline or storage tank,it will contact the insulation layer outside;hence,the processes of penetration and spreading play an important role in the development of leakage accidents.In this study,the penetration and diffusion of leaking molten salt(LMS)in an aluminum silicate fiber(ASF)thermal insulation layer were studied experimentally.A molten salt tank with an adjustable outlet was designed to simulate the leakage of molten salt,and the subsequent behavior in the thermal insulation layer was evaluated by measuring the penetra-tion time and penetration mass of the LMS.The results show that when the molten salt discharges from the outlet and reaches the thermal insulation layer,the LMS will penetrate and seep out from the ASF,and a higher flow rate of LMS requires less penetration time and leaked mass of LMS.As the temperature of the LMS and thickness of the ASF increased,the penetration time became longer and the leaked mass became greater at a lower LMS flow rate;when the LMS flow rate increased,the penetration time and leaked mass decreased rapidly and tended to flatten.展开更多
Carbonic composite materials and ceramics appear to be excellent structural materials for parts subjected to very high temperatures in molten salt reactors(MSRs), in which the reactor core outlet temperature is normal...Carbonic composite materials and ceramics appear to be excellent structural materials for parts subjected to very high temperatures in molten salt reactors(MSRs), in which the reactor core outlet temperature is normally above 700℃. Because of the high temperature,there are major challenges in the sealing of flanged connections for tubes made of alloys and nonmetallic materials. In this study, an improved method for sealing bolted flange connections for tubes made of dissimilar materials at high temperature is analyzed. The study focuses on the compensation mechanism for the difference in thermal expansion between the bolts and the flanges. An angle is introduced for the sealing surface in the flanged connection to provide effective sealing. The arctangent of the angle is the ratio of the thickness between the theoretical core of the sealing surface and the outside end face of the flange to the distances between the axis of the flanged joint and the theoretical core of the sealing surface of the flange; the sealing surface of the flange, which is made of the same material as the fastening assemblies, faces the fastening assemblies. To ensure effective sealing, the frictional coefficient between the two sealing surfaces should not exceed the tangent of the angle. This result does not agree well with the solution given by previous researchers. Further, in the modified flanged connection, the compression of each bolt in the clamped condition is increased to maintain the compaction force unchanged without increasing the number of bolts on the flanged joint.展开更多
Previous studies showed that acetyl-11-keto-beta-boswellic acid(AKBA),the active ingredient in the natural Chinese medicine Boswellia,can stimulate sciatic nerve injury repair via promoting Schwann cell proliferation....Previous studies showed that acetyl-11-keto-beta-boswellic acid(AKBA),the active ingredient in the natural Chinese medicine Boswellia,can stimulate sciatic nerve injury repair via promoting Schwann cell proliferation.However,the underlying molecular mechanism remains poorly understood.In this study,we performed genomic sequencing in a rat model of sciatic nerve crush injury after gastric AKBA administration for 30 days.We found that the phagosome pathway was related to AKBA treatment,and brain-derived neurotrophic factor expression in the neurotrophic factor signaling pathway was also highly up-regulated.We further investigated gene and protein expression changes in the phagosome pathway and neurotrophic factor signaling pathway.Myeloperoxidase expression in the phagosome pathway was markedly decreased,and brain-derived neurotrophic factor,nerve growth factor,and nerve growth factor receptor expression levels in the neurotrophic factor signaling pathway were greatly increased.Additionally,expression levels of the inflammatory factors CD68,interleukin-1β,pro-interleukin-1β,and tumor necrosis factor-αwere also decreased.Myelin basic protein-andβ3-tubulin-positive expression as well as the axon diameter-to-total nerve diameter ratio in the injured sciatic nerve were also increased.These findings suggest that,at the molecular level,AKBA can increase neurotrophic factor expression through inhibiting myeloperoxidase expression and reducing inflammatory reactions,which could promote myelin sheath and axon regeneration in the injured sciatic nerve.展开更多
A proton therapy(PT)facility with multiple treatment rooms based on the superconducting cyclotron scheme is under development at Huazhong University of Science and Technology(HUST).This paper attempts to describe the ...A proton therapy(PT)facility with multiple treatment rooms based on the superconducting cyclotron scheme is under development at Huazhong University of Science and Technology(HUST).This paper attempts to describe the design considerations and implementation of the PT beamline from a systematic viewpoint.Design considerations covering beam optics and the influence of high-order aberrations,beam energy/intensity modulation,and beam orbit correction are described.In addition to the technical implementation of the main beamline components and subsystems,including the energy degrader,fast kicker,beamline magnets,beam diagnostic system,and beamline control system are introduced.展开更多
Underground caverns have important military and civilian uses, but their internal natural radiation may endanger human health, and it is necessary to implement protection. The protective measures taken for an undergro...Underground caverns have important military and civilian uses, but their internal natural radiation may endanger human health, and it is necessary to implement protection. The protective measures taken for an underground cavern in Chongqing have obvious effects. The results show that cleaning the radiation source in the environment and sealing the gap of the hole can re-duce the natural radiation intensity inside the cavern to a certain extent, reducing the ambient temperature can significantly reduce the natural radiation intensity inside the cavern, the use of press-in ventilation can greatly reduce the natural radiation intensity inside the cavern, the cumulative drop can reach 25.63%, and the protective effect is obvious. These protective measures can be used in underground caverns to improve the safety of military and civilian activities.展开更多
Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolat...Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF.展开更多
文摘To investigate the relationship between food insecurity(FI)and overweight/obesity(OW/OB)or corresponding chronic diseases in adolescents,33 studies with 181135 individuals were included in this meta-analysis.Six studies and 10 studies,reported a higher risk of overweight and obesity in adolescents experiencing FI,respectively(OR 1.38,95%CI 1.20‒1.58,P<0.0001;OR 1.11,95%CI 1.01‒1.22,P=0.035,respectively).Based on the pooled results,adolescents with severe FI had the highest risk of OW/OB(OR 1.45,95%CI 1.20‒1.75,P<0.0001).The pooled OR indicated no signifi cant association between FI and OW/OB,when the adolescents were stratifi ed into those under 6 years old and those between 6 and 18 years old.Eleven studies assessed the relationship between FI and the risk of chronic diseases.The anemia subgroup was significantly associated with FI(OR 1.67,95%CI 1.30‒2.13,P<0.0001).Severe FI was reported to increase the risk of hypertension(OR 1.59,95%CI 1.28‒1.98,P<0.0001).Furthermore,a pooled analysis revealed a signifi cant association between FI and the risk of chronic diseases in both 6 and 6-18-year-old subgroups.
基金Supported by the Project for Undergraduate Education and Teaching Reform and Research at the District Level of Guangxi (2020JGB233)the Key Project for Undergraduate Education and Teaching Reform and Research of Guangxi University of Chinese Medicine (2018B07)。
文摘Taking construction of the online and offline integrated first-class undergraduate curriculum teaching modes of Histology and Embryology in Guangxi as an opportunity,under the guidance of student-centered teaching concept,efforts were made to innovate online and offline integrated teaching mode to overcome the shortcomings and dilemma of traditional Histology and Embryology teaching,with attention paid to the competence education in students including schematic knowledge,professional techniques,analytical thinking,and ideological and political theories,which would be of great significance for the cultivation of high-quality professionals specialized in traditional Chinese medicine.
基金Supported by Guangxi Natural Science Foundation (2020GXNSFAA238022)National Natural Sciences Foundation of China (82060280)+1 种基金Doctoral Research Start-up Fund of Guangxi University of Chinese Medicine (2017BS011)Science and Technology Plan Project of Guangxi University of Chinese Medicine (2018ZD003).
文摘Polycystic ovary syndrome(PCOS)is a reproductive endocrine disease characterized by ovulation disorder,hyperandrogenism and/or polycystic ovary.Follicular development disorder caused by PCOS accounts for up to 75%of anovulatory infertility,which is a common cause of infertility and affects up to 15%of reproductive aged women worldwide.Oxidative stress,chronic inflammation,endoplasmic reticulum stress and other pathological conditions coexist in the ovarian microenvironment of PCOS,which are further aggravated under the action of high levels of androgens,synergistically deteriorating the follicular microenvironment,leading to ovulation disorders in PCOS patients.This paper briefly reviewed the research on the mechanism of PCOS ovulation disorder in recent years.
基金supported by the“Strategic Priority Research Program”of the Chinese Academy of Sciences(No.XDA0201002)the Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.2018301).
文摘The molten salt leakage accident is an important issue in the nuclear safety analysis of molten salt reactors.While the molten salt leaks from the pipeline or storage tank,it will contact the insulation layer outside;hence,the processes of penetration and spreading play an important role in the development of leakage accidents.In this study,the penetration and diffusion of leaking molten salt(LMS)in an aluminum silicate fiber(ASF)thermal insulation layer were studied experimentally.A molten salt tank with an adjustable outlet was designed to simulate the leakage of molten salt,and the subsequent behavior in the thermal insulation layer was evaluated by measuring the penetra-tion time and penetration mass of the LMS.The results show that when the molten salt discharges from the outlet and reaches the thermal insulation layer,the LMS will penetrate and seep out from the ASF,and a higher flow rate of LMS requires less penetration time and leaked mass of LMS.As the temperature of the LMS and thickness of the ASF increased,the penetration time became longer and the leaked mass became greater at a lower LMS flow rate;when the LMS flow rate increased,the penetration time and leaked mass decreased rapidly and tended to flatten.
