The antigen gene of ABO blood group system,called ABO,is located on human chromosome 9,with a total length of 19.5 kb.It is the first blood group system found by human beings.[1]ABO blood group subtypes are formed by ...The antigen gene of ABO blood group system,called ABO,is located on human chromosome 9,with a total length of 19.5 kb.It is the first blood group system found by human beings.[1]ABO blood group subtypes are formed by ABO genovariation,i.e.,gene A variation for A subtype,gene B variation for B subtype and gene O variation for new O alleles.ABO subtypes contain A3,Ax,Ael,Aw,Am,B3,Bx,Bel,Bw,cis-AB,B(A).Generally,an individual with AB blood group has an A allele on one chromosome,with B allele on its paired chromosome.This phenomenon is called trans-AB.However,cis-AB is a unique ABO phenotype that A and B alleles are located on the same chromosome,so that it can be inherited by the next generation.[2]This special mode of inheritance often causes a discrepancy of ABO blood grouping and then reduces the effectiveness and safety of blood transfusion.Therefore,to accurately identify the blood group of cis-AB is a precondition for the safety of blood transfusion.[3]The serological and genotyping analysis on a case of cis-AB patient in our hospital is reported as follows.展开更多
Hydroxyphosphoric acids display the unique biological activities,and they have some attractive prospects as clinical drug moleculars.Herein,a new approach for the synthesis ofγ-oxo-phosphonates(the precursor of hydro...Hydroxyphosphoric acids display the unique biological activities,and they have some attractive prospects as clinical drug moleculars.Herein,a new approach for the synthesis ofγ-oxo-phosphonates(the precursor of hydroxyphosphoric acid)has been established through the semipinacol rearrangement tactic involved the photo-induced phosphorus radical process.Most important,this transformation is avoid of the external oxidants,and occurs very well under the sunlight irradiation,meanwhile theγ-oxo-phosphonate was easily derivatized to obtainγ-hydroxyphosphoric acid,thus highlights the synthesis value of this method.展开更多
文摘The antigen gene of ABO blood group system,called ABO,is located on human chromosome 9,with a total length of 19.5 kb.It is the first blood group system found by human beings.[1]ABO blood group subtypes are formed by ABO genovariation,i.e.,gene A variation for A subtype,gene B variation for B subtype and gene O variation for new O alleles.ABO subtypes contain A3,Ax,Ael,Aw,Am,B3,Bx,Bel,Bw,cis-AB,B(A).Generally,an individual with AB blood group has an A allele on one chromosome,with B allele on its paired chromosome.This phenomenon is called trans-AB.However,cis-AB is a unique ABO phenotype that A and B alleles are located on the same chromosome,so that it can be inherited by the next generation.[2]This special mode of inheritance often causes a discrepancy of ABO blood grouping and then reduces the effectiveness and safety of blood transfusion.Therefore,to accurately identify the blood group of cis-AB is a precondition for the safety of blood transfusion.[3]The serological and genotyping analysis on a case of cis-AB patient in our hospital is reported as follows.
基金the National Natural Science Foundation of China(No.21532001)International Joint Research Centre for Green Catalysis and Synthesis,Gansu provincial Sci.&Tech.Department(No.2016B01017)for financial support。
文摘Hydroxyphosphoric acids display the unique biological activities,and they have some attractive prospects as clinical drug moleculars.Herein,a new approach for the synthesis ofγ-oxo-phosphonates(the precursor of hydroxyphosphoric acid)has been established through the semipinacol rearrangement tactic involved the photo-induced phosphorus radical process.Most important,this transformation is avoid of the external oxidants,and occurs very well under the sunlight irradiation,meanwhile theγ-oxo-phosphonate was easily derivatized to obtainγ-hydroxyphosphoric acid,thus highlights the synthesis value of this method.
