DEAR EDITOR,Understanding the different immune responses of wild and domestic caprid species is critical for addressing certain zoonotic diseases.In this study,we generated blood transcriptomes of 13 Siberian ibex and...DEAR EDITOR,Understanding the different immune responses of wild and domestic caprid species is critical for addressing certain zoonotic diseases.In this study,we generated blood transcriptomes of 13 Siberian ibex and domestic goat hybrids and performed allele-specific expression and splicing analyses.Results showed that genes exhibiting significant imbalance between the ibex and goat were highly related to the Toll-like receptor(TLR),antigen recognition,and immune activation pathways.Comparative genomic analysis of the species revealed that immune function-related genes were under strong selection pressure in the domestic goat.展开更多
基金supported by the National Natural Science Foundation of China(32002140,32050410304)China Agriculture Research System of MOF and MARA(CARS-39-21)+3 种基金Natural Science Basic Research Program of Shaanxi(2021JCW-11)Natural Science Basic Research Program of Xinjiang(2022 XJRMY-01)Special Fund for Animal Husbandry of Shaanxi(K3030821073)China Postdoctoral Science Foundation(2020M682446)。
文摘DEAR EDITOR,Understanding the different immune responses of wild and domestic caprid species is critical for addressing certain zoonotic diseases.In this study,we generated blood transcriptomes of 13 Siberian ibex and domestic goat hybrids and performed allele-specific expression and splicing analyses.Results showed that genes exhibiting significant imbalance between the ibex and goat were highly related to the Toll-like receptor(TLR),antigen recognition,and immune activation pathways.Comparative genomic analysis of the species revealed that immune function-related genes were under strong selection pressure in the domestic goat.