基金supported by the Chinese TMSR Strategic Pioneer Science and Technology Project(No.XDA02010000)the Frontier Science Key Program of Chinese Academy of Sciences(No.QYZDY-SSW-JSC016)
文摘Carbonic composite materials and ceramics appear to be excellent structural materials for parts subjected to very high temperatures in molten salt reactors(MSRs), in which the reactor core outlet temperature is normally above 700℃. Because of the high temperature,there are major challenges in the sealing of flanged connections for tubes made of alloys and nonmetallic materials. In this study, an improved method for sealing bolted flange connections for tubes made of dissimilar materials at high temperature is analyzed. The study focuses on the compensation mechanism for the difference in thermal expansion between the bolts and the flanges. An angle is introduced for the sealing surface in the flanged connection to provide effective sealing. The arctangent of the angle is the ratio of the thickness between the theoretical core of the sealing surface and the outside end face of the flange to the distances between the axis of the flanged joint and the theoretical core of the sealing surface of the flange; the sealing surface of the flange, which is made of the same material as the fastening assemblies, faces the fastening assemblies. To ensure effective sealing, the frictional coefficient between the two sealing surfaces should not exceed the tangent of the angle. This result does not agree well with the solution given by previous researchers. Further, in the modified flanged connection, the compression of each bolt in the clamped condition is increased to maintain the compaction force unchanged without increasing the number of bolts on the flanged joint.
基金supported by the National Natural Science Foundation of China, No.31972725(to WHY)
文摘Previous studies showed that acetyl-11-keto-beta-boswellic acid(AKBA),the active ingredient in the natural Chinese medicine Boswellia,can stimulate sciatic nerve injury repair via promoting Schwann cell proliferation.However,the underlying molecular mechanism remains poorly understood.In this study,we performed genomic sequencing in a rat model of sciatic nerve crush injury after gastric AKBA administration for 30 days.We found that the phagosome pathway was related to AKBA treatment,and brain-derived neurotrophic factor expression in the neurotrophic factor signaling pathway was also highly up-regulated.We further investigated gene and protein expression changes in the phagosome pathway and neurotrophic factor signaling pathway.Myeloperoxidase expression in the phagosome pathway was markedly decreased,and brain-derived neurotrophic factor,nerve growth factor,and nerve growth factor receptor expression levels in the neurotrophic factor signaling pathway were greatly increased.Additionally,expression levels of the inflammatory factors CD68,interleukin-1β,pro-interleukin-1β,and tumor necrosis factor-αwere also decreased.Myelin basic protein-andβ3-tubulin-positive expression as well as the axon diameter-to-total nerve diameter ratio in the injured sciatic nerve were also increased.These findings suggest that,at the molecular level,AKBA can increase neurotrophic factor expression through inhibiting myeloperoxidase expression and reducing inflammatory reactions,which could promote myelin sheath and axon regeneration in the injured sciatic nerve.
基金the National Key Research and Development Program of China(No.2016YFC0105305)the National Natural Science Foundation of China(11975107)the Program for HUST Academic Frontier Youth Team.
文摘A proton therapy(PT)facility with multiple treatment rooms based on the superconducting cyclotron scheme is under development at Huazhong University of Science and Technology(HUST).This paper attempts to describe the design considerations and implementation of the PT beamline from a systematic viewpoint.Design considerations covering beam optics and the influence of high-order aberrations,beam energy/intensity modulation,and beam orbit correction are described.In addition to the technical implementation of the main beamline components and subsystems,including the energy degrader,fast kicker,beamline magnets,beam diagnostic system,and beamline control system are introduced.
文摘Underground caverns have important military and civilian uses, but their internal natural radiation may endanger human health, and it is necessary to implement protection. The protective measures taken for an underground cavern in Chongqing have obvious effects. The results show that cleaning the radiation source in the environment and sealing the gap of the hole can re-duce the natural radiation intensity inside the cavern to a certain extent, reducing the ambient temperature can significantly reduce the natural radiation intensity inside the cavern, the use of press-in ventilation can greatly reduce the natural radiation intensity inside the cavern, the cumulative drop can reach 25.63%, and the protective effect is obvious. These protective measures can be used in underground caverns to improve the safety of military and civilian activities.
基金This work was supported by grants from the National Natural Science Foundation of China(NSFC31871378 and 31671460 to X.Y.and 81760509 to X.X.)the Natural Science Foundation of Jiangxi Provinee of China(20171ACB21004 to X.Y.and 20181BAB205043 to X.X.).
文摘Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF.
