Correction to:Signal Transduction and Targeted Therapy https:/l doi.org/10.1038/s41392-022-00948-6,publishedonline18 April2022 In the process of collating the raw data,the authors noticed an inadvertent error occurred...Correction to:Signal Transduction and Targeted Therapy https:/l doi.org/10.1038/s41392-022-00948-6,publishedonline18 April2022 In the process of collating the raw data,the authors noticed an inadvertent error occurred in Supplementary Fig.5d that needs to be corrected after online publication of the article 1.展开更多
We systematically investigated the catalytic performance of 3d,4d,and 5d transition metals anchored onto two-dimensional extended porphyrin(PP)substrates as nitrogen reduction reaction(NRR)electrocatalysts,employing d...We systematically investigated the catalytic performance of 3d,4d,and 5d transition metals anchored onto two-dimensional extended porphyrin(PP)substrates as nitrogen reduction reaction(NRR)electrocatalysts,employing density functional theory(DFT)calculations and four-step high-throughput screening.Four novel metalloporphyrin(MPP,M=Zr,Nb,Hf,and Re)single-atom catalyst candidates have been identified due to their excellent catalytic performance(low onset potential,high stability,and selectivity).Through comprehensive reaction path search,the maximum Gibbs free energy changes for NRR on the ZrPP(enzymatic-consecutive hybrid path),NbPP(consecutive path),HfPP(enzymatic-consecutive hybrid path),and RePP(distal path)catalysts are 0.38,0.41,0.53,and 0.53 eV,respectively.Band structures,projected density of states,and charge/spin distributions show that the high catalytic activity is due to significant orbital hybridizations and charge transfer between N_(2) and MPP catalysts.We hope our work will promote experimental synthesis of these NRR electrocatalysts and provide new opportunities to the electrochemical conversion of N_(2) to NH_(3) under ambient conditions.展开更多
B cells secreting IL-10 functionally are recognized as functional regulatory B(B_(reg))cells;however,direct evidence concerning the phenotype,regulation,and functional and clinical relevance of IL-10-secreting B_(reg)...B cells secreting IL-10 functionally are recognized as functional regulatory B(B_(reg))cells;however,direct evidence concerning the phenotype,regulation,and functional and clinical relevance of IL-10-secreting B_(reg)cells in humans is still lacking.Here,we demonstrate that,although IL-10 itself is anti-inflammatory,IL-10+functional B_(reg)cells in patients with systemic lupus erythematosus(SLE)display aggressive inflammatory features;these features shift their functions away from inducing CD8^(+)T cell tolerance and cause them to induce a pathogenic CD4^(+)T cell response.展开更多
文摘Correction to:Signal Transduction and Targeted Therapy https:/l doi.org/10.1038/s41392-022-00948-6,publishedonline18 April2022 In the process of collating the raw data,the authors noticed an inadvertent error occurred in Supplementary Fig.5d that needs to be corrected after online publication of the article 1.
基金C.-X.H.,S.-Y.L.,C.L.,and L.-M.Y.gratefully acknowledge support from the National Natural Science Foundation of China(Nos.22073033,21873032,21673087,and 21903032)the startup fund(Nos.2006013118 and 3004013105)from Huazhong University of Science and Technology,the Fundamental Research Funds for the Central Universities(No.2019kfyRCPY116)+1 种基金the Innovation and Talent Recruitment Base of New Energy Chemistry and Device(B21003)C.-X.H.,S.-Y.L.,and G.-L.L.gratefully acknowledge support from Guangdong Basic and Applied Basic Research Foundation(No.2021A1515010382).
文摘We systematically investigated the catalytic performance of 3d,4d,and 5d transition metals anchored onto two-dimensional extended porphyrin(PP)substrates as nitrogen reduction reaction(NRR)electrocatalysts,employing density functional theory(DFT)calculations and four-step high-throughput screening.Four novel metalloporphyrin(MPP,M=Zr,Nb,Hf,and Re)single-atom catalyst candidates have been identified due to their excellent catalytic performance(low onset potential,high stability,and selectivity).Through comprehensive reaction path search,the maximum Gibbs free energy changes for NRR on the ZrPP(enzymatic-consecutive hybrid path),NbPP(consecutive path),HfPP(enzymatic-consecutive hybrid path),and RePP(distal path)catalysts are 0.38,0.41,0.53,and 0.53 eV,respectively.Band structures,projected density of states,and charge/spin distributions show that the high catalytic activity is due to significant orbital hybridizations and charge transfer between N_(2) and MPP catalysts.We hope our work will promote experimental synthesis of these NRR electrocatalysts and provide new opportunities to the electrochemical conversion of N_(2) to NH_(3) under ambient conditions.
基金The study was supported by project grants from the National Natural Science Foundation of China(82071767,82025016,31830025,81901585,and 81802403)the Natural Science Foundation of Guangdong Province,China(2018B030308010 and 2019A1515011770).
文摘B cells secreting IL-10 functionally are recognized as functional regulatory B(B_(reg))cells;however,direct evidence concerning the phenotype,regulation,and functional and clinical relevance of IL-10-secreting B_(reg)cells in humans is still lacking.Here,we demonstrate that,although IL-10 itself is anti-inflammatory,IL-10+functional B_(reg)cells in patients with systemic lupus erythematosus(SLE)display aggressive inflammatory features;these features shift their functions away from inducing CD8^(+)T cell tolerance and cause them to induce a pathogenic CD4^(+)T cell response.