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Control strategy optimization using dynamic programming method for synergic electric system on hybrid electric vehicle
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作者 Yuan-Bin Yu Qing-Nian Wang +2 位作者 Hai-Tao Min Peng-Yu Wang chun-guang hao 《Natural Science》 2009年第3期222-228,共7页
Dynamic Programming (DP) algorithm is used to find the optimal trajectories under Beijing cycle for the power management of synergic electric system (SES) which is composed of battery and super capacitor. Feasible rul... Dynamic Programming (DP) algorithm is used to find the optimal trajectories under Beijing cycle for the power management of synergic electric system (SES) which is composed of battery and super capacitor. Feasible rules are derived from analyzing the optimal trajectories, and it has the highest contribution to Hybrid Electric Vehicle (HEV). The methods of how to get the best performance is also educed. Using the new Rule-based power management strat-egy adopted from the optimal results, it is easy to demonstrate the effectiveness of the new strategy in further improvement of the fuel economy by the synergic hybrid system. 展开更多
关键词 DYNAMIC PROGRAMMING Control STRATEGY Optimization Synergic ELECTRIC System HEV
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Study on the mechanism of microporous sheep ADM combined with hUCMSC in promoting wound healing
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作者 Xiao-yan Yang chun-guang hao +2 位作者 Jun-liang Li Xue Fu Ling-feng Wang 《Discussion of Clinical Cases》 2021年第3期15-21,共7页
Objective:To explore the therapeutic mechanism of microporous sheep acellular dermal matrix(ADM)combined with human umbilical cord mesenchymal stem cell(hUCMSC)to promote the healing of full-thickness skin defect.Meth... Objective:To explore the therapeutic mechanism of microporous sheep acellular dermal matrix(ADM)combined with human umbilical cord mesenchymal stem cell(hUCMSC)to promote the healing of full-thickness skin defect.Methods:hUCMSC was co-cultured on microporous sheep ADM to form composite biological dressings.Seventy-two nude mice were selected to make full-thickness skin injury models and randomly divided into 3 groups(hUCMSC+microporous sheep ADM group,sheep ADM group and iodophor gauze group),with 24 mice in each group.The wound healing rate of each group was detected at 14 d,21 d and 28 d after operation,qRT-PCR technique was used to detect the expression of Bax and Bcl-2 in the wound tissues,and the immunohistochemical staining technique was used to detect the expression of Collagen I and vascular endothelial growth factor(VEGF).Data were analyzed with one-way ANOVA and t test.Results:At 14 d after operation,the wound healing rate of the hUCMSC+microporous sheep ADM group was(65.34±14.72)%,which was significantly higher than that of the iodophor gauze group[(37.54±10.21)%],and higher than that of the sheep ADM group[(49.08±11.16)%],the differences were statistically significant(t=19.52,14.72;p<.05).With the gradual healing of the wound,at 28 d after operation,the wound healing rate of the hUCMSC+microporous sheep ADM group was(98.63±15.41)%,which was significantly higher than that of the iodophor gauze group[(81.74±16.27)%],and higher than that of the sheep ADM group[(63.47±14.80)%],the differences were statistically significant(t=-16.42,20.35;p<.05).The expression of Bax in the wound tissues of the hUCMSC+microporous sheep ADM group was significantly reduced,especially at 21 d after operation,the expression level was 0.25±0.06,which was significantly lower than the iodophor gauze group(0.53±0.16)and the sheep ADM group(0.41±0.12),the differences were statistically significant(t=3.52,-2.83;p<.05).The expression of Bcl-2 in the wound tissues of the hUCMSC+microporous sheep ADM group was significantly higher than those of the other two groups,especially at 21 d after operation,the expression level was 0.63±0.19,which was significantly higher than the iodophor gauze group(0.34±0.09)and the sheep ADM group(0.46±0.13),the differences were statistically significant(t=5.31,-6.07;p<.05).Immunohistochemical detection showed that the expression of Collagen I and VEGF in the hUCMSC+microporous sheep ADM group was slightly more than that of the sheep ADM group and the iodophor gauze group,but the effect was not remarkable.Conclusions:hUCMSC+microporous sheep ADM composite dressing can promote the healing of the full-thickness skin injury and reduce the production of apoptotic cells by carrying hUCMSC. 展开更多
关键词 MICE Wounds and injuries Mesenchymal stem cells Microporation Sheep acellular dermal matrix Wound healing
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